期刊
IMMUNOLOGICAL REVIEWS
卷 281, 期 1, 页码 62-73出版社
WILEY
DOI: 10.1111/imr.12613
关键词
cytokines; endotoxin shock; inflammation; inflammatory bowel disease; signaling proteins; toll-like receptors/pattern recognition receptors
类别
资金
- Japan Society for the Promotion of Science [26713005]
- Ministry of Education, Culture, Sports, Science and Technology [17H06415]
- Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology
- Grants-in-Aid for Scientific Research [17H06413] Funding Source: KAKEN
Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. Therefore, inflammasomes must be activated at a proper strength to protect against infection and avoid tissue damage. Recent studies have highlighted the cross-talk between inflammasome activation and autophagy, the cellular machinery associated with the degradation of intracellular components and maintenance of cellular homeostasis. Notably, deficiencies in autophagy-related proteins induce the aberrant activation of inflammasomes, causing severe tissue damage. In contrast, autophagy inducers ameliorate symptoms of inflammasome-related diseases. In this review, we discuss recent advances in the involvement of autophagy in regulating inflammasomes activation and in the development of inflammatory diseases.
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