Article
Immunology
Barbara Poniedzialek, Ewelina Hallmann, Dominika Sikora, Karol Szymanski, Katarzyna Kondratiuk, Jakub Zurawski, Piotr Rzymski, Lidia Brydak
Summary: Evidence suggests that vaccination against seasonal influenza can enhance innate immune responses to COVID-19 and reduce disease severity. This study aimed to compare humoral responses to SARS-CoV-2 in non-hospitalized, COVID-19 unvaccinated patients and mild COVID-19 convalescent patients who were and were not vaccinated against influenza. The results showed that influenza-vaccinated patients had higher levels of antibodies against nucleocapsid and receptor binding domain compared to non-vaccinated patients.
Article
Medicine, Research & Experimental
Rachel M. Gittelman, Enrico Lavezzo, Thomas M. Snyder, H. Jabran Zahid, Cara L. Carty, Rebecca Elyanow, Sudeb Dalai, Ilan Kirsch, Lance Baldo, Laura Manuto, Elisa Franchin, Claudia Del Vecchio, Monia Pacenti, Caterina Boldrin, Margherita Cattai, Francesca Saluzzo, Andrea Padoan, Mario Plebani, Fabio Simeoni, Jessica Bordini, Nicola Lore, Dejan Lazarevic, Daniela M. Cirillo, Paolo Ghia, Stefano Toppo, Jonathan M. Carlson, Harlan S. Robins, Andrea Crisanti, Giovanni Tonon
Summary: This study investigates the role of T cells in the immune response to SARS-CoV-2 infection, demonstrating their importance in both clinical presentation and long-term immunity. The findings show that T cells contribute to the production of neutralizing antibodies and remain detectable up to 15 months after infection.
Article
Immunology
Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E. Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki
Summary: Through single-cell TCR and RNA sequencing, researchers identified public cTfh clonotypes expanded in recovered COVID-19 patients, determined their epitopes in the conserved regions of spike protein, and found that these epitopes may be valuable candidates for booster antigens to enhance adaptive immunity against the virus.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Ecology
Rishi V. Shridharan, Neha Kalakuntla, Narendra Chirmule, Bhavana Tiwari
Summary: Nearly 50% of the human genome is derived from transposable elements, some of which can cause diseases when dysregulated, while others can generate new cellular functions. The adaptive immune system in jawed vertebrates is associated with Class II TEs, and the somatic rearrangement process in T and B cells is also influenced by TEs, laying the foundation for the generation of antibodies and receptors.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Immunology
Ya-Lin Lin, Mei-Yi Lu, Chi-Fen Chuang, Yali Kuo, Hong-En Lin, Fu-An Li, Jen-Ren Wang, Yi-Ping Hsueh, Fang Liao
Summary: The study found that TLR7 is not the absolute PRR for EV71 in the spinal cord, but plays a critical role in anti-viral humoral immunity. TLR7KO mice infected with EV71 showed delayed recovery from limb paralysis and significantly decreased levels of important antibodies for antiviral humoral immunity compared to WT mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jiaxin Zheng, Yingying Deng, Zhenyu Zhao, Binli Mao, Mengji Lu, Yong Lin, Ailong Huang
Summary: Understanding the dynamics and characteristics of virus-specific humoral immunity in SARS-CoV-2-infected patients is crucial for controlling the COVID-19 pandemic. Further research is needed to examine the correlations between antibody titers, especially neutralizing antibodies, and protection against SARS-CoV-2 reinfection. Children have been shown to have a more effective humoral immune response to SARS-CoV-2 infection compared to adults.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhuoyi Liang, Lijuan Zhao, Adam Yongxin Ye, Sherry G. Lin, Yiwen Zhang, Chunguang Guo, Hai-Qiang Dai, Zhaoqing Ba, Frederick W. Alt
Summary: Immunoglobulin heavy chain variable region exons are assembled in progenitor -B cells, with VH, D, and JH gene segments located in separate clusters. CTCF-binding elements (CBEs) in the IGCR1 element and 3' Igh-CBEs play a role in segregating different domains and impeding RAG scanning. Downregulation of WAPL in progenitor -B cells neutralizes CBEs and promotes VH-to-DJH rearrangements. The gradual WAPL downregulation mechanism and the reinforcement of CBEs contribute to ordered V(D)J recombination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biotechnology & Applied Microbiology
Yuan-Chin Hsieh, Jun-Min Liao, Kuo-Hsiang Chuang, Kai-Wen Ho, Shih-Ting Hong, Hui-Ju Liu, Bo-Cheng Huang, I-Ju Chen, Yen-Ling Liu, Jaw-Yuan Wang, Hsiang-Lin Tsai, Yu-Cheng Su, Yen-Tseng Wang, Tian-Lu Cheng
Summary: A computer simulation-based V(D)J recombination platform was developed to predict the binding affinity of humanized antibodies and successfully identify high-affinity antibodies. This platform can facilitate the development of humanized antibodies with low immunogenicity and high binding affinities.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Immunology
Justin H. M. Heltzel, Robert W. Maul, William Yang, Patricia J. Gearhart
Summary: This study demonstrates that the distance between the V region and J gene does not affect the extent of mutation. The majority of mutations occur within a 1 kb region downstream of the J gene, regardless of the specific J gene used. This suggests that mutations are targeted by AID interactions with RNA polymerase II.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Clea Melenotte, Pierre Pontarotti, Lucile Pinault, Jean-Louis Mege, Christian Devaux, Didier Raoult
Summary: Treatment with beta-lactam antibiotics can induce leukopenia, candidemia, and affect the immune function by inhibiting metallo-beta-lactamase proteins. This inhibition may lead to transient immunodeficiency in humans, as seen in SNM1C/Artemis mutations associated with severe combined immunodeficiency. Further research in this area could provide new therapeutic insights for oncology, immunology, and infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Roberta Rizzo, Daria Bortolotti, Luca Morandi, Sabrina Rizzo, Giovanna Schiuma, Silvia Beltrami, Alberto Papi, Marco Contoli
Summary: This study reports the relevance of serum antibody levels and the immune response to SARS-CoV-2 vaccines. The findings show that booster dose induces enhanced humoral and adaptive immune responses and early activation of memory CD8+ T subset.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biology
Waleed Mahallawi, Mohammad Alzahrani, Ziab Alahmadey
Summary: This study aimed to investigate the persistence of SARS-CoV-2 antibodies in recovered patients in Al Madinah region of Saudi Arabia. The findings provide evidence to support the use of an anti-S IgG ELISA as a diagnostic tool to indicate SARS-CoV-2 infection, with IgG seropositivity sustained in recovered patients up to a hundred days post-infection.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Stephanie C. Pero, Aaron M. Rosenfeld, Girja S. Shukla, Linda Mei, Yujing Sun, Wenzhao Meng, David J. Fournier, Seth P. Harlow, Matthew K. Robinson, David N. Krag, Eline T. Luning Prak, Benjamin C. Harman
Summary: This study analyzed B cell antibody repertoires in breast cancer patients and found overlapping B cell clones in the tumor and lymph nodes, with extensive somatic hypermutations. These findings suggest an evolving humoral immune response targeting the tumor and the possibility of monitoring B cell clones in the blood. Insights into the dynamics and specificity of B cell responses may lead to better understanding of anti-tumor immunity and personalized therapies.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Review
Immunology
Julien Subburayalu
Summary: T follicular helper cells are a specialized subset of T helper cells that can influence B cell responses in lymphoid tissues, leading to the production of protecting antibodies and humoral memory. In the context of kidney transplantation, however, T follicular helper cells can cause immune surveillance that can result in subclinical and clinical rejection episodes, posing a risk for allograft loss.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kin Israel Notarte, Jesus Alfonso Catahay, Princess Juneire Peligro, Jacqueline Veronica Velasco, Abbygail Therese Ver, Jonathan Jaime Guerrero, Jin Liu, Giuseppe Lippi, Stefanie W. Benoit, Brandon Michael Henry, Cesar Fernandez-de-las-Penas
Summary: This systematic review aimed to assess the humoral response of hemodialysis patients post-mRNA SARS-CoV-2 vaccination. A total of nine studies met the inclusion criteria, and the results showed that hemodialysis patients developed lower antibody levels compared to the control group. These findings imply the need for robust vaccination strategies to address waning immune responses in vulnerable populations.
Article
Cell Biology
Sandra C. A. Nielsen, Krishna M. Roskin, Katherine J. L. Jackson, Shilpa A. Joshi, Parastu Nejad, Ji-Yeun Lee, Lisa E. Wagar, Tho D. Pham, Ramona A. Hoh, Khoa D. Nguyen, Hannah Y. Tsunemoto, Sonal B. Patel, Robert Tibshirani, Catherine Ley, Mark M. Davis, Julie Parsonnet, Scott D. Boyd
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Carl W. Davis, Katherine J. L. Jackson, Anita K. McElroy, Peter Halfmann, Jessica Huang, Chakravarthy Chennareddy, Ashley E. Piper, Yvonne Leung, Cesar G. Albarino, Ian Crozier, Ali H. Ellebedy, John Sidney, Alessandro Sette, Tianwei Yu, Sandra C. A. Nielsen, Arthur J. Goff, Christina F. Spiropoulou, Erica Ollman Saphire, Guy Cavet, Yoshihiro Kawaoka, Aneesh K. Mehta, Pamela J. Glass, Scott D. Boyd, Rafi Ahmed
Article
Multidisciplinary Sciences
Mandeep Singh, Ghamdan Al-Eryani, Shaun Carswell, James M. Ferguson, James Blackburn, Kirston Barton, Daniel Roden, Fabio Luciani, Tri Giang Phan, Simon Junankar, Katherine Jackson, Christopher C. Goodnow, Martin A. Smith, Alexander Swarbrick
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Corey T. Watson, Justin T. Kos, William S. Gibson, Leah Newman, Gintaras Deikus, Christian E. Busse, Melissa L. Smith, Katherine J. L. Jackson, Andrew M. Collins
IMMUNOLOGY AND CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Mandeep Singh, Katherine J. L. Jackson, Jing J. Wang, Peter Schofield, Matt A. Field, David Koppstein, Timothy J. Peters, Deborah L. Burnett, Simone Rizzetto, Damien Nevoltris, Etienne Masle-Farquhar, Megan L. Faulks, Amanda Russell, Divya Gokal, Asami Hanioka, Keisuke Horikawa, Alexander D. Colella, Timothy K. Chataway, James Blackburn, Tim R. Mercer, David B. Langley, D. Margaret Goodall, Roy Jefferis, Muralikrishna Gangadharan Komala, Anthony D. Kelleher, Dan Suan, Maureen Rischmueller, Daniel Christ, Robert Brink, Fabio Luciani, Tom P. Gordon, Christopher C. Goodnow, Joanne H. Reed
Article
Immunology
Anthony Lau, Danielle T. Avery, Katherine Jackson, Helen Lenthall, Stefano Volpi, Henry Brigden, Amanda J. Russell, Julia Bier, Joanne H. Reed, Joanne M. Smart, Theresa Cole, Sharon Choo, Paul E. Gray, Lucinda J. Berglund, Peter Hsu, Melanie Wong, Michael O'Sullivan, Kaan Boztug, Isabelle Meyts, Gulbu Uzel, Luigi D. Notarangelo, Robert Brink, Christopher C. Goodnow, Stuart G. Tangye, Elissa K. Deenick
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Immunology
Krishna M. Roskin, Katherine J. L. Jackson, Ji-Yeun Lee, Ramona A. Hoh, Shilpa A. Joshi, Kwan-Ki Hwang, Mattia Bonsignori, Isabela Pedroza-Pacheco, Hua-Xin Liao, M. Anthony Moody, Andrew Z. Fire, Persephone Borrow, Barton F. Haynes, Scott D. Boyd
Article
Multidisciplinary Sciences
Ali H. Ellebedy, Raffael Nachbagauer, Katherine J. L. Jackson, Ya-Nan Dai, Julianna Han, Wafaa B. Alsoussi, Carl W. Davis, Daniel Stadlbauer, Nadine Rouphael, Veronika Chromikova, Megan McCausland, Cathy Y. Chang, Mario Cortese, Mary Bower, Chakravarthy Chennareddy, Aaron J. Schmitz, Veronika I. Zarnitsyna, Lilin Lai, Arvind Rajabhathor, Cheyann Kazemian, Rustom Antia, Mark J. Mulligan, Andrew B. Ward, Daved H. Fremont, Scott D. Boyd, Bali Pulendran, Florian Krammer, Rafi Ahmed
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Carl W. Davis, Katherine J. L. Jackson, Megan M. McCausland, Jaime Darce, Cathy Chang, Susanne L. Linderman, Chakravarthy Chennareddy, Rebecca Gerkin, Shantoria J. Brown, Jens Wrammert, Aneesh K. Mehta, Wan Cheung Cheung, Scott D. Boyd, Edmund K. Waller, Rafi Ahmed
Article
Microbiology
Sandra C. A. Nielsen, Fan Yang, Katherine J. L. Jackson, Ramona A. Hoh, Katharina Roltgen, Grace H. Jean, Bryan A. Stevens, Ji-Yeun Lee, Arjun Rustagi, Angela J. Rogers, Abigail E. Powell, Molly Hunter, Javaria Najeeb, Ana R. Otrelo-Cardoso, Kathryn E. Yost, Bence Daniel, Kari C. Nadeau, Howard Y. Chang, Ansuman T. Satpathy, Theodore S. Jardetzky, Peter S. Kim, Taia T. Wang, Benjamin A. Pinsky, Catherine A. Blish, Scott D. Boyd
CELL HOST & MICROBE
(2020)
Article
Cell Biology
Zhiguo Zhang, Christopher J. Jara, Mandeep Singh, Huji Xu, Christopher C. Goodnow, Katherine J. L. Jackson, Joanne H. Reed
Summary: The study found that mature naive B cells with lower IgM surface expression in peripheral blood exhibit more diverse IGH features, while B cells with higher surface IgM display more limited IGH repertoire characteristics.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Fan Yang, Sandra C. A. Nielsen, Ramona A. Hoh, Katharina Roltgen, Oliver Fabian Wirz, Emily Haraguchi, Grace H. Jean, Ji-Yeun Lee, Tho D. Pham, Katherine J. L. Jackson, Krishna M. Roskin, Yi Liu, Khoa Nguyen, Robert S. Ohgami, Eleanor M. Osborne, Kari C. Nadeau, Claus U. Niemann, Julie Parsonnet, Scott D. Boyd
Summary: The study found that B cell memory varies for different pathogens, with pediatric blood containing abundant class-switched clones and adult lymphoid tissues having more class-switched clones. Early childhood B cell clonal expansions and cross-reactivity play a significant role in future responses to novel pathogens.
Article
Immunology
Deborah L. Burnett, Katherine J. L. Jackson, David B. Langley, Anupria Aggrawal, Alberto Ospina Stella, Matt D. Johansen, Harikrishnan Balachandran, Helen Lenthall, Romain Rouet, Gregory Walker, Bernadette M. Saunders, Mandeep Singh, Hui Li, Jake Y. Henry, Jennifer Jackson, Alastair G. Stewart, Franka Witthauer, Matthew A. Spence, Nicole G. Hansbro, Colin Jackson, Peter Schofield, Claire Milthorpe, Marianne Martinello, Sebastian R. Schulz, Edith Roth, Anthony Kelleher, Sean Emery, Warwick J. Britton, William D. Rawlinson, Rudolfo Karl, Simon Schaefer, Thomas H. Winkler, Robert Brink, Rowena A. Bull, Philip M. Hansbro, Hans-Martin Jaeck, Stuart Turville, Daniel Christ, Christopher C. Goodnow
Summary: Viral mutations pose a challenge to the efficacy of COVID-19 vaccines, but research has shown that antibodies targeting conserved sites can generate effective neutralization.
Article
Immunology
Rui Yang, Danielle T. Avery, Katherine J. L. Jackson, Masato Ogishi, Ibtihal Benhsaien, Likun Du, Xiaofei Ye, Jing Han, Jeremie Rosain, Jessica N. Peel, Marie-Alexandra Alyanakian, Benedicte Neven, Sarah Winter, Anne Puel, Bertrand Boisson, Kathryn J. Payne, Melanie Wong, Amanda J. Russell, Yoko Mizoguchi, Satoshi Okada, Gulbu Uzel, Christopher C. Goodnow, Sylvain Latour, Jalila El Bakkouri, Aziz Bousfiha, Kahn Preece, Paul E. Gray, Baerbel Keller, Klaus Warnatz, Stephanie Boisson-Dupuis, Laurent Abel, Qiang Pan-Hammarstrom, Jacinta Bustamante, Cindy S. Ma, Jean-Laurent Casanova, Stuart G. Tangye
Summary: This study describes a patient with inherited T-bet deficiency who showed largely normal humoral immunity but exhibited skewed class switching and a specific subset of B cell development. T-bet was found to play an essential role in the development of a distinct subset of human B cells characterized by reduced expression of CD21 and high expression of CD19, CD20, CD11c, FCRL5, and T-bet.
SCIENCE IMMUNOLOGY
(2022)
Review
Immunology
Mats Ohlin, Cathrine Scheepers, Martin Corcoran, William D. Lees, Christian E. Busse, Davide Bagnara, Linnea Thornqvist, Jean-Philippe Burckert, Katherine J. L. Jackson, Duncan Ralph, Chaim A. Schramm, Nishanth Marthandan, Felix Breden, Jamie Scott, Frederick A. Matsen, Victor Greiff, Gur Yaari, Steven H. Kleinstein, Scott Christley, Jacob S. Sherkow, Sofia Kossida, Marie-Paule Lefranc, Menno C. van Zelm, Corey T. Watson, Andrew M. Collins
FRONTIERS IN IMMUNOLOGY
(2019)