The roles of MHC class II genes and post-translational modification in celiac disease

Circulating gluten-specific FOXP3 + CD39 + regulatory T cells have impaired suppressive function in patients with celiac disease

(2017) Laura Cook et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HLA-DQ2.5 genes associated with celiac disease risk are preferentially expressed with respect to non-predisposing HLA genes: Implication for anti-gluten T cell response

(2016) Laura Pisapia et al.   JOURNAL OF AUTOIMMUNITY

Healthy HLA-DQ2.5+Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease

(2016) Asbjørn Christophersen et al.   JOURNAL OF IMMUNOLOGY

Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution

(2016) Jan Petersen et al.   STRUCTURE

Understanding Celiac Disease by Genomics

(2016) Sebo Withoff et al.   TRENDS IN GENETICS

Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing

(2016) Robert J. Pantazes et al.   Scientific Reports

Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes

(2016) Siri Dørum et al.   Scientific Reports

Determinants of Gliadin-Specific T Cell Selection in Celiac Disease

(2015) Jan Petersen et al.   JOURNAL OF IMMUNOLOGY

Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease

(2015) R. Iversen et al.   JOURNAL OF IMMUNOLOGY

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

(2015) Javier Gutierrez-Achury et al.   NATURE GENETICS

Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization

(2015) Jorunn Stamnaes et al.   PLoS One

Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires

(2014) Elin Bergseng et al.   IMMUNOGENETICS

How T cells taste gluten in celiac disease

(2014) Bana Jabri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

(2014) Jan Petersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells

(2014) Øyvind Steinsbø et al.   Nature Communications

Biased usage and preferred pairing of  - and  -chains of TCRs specific for an immunodominant gluten epitope in coeliac disease

(2013) S.-W. Qiao et al.   INTERNATIONAL IMMUNOLOGY

Antibody biomarker discovery through in vitro directed evolution of consensus recognition epitopes

(2013) J. T. Ballew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary gluten triggers concomitant activation of CD4+ and CD8+    T cells and    T cells in celiac disease

(2013) A. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease

(2012) Sophie E. Broughton et al.   IMMUNITY

Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules

(2012) Ludvig M. Sollid et al.   IMMUNOGENETICS

High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions

(2012) Roberto Di Niro et al.   NATURE MEDICINE

T-Cell Response to Gluten in Patients With HLA-DQ2.2 Reveals Requirement of Peptide-MHC Stability in Celiac Disease

(2011) Michael Bodd et al.   GASTROENTEROLOGY

Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease

(2011) S.-W. Qiao et al.   JOURNAL OF IMMUNOLOGY

European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease

(2011) S. Husby et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22

(2010) M Bodd et al.   Mucosal Immunology

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

The Preferred Substrates for Transglutaminase 2 in a Complex Wheat Gluten Digest Are Peptide Fragments Harboring Celiac Disease T-Cell Epitopes

(2010) Siri Dørum et al.   PLoS One

Two HLA-D and DR Alleles are Associated with Coeliac Disease

(2010) Mario DeMarchi et al.   TISSUE ANTIGENS

Strong Association between an HLA-Dw3 Associated B Cell Alloantigen and Dermatitis Herpetiformis

(2010) B. G. Solheim et al.   TISSUE ANTIGENS

Adult Celiac Disease Associated with HLA-DRw3 and -DRw7

(2010) H. Betuel et al.   TISSUE ANTIGENS

Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

(2009) Lars-Egil Fallang et al.   NATURE IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Newly identified genetic risk variants for celiac disease related to the immune response

(2008) Karen A Hunt et al.   NATURE GENETICS