Accelerating Biomedical Discoveries through Rigor and Transparency

The ASA's Statement onp-Values: Context, Process, and Purpose

(2016) Ronald L. Wasserstein et al.   AMERICAN STATISTICIAN

Toward an Evidence-Based Nonclinical Road Map for Evaluating the Efficacy of New Tuberculosis (TB) Drug Regimens: Proceedings of a Critical Path to TB Drug Regimens-National Institute of Allergy and Infectious DiseasesIn VivoPharmacology Workshop for TB Drug Development

(2016) Eric Nuermberger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Studying both sexes: a guiding principle for biomedicine

(2016) Janine Austin Clayton   FASEB JOURNAL

Quality of reporting of confounding remained suboptimal after the STROBE guideline

(2016) Koen B. Pouwels et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

1,500 scientists lift the lid on reproducibility

(2016) Monya Baker   NATURE

RRIDs: A Simple Step toward Improving Reproducibility through Rigor and Transparency of Experimental Methods

(2016) Anita E. Bandrowski et al.   NEURON

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships

(2016) Laura J. Sittig et al.   NEURON

Standards for Cell Line Authentication and Beyond

(2016) Jamie L. Almeida et al.   PLOS BIOLOGY

Female rats are not more variable than male rats: a meta-analysis of neuroscience studies

(2016) Jill B. Becker et al.   Biology of Sex Differences

Chemicals eluting from disposable plastic syringes and syringe filters alter neurite growth, axogenesis and the microtubule cytoskeleton in cultured hippocampal neurons

(2015) Tet Woo Lee et al.   JOURNAL OF NEUROCHEMISTRY

Reproducibility: Use mouse biobanks or lose them

(2015) Kent Lloyd et al.   NATURE

A resource for cell line authentication, annotation and quality control

(2015) Mamie Yu et al.   NATURE

The fickle P value generates irreproducible results

(2015) Lewis G Halsey et al.   NATURE METHODS

Promoting an open research culture

(2015) B. A. Nosek et al.   SCIENCE

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

(2015) Malcolm R. Macleod et al.   PLOS BIOLOGY

The Extent and Consequences of P-Hacking in Science

(2015) Megan L. Head et al.   PLOS BIOLOGY

Are females more variable than males in gene expression? Meta-analysis of microarray datasets

(2015) Yuichiro Itoh et al.   Biology of Sex Differences

SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy

(2014) John P Didion et al.   BMC GENOMICS

Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

(2014) Emily S Sena et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lack of blinding of outcome assessors in animal model experiments implies risk of observer bias

(2014) Segun Bello et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Journals unite for reproducibility

(2014)   NATURE

Scientific method: Statistical errors

(2014) Regina Nuzzo   NATURE

Policy: NIH plans to enhance reproducibility

(2014) Francis S. Collins et al.   NATURE

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Female mice liberated for inclusion in neuroscience and biomedical research

(2014) Brian J. Prendergast et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Need for Randomization in Animal Trials: An Overview of Systematic Reviews

(2014) Jennifer A. Hirst et al.   PLoS One

Journals unite for reproducibility

(2014) M. McNutt   SCIENCE

Fixing problems with cell lines

(2014) Jon R. Lorsch et al.   SCIENCE

The Future of Preclinical Animal Models in Pharmaceutical Discovery and Development

(2014) Jeffrey I. Everitt   TOXICOLOGIC PATHOLOGY

Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies

(2014) David Baker et al.   PLOS BIOLOGY

Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation

(2014) Jonathan Kimmelman et al.   PLOS BIOLOGY

An investigation of the false discovery rate and the misinterpretation of p-values

(2014) D. Colquhoun   Royal Society Open Science

Mouse cell line authentication

(2013) Jamie L. Almeida et al.   CYTOTECHNOLOGY

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Evidence-based Translational Medicine

(2013) David W. Howells et al.   STROKE

On the reproducibility of science: unique identification of research resources in the biomedical literature

(2013) Nicole A. Vasilevsky et al.   PeerJ

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Science mapping analysis characterizes 235 biases in biomedical research

(2010) David Chavalarias et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

(2008) Malcolm R. Macleod et al.   STROKE