Article
Chemistry, Multidisciplinary
Yehhyun Jo, Sang-Mok Lee, Taesub Jung, Gijae Park, Chanhee Lee, Geun Ho Im, Seongju Lee, Jin Soo Park, Chaerin Oh, Geon Kook, Hyunggug Kim, Seongyeon Kim, Byung Chul Lee, Greg S. B. Suh, Seong-Gi Kim, Jeongyeon Kim, Hyunjoo J. Lee
Summary: This study presents a general-purpose ultrasound neuromodulation system for chronic, closed-loop preclinical studies in freely behaving rodents. The system, utilizing microelectromechanical systems (MEMS) technology, includes a small and lightweight artifact-free transducer for stimulation and neural recording.
Article
Clinical Neurology
Olga Bukhtiyarova, Sylvain Chauvette, Josee Seigneur, Igor Timofeev
Summary: By studying the sleep and wake states of common marmosets, the researchers found that their distribution and electrographic patterns closely resemble those of humans. This suggests that marmosets are an excellent animal model to study the origin of human electrographical rhythms and brain states.
Review
Biology
Dylan J. J. Terstege, Jonathan R. R. Epp
Summary: Understanding the relationships between different regions in the brain is crucial for understanding cognitive function. Graph theoretical analyses applied to brain-wide immediate early gene expression density offer a way to study these relationships in freely behaving animal models. This article provides an overview of the steps involved in applying these techniques and discusses important considerations when designing and conducting these experiments.
Article
Zoology
Xinsong Guo, Shan Li, Xuejie Yu, Tingting Wu, Penglai Liu, Yufeng Shao, Anan Li
Summary: The article introduces a new odor stimulation system that can precisely present odors in freely moving mice. The system can be combined with neural recordings and olfactory behavioral tests to investigate how neurons in the brain represent odor information during individual olfactory behaviors.
INTEGRATIVE ZOOLOGY
(2023)
Article
Clinical Neurology
A. C. Medina, A. Kabani, C. Reyes-Vasquez, N. Dafny
Summary: Methylphenidate (MPD) elicits varied responses in behavior and neuronal firing rates, with some animals showing tolerance and others showing sensitization, particularly at higher doses in adult animals.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Review
Biochemistry & Molecular Biology
Changliang Guo, Aimin Wang, Heping Cheng, Liangyi Chen
Summary: In recent years, novel optical imaging tools have been developed to study neuronal activities using fluorescent indicators with brighter expression and higher sensitivity. Miniature microscopes offer a revolutionary approach to imaging large populations of neurons in freely behaving animals, allowing for exploration of the neural basis of behaviors. This review summarizes the historical development of two-photon miniature microscopy techniques and discusses their potential for neuroscientific inquiries. It also addresses the progress in mesoscale single-photon miniature microscopy and the registration of single cells from two-photon and large field-of-view miniature microscopy data. Furthermore, the potential future evolution of these techniques is presented.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Behavioral Sciences
Goncalo Lopes, Patricia Monteiro
Summary: The ability to dynamically control behavioral tasks based on real-time animal behavior is crucial for experimental neuroscientists, but designing automated devices for such studies used to be challenging for most researchers. Advances in open-source hardware and software have now changed this landscape, allowing researchers to easily design simple neuroscience experiments.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Shanel C. Pickard, David J. Bertsch, Zoe Le Garrec, Roy E. Ritzmann, Roger D. Quinn, Nicholas S. Szczecinski
Summary: The interaction with the environment depends on external cues and internal states. The behavioral responses of praying mantises are influenced by satiety levels, with starvation leading to more stereotyped behavior sequences motivated by prey capture while increased satiety results in more flexible behavior sequences.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Chemistry, Analytical
Kaoru Ide, Susumu Takahashi
Summary: Simultaneous monitoring of animal behavior and neuronal activity allows us to investigate the neural basis of behaviors. Traditional tethered recording systems have limitations in terms of animal movement and application to humans. However, the development of wireless neurologgers has overcome these challenges and provided new insights into studying behavior in natural environments.
Article
Multidisciplinary Sciences
P. Wijdenes, K. Haider, C. Gavrilovici, B. Gunning, M. D. Wolff, T. Lijnse, R. Armstrong, G. C. Teskey, J. M. Rho, C. Dalton, Naweed Syed
Summary: This study presents a fully configurable neural microelectrode that can be used for both in-vitro and in-vivo applications, demonstrating high signal-to-noise ratio and diagnostic potential for neurological disorders. The microelectrodes enable the study of brain activity under normal and pathological conditions, aiding in the development of drug screening and neuromodulation systems.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Ian G. Malone, Mia N. Kelly, Rachel L. Nosacka, Marissa A. Nash, Sijia Yue, Wei Xue, Kevin J. Otto, Erica A. Dale
Summary: More than half of spinal cord injuries are cervical, leading to paralysis and respiratory compromise. Existing treatments for restoring breathing after severe cervical injuries are lacking. Closed-loop stimulation triggered by healthy muscle activity has the potential to promote neuroplasticity in the respiratory pathways of the spinal cord.
Article
Multidisciplinary Sciences
Aurelio Cortese, Saori C. Tanaka, Kaoru Amano, Ai Koizumi, Hakwan Lau, Yuka Sasaki, Kazuhisa Shibata, Vincent Taschereau-Dumouchel, Takeo Watanabe, Mitsuo Kawato
Summary: Decoded neurofeedback (DecNef) combines fMRI with machine learning to potentially benefit clinical applications. By releasing datasets from studies, researchers can analyze brain dynamics and modulation mechanisms.
Article
Multidisciplinary Sciences
Changliang Guo, Garrett J. Blair, Megha Sehgal, Federico N. Sangiuliano Jimka, Arash Bellafard, Alcino J. Silva, Peyman Golshani, Michele A. Basso, Hugh Tad Blair, Daniel Aharoni
Summary: We have developed an open-source miniature microscope called MiniLFOV for neural imaging in freely behaving rats. It offers a large field of view and cellular resolution imaging, with the capability of deep brain and cortical imaging. The MiniLFOV has been successfully validated in both rats and head-fixed mice, and it also supports wire-free operation with a novel data acquisition expansion board. We believe that this new implementation of the UCLA Miniscope platform will greatly benefit researchers in studying brain function in freely behaving animals.
Article
Biotechnology & Applied Microbiology
Dylan T. Berry, Joanne Choi, Calla A. Dexheimer, Morgan A. Verhaalen, Amir Javan-Khoshkholgh
Summary: The development of an implantable system for studying the electrophysiology of the GI tract is crucial for understanding functional GI disorders and motility dysfunctions. This system allows monitoring and modulation of the bioelectrical activity of the gastric system in freely behaving rodents, providing insights into the relationship between GI disorders and gastric dysrhythmias and the potential of electroceutical therapies for motility dysfunctions in clinical settings.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Biomedical
Yonghee Chang, Juntae Jang, Jaeouk Cho, Jingu Lee, Yeonzu Son, Seongjun Park, Chul Kim
Summary: This research presents a seamless capacitive body channel wireless power transmission system that enables stable power delivery to multiple living animals. The system is designed to allow long-term and real-time neural monitoring in preclinical research. Experimental results show that the power efficiency remains stable in diverse scenarios, with a maximum difference of 6.66% even with a 90 degrees rotation of the receiver against the cage. In-vivo experiments conducted with untethered rats demonstrate the system's capability of continuous long-term power delivery in practical situations.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)
Article
Engineering, Electrical & Electronic
Jaemyung Lim, Coskun Tekes, Evren F. Arkan, Ahmad Rezvanitabar, F. Levent Degertekin, Maysam Ghovanloo
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2020)
Article
Engineering, Electrical & Electronic
Ulkuhan Guler, Yaoyao Jia, Maysam Ghovanloo
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2020)
Correction
Engineering, Biomedical
Yaoyao Jia, Byunghun Lee, Fanpeng Kong, Zhaoping Zeng, Mark Connolly, Babak Mahmoudi, Maysam Ghovanloo
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2020)
Article
Engineering, Biomedical
S. Abdollah Mirbozorgi, Yaoyao Jia, Pengcheng Zhang, Maysam Ghovanloo
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2020)
Article
Chemistry, Analytical
Yaoyao Jia, Yan Gong, Arthur Weber, Wen Li, Maysam Ghovanloo
Article
Engineering, Electrical & Electronic
Ahmad Rezvanitabar, Gwangrok Jung, Yusuf Samet Yaras, F. Levent Degertekin, Maysam Ghovanloo
IEEE SENSORS JOURNAL
(2020)
Article
Engineering, Electrical & Electronic
Yuhua Cheng, Chunwu Liu, Minghao Wang, Gaofeng Wang, Maysam Ghovanloo, Wenjun Li
Summary: To accurately capture the activity of large neural populations, researchers have developed a three-layer power transmitting array system capable of generating an omnidirectional and homogeneous magnetic field within the brain, thus improving wireless power transfer efficiency.
INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS
(2021)
Article
Computer Science, Artificial Intelligence
Zheyuan Wang, Chen Liu, Matthew Gombolay
Summary: In this paper, a novel heterogeneous graph attention network model called ScheduleNet is proposed to learn scheduling policies that overcome the limitations of conventional methods. By introducing robot- and proximity-specific nodes into the simple temporal network, a nonparametric heterogeneous graph structure is obtained. The model is shown to be end-to-end trainable on small-scale problems and generalizes to large, unseen problems, outperforming existing state-of-the-art methods in various testing scenarios involving both homogeneous and heterogeneous robot teams.
Article
Engineering, Electrical & Electronic
Pyungwoo Yeon, Sreejith Kochupurackal Rajan, Jessica Falcone, Joe L. Gonzalez, Gary S. May, Ravi V. Bellamkonda, Oliver Brand, Muhannad S. Bakir, Maysam Ghovanloo
Summary: This study presents a micromachining process for small neural probes with a robust design against mechanical and material failures. The probes are made using a silicon die as a substrate supporting components and wound coils, and then hermetically sealed for physical protection. The inductance and Q-factor of the wound coils are studied in relation to power transmission efficiency, and the probe prototypes are estimated for lifetime under accelerated conditions.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Electrical & Electronic
Yuhua Cheng, Wenyu Kang, Gaofeng Wang, Maysam Ghovanloo, Wenjun Li
Summary: The study proposes a method to optimize the efficiency of wireless power transmission systems by varying the trace width and turn-to-turn spacing of the coils and establishing an accurate analytical model. Through validation, it is found that this method can effectively improve system efficiency.
INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS
(2021)
Article
Environmental Sciences
Zhenxuan Zhang, Boris Prilutsky, Andrew J. Butler, Minoru Shinohara, Maysam Ghovanloo
Summary: The study evaluated a tongue-operated exoskeleton system for upper limb rehabilitation, demonstrating successful outcomes in aiding stroke survivors in restoring arm function.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Editorial Material
Engineering, Biomedical
Alison Burdett, Pedram Mohseni, Maysam Ghovanloo, Roman Genov
Summary: The papers in this special section were presented at the 2021 IEEE International Solid-State Circuits Conference.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Article
Engineering, Biomedical
Ahmad Rezvanitabar, M. Sait Kilinc, Coskun Tekes, Evren F. Arkan, Maysam Ghovanloo, F. Levent Degertekin
Summary: This paper presents an active impedance matching scheme to optimize electrical power transfer and acoustic reflectivity in ultrasound transducers. Leveraging negative capacitance-based impedance matching improves bandwidth and electrical power transfer, while reducing acoustic reflection and crosstalk.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)
Article
Materials Science, Multidisciplinary
Pyungwoo Yeon, Min-gu Kim, Pingyu Wang, Choongsoon Kim, Oliver Brand, Maysam Ghovanloo
Summary: This paper describes an automated and wireless accelerated heat soak testing system for assessing hermetic failure mechanisms in small mm-sized inductively powered IMDs. The system utilizes a high-throughput readout coil array printed circuit board to test the hermeticity of multiple wireless IMDs simultaneously in harsh environments. An accelerated heat soak test is performed to evaluate electronic durability and estimate the lifetime of the devices.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Proceedings Paper
Computer Science, Information Systems
Ahmad Rezvanitabar, M. Sait Kilinc, Coskun Tekes, Evren F. Arkan, Maysam Ghovanloo, F. Levent Degertekin
Summary: This paper introduces an ultrasound imaging front-end system-on-a-chip that reduces the acoustic reflectivity of the ultrasound transducer array in a broad bandwidth. The system integrates an ultrasound transceiver and an active capacitive impedance cancellation scheme for the first time, designed for low frame rate applications. This system-on-a-chip is used with a CMUT array in the 2-4 MHz range and has successfully demonstrated reduced acoustic reflectivity and imaging capabilities through experiments.
2021 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (IEEE BIOCAS 2021)
(2021)
