Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Falin He, Qiang Liu, Mingyang Jing, Jingqiang Wan, Chengqian Huo, Wansong Zong, Jingchun Tang, Rutao Liu
Summary: Phenanthrene (PHE) is a significant organic compound found widely in soil, which can induce oxidative stress and cytotoxicity in earthworm coelomocytes at high concentrations. The interaction between PHE and antioxidant enzymes SOD/CAT plays a role in these toxic effects.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Zhihan Cui, Falin He, Xiangxiang Li, Yuze Li, Chengqian Huo, Hao Wang, Yuntao Qi, Guang Tian, Wansong Zong, Rutao Liu
Summary: This study reveals the response mechanisms of SOD/CAT under the regulation of TCC-induced oxidative stress and sheds new light on the toxic pathways of exogenous pollutants on antioxidant-related proteins function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Horticulture
Mohammad Pourebrahimi, Saeid Eshghi, Asghar Ramezanian, Shiva Faghih
Summary: High salinity levels can lead to various adverse effects on plants, including osmotic stress and nutritional disorders. In this study, the combined use of hydrogen sulfide and selenium compounds was found to alleviate the negative effects of salt stress on strawberry yield and enhance the antioxidant and nutritional quality of the fruits.
SCIENTIA HORTICULTURAE
(2023)
Review
Biotechnology & Applied Microbiology
Giannina Espina, Joaquin Atalah, Jenny M. Blamey
Summary: The demand for enzymes in industrial processes is increasing globally, with extremophilic enzymes showing higher stability and activity, leading to diverse potential applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pavlina Hemerkova, Martin Valis
Summary: ALS is a neurodegenerative disease that affects motor neurons and currently has no cure. Free oxygen radicals are known to play a role in the pathogenesis of ALS, while antioxidant enzymes like SOD1 are crucial for antioxidant protection.
Review
Biochemistry & Molecular Biology
Yu Ah Hong, Cheol Whee Park
Summary: Reactive oxygen and nitrogen species play crucial roles in kidney injuries, making antioxidant agents, especially catalytic antioxidants that mimic antioxidant enzymes, effective in combating oxidative stress-related kidney diseases. Research has shown the effectiveness of several catalytic antioxidants in treating disease models associated with oxidative stress.
Article
Environmental Sciences
Paolo Pastorino, Elisabetta Pizzul, Damia Barcelo, Maria Cesarina Abete, Gabriele Magara, Paola Brizio, Rosa Avolio, Marco Bertoli, Alessandro Dondo, Marino Prearo, Antonia Concetta Elia
Summary: This study investigated the oxidative stress ecology in Danube barbel from the Barbucina creek, analyzing the levels of antioxidant biomarkers and trace elements in the fish. Results indicated a significant association between certain trace elements and enzyme activity, suggesting their role as stressors in the aquatic environment. The study provides insights into the biochemical defensive response of fish to environmental disturbances, advancing our understanding of the effects of environmental factors on oxidative stress in aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Diana Ofelia Lopez-Cantu, Reyna Berenice Gonzalez-Gonzalez, Elda M. Melchor-Martinez, Saul Antonio Hernandez Martinez, Rafael G. Araujo, Lizeth Parra-Arroyo, Juan Eduardo Sosa-Hernandez, Roberto Parra-Saldivar, Hafiz M. N. Iqbal
Summary: Nanozymes, artificial enzymes based on engineered nanomaterials, have been developed to overcome inherent drawbacks of natural enzymes, showing great potential for various applications. Carbon dots have garnered significant attention for their high catalytic activity and biocompatibility, serving as possible alternatives in biomedical and environmental fields. Studies have shown that carbon dots can mimic different oxidoreductases, exhibiting multiple enzyme-like activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Fatemeh Najafi, Gholamreza Kavoosi, Roghayeh Siahbalaei, Amina Kariminia
Summary: The study demonstrated that Agastache foeniculum essential oil and oil fraction have inhibitory effects on oxidative stress induced by hyperglycemia and inflammation, mainly by regulating the activity and expression levels of relevant enzymes to reduce the production of oxidative stress. At the molecular level, the components of AFEO and AFoil were found to interact with corresponding proteins through molecular docking, showing antioxidant and anti-diabetic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Article
Veterinary Sciences
Rejane Santos Sousa, Caroline Santos Sousa, Francisco Leonardo Costa Oliveira, Paulo Ricardo Firmino, Isadora Karolina Freitas Sousa, Valeria Veras Paula, Nohora Mercado Caruso, Enrico Lippi Ortolani, Antonio Humberto Hamad Minervino, Raimundo Alves Barreto-Junior
Summary: Blood loss in sheep can cause clinical, hematological, blood gas, and biochemical alterations, leading to oxidative stress and reduced antioxidant activity.
VETERINARY SCIENCES
(2022)
Article
Environmental Sciences
Mustafa Bilgin, Esin Uluturhan, Enis Darilmaz, Selma Katalay
Summary: This study investigated the effects of metal accumulation in Sparus aurata and Chelon labrosus in the Izmir Bay using biomarkers. The results showed higher levels of metals and biomarkers in the liver and gill tissues compared to muscle tissues. Biochemical biomarkers were found to be significant predictors of metal bio-accumulation, and histological changes were observed in the liver and gills.
MARINE POLLUTION BULLETIN
(2023)
Article
Horticulture
Naushad Alam, Waseem Siddique, Manoj K. Mishra, Anukriti Pandey, Dhermendra K. Purshottam, Khuraijam Jibankumar Singh, Shri Krishna Tewari, Debasis Chakrabarty
Summary: This study aims to develop an affordable and easy-to-use hydroponic system for the conservation and mass production of four Hoya species. The optimal medium for root growth was determined to be 1/2 MS + IBA (2.5μM). Zinc sulfate (ZnSO4) at concentrations of 25, 50, 100, 150, and 200μM was found to improve root number. The findings of this study are important for the conservation and mass propagation of Hoya species.
SCIENTIA HORTICULTURAE
(2023)
Review
Marine & Freshwater Biology
Martin Gabriel Frias-Espericueta, Juan Carlos Bautista-Covarrubias, Carmen Cristina Osuna-Martinez, Carolina Delgado-Alvarez, Carolina Bojorquez, Marisela Aguilar-Juarez, Sarahi Roos-Munoz, Isidro Osuna-Lopez, Federico Paez-Osuna
Summary: Aquatic decapod crustaceans exhibit varied antioxidant defense strategies in response to metal-induced oxidative stress. Antioxidant enzymes may be induced or inhibited by metals depending on species, concentration, and exposure time. Superoxide dismutase, for example, shows increased activity at low metal levels and exposure durations, but is inhibited at higher concentrations and longer exposure times.
AQUATIC TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Hossein Sharideh, Mahdi Zhandi, Saeed Zeinoaldini, Mojtaba Zaghari, Mostafa Sadeghi, Amir Akhlaghi, Edgar David Peebles
ANIMAL REPRODUCTION SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
M. Zhandi, A. Talebnia-Chalanbar, A. Towhidi, M. Sharafi, A. R. Yousefi, S. M. H. Hussaini
BRITISH POULTRY SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
H. Sharideh, M. Zhandi, S. Zeinoaldini, M. Zaghari, M. Sadeghi
BRITISH POULTRY SCIENCE
(2020)
Article
Reproductive Biology
Hossein Sharideh, Saeed Zeinoaldini, Mahdi Zhandi, Mojtaba Zaghari, Mostafa Sadeghi, Amir Akhlaghi, Edgar David Peebles
Article
Agriculture, Dairy & Animal Science
K. Rasouli-Gharehsaghal, M. Shakeri, M. Zhandi, H. R. Amini, A. R. Yousefi, M. Asadirad
BRITISH POULTRY SCIENCE
(2020)
Article
Reproductive Biology
Ali Asghar Khalil-Khalili, Mahdi Zhandi, Mojtaba Zaghari, Hassan Mehrabani-Yeganeh, Ali Reza Yousefi, Meysam Tavakoli-Alamooti
Summary: This study found that dietary supplementation of organic selenium could improve semen quality and fertility in male broiler breeder roosters under stress induced by dexamethasone. The injection of dexamethasone had negative effects on semen quality parameters, but these effects were mitigated by the addition of organic selenium in the diet. Overall, the results suggest that organic selenium supplementation may have a beneficial impact on mitigating the harmful effects of stress on semen quality and fertility in broiler breeder roosters.
Article
Reproductive Biology
Amirhossein Abazarikia, Mahdi Zhandi, Armin Towhidi, Malak Shakeri, Ali Reza Youse, Amir Aliyan
Summary: The study showed that introducing conjugated linoleic acid (CLA) can improve oocyte developmental competence, reduce aberrant spindle organization of heat-stressed oocytes, and does not cause epigenetic alteration in the obtained blastocysts.
Article
Agriculture, Dairy & Animal Science
Touba Nadri, Armin Towhidi, Saeed Zeinoaldini, Gholamhossein Riazi, Mohsen Sharafi, Mahdi Zhandi, John Kastelic, Dariush Gholami
Summary: This study compared the effects of encapsulated or free glutathione (GSH) on the quality of frozen-thawed bull sperm. The results showed that 2.5 mM encapsulated GSH significantly improved the quality of frozen-thawed bull sperm.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Agriculture, Dairy & Animal Science
Hamid R. Rafieian-Naeini, Mahdi Zhandi, Mostafa Sadeghi, Ali R. Yousefi, Havva Marzban, Andrew P. Benson
Summary: This study investigated the potential of dietary coenzyme Q10 (CoQ10) supplementation to mitigate the negative effects of cadmium (Cd) administration on egg quality and liver histopathology in Japanese quail. The results showed that CoQ10 supplementation partially alleviated the adverse effects of Cd on egg production and some egg quality indices. Furthermore, CoQ10 enhanced egg yolk color intensity in Cd-challenged quail.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Cell Biology
Saeideh Imani, Mahdi Zhandi, Armin Towhidi, Mojtaba Zaghari, Ali Reza Yousefi, Mohsen Sharafi, Touba Nadri
Summary: The study aimed to determine the optimal dose of lecithin nanoliposome added to the rooster semen extender. The results showed that supplementing the extender with 1.10% of lecithin nanoliposome significantly improved the post-thawed rooster sperm velocity measurements.
BIOPRESERVATION AND BIOBANKING
(2022)
Article
Veterinary Sciences
Saba Irani, Mahdi Zhandi, Mostafa Sadeghi, Ali Reza Yousefi, Havva Marzban, Hamid Reza Rafieian-Naeini
Summary: Cadmium has adverse effects on reproductive variables in poultry, but some of them can be mitigated by CoQ10 supplementation.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Kimia Aliverdi-Nasab, Mahdi Zhandi, Ali Reza Yousefi, Vahid Zahedi, Hamid Reza Rafieian-Naeini
Summary: This study aimed to investigate the effect of dietary supplementation of a commercial acidifier on egg production and histology of the small intestine in laying Japanese quail. The results showed that appropriate supplementation of acidifier can improve egg production and related indicators of the small intestine.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Reproductive Biology
Kazem Rasouli-Gharehsaghal, Malak Shakeri, Mahdi Zhandi, Hamid-Reza Amini, Fereshteh Ghadimi, Afsaneh Golkar-Narenji, Paul Edward Mozdziak
Summary: The study aimed to investigate the feasibility of regenerating spermatogenesis in infertile roosters by transplanting transfected SSCs into testes. The results showed that transfected SSCs transplanted into testes could lead to the detection of transgenic material in the roosters' spermatozoa and offspring. However, no transgenic offspring were found through mating and PCR testing.
Article
Veterinary Sciences
Negin Ramazani, Farid Mahd Gharebagh, Ali Soleimanzadeh, Halil Ozancan Arslan, Esin Keles, Desislava Georgieva Gradinarska-Yanakieva, Damla Arslan-Acaroz, Mahdi Zhandi, Alper Baran, Esmail Ayen, Dursun Ali Dinc
Summary: This study investigates the effects of cryopreservation and supplementation of Azeri water buffalo's semen with proline (Lp) and fulvic acid (FA). It aims to assess motility parameters, sperm viability, oxidative stress parameters, and DNA damage to determine the optimal concentrations of Lp and FA for buffalo semen cryopreservation. The results show that L-proline and fulvic acid supplementation can improve the quality parameters of post-thawed buffalo bull semen.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Developmental Biology
Amirhossein Abazarikia, Federica Ariu, Mahsa Rasekhi, Mahdi Zhandi, Sergio Ledda
REPRODUCTION FERTILITY AND DEVELOPMENT
(2020)
Article
Biology
Charles A. Elder, Jensen S. Smith, Mustafa Almosawi, Ethan Mills, Brett R. Janis, Jonathan A. Kopechek, Willem F. Wolkers, Michael A. Menze
Summary: By using a biomimetics approach and trehalose as a cryoprotective agent, red blood cells can be successfully preserved for long-term storage without the need for time-consuming washing steps.