Article
Multidisciplinary Sciences
Michael F. La Fountaine, Asante N. Hohn, Caroline L. Leahy, Anthony J. Testa, Joseph P. Weir
Summary: This study found that after 48 hours of concussion, patients had significantly lower Mayer wave activity compared to controls, which returned to normal levels by 1 week post-injury. Additionally, early after concussion, attenuated sympathetic vasomotor tone was present as the main manifestation of autonomic dysfunction.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Medicine, General & Internal
Naseha Wafa Qammar, Ugne Orinaite, Vaiva Siauciunaite, Alfonsas Vainoras, Gintare Sakalyte, Minvydas Ragulskis
Summary: This study categorizes and analyzes the cardiovascular system responses of individuals with normal and high blood pressure during a bicycle stress test using machine learning algorithms. The findings demonstrate the significance of data collected during the load phase in measuring differences in reactions.
Review
Peripheral Vascular Disease
Takuya Kishi
Summary: Sympathoexcitation in hypertension is regulated by the brain, with key structures in the brainstem involved in the modulation of sympathetic nerve activity. Research has highlighted the role of nitric oxide, oxidative stress, the renin-angiotensin system, and brain inflammation in regulating the sympathetic nervous system. Studies on conscious subjects using advanced techniques have revealed significant findings, such as the involvement of NO and AT(1) receptor-induced oxidative stress in the RVLM and NTS. Clinical interventions targeting brain mechanisms have been developed, but further research is needed.
HYPERTENSION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Julia Krzeminska, Magdalena Wronka, Ewelina Mlynarska, Beata Franczyk, Jacek Rysz
Summary: Arterial hypertension is a major cause of cardiovascular diseases, and oxidative stress and inflammation play important roles in its development, influenced by factors such as diet, supplementation, and pharmacotherapy.
Article
Biology
Hossein Sharifi, Lik Chuan Lee, Kenneth S. Campbell, Jonathan F. Wenk
Summary: In this study, a new multiscale model of the cardiovascular system named MyoFE is presented. The model integrates a mechanistic model of contraction at the myosin level into a finite element-based model of the left ventricle pumping blood through the systemic circulation. The model is coupled with a closed-loop feedback control of arterial pressure inspired by a baroreflex algorithm, showing the ability to maintain arterial pressure in different conditions.
COMPUTERS IN BIOLOGY AND MEDICINE
(2024)
Article
Cardiac & Cardiovascular Systems
Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J. Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A. Mendiola Pla, Dawn E. Bowles, Andreas M. Beyer, Xinping Yue, Eric Lazartigues, Catalin M. Filipeanu
Summary: This study aimed to identify E3 ubiquitin ligases associated with ACE2 ubiquitination in neurogenic hypertension and establish their clinical relevance. By combining bioinformatics and proteomics, the researchers were able to identify Nedd4-2 as the first E3 ubiquitin ligase involved in ACE2 ubiquitination in Ang-II-mediated hypertension. They also demonstrated the important role of ACE2 in GABAergic neurons in maintaining inhibitory tone and regulating pre-sympathetic activity. These findings provide a new understanding of the development of neurogenic hypertension and potential therapeutic strategies. Rating: 9/10.
CARDIOVASCULAR RESEARCH
(2023)
Article
Peripheral Vascular Disease
Hiroyuki Kinoshita, Keita Saku, Jumpei Mano, Hiroshi Mannoji, Shigehiko Kanaya, Kenji Sunagawa
Summary: Resting very short-term blood pressure variability is correlated with nocturnal blood pressure variability, and may serve as a predictor for nocturnal blood pressure variability.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Hiroyuki Kinoshita, Keita Saku, Jumpei Mano, Hiroshi Mannoji, Shigehiko Kanaya, Kenji Sunagawa
Summary: This study suggests that very short-term blood pressure variability at rest may predict nocturnal blood pressure variability. This finding has the potential to develop a novel index of blood pressure variability.
HYPERTENSION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Neil J. McMillan, Rogerio N. Soares, Jennifer L. Harper, Brian Shariffi, Alfonso Moreno-Cabanas, Timothy B. Curry, Camila Manrique-Acevedo, Jaume Padilla, Jacqueline K. Limberg
Summary: This study examines whether peripheral vasodilation induced by insulin contributes to increased muscle sympathetic nerve activity (MSNA) via arterial baroreflex-mediated mechanisms. The results show that insulin-induced peripheral vasodilation plays a role in the increase of MSNA during hyperinsulinemia.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Medicine, Research & Experimental
Baoyuan Zhang, Xuesong Zhang, Moussa Omorou, Kai Zhao, Yang Ruan, Haiyan Luan
Summary: DIP2A, a protein expressed throughout the body and abundantly in the brain, plays a role in various biological processes and has been implicated in brain disorders. Regulation of DIP2A could offer new diagnostic and therapeutic approaches for brain disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Physiology
Kenju Miki, Shizuka Ikegame, Misa Yoshimoto
Summary: This review discusses how multiple baroreflex loops modulate sympathetic nerve activity in a region-specific and coordinated manner throughout the body, through evaluating the responses during freezing, REM sleep, and treadmill exercise.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biology
Krasimir Kostov
Summary: Hypertension is a common global disease, with an imbalance in vasoactive factors produced by endothelial cells potentially being a key factor in its development.
Review
Neurosciences
Helen Y. Weng, Jack L. Feldman, Lorenzo Leggio, Vitaly Napadow, Jeanie Park, Cynthia J. Price
Summary: The study explores the possibility of improving symptoms of disorders by manipulating interoceptive pathways, primarily through the respiratory system. Interventions such as neuromodulation, respiratory control, and mindfulness can alter interoception, enhancing interconnected physiological systems and improving overall functioning and behavior.
TRENDS IN NEUROSCIENCES
(2021)
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Mazher Mohammed, Dominique N. Johnson, Lei A. Wang, Scott W. Harden, Wanhui Sheng, Eliot A. Spector, Khalid Elsaafien, Michael Bader, U. Muscha Steckelings, Karen A. Scott, Charles J. Frazier, Colin Sumners, Eric G. Krause, Annette D. de Kloet
Summary: These studies use advanced techniques to investigate the role of AT2R-expressing neurons in the NTS in blood pressure regulation. Optogenetic stimulation of these neurons increases GABA release and blood pressure. Central activation of AT2R also reduces GABA-related gene expression and blunts pressor responses.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Changhai Tian, Lie Gao, Matthew C. Zimmerman, Irving H. Zucker
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Substance Abuse
Michael E. Price, Carresse L. Gerald, Jacqueline A. Pavlik, Sarah L. Schlichte, Matthew C. Zimmerman, Jane M. DeVasure, Todd A. Wyatt, Joseph H. Sisson
Article
Biochemistry & Molecular Biology
Dahn L. Clemens, Michael J. Duryee, Cleofes Sarmiento, Andrew Chiou, Jacob D. McGowan, Carlos D. Hunter, Sarah L. Schlichte, Jun Tian, Lynell W. Klassen, James R. O'Dell, Geoffrey M. Thiele, Ted R. Mikuls, Matthew C. Zimmerman, Daniel R. Anderson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Nursing
Tiffany A. Moore, Adam J. Case, Therese L. Mathews, Crystal Modde Epstein, Katherine Laux Kaiser, Matthew C. Zimmerman
Article
Biochemistry & Molecular Biology
Urmi Basu, Adam J. Case, Jinxu Liu, Jun Tian, Yu-Long Li, Matthew C. Zimmerman
Article
Nursing
Tiffany A. Moore, Iman M. Ahmad, Kendra K. Schmid, Ann M. Berger, R. Jeanne Ruiz, Rita H. Pickier, Matthew C. Zimmerman
BIOLOGICAL RESEARCH FOR NURSING
(2019)
Editorial Material
Biochemistry & Molecular Biology
Matthew C. Zimmerman, Adam J. Case
Review
Pharmacology & Pharmacy
Dahn L. Clemens, Michael J. Duryee, Johnathan H. Hall, Geoffrey M. Thiele, Ted R. Mikuls, Lynell W. Klassen, Matthew C. Zimmerman, Daniel R. Anderson
PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Obstetrics & Gynecology
Iman M. Ahmad, Matthew C. Zimmerman, Tiffany A. Moore
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2019)
Article
Nursing
Tiffany A. Moore, Kaeli Samson, Iman M. Ahmad, Adam J. Case, Matthew C. Zimmerman
Article
Immunology
Aneesha Dasgupta, Surendra K. Shukla, Enza Vernucci, Ryan J. King, Jaime Abrego, Scott E. Mulder, Nicholas J. Mullen, Gavin Graves, Kyla Buettner, Ravi Thakur, Divya Murthy, Kuldeep S. Attri, Dezhen Wang, Nina Chaika, Camila G. Pacheco, Ibha Rai, Dannielle D. Engle, Paul M. Grandgenett, Michael Punsoni, Bradley N. Reames, Melissa Teoh-Fitzgerald, Rebecca Oberley-Deegan, Fang Yu, Kelsey A. Klute, Michael A. Hollingsworth, Matthew C. Zimmerman, Kamiya Mehla, Junichi Sadoshima, David A. Tuveson, Pankaj K. Singh
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Sarah L. Schlichte, Svetlana Romanova, Kenichi Katsurada, Elizabeth A. Kosmacek, Tatiana K. Bronich, Kaushik P. Patel, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman
Article
Biochemistry & Molecular Biology
Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran, Martonio Ponte Viana, Sarah L. Schlichte, Matthew C. Zimmerman, Oleh Khalimonchuk, Mark W. Feinberg, Xinghui Sun
Summary: The study found that the lncRNA Meg3 plays a role in obesity-induced insulin resistance by inducing cellular senescence of endothelial cells. Knockdown of Meg3 exacerbates the disease progression by promoting cellular senescence in hepatic endothelium.
Article
Medicine, General & Internal
Rachel K. Spooner, Brittany K. Taylor, Cassandra M. Moshfegh, Iman M. Ahmad, Kelsey N. Dyball, Katy Emanuel, Sarah L. Schlichte, Mikki Schantell, Pamela E. May, Jennifer O'Neill, Maureen Kubat, Sara H. Bares, Susan Swindells, Howard S. Fox, Kelly L. Stauch, Tony W. Wilson, Adam J. Case, Matthew C. Zimmerman
Summary: The study revealed disturbances in mitochondrial function and the redox environment in PLWH, which predicted neuroinflammation and cognitive dysfunction. Changes in superoxide- and hydrogen peroxide-sensitive redox environments were found to impact the predictive capacity of neuroinflammation.
Article
Biochemistry & Molecular Biology
Iman M. Ahmad, Maher Y. Abdalla, Tiffany A. Moore, Lisa Bartenhagen, Adam J. Case, Matthew C. Zimmerman