Article
Medicine, General & Internal
Carmen Garrido-Gimenez, Monica Cruz-Lemini, Francisco V. Alvarez, Madalina Nicoleta Nan, Francisco Carretero, Antonio Fernandez-Oliva, Josefina Mora, Olga Sanchez-Garcia, Alvaro Garcia-Osuna, Jaume Alijotas-Reig, Elisa Llurba
Summary: N-terminal pro-brain natriuretic peptide (NT-proBNP) and uric acid levels are increased in preeclampsia pregnancies. Using angiogenic factors for short-term prediction of preeclampsia has limitations. A machine-learning model (MLM) combining NT-proBNP, uric acid, and sFlt-1/PlGF ratio improves the prediction accuracy for preterm preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Hae Rin Jeon, Da Hoe Jeong, Jin Young Lee, Eun Young Woo, Gwi Taek Shin, Suk-Young Kim
Summary: The sFlt-1/PlGF ratio is a useful indicator in predicting adverse pregnancy outcomes in preeclampsia. The high-risk group had lower gestational weeks, lighter neonatal weight, and longer stay in the neonatal intensive care unit compared to the low-risk group.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Review
Obstetrics & Gynecology
Stefan Verlohren, Lisa-Antonia Droege
Summary: The definition of preeclampsia is changing to include organ symptoms alongside hypertension in pregnancy, rather than relying solely on proteinuria. Angiogenic and antiangiogenic factors have emerged as important tools for predicting and diagnosing preeclampsia with high accuracy. This review highlights their central role in the differential diagnosis of high-risk women and their ability to predict preeclampsia-associated adverse outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Developmental Biology
Fengyuan Zhang, Mengqi Gu, Pengzheng Chen, Shuting Wan, Qian Zhou, Yuan Lu, Lei Li
Summary: This study found that the concentrations of sFlt-1 and PLGF, as well as the sFlt-1/PLGF ratio, can help distinguish patients with placenta accreta from those with placenta previa.
Article
Peripheral Vascular Disease
Akihide Ohkuchi, Hisashi Masuyama, Tatsuo Yamamoto, Takashi Kikuchi, Naoko Taguchi, Cyrill Wolf, Shigeru Saito
Summary: The introduction of the sFlt-1/PlGF ratio test with a cutoff value of 38 can reduce unnecessary hospitalizations in low-risk patients and identify high-risk individuals for appropriate management. This would result in significant cost savings in the Japanese healthcare system.
HYPERTENSION RESEARCH
(2021)
Article
Medicine, General & Internal
Katarzyna Kosinska-Kaczynska, Ewa Malicka, Iwona Szymusik, Norbert Dera, Michal Pruc, Stepan Feduniw, Zubaid Rafique, Lukasz Szarpak
Summary: COVID-19 infection in pregnant women is associated with an increased risk of adverse pregnancy outcomes, including preeclampsia. This meta-analysis found that pregnant women with COVID-19 have higher sFlt-1/PlGF ratios compared to those without COVID-19. Severe COVID-19 and SARS-CoV-2 infection in hypertensive pregnant women were also associated with significantly higher sFlt-1/PlGF ratios.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Anca-Florina Tataru-Copos, Mircea Ioachim Popescu, Romina Murvai, Amin El Kharoubi
Summary: This study investigates the correlation between sFlt-1/PlGF ratio and preeclampsia in pregnant women. The results show a positive correlation between sFlt-1/PlGF values and the severity of preeclampsia, which can be used to predict the development of early-onset severe preeclampsia. Additionally, the sFlt-1/PlGF ratio has high accuracy in differentiating preeclampsia patients from pregnant women without symptoms of preeclampsia.
MEDICINA-LITHUANIA
(2022)
Article
Obstetrics & Gynecology
Karoline Mayer-Pickel, Christina Stern, Katharina Eberhard, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
Summary: Preeclampsia is characterized by increased platelet consumption and elevated mean platelet volume (MPV). Research suggests that MPV can be a valuable predictor for preeclampsia, particularly for early onset cases. This study found that MPV is significantly elevated in women who develop preeclampsia in early pregnancy, indicating its potential for early detection of the condition. Additionally, ROC curve analysis showed that MPV has a high predictive value for early-onset preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lise Lotte Torvin Andersen, Annemarie Helt, Lene Sperling, Martin Overgaard
Summary: The study evaluated the predictive performance and decision threshold of Kryptor sFlt-1/PlGF ratio in managing women with symptoms of preeclampsia, showing good predictive value for both early-onset and late-onset preeclampsia. A single threshold of 66 is recommended for clinical use in ruling out and ruling in preeclampsia within 1 week.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Review
Medicine, Research & Experimental
Alexandros Velegrakis, Elisavet Kouvidi, Persefoni Fragkiadaki, Stavros Sifakis
Summary: Preeclampsia (PE) is a serious complication of pregnancy with a high incidence rate and causes significant maternal and fetal health risks. Studies have shown that differences in maternal serum levels of angiogenic factors can be used as biomarkers to predict the development of PE. Specifically, the sFlt-1/PlGF ratio has been identified as the optimal predictive tool. However, further research is needed to enhance its clinical applicability and provide universal guidelines for consistent management of PE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Szymon Kozlowski, Anna Stelmaszczyk-Emmel, Iwona Szymusik, Aleksandra Saletra-Bielinska, Robert Brawura-Biskupski-Samaha, Pawel Pietruski, Agnieszka Osinska, Katarzyna Kosinska-Kaczynska
Summary: In this study, it was found that the concentration of sFlt-1 is higher in dichorionic twin pregnancies compared to monochorionic pregnancies. PlGF and sEng levels did not significantly differ between mono- and dichorionic gestation. Additionally, the concentrations of PlGF, sFlt-1 and sEng increased significantly during gestation and were much higher in the third trimester compared to the first trimester.
Article
Obstetrics & Gynecology
Shuyuan Xue, Ying Feng, Wei Li, Guifeng Ding
Summary: This study demonstrates that sFlt-1/PLGF ratio has better predictive and diagnostic value for preeclampsia, with improved auxiliary efficiency compared to just considering sFlt-1 levels.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi
Summary: The study demonstrates the involvement of NADPH oxidase in the secretion of sFlt-1 and PlGF in first trimester chorionic villi, and indicates the participation of p38 MAPK pathway in sFlt-1 production and Nox activation. Additionally, the research highlights the major role of placental NADPH oxidase in mediating the signal transduction cascade of sFlt-1 production, as well as the involvement of p38 activation in first trimester placental Nox activity.
Article
Acoustics
D. Di Mascio, G. Rizzo, A. Khalil, F. D'Antonio
Summary: This study aimed to investigate the role of fetal brain MRI in detecting associated anomalies in fetuses with congenital CMV infection and normal neurosonography. The results showed that fetal brain MRI can detect additional anomalies in fetuses with congenital CMV infection and negative neurosonography, and the viral load in the amniotic fluid is an independent predictor of the risk of associated anomalies in these fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Pediatrics
Christine E. Jones, Heather Bailey, Alasdair Bamford, Anna Calvert, Robert B. Dorey, Simon B. Drysdale, Asma Khalil, Paul T. Heath, Hermione Lyall, Kate Monica Isabel Ralph, Shari Sapuan, Tushna Vandrevala, Simone Walter, Elizabeth Whittaker, Sharon Wood
Summary: Congenital human cytomegalovirus (CMV) infection is a common condition with long-term consequences for children. However, it is not well-known among pregnant women, families, and healthcare providers. Timely diagnosis and treatment are important for reducing transmission and improving outcomes for infants. Further research is needed to inform screening, outcomes, and treatment decisions.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Acoustics
B. Poljak, U. Agarwal, Z. Alfirevic, S. Allen, N. Canham, J. Higgs, A. Kaelin Agten, A. Khalil, D. Roberts, F. Mone, K. Navaratnam
Summary: This study examines the utilization and diagnostic yield of prenatal exome sequencing (pES) in a UK fetal medicine unit, as well as its impact on perinatal outcomes. The results show a diagnostic yield of 23.4% for pES, and the detection of causative variants significantly increases the rate of late termination of pregnancy (TOP).
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Acoustics
F. D'Antonio, D. Marinceu, S. Prasad, A. Khalil
Summary: The objective of this systematic review and meta-analysis was to investigate the safety and effectiveness of prenatal valacyclovir therapy in pregnancies with maternal CMV infection. The findings suggest that valacyclovir therapy can reduce the risk of congenital CMV infection. However, further research is needed to determine the impact of valacyclovir on the course of infection in the fetus and the risk of symptomatic fetal or neonatal infection.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
E. Kalafat, B. Liu, I. Barratt, R. Bhate, A. Papageorghiou, A. Khalil
Summary: This study investigated the perinatal outcomes of dichorionic twin pregnancies complicated by selective fetal growth restriction (sFGR). The umbilical artery Z-scores were found to be associated with both intrauterine death and adverse perinatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dorota Sroka, Lisa-Antonia Lorenz-Meyer, Valerie Scherfeld, Julie Thoma, Andreas Busjahn, Wolfgang Henrich, Stefan Verlohren
Summary: A retrospective study found that integrating the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio with other markers in a multi-marker regression model had better predictive performance for adverse maternal and fetal outcomes related to preeclampsia in women beyond 34 weeks of gestation.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Immunology
Dirk Reinhold, Vadim Farztdinov, Yan Yan, Christian Meisel, Henrik Sadlowski, Joachim Kuehn, Frank H. Perschel, Matthias Endres, Emrah Duezel, Stefan Vielhaber, Karina Guttek, Alexander Goihl, Morten Veno, Bianca Teegen, Winfried Stoecker, Paula Stubbemann, Florian Kurth, Leif E. Sander, Markus Ralser, Carolin Otto, Simon Streit, Sven Jarius, Klemens Ruprecht, Helena Radbruch, Jorgen Kjems, Michael Muelleder, Frank Heppner, Peter Koertvelyessy
Summary: Patients with COVID-19 may experience various neurological symptoms, but the role of the central nervous system (CNS) in COVID-19 is still unclear. The inflammatory response in the cerebrospinal fluid (CSF) of COVID-19 patients was studied, and it was found that there were attenuated inflammatory changes compared to patients with herpes simplex virus encephalitis (HSVE). The inflammatory mediators in the CSF of COVID-19 patients were likely derived from the systemic circulation rather than produced within the CNS. Further investigation is needed to understand the relevance of blood-derived mediators of inflammation in the CSF for neurological COVID-19 and post-COVID-19 symptoms.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Acoustics
F. D'Antonio, D. Marinceu, S. Prasad, N. Eltaweel, A. Khalil
Summary: This systematic review examines the outcomes of laser surgery for twin-twin transfusion syndrome (TTTS) in monochorionic diamniotic (MCDA) twin pregnancies complicated by selective fetal growth restriction (sFGR). The study finds that MCDA twin pregnancies with TTTS and sFGR have a higher risk of fetal loss after laser surgery, as well as a higher risk of neurological morbidity in the donor twin.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
S. Prasad, C. Di Fabrizio, N. Eltaweel, E. Kalafat, A. Khalil
Summary: The objective of this study was to assess the predictive accuracy of first-trimester choroid-plexus-to-lateral-ventricle/head ratios for development of ventriculomegaly at a later gestational age. The study found that first-trimester fetal choroid-plexus-to-lateral-ventricle/head ratios have good predictive accuracy for the development of ventriculomegaly.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Genetics & Heredity
Hiba J. Mustafa, Faezeh Aghajani, Zinah A. Bairmani, Asma Khalil
Summary: This study is the first systematic review and meta-analysis comparing expectant management (EM) versus treatment with NSAIDs in fetuses with EA/TVD with a circular shunt. The results showed that the NSAID group had significantly higher rates of live birth and survival to hospital discharge compared with the EM group, but the number of cases treated with NSAIDs was small, with limited safety data.
PRENATAL DIAGNOSIS
(2023)
Review
Genetics & Heredity
Hiba J. Mustafa, Faezeh Aghajani, Mohammad Jawwad, Nensi Shah, Alfred Abuhamad, Asma Khalil
Summary: This study investigated the outcomes of fetuses with hypoplastic left heart syndrome (HLHS) and intact or restrictive atrial septum (I/RAS) managed expectantly or with fetal atrial septal intervention (FASI). The study found no differences in survival rates between the two groups, but FASI may lead to a less restrictive septum at birth. Future multicenter studies are needed for better identification of cases with improved outcomes and standardized techniques and definitions.
PRENATAL DIAGNOSIS
(2023)
Article
Obstetrics & Gynecology
Florence Vibert, Guel Schmidt, Kerstin Loeffler, Adam Gasiorek-Wiens, Wolfgang Henrich, Stefan Verlohren
Summary: The purpose of this study was to determine the accuracy of prenatal ultrasound in classifying facial clefts. The study found that prenatal ultrasound had a high accuracy of 88.9% in diagnosing facial clefts, which can help guide parents in postnatal care and surgical treatment.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Pediatrics
Joachim Carsten Will, Nina Siedentopf, Oliver Schmid, Teresa Mira Gruber, Wolfgang Henrich, Christoph Hertzberg, Bernhard Weschke
Summary: Cardiac rhabdomyomas can potentially indicate the presence of Tuberous Sclerosis Complex (TSC). Though they usually regress without intervention, they can grow and disrupt heart function, posing a threat to the child's life. Administering rapalogs, like sirolimus, to a pregnant mother with TSC can effectively stop the growth of cardiac tumors and cause them to shrink. This article presents a successful case of treating a fetal cardiac rhabdomyoma in a TSC patient using sirolimus.
Article
Obstetrics & Gynecology
Charlotte K. Metz, Anna S. Skof, Jalid Sehouli, Jan-Peter Siedentopf, Pimrapat Gebert, Fabian Weiss, Irene Alba Alejandre, Michaela Heinrich-Rohr, Katharina Weizsaecker, Wolfgang Henrich, Andreas M. Kaufmann, Irena Rohr
Summary: The purpose of this study was to investigate the influence of HIV infection and pregnancy on HR-HPV infection and progression. The study found that a high HIV viral load and a low CD4 T cell count were associated with a higher prevalence of HR-HPV infections and multiple infections. It is recommended to perform more attentive and comprehensive HPV screening and cytological examination for pregnant women with HIV infection.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Madeleine Schauer, Elisabetta Latartara, Maria Alonso-Espias, Emma Rossetti, Pimrapat Gebert, Wolfgang Henrich, Larry Hinkson
Summary: This study found that women with breech presentation do not have higher levels of psychological distress compared to women with cephalic presentation. However, they still experience symptoms of potential mental disorders. Younger women and multiparous women may need additional support and should be assessed using a standardized screening tool for perinatal psychological distress.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)