Article
Endocrinology & Metabolism
Klara Beitl, Didier Dewailly, Rudolf Seemann, Marlene Hager, Jakob Buenker, Daniel Mayrhofer, Iris Holzer, Johannes Ott
Summary: Polycystic ovary syndrome (PCOS) and functional hypothalamic amenorrhea (FHA) are the two most frequent causes of secondary amenorrhea, and distinguishing between them remains challenging. A retrospective case-control study found significant differences in hormone levels and protein binding globulin between PCOS-D patients and FHA-PCOM patients. The authors proposed a model including serological parameters as a reliable tool to distinguish between the two conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Robert Tarszabo, Balint Banyai, Eva Ruisanchez, Borbala Peterffy, Agnes Korsos-Novak, Krisztina Lajtai, Reka Eszter Sziva, Dora Gerszi, Adam Hosszu, Rita Benko, Zoltan Benyo, Eszter Maria Horvath, Gabriella Masszi, Szabolcs Varbiro
Summary: In a rat model, vitamin D deficiency was found to impair the vasoactive effect of estradiol, while short-term chronic hyperandrogenism did not have this effect. Additionally, vitamin D deficiency also affected the immunostaining of estrogen receptor and nitric oxide synthase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study demonstrated that in women with PCOS, lifestyle modifications combined with synbiotic supplementation can significantly decrease body weight, waist circumference, hip circumference, and thigh circumference, as well as lead to a significant reduction in serum testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study found that synbiotic supplementation can enhance the effects of lifestyle modifications on weight and testosterone levels in patients with PCOS, leading to significant improvements.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Evolutionary Biology
Natalie L. Dinsdale, Bernard J. Crespi
Summary: Evolutionary and comparative approaches can provide new insights into human adaptation and disease. The study proposes the diametric disorder hypothesis between endometriosis and PCOS, with support from diverse fields of research. Findings suggest that PCOS and endometriosis represent maladaptive extremes of female life-history variation and expression of sexually dimorphic female reproductive traits.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Endocrinology & Metabolism
Xiang Hong, Pengfei Qin, Jiechen Yin, Yong Shi, Yan Xuan, Zhengqi Chen, Xu Zhou, Hong Yu, Danhong Peng, Bei Wang
Summary: The vaginal microbiome of PCOS patients is associated with specific clinical manifestations, such as acanthosis nigricans, intermenstrual bleeding, pregnancy history, testosterone level, and anti-mullerian hormone level. The abundance of certain bacterial species, such as Lactobacillus crispatus, was found to be higher among PCOS patients with elevated testosterone levels. Further studies are needed to explore the microbiota and molecular mechanisms underlying this relationship.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Clementine Marie, Alice Pierre, Anne Mayeur, Frank Giton, Raphael Corre, Michael Grynberg, Joelle Cohen-Tannoudji, Celine J. Guigon, Stephanie Chauvin
Summary: This study investigated the dysfunction of estradiol (E2) signaling in non-hyperandrogenic overweight women with polycystic ovary syndrome (PCOS). The findings showed increased expressions of androgen and progesterone receptors, and down-regulated expressions of steroidogenic enzymes in granulosa cells of PCOS patients. Moreover, the study revealed the ineffectiveness of E2 in regulating the expression of key endocrine genes and a significant decline in E2 concentration in PCOS follicular fluid. These findings provide new insights into the pathogenesis of PCOS in non-hyperandrogenic women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kristen J. Polinski, Sonia L. Robinson, Diane L. Putnick, Rajeshwari Sundaram, Erin Bell, Paule V. Joseph, James Segars, Weihua Guan, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford, Edwina H. Yeung
Summary: Research suggests that newborns exposed to PCOS, particularly those born to mothers with hirsutism, have differential DNA methylation at certain CpG sites. Additionally, newborns of women with higher preconception testosterone levels also show differential DNA methylation. These differences may be under fetal genetic control.
Review
Endocrinology & Metabolism
Vahid Maleki, Ehsaneh Taheri, Parisa Varshosaz, Fatemeh Pourteymour Fard Tabrizi, Jalal Moludi, Hamed Jafari-Vayghan, Mahdi Shadnoush, Seyed Hossein Yahyazadeh Jabbari, Mehri Seifoleslami, Mohammad Alizadeh
Summary: Green tea extract (GTE) may have therapeutic effects on polycystic ovary syndrome (PCOS), mainly reflected in weight loss and improvement of glycemic levels. Current research results show that GTE can reduce testosterone and luteinizing hormone levels, and increase follicle-stimulating hormone and progesterone levels in animal models. Additional studies are needed to determine the effects and mechanisms of GTE in PCOS.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hao-Ran Shen, Xiao Xu, Xue-Lian Li
Summary: This study found that berberine (BBR) can reduce insulin resistance and testosterone levels in PCOS rats by inhibiting cell apoptosis and regulating the expression levels of various genes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Endocrinology & Metabolism
D. Abdulkhalikova, A. Sustarsic, E. Vrtacnik Bokal, N. Jancar, M. Jensterle, T. Burnik Papler
Summary: This study aimed to investigate the effects of weight loss on the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. The results showed increased protein abundance in certain proteins and decreased abundance in others in the endometrium after weight loss, as well as significant reductions in fasting blood glucose and free testosterone levels, and improvements in body composition and physical capacity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Dongxu Wang, Nan Nan, Hao Bing, Bing He
Summary: Obese patients with PCOS are more prone to develop NAFLD. Compared to the control group, the obese PCOS group showed significant increases in ALT, AST, CAP, TG, TC, LDL-C, TT, FAI, FIns, and HOMA-IR levels, along with lower HDL-C and SHBG levels. Liver CAP in PCOS patients with obesity was positively correlated with ALT, AST, TG, TT, FAI, FIns, and HOMA-IR, and negatively correlated with SHBG. Logistic regression analysis showed that TG, TT, FIns, and HOMA-IR were risk factors for NAFLD, while TT was an independent risk factor for NAFLD in PCOS patients with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Jennifer F. Kawwass, Lisa M. Shandley, Sheree L. Boulet, Heather S. Hipp
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Genetics & Heredity
Jennifer F. Kawwass, Patrick Ten Eyck, Patrick Sieber, Heather S. Hipp, Brad Van Voorhis
Summary: This study characterized national oocyte donation practice patterns in the US, focusing on individual donors rather than recipients. The average donor age was 26.3 years, with an average of 2.4 retrievals per donor. Pregnancy rates were 47.1% among donor oocyte recipient transfers, with a higher likelihood of good perinatal outcome in singleton pregnancies.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Medicine, General & Internal
Sina Abhari, Jennifer F. Kawwass
Summary: PGT-A aims to identify embryos with normal chromosome complement during IVF to increase implantation success and reduce the risk of multiple pregnancies. The emergence of new technologies has led to increased diagnosis of embryonic mosaicism, with over 100 live births documented with reassuring outcomes and no abnormal phenotype.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Obstetrics & Gynecology
Jacqueline C. Lee, Jennifer F. Kawwass
FERTILITY AND STERILITY
(2021)
Article
Nursing
Kamini Doraivelu, Anjum Mandani, Anandi N. Sheth, Jennifer F. Kawwass, Sophia A. Hussen
JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
(2022)
Article
Urology & Nephrology
Julie M. Shabto, Dattatraya Patil, Katherine Poulose, Mackenzie P. Bennett, Angel X. Xiao, Heather S. Hipp, Jennifer F. Kawwass, Akanksha Mehta
Summary: This study evaluated the management of male factor infertility in fertility clinics, including website educational content and factors related to referral for urologic evaluation and care. The findings showed that variability in patient-facing education, infertility practice setting, and size influenced access to urologic care for couples with male factor infertility.
Editorial Material
Surgery
Jennifer F. Kawwass, Peter W. Thompson
AESTHETIC SURGERY JOURNAL
(2022)
Review
Obstetrics & Gynecology
Vinita M. Alexander, Caitlin E. Martin, Allison P. Schelble, Alexandra B. Laufer, Angela Hardi, Laurie J. McKenzie, Heather S. Hipp, Jennifer F. Kawwass, Jessica B. Spencer, Emily S. Jungheim
Summary: This study compared clinical outcomes between female cancer patients undergoing conventional early follicular phase-start ovarian stimulation cycles and random-start ovarian stimulation cycles. While random-start cycles may be slightly longer and use more gonadotropins, they show similar numbers of mature oocytes retrieved, fertilization rates, and number of embryos cryopreserved compared to conventional-start cycles. The slight differences in stimulation duration and gonadotropin use do not significantly affect treatment costs.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Anisha R. Chada, Sara Crawford, Heather S. Hipp, Jennifer F. Kawwass
FERTILITY AND STERILITY
(2022)
Editorial Material
Obstetrics & Gynecology
Jamie M. Merkison, Jennifer F. Kawwass
FERTILITY AND STERILITY
(2023)
Article
Medicine, Research & Experimental
Tammy L. Loucks, Jillian Harvey, Diana Lee-Chavarria, Rechelle Paranal, Kathleen A. Lenert, Heather S. Bonilha, Carol Feghali-Bostwick
Summary: The survey results revealed unique training needs for faculty and staff across different areas, with time and lack of awareness being the main barriers to training. Additional training was seen as a way to enhance confidence in job responsibilities for both faculty and staff.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Perry Halushka, Tammy L. Loucks, Rechelle Paranal, Jillian Harvey, Kristen Briggman, Diana Lee-Chavarria, Carol Feghali-Bostwick
Summary: NCATS aims to accelerate drug development process from discovery to approval, with a focus on translational research. The TL1 training grant provides doctoral students with clinical exposure to enhance their research and patient care skills, and has been highly valued by both trainees and clinical mentors involved in the program.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Kimberly McGhee, Tammy Loucks, Sheila Champlin, Matthew Greseth, Paula Traktman
Summary: The Science Writing Initiative for Trainees at the Medical University of South Carolina is a science communications internship program for biomedical graduate students and postdoctoral fellows, training them to effectively communicate research findings to a lay audience. Since its inception in 2016, interns have written over 100 EurekAlert! press releases with more than half a million views, serving as ambassadors for science.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Tammy L. Loucks, Clare Tyson, David Dorr, Vesna D. Garovic, James Hill, S. David McSwain, Sally Radovick, Frank A. Sonnenberg, Jennifer A. Weis, Kathleen T. Brady
Summary: Clinical trials have shifted to virtual methods during the pandemic to adapt to social distancing challenges, but a hybrid approach is expected in the future to combine remote activities and in-person interactions effectively.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Caitlin E. Martin, Heather S. Hipp, Melissa Kottke, Lisa B. Haddad, Jennifer F. Kawwass
MATERNAL AND CHILD HEALTH JOURNAL
(2019)