Review
Oncology
Wuhan Yu, Ning Liu, Xiaogang Song, Lang Chen, Mancai Wang, Guohui Xiao, Tengfei Li, Zheyuan Wang, Youcheng Zhang
Summary: This article focuses on the value of EZH2 research in gastric cancer by examining its crucial involvement in gastric cancer progression. The article first introduces the two main functions of EZH2: histone methylation modification and DNA methylation. It then provides a detailed description of the mechanisms of EZH2 in gastric cancer-related events, and concludes with a summary of the progress in the development of EZH2 inhibitors. This review article provides researchers studying the epigenetics of gastric cancer with new research ideas to find new targets for studying the pathogenesis of gastric cancer.
Article
Chemistry, Medicinal
Bin Zhou, Beilei Wang, Fengming Zou, Husheng Mei, Qingwang Liu, Shuang Qi, Wenliang Wang, Rui Jin, Aoli Wang, Yongfei Chen, Feiyang Liu, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: A novel covalent EZH2 degrader was discovered, which can reduce the expression of EZH2 in multiple types of cancer and exhibit antiproliferation activity. This study provides an opportunity for the development of new drug candidates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Daniel Marrero-Rodriguez, Keiko Taniguchi-Ponciano, Jacobo Kerbel, Amayrani Cano-Zaragoza, Ilan Remba-Shapiro, Gloria Silva-Roman, Sandra Vela-Patino, Sergio Andonegui-Elguera, Alejandra Valenzuela-Perez, Moises Mercado
Summary: This review evaluates the biological processes underlying malignant transformation and their relevance to the development of pituitary adenomas. It addresses various processes such as genome instability, epigenetic reprogramming, angiogenesis, proliferative signals, immune evasion, and inflammation in relation to pituitary tumors. Additionally, it discusses the existence of oncogene-induced senescence in these tumors. Understanding these processes can provide insights into the resistance of pituitary tumors to malignant transformation and contribute to the development of novel anticancer treatments.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Lin Xu, Jiandong Gao, Di Huang, Pinglan Lin, Dongsheng Yao, Feng Yang, Yaheng Zhang, Xuejun Yang, Ming Wu, Chaoyang Ye
Summary: Emodin delays the progression of chronic renal failure and inhibits renal tubulointerstitial fibrosis by reducing extracellular collagen deposition and inhibiting pro-fibrotic signaling pathways, through down-regulation of EZH2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Clinical Neurology
Odelia Cooper, Vivien Bonert, Adam N. Mamelak, Serguei Bannykh, Shlomo Melmed
Summary: This study aimed to evaluate whether microscopic dural invasion predicts the behavior of aggressive pituitary adenomas and to investigate the expression of MMP9 and cofilin. The results showed that dural invasion is associated with tumor size, suprasellar and sphenoid sinus invasion, and pituitary failure but does not predict the postoperative course. Differential expression of phospho-cofilin is associated with growth hormone deficiency and compressive pituitary mass effects.
Article
Cell Biology
Dexin Jia, Ying Xing, Yuning Zhan, Mengru Cao, Fanglin Tian, Weina Fan, Jian Huang, Yimeng Cui, Ruixue Gu, Yaowen Cui, Yuechao Liu, Shuai Zhang, Li Cai, Xiaomei Li
Summary: The study identified LINC02678 as an upregulated lncRNA in NSCLC, associated with poor prognosis in lung cancer patients. It was found to promote NSCLC progression by binding with EZH2 and enhancing cell proliferation and metastasis, suggesting its potential as a biomarker for cancer diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaomin Gao, Yonghan Peng, Ziyu Fang, Ling Li, Shaoxiong Ming, Hao Dong, Rui Li, Yasheng Zhu, Wei Zhang, Baoyi Zhu, Junhao Liao, Zeyu Wang, Min Liu, Weijian Li, Jianwen Zeng, Xiaofeng Gao
Summary: Inhibition of EZH2 attenuates hyperoxaluria-induced TECs injury and reduces CaOx crystal deposition by modulating the JNK/FoxO3a pathway. EZH2 may be a promising therapeutic target in TECs injury.
Article
Endocrinology & Metabolism
Xiao-Kai Duan, Yong-Xiang Sun, Hong-Yun Wang, Yan-Yan Xu, Shi-Zhen Fan, Jin-Ya Tian, Yong Yu, Yan-Yun Zhao, Yan-Li Jiang
Summary: The expression of miR-124 is upregulated in diabetic mice and HG-induced Min6 cells, and is involved in regulating insulin secretion, proliferation, and apoptosis of islet beta-cells by targeting EZH2.
WORLD JOURNAL OF DIABETES
(2023)
Article
Cell Biology
Sumukh Thakar, Yash T. Katakia, Shyam Kumar Ramakrishnan, Niyati Pandya Thakkar, Syamantak Majumder
Summary: The research reveals that intermittent high glucose exposure induces endothelial inflammation, possibly through increased H3K27me3 levels, EZH2 nuclear retention, and inhibition of KLF2 and KLF4 gene expression.
Article
Medicine, Research & Experimental
Nisha Gautam, Satbir Kaur, Surender Kashyap
Summary: In this study, three SNPs (rs.2302427C>G, rs.3757441C>T, and rs.6950683T>C) of the EZH2 gene were analyzed for genetic polymorphism. The results showed that two of these SNPs have a protective role in breast cancer development, and two haplotypes were associated with a lower risk of breast cancer. Specifically, the SNP rs.2302427C>G was identified as an important prognostic biomarker for breast cancer patient survival.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Min-Kyoung Kim, Hye Sun Shin, Mi Hee Shin, Haesoo Kim, Dong Hun Lee, Jin Ho Chung
Summary: This study reveals the role of EZH2 in regulating MMP-1 and type I procollagen expression in UV-induced skin responses and photoaging. EZH2 acts as a dual regulator, increasing NF-KB activity and binding to the MMP-1 promoter, while also forming a complex with DNMT1 to enhance H3K27me3 enrichment on the COL1A2 promoter. Inhibiting EZH2 could be a potential anti-aging strategy for preventing UV-induced skin aging.
Article
Cell Biology
Norihiko Sasaki, Kazumi Hirano, Yuuki Shichi, Yoko Itakura, Toshiyuki Ishiwata, Masashi Toyoda
Summary: Atherosclerosis is a disease characterized by the phenotypic switching of vascular smooth muscle cells (VSMCs) from a contracted state to a proliferative state. This study reveals that the upregulation of a- and b-series gangliosides, which are regulated by polycomb repressor complex 2 (PRC2), is associated with VSMC dedifferentiation. Downregulation of ganglioside expression attenuates the proliferation and migration of dedifferentiated VSMCs. Gangliosides may serve as an effective target for the prevention and treatment of atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Xiaxia Shao, Tao Zhao, Lei Xi, Yuhong Zhang, Jia He, Jie Zeng, Lichun Deng
Summary: The study demonstrated that the upregulation of LINC00565 and EZH2 in CRC tissues, especially in advanced stages and large tumor sizes, highlights their diagnostic value in CRC. LINC00565, predominantly located in the cytoplasm, binds with EZH2 and together they co-regulate the functions of CRC cells.
Article
Medicine, Research & Experimental
Dongyou Yue, Zhiying Wang, Yongan Yang, Zhenjun Hu, Ganping Luo, Fu Wang
Summary: The study showed that the EZH2 inhibitor GSK343 could protect the intestine from sepsis-induced injury in mice by reducing inflammation, suppressing cell apoptosis, and promoting tight junction protein expression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Lihong Shi, Qiangsheng Zhang, Shirui Zhu, Qing Tang, Xin Chen, Rui Lan, Ningyu Wang, Yongxia Zhu
Summary: The expression of EZH2 is associated with the migration and invasion of OC cells. Inhibition of EZH2 using SKLB-03220 reduces the migration and invasion ability of OC cells by upregulating TIMP2 and downregulating MMP9.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hua Xin, Hai-yang Hu, Bin Liu, Xiang Liu, Xia Li, Jie Li
JOURNAL OF MEDICAL ULTRASONICS
(2017)
Article
Oncology
Huajie Liu, Bin Liu, Xianzeng Hou, Bo Pang, Pengbo Guo, Wanli Jiang, Qian Ding, Rui Zhang, Tao Xin, Hua Guo, Shangchen Xu, Qi Pang
JOURNAL OF NEURO-ONCOLOGY
(2017)
Article
Pathology
Qian Ding, Zhen Li, Bin Liu, Liping Ling, Xiangguo Tian, Chunqing Zhang
Article
Clinical Neurology
Daiki Murata, Yohei Mineharu, Yoshiki Arakawa, Bin Liu, Masahiro Tanji, Makoto Yamaguchi, Ko-ichi Fujimoto, Nobuyuki Fukui, Yukinori Terada, Ryuta Yokogawa, Maki Yamaguchi, Sachiko Minamiguchi, Susumu Miyamoto
JOURNAL OF NEUROSURGERY
(2018)
Article
Multidisciplinary Sciences
Bin Liu, Yoshiki Arakawa, Ryuta Yokogawa, Shinya Tokunaga, Yukinori Terada, Daiki Murata, Yasuzumi Matsui, Ko-ichi Fujimoto, Nobuyuki Fukui, Masahiro Tanji, Yohei Mineharu, Sachiko Minamiguchi, Susumu Miyamoto
Article
Acoustics
Hua Xin, Lijun Wang, Wei Hao, Haiyang Hu, Hecui Li, Bin Liu
Summary: The purpose of this study was to examine the impact of bedside lung ultrasound (LUS) and LUS scores in evaluating and grading neonatal respiratory distress syndrome (NRDS). The results showed that LUS and LUS scores can effectively evaluate and grade NRDS and are similar to chest X-ray examination results.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Immunology
Qiang Wen, Qian Ding, Jinchao Wang, Yanhua Yin, Shangchen Xu, Yuanrong Ju, Hongsheng Ji, Bin Liu
Summary: Sepsis-associated encephalopathy (SAE) is a life-threatening condition characterized by cognitive dysfunction. Cortistatin-14, a neuropeptide, has been shown to have neuroprotective effects in sepsis. In this study, cortistatin-14 was found to improve cognitive impairment and relieve anxiety-related behaviors in a mouse model of sepsis. It also reduced levels of inflammatory cytokines, protected the integrity of the blood-brain barrier, and inhibited microglial activation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Bin Liu, Jinchao Wang, Guangchuan Wang, Wanli Jiang, Zhen Li, Yongjun Shi, Junyong Zhang, Qingshan Pei, Guangjun Huang, Lifen Wang, Shengqiang Zhao, Lei Wu, Mingyan Zhang, Wenwen Wang, Xiao Li, Tong Mou, Chunqing Zhang, Qian Ding
Summary: This study explores the effects of exosomal H2AFJ derived from hepatocytes on the activation of hepatic stellate cells (HSCs) and liver fibrosis. It was found that H2AFJ, released by hepatocytes through exosomes, promotes HSC migration and invasion by activating the MAPK/STMN1 signaling pathway, exacerbating liver fibrosis. Silencing H2AFJ attenuates liver fibrosis in mice, while restoration of STMN1 negates this effect. This study provides a potential therapeutic target for alleviating liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Surgery
Bao Zhao, Hong-Sheng Ji, Chun-Yang Xu, De-Jun Li, Zhi-Qun Xing, Bin Liu, Yu Han, Wen-Jun Xia, Li-Hui Han
Summary: This retrospective analysis of 196 patients who had undergone pancreatic cancer surgery found an incidence of postoperative delirium (POD) of 20.41%, which increased to 29.03% for patients aged ≥70 years. POD was associated with age, smoking, ASA classification, APACHE II score, and cancer TNM stage. Although there was no significant difference in the length of ICU stay between the delirium and non-delirium groups, POD tended to prolong postoperative hospital stay and increase the risk of mortality. Additionally, the incidence of POD showed a gradual decline between 2015 and 2019 after preventive measures were implemented.
Article
Surgery
Jinchao Wang, Zhigang Yao, Shangchen Xu, Bin Liu
Summary: Malignant triton tumor (MTT) is a rare kind of malignant peripheral nerve sheath tumors characterized by rhabdomyoblastic differentiation. Limited reports of MTT occurring in the intracranial area exist. The treatment modality of total surgical resection plus post-operative radiotherapy is generally accepted, but the prognosis remains poor. We report the first case of MTT occurring in the sellar area, with concurrent relapsed pituitary tumors. This case suggests a possible relationship between MTT and radiation therapy.
FRONTIERS IN SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Bin Liu, Zhiqun Xing, Feng Song, Dejun Li, Bao Zhao, Chunyang Xu, Wenjun Xia, Hongsheng Ji
Summary: This study investigates the mechanism of m6A methyltransferase METTL3 in neuronal damage in ischemic stroke. The results show that METTL3 reduces ANXA2 expression in T lymphocytes through m6A modification, inhibits p38MAPK/MMP-9 pathway activation, and exerts protective effects against neuronal damage in ischemic stroke.
Article
Multidisciplinary Sciences
Qian Ding, Jinchao Wang, Haitao Fan, Wanli Jiang, Hua Guo, Hongsheng Ji, Tao Song, Shangchen Xu, Bin Liu
Summary: Ventriculoperitoneal shunt (VPS) placement is a standard procedure for hydrocephalus treatment. Laparoscopy helps improve visualization and achieve more reliable placement of the peritoneal terminal of the catheter, reducing postoperative complications. However, the fixation methods of the peritoneal terminal of the catheter have not been previously discussed. This study compared different techniques and complications between conventional VPS and laparoscopy-guided VPS, as well as different fixation methods within the laparoscopy-guided VPS group.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Jinchao Wang, Linzong Xu, Qian Ding, Xiaoru Li, Kai Wang, Shangchen Xu, Bin Liu
Summary: In this study, the prognostic value and immunotherapeutic potential of Siglec15 in gliomas were explored using bioinformatics and clinicopathological methods. The findings showed that high expression of Siglec15 predicted poor prognosis and adverse recurrence time in glioma patients. Siglec15 is a potential target for immunotherapy and may be involved in the immunosuppressive microenvironment in gliomas.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
W. Jiang, B. Liu, Y. Liu, J. Wang, Q. Ding, H. Ji, Y. Cui, Y. Wang, Q. Pang, Q. Zeng
Summary: 3D-MRI sequences have good sensitivity and specificity in detecting NVCs in patients with trigeminal neuralgia. 3D-FIESTA combined with 3D-TOF MRA is a crucial MRI sequence for the preoperative diagnosis and surgical planning of NVCs.
INTERNATIONAL JOURNAL OF RADIATION RESEARCH
(2022)