Homeostatic plasticity can be induced and expressed to restore synaptic strength at neuromuscular junctions undergoing ALS-related degeneration

A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation

(2017) Beril Kiragasi et al.   Cell Reports

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

(2016) Jean-Philippe Loeffler et al.   BRAIN PATHOLOGY

Human SOD1 ALS Mutations in a Drosophila Knock-In Model Cause Severe Phenotypes and Reveal Dosage-Sensitive Gain- and Loss-of-Function Components

(2016) Aslı Şahin et al.   GENETICS

Reversible Recruitment of a Homeostatic Reserve Pool of Synaptic Vesicles Underlies Rapid Homeostatic Plasticity of Quantal Content

(2016) X. Wang et al.   JOURNAL OF NEUROSCIENCE

The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease

(2016) Aaron R. Haeusler et al.   NATURE REVIEWS NEUROSCIENCE

The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration

(2016) Brock Grill et al.   Neural Development

Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals

(2016) Kelvin Xi Zhang et al.   Cell Reports

Human SOD1 ALS Mutations in a Drosophila Knock-In Model Cause Severe Phenotypes and Reveal Dosage-Sensitive Gain- and Loss-of-Function Components

(2016) Aslı Şahin et al.   GENETICS

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

(2015) Johnathan Cooper-Knock et al.   ACTA NEUROPATHOLOGICA

Homeostatic Control of Presynaptic Neurotransmitter Release

(2015) Graeme W. Davis et al.   Annual Review of Physiology

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

(2015) Brian D. Freibaum et al.   NATURE

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

(2015) Mercedes Prudencio et al.   NATURE NEUROSCIENCE

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

(2015) Owen M. Peters et al.   NEURON

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD

(2015) Jacqueline G. O’Rourke et al.   NEURON

FlyBase: establishing a Gene Group resource forDrosophila melanogaster

(2015) Helen Attrill et al.   NUCLEIC ACIDS RESEARCH

Functional reconstitution ofDrosophila melanogasterNMJ glutamate receptors

(2015) Tae Hee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

(2015) J. Chew et al.   SCIENCE

Signaling mechanisms regulating Wallerian degeneration

(2014) Marc R Freeman   CURRENT OPINION IN NEUROBIOLOGY

Drosophila Models of Neuronal Injury

(2014) T. M. Rooney et al.   ILAR JOURNAL

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

(2014) Zhaoming Su et al.   NEURON

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

(2014) Xinmei Wen et al.   NEURON

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

(2014) S. Mizielinska et al.   SCIENCE

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

(2014) I. Kwon et al.   SCIENCE

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

(2014) Elizabeth B. Moloney et al.   Frontiers in Neuroscience

Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

(2013) Sandra Almeida et al.   ACTA NEUROPATHOLOGICA

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis

(2013) I. Fogh et al.   HUMAN MOLECULAR GENETICS

New Approaches for Studying Synaptic Development, Function, and Plasticity Using Drosophila as a Model System

(2013) C. A. Frank et al.   JOURNAL OF NEUROSCIENCE

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Homeostatic plasticity at the Drosophila neuromuscular junction

(2013) C. Andrew Frank   NEUROPHARMACOLOGY

Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

(2013) Z. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

(2013) C. Lagier-Tourenne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

(2013) D. Sareen et al.   Science Translational Medicine

Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis

(2013) Caty Casas et al.   Brain and Behavior

A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance

(2012) Vera Valakh et al.   DEVELOPMENTAL BIOLOGY

Retrograde Changes in Presynaptic Function Driven by Dendritic mTORC1

(2012) F. E. Henry et al.   JOURNAL OF NEUROSCIENCE

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

(2012) Elisa Majounie et al.   LANCET NEUROLOGY

TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction

(2012) Jay Penney et al.   NEURON

Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome

(2011) Chrystian Junqueira Alves et al.   BRAIN RESEARCH

Rab3-GAP Controls the Progression of Synaptic Homeostasis at a Late Stage of Vesicle Release

(2011) Martin Müller et al.   NEURON

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Genetic dissection of axon regeneration

(2010) Zhiping Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

(2010) Xin Xiong et al.   JOURNAL OF CELL BIOLOGY

Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis

(2010) Sonya K. Jakawich et al.   NEURON

Non-ATG-initiated translation directed by microsatellite expansions

(2010) T. Zu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila

(2009) Y. Batlevi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Schizophrenia Susceptibility Gene dysbindin Controls Synaptic Homeostasis

(2009) D. K. Dickman et al.   SCIENCE

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

(2008) Myriam Heiman et al.   CELL

ADrosophilaModel for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1

(2008) Melanie R. Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-dependent site-specific changes of glutamate receptor composition in vivo

(2008) Andreas Schmid et al.   NATURE NEUROSCIENCE