Article
Radiology, Nuclear Medicine & Medical Imaging
Wenji Xu, Xiangru Sun, Haoru Jiang, Xiaochun Wang, Bin Wang, Qiao Niu, Huaxing Meng, Jiangfeng Du, Guoqiang Yang, Bo Liu, Hui Zhang, Yan Tan
Summary: This study investigates the use of diffusion kurtosis imaging (DKI) to differentiate mild cognitive impairment (MCI) from normal controls (NC) in aluminum (Al)-exposed workers, and explores the association between DKI, cognitive performance, and plasma Al concentration. The results indicate that DKI can be a sensitive imaging biomarker for diagnosing MCI and assessing the severity of cognitive impairment. The right hippocampus shows the most significant correlation with cognitive performance. However, there is no correlation between DKI parameters and plasma Al levels.
ACADEMIC RADIOLOGY
(2023)
Article
Neurosciences
Qiyuan Zhu, Zichun Yan, Zhuowei Shi, Dan Luo, Shuang Ding, Xiaoya Chen, Yongmei Li
Summary: Specific biomarkers for cortical gray matter (cGM) pathology in multiple sclerosis (MS) are needed to understand the disease progression. Our study evaluated the association between different types of cortical lesions and cGM damage using diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI). We found that kurtosis fractional anisotropy (KFA) was the most sensitive in characterizing cGM damage, and leukocortical lesion (LCL) volume was more related to cGM damage.
Article
Geriatrics & Gerontology
Xiaoqi Chu, Peng Wu, Hongting Yan, Xuejing Chen, Liting Fan, Zheng Wu, Chunmei Tao, Yue Ma, Yu Fu, Yunchu Guo, Yang Dong, Chao Yang, Yusong Ge
Summary: This study used diffusion kurtosis imaging to analyze the differences in brain microstructure between patients with Alzheimer's disease, patients with mild cognitive impairment, and cognitively normal individuals. The findings suggest that hippocampal mean kurtosis is the most sensitive parameter for differentiating between these groups. This study contributes to the search for potential non-invasive biomarkers of Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Eun Jin Yoon, Jun-Young Lee, Seyul Kwak, Yu Kyeong Kim
Summary: Mild behavioral impairment (MBI) is a neurobehavioral syndrome associated with a higher risk of progression to Alzheimer's disease (AD) in individuals with amnestic mild cognitive impairment (MCI). The presence of multiple MBI domains is also associated with cortical thinning in specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Yongjia Shao, Zijian Wang, Bin Ji, Hang Qi, Shangci Hao, Gang Li, Yue Zhang, Qian Xi
Summary: The olfactory ability of patients with mild cognitive impairment was found to be lower overall and positively correlated with cognitive assessment results. Fractional anisotropy changes significantly in regions such as the corpus callosum, the orbitofrontal gyrus, and the left occipital lobe among MCI patients. Fibrous connections in certain brain regions, like the entorhinal cortex, were stronger in MCI patients, indicating a potential compensatory mechanism in the olfactory pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Critical Care Medicine
Jonas Stenberg, Toril Skandsen, Kent Goran Moen, Anne Vik, Live Eikenes, Asta K. Haberg
Summary: This prospective cohort study aimed to characterize diffusion changes in white matter the first year after mild traumatic brain injury (MTBI). The results showed that there were significant differences in white matter diffusion between MTBI patients and controls at 72 h, 3 months, and 12 months. These findings suggest that there are differences in white matter integrity between MTBI patients and healthy individuals.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Jonas Stenberg, Live Eikenes, Kent Goran Moen, Anne Vik, Asta K. Haberg, Toril Skandsen
Summary: This prospective cohort study investigated the associations between acute diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics and persistent post-concussion symptoms (PPCS) 3 months after mild traumatic brain injury (mTBI). Patients who developed PPCS had poorer white matter microstructural integrity acutely after the injury, compared with patients who recovered and healthy controls. Differences became less pronounced when cognitive reserve was controlled for, suggesting that pre-existing individual differences in axonal integrity accounted for some of the observed differences.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Mikkel K. E. Nygaard, Martin Langeskov-Christensen, Ulrik Dalgas, Simon F. Eskildsen
Summary: The study found that cortical diffusion and thalamic volume are closely associated with walking and cognitive performance in patients with relapsing-remitting multiple sclerosis (RRMS), and are highly affected by the presence of white matter lesions.
JOURNAL OF NEUROLOGY
(2021)
Article
Engineering, Biomedical
V. P. Subramanyam Rallabandi, K. Seetharaman
Summary: This study proposes an automated classification method using transfer learning to classify dementia stages based on white matter Gaussian diffusion and non-Gaussian diffusion indices. The results show that the proposed method achieves high accuracy on imbalanced sample datasets.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Clinical Neurology
Keun You Kim, Junghee Ha, Minae Kim, So Yeon Cho, Hyunjeong Kim, Eosu Kim
Summary: This study investigated the association between blood adiponectin and leptin levels and future cognitive decline and cortical thinning. The results showed that higher plasma adiponectin levels were associated with faster cognitive decline and cortical thinning in individuals with Aβ(+) MCI. Plasma leptin levels were not predictive of cognition or cortical thickness regardless of Aβ status.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Mario Torso, Gerard R. Ridgway, Michele Valotti, Ian Hardingham, Steven A. Chance
Summary: This study aimed to investigate the associations between cortical diffusion imaging and post-mortem neuropathology of Alzheimer's disease (AD). The results showed significant associations between cortical diffusivity measures and AD neuropathological hallmarks. The study also highlighted the impact of co-pathologies on cortical microstructure, emphasizing the importance of recognizing these factors in diagnosis and treatment decision-making.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Min-Chien Tu, Sheng-Min Huang, Yen-Hsuan Hsu, Jir-Jei Yang, Chien-Yuan Lin, Li-Wei Kuo
Summary: The study found that DKI metrics may be more sensitive than DTI metrics in reflecting microstructural changes within the gray matter, providing complementary information for the pathogenesis of SIVD and AD.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Hanjing Liu, Yayun Xiang, Junhang Liu, Jinzhou Feng, Silin Du, Tianyou Luo, Yongmei Li, Chun Zeng
Summary: This study compared parameters of DTI and DKI to evaluate the microstructural changes in anti-NMDAR encephalitis patients. The results showed that DKI parameters were better at describing the changes and correlated with cognitive impairment and neurofunctional recovery severity. The gray matter damage was more extensive than white matter damage in these patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ayu Imai, Teruyuki Matsuoka, Jin Narumoto
Summary: This study investigated the relationship between mild behavioral impairment (MBI) and volume, cortical thickness, and surface area in the temporal and parietal lobes. The results showed that MBI, specifically in the emotional dysregulation domain, was associated with reduced cortical thickness in the right parahippocampal and supramarginal gyri. This suggests that MBI may serve as a predictor of early Alzheimer's disease (AD) below the diagnostic threshold.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Clinical Neurology
Nandakumar Nagaraja
Summary: DWI is a widely used imaging technique for evaluating patients with stroke, but it has potential pitfalls to be recognized, such as false negative results and ischemic stroke mimics that may occur during interpretation. Advanced diffusion imaging techniques like Diffusion Kurtosis Imaging and Diffusion Tensor Imaging are being studied to evaluate ischemic core.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Hongjiang Wei, Chencheng Zhang, Tao Wang, Naying He, Dianyou Li, Yuyao Zhang, Chunlei Liu, Fuhua Yan, Bomin Sun
JOURNAL OF NEUROSURGERY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongjiang Wei, Kyle Decker, Hien Nguyen, Steven Cao, Tsung-Yuan Tsai, Cynthia Dianne Guy, Mustafa Bashir, Chunlei Liu
MAGNETIC RESONANCE IN MEDICINE
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Octavia Bane, Iosif A. Mendichovszky, Bastien Milani, Ilona A. Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E. Hall, Tsutomu Inoue, Christoffer Laustsen, Lilach O. Lerman, Chunlei Liu, Glen Morrell, Michael Pedersen, Menno Pruijm, Elizabeth A. Sadowski, Erdmann Seeliger, Kanishka Sharma, Harriet Thoeny, Peter Vermathen, Zhen J. Wang, Zbigniew Serafin, Jeff L. Zhang, Susan T. Francis, Steven Sourbron, Andreas Pohlmann, Sean B. Fain, Pottumarthi V. Prasad
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Valeria Elisa Contarino, Giorgio Conte, Claudia Morelli, Francesca Trogu, Elisa Scola, Sonia Francesca Calloni, Luis Carlos Sanmiguel Serpa, Chunlei Liu, Vincenzo Silani, Fabio Triulzi
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Victor Han, Chunlei Liu
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sonoko Oshima, Yasutaka Fushimi, Tomohisa Okada, Kyoko Takakura, Chunlei Liu, Yusuke Yokota, Yoshiki Arakawa, Nobukatsu Sawamoto, Susumu Miyamoto, Kaori Togashi
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijia Zhang, Susan Ellor, Jessica M. Sun, Chunlei Liu, Joanne Kurtzburg, Allen W. Song
Summary: This study utilized quantitative susceptibility mapping (QSM) to analyze pediatric CP patients who underwent autologous umbilical cord blood stem-cell therapy. The changes in magnetic susceptibility and susceptibility anisotropy along the corticospinal tracts were found to be associated with behavioral improvements, suggesting the potential of QSM in evaluating treatment outcomes for CP children.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Biophysics
Nan-Jie Gong, Russell Dibb, Mikhail Pletnikov, Eric Benner, Chunlei Liu
NMR IN BIOMEDICINE
(2020)
Article
Cell Biology
Xiaojun Guan, Tao Guo, Cheng Zhou, Jingjing Wu, Ting Gao, Xueqin Bai, Hongjiang Wei, Yuyao Zhang, Min Xuan, Quanquan Gu, Peiyu Huang, Chunlei Liu, Baorong Zhang, Jiali Pu, Zhe Song, Yaping Yan, Feng Cui, Minming Zhang, Xiaojun Xu
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongmei Wang, Lu Wang, Edward H. Lee, Jimmy Zheng, Wei Zhang, Safwan Halabi, Chunlei Liu, Kexue Deng, Jiangdian Song, Kristen W. Yeom
Summary: This study compared feature engineering and deep learning methods to identify high-dimensional image features for predicting COVID-19 pneumonia. By extracting deep learning and radiomics features, models were developed and validated for COVID-19 diagnosis, showing improved diagnostic performance when combining deep learning and radiomics models.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chun Ki Franklin Au, Jill Abrigo, Chunlei Liu, Wanting Liu, Jack Lee, Lisa Wing Chi Au, Queenie Chan, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Ho Ko, Vincent Chung Tong Mok, Weitian Chen
Summary: AD is associated with higher magnetic susceptibility in the fimbria compared with controls. QSM values showed significant differences between the control and early AD groups, and could be used for differentiation, with a model incorporating clinical and radiologic data correctly classifying up to 76% of subjects.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Biophysics
Jing Wu, Siyue Peng, Yuhua Zhang, Boyang Pan, Honghua Chen, Xintian Hu, Nan-Jie Gong
Summary: Quantitative susceptibility mapping (QSM) was used to quantify iron deposition in the brains of non-human primates. The study found a significant correlation between iron deposition and age in most regions of interest, with different trends observed in the thalamus and red nucleus. This research provides valuable insights into the developmental trajectory of magnetic susceptibility and its correlation with age in animal models, as well as serving as a normative basis for further clinical studies using QSM for iron content quantification.
NMR IN BIOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Boyang Pan, Na Qi, Qingyuan Meng, Jiachen Wang, Siyue Peng, Chengxiao Qi, Nan-Jie Gong, Jun Zhao
Summary: Using a deep learning method, high-quality SPECT images can be generated from fast SPECT/CT images, and it has shown better quality in clinical evaluation. The enhanced images outperformed 1/7 SPECT in terms of SUVmax, SUVmean, SSIM, and PSNR.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruimin Feng, Steven Cao, Jie Zhuang, Jiayi Zhao, Xiaojun Guan, Yuyao Zhang, Chunlei Liu, Hongjiang Wei
Summary: This study proposed an improved reconstruction method for susceptibility tensor imaging (STI), which reduces the effects of non-bulk-magnetic-susceptibility (NBMS) related frequency shifts on the susceptibility tensors in the brain white matter. Experimental results demonstrate that the proposed method achieves better reconstruction performance in simulation, ex vivo mouse brain, and in vivo human brain data.
MAGNETIC RESONANCE IN MEDICINE
(2023)