Article
Cell Biology
R. A. Skolik, J. Solocinski, M. E. Konkle, N. Chakraborty, M. A. Menze
Summary: This study found that substituting glucose with galactose in the cell culture medium can shift ATP production in tumor cells from substrate-level phosphorylation to mitochondrial OXPHOS, leading to a global metabolic reorganization and restoring metabolic balance in the cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Austin C. Boese, Sumin Kang
Summary: Cancer cells exhibit abnormal metabolic activity, often preferring aerobic glycolysis, and mitochondrial metabolic pathways are also reprogrammed in cancer. Cancer cells have higher levels of reactive oxygen species compared to non-cancerous cells and must employ diverse metabolic strategies to prevent oxidative stress.
Review
Biochemistry & Molecular Biology
Elisabetta Catalani, Kashi Brunetti, Simona Del Quondam, Davide Cervia
Summary: This article discusses the relationship between mitochondrial dysfunction and retinal pathology related to RGC degeneration, as well as the potential for neuroprotection using redox-related strategies.
Article
Chemistry, Multidisciplinary
Bin Lv, Jingru Ma, Yumeng Wang, Xinyu Qu, Junjun Qiu, Keqin Hua
Summary: In this study, TPP-modified DMON nanoplatforms were developed to deliver DDP to mitochondria, overcoming DDP resistance. TPP facilitated the migration of nanoplatforms to mitochondria, and the S-S bond of DMON depleted mitochondrial glutathione, leading to mitochondrial redox dyshomeostasis and increased sensitivity to DDP.
FRONTIERS IN CHEMISTRY
(2022)
Article
Food Science & Technology
Sreelekshmi Mohan, Genu George, K. G. Raghu
Summary: The study found that vanillic acid has potential nutraceutical effects by reducing oxidative stress and lipid peroxidation, protecting mitochondria, and preventing glycation during hyperinsulinemia. It acts through the AMPK/Sirt1/PGC-1 alpha pathway to achieve its beneficial activities.
Review
Biochemistry & Molecular Biology
Robert T. Mallet, Johannes Burtscher, Vincent Pialoux, Qadar Pasha, Yasmin Ahmad, Gregoire P. Millet, Martin Burtscher
Summary: High-altitude illnesses result from acute exposure to high altitude/hypoxia. Understanding molecular mechanisms is essential for optimizing hypoxic acclimatization for efficient prophylaxis and treatment of these illnesses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yanqi Lin, Xiaowen Wu, Lingli Lin, Yuanyuan Mei, Jing Zhou, Chaoxiang Chen, Jian Li, Daren Wu, Jingwen Liu, Guiling Li
Summary: This study found that EPA can upregulate miR-494-5p to regulate cellular oxidative stress and enhance antioxidant capacity. miR-494-5p inhibits the expression of MIEF1 gene, leading to the modulation of mitochondrial structure and activity, thus improving cellular antioxidant capacity. This study provides novel insights into the post-translational regulation of antioxidation reactions involving mitochondria.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wei Ou, Yu Liang, Yu Qing, Wei Wu, Maodi Xie, Yabing Zhang, Yarong Zhang, Liwei Ji, Haiyang Yu, Tao Li
Summary: The study revealed that hypoxic acclimation (HA) can alleviate cardiac ischemia-reperfusion (I/R) injury by enhancing antioxidative capacity through activation of glucose metabolism, particularly by upregulating the enzyme G6PDH. This cardioprotective effect highlights the potential of HA as a promising strategy against I/R injury, suggesting that O-GlcNAc modification of G6PDH could be a therapeutic target for ischemic heart disease.
Article
Biochemistry & Molecular Biology
Sonia A. Pinho, Sandra I. Anjo, Teresa Cunha-Oliveira
Summary: Theragnostics is a promising strategy that combines diagnostics and therapeutics in a personalized manner. This review emphasizes the significance of redox homeostasis and mitochondrial function in personalized theragnostics. Disruption of redox homeostasis can lead to oxidative stress and cellular damage, which are associated with various diseases. Developing models of oxidative stress and mitochondrial dysfunction in metabolically conditioned cells allows for studying disease mechanisms and developing new therapies. By selecting appropriate cellular models, optimizing cell culture conditions, and validating the models, it is possible to identify the most promising therapeutic options and tailor treatments to individual patients. Overall, this review highlights the importance of precise and individualized approaches in theragnostics and the need for accurate in vitro models reflecting in vivo conditions.
Review
Immunology
Yubo Li, Chengming Li, Tao Luo, Tian Yue, Wenjing Xiao, Ling Yang, Zaiyuan Zhang, Fei Han, Pan Long, Yonghe Hu
Summary: With the increasing participation of low-altitude individuals in high-altitude activities, the study of high altitude cerebral edema (HACE) has regained attention. HACE is a severe acute mountain sickness that occurs due to hypobaric hypoxia at high altitudes and is characterized by consciousness disturbance and ataxia. Previous research has suggested that the pathogenesis of HACE may involve cerebral blood flow disorders, blood-brain barrier disruption, and brain parenchymal cell injury caused by inflammatory factors. Recent studies have also shown that the imbalance of REDOX homeostasis is involved in HACE, resulting in abnormal activation of microglia and disruption of tight junctions in vascular endothelial cells through excessive production of mitochondrial-related reactive oxygen species. Therefore, this review focuses on the role of REDOX homeostasis and its potential in HACE treatment, which is of great importance for expanding the understanding of HACE pathogenesis and exploring possible therapeutic approaches targeting REDOX homeostasis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Medicinal
Yu-Ki Tanaka, Hana Usuzawa, Miyu Yoshida, Kazuhiro Kumagai, Keita Kobayashi, Satoshi Matsuyama, Takato Inoue, Akihiro Matsunaga, Mari Shimura, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Yasunori Fukumoto, Noriyuki Suzuki, Yasumitsu Ogra
Summary: This study elucidated the antagonistic effect of Na2SeO3 on Hg2+ toxicity in HepG2 cells, demonstrating that HgSe granules are primarily biogenically generated and considered the ultimate metabolite in Hg detoxification.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Review
Neurosciences
Melanie Gil, Vivian Gama
Summary: Oligodendrocytes are important for the central nervous system's signal transmission and metabolic support. However, the role of mitochondrial-related pathways in oligodendrocyte development is not well understood. Maintaining mitochondrial dynamics is crucial for cellular bioenergetics and the distribution of mitochondria in oligodendrocytes. Understanding the interplay between mitochondrial dynamics, metabolism, and apoptosis will shed light on the mechanisms of oligodendrocyte development. This review provides an overview of oligodendrocyte development and discusses the potential contribution of mitochondrial-mediated mechanisms to oligodendrocyte bioenergetics and development.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tokuji Tsuji, Shin-ya Morita, Yoshinobu Nakamura, Yoshito Ikeda, Taiho Kambe, Tomohiro Terada
Summary: The study revealed that the phospholipid class compositions in HepG2 cells change significantly with cell growth, with different membrane compartments showing varying ratios of phospholipid classes. This suggests that the phospholipid metabolism in organellar membranes is tightly regulated by cell growth.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Anne-Francoise Close, Heeyoung Chae, Jean-Christophe Jonas
Summary: The study compared the impact of Nnt(Tr) and other genetic variants between C57BL/6J and C57BL/6N mice on mitochondrial redox state, glucose-stimulated insulin secretion, and glucose tolerance. While NNT was found to play a crucial role in regulating mitochondrial redox state, its effects on GSIS and glucose tolerance were minimized, suggesting that the Nnt(WT) genotype in C57BL/6 mice may not necessarily indicate superior glucose tolerance compared to C57BL/6N mice.
Article
Chemistry, Medicinal
Xu Wang, Wenzhuang Shi, Kang Wang, Zifan Ye, Runying Wang, Hui Wang, Huaixin Yang, Zeping Xie, Haining Yu, Yipeng Wang
Summary: In this study, a nonapeptide named PWH was screened and found to have antioxidant activity, promote the secretion of type 1 collagen, and repair damaged skin. PWH could alleviate UV-A-induced oxidative stress, restrain pro-inflammatory cytokine production, protect mitochondrial function, and maintain autophagy activity. In addition, inhibiting the PI3K/AKT/mTOR signaling pathway and restoration of autophagy activity were found to delay the photoaging process in skin cells. Topical applications of PWH showed significant protection against full-wavelength UV-induced skin aging in mice models, both in prophylaxis and treatment. With good stability and no toxicity or anaphylaxis, PWH holds promise as a candidate for cosmetics and pharmaceuticals.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Thomas Nury, Amira Zarrouk, Aline Yammine, John J. Mackrill, Anne Vejux, Gerard Lizard
Summary: Oxysterols, oxidized forms of cholesterol, induce cell death through oxidative stress, apoptosis, and autophagy at cytotoxic concentrations. This process involves activation of mitochondrial pathway, changes in mitochondrial permeability, and alterations in peroxisome function, ultimately leading to cell damage.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Sudhakaran Sruthi, Thomas Nury, Nadine Millot, Gerard Lizard
Summary: Zinc oxide nanoparticles have great potential for applications, but their toxicity, particularly in causing neurotoxicity, is a significant concern. In studies on murine microglial BV-2 cells, it was found that ZnO NPs could induce non-apoptotic cell death associated with an accumulation of reactive oxygen species, mitochondrial and lysosomal dysfunction, and plasma membrane damages.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Berengere Papegay, Vincent Nuyens, Adelin Albert, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Oberdan Leo, Veronique Kruys, Jean G. Boogaerts, Joseph Vamecq
Summary: Studies comparing livers isolated from rats starved for different durations found that AMPK, P2Y13 receptor, and ADP play crucial roles in liver protection and autophagy activation during ex vivo perfusion.
LIVER TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Naira Sahakyan, Pierre Andreoletti, Mustapha Cherkaoui-Malki, Margarit Petrosyan, Armen Trchounian
Summary: The study investigated the impact of essential oil extracted from Artemisia dracunculus on the antioxidant capacity of cells, showing that it can increase cell viability and promote the activity of antioxidant enzymes.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Cell Biology
T. Nury, A. Yammine, I Ghzaiel, K. Sassi, A. Zarrouk, F. Brahmi, M. Samadi, S. Rup-Jacques, D. Vervandier-Fasseur, J. P. Pais de Barros, V Bergas, S. Ghosh, M. Majeed, A. Pande, A. Atanasov, S. Hammami, M. Hammami, J. Mackrill, B. Nasser, P. Andreoletti, M. Cherkaoui-Malki, A. Vejux, G. Lizard
Summary: Age-related diseases such as cardiovascular diseases, neurodegenerative diseases, and eye disorders are associated with increased levels of cholesterol derivatives, specifically 7-ketocholesterol and 7 beta-hydroxycholesterol, which may lead to cell death. Understanding the signaling pathways associated with the toxicity of these oxysterols is essential for identifying pharmacological targets, nutrients, and synthetic molecules that can attenuate or inhibit their cytotoxic activities to potentially treat these diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Thomas Nury, Mohamed Ksila, Valerio Leoni, Balkiss Bouhaouala-Zahar, Sonia Hammami, Mohamed Hammami, John J. Mackrill, Mohammad Samadi, Taoufik Ghrairi, Anne Vejux, Gerard Lizard
Summary: 7-Ketocholesterol, a cholesterol oxidization product, plays a role in the development of age-related diseases and has antimicrobial properties. However, elevated levels in COVID-19 patients may worsen symptoms, suggesting it could be a potential biomarker for disease outcome. Counteracting its toxic effects with adjuvant therapies could have beneficial effects in COVID-19 patients.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Adil El Midaoui, Imen Ghzaiel, Dominique Vervandier-Fasseur, Mohamed Ksila, Amira Zarrouk, Thomas Nury, Farid Khallouki, Aboubaker El Hessni, Salama Ouazzani Ibrahimi, Norbert Latruffe, Rejean Couture, Omar Kharoubi, Fatiha Brahmi, Sonia Hammami, Olfa Masmoudi-Kouki, Mohamed Hammami, Taoufik Ghrairi, Anne Vejux, Gerard Lizard
Summary: Saffron, a medicinal plant rich in carotenoids and terpenes, has powerful antioxidant and anti-inflammatory properties. Its beneficial effects on neuropsychiatric and age-related diseases make it significant in promoting human health.
Article
Biochemistry & Molecular Biology
Mohamed Ksila, Anne Vejux, Emmanuelle Prost-Camus, Philippe Durand, Imen Ghzaiel, Thomas Nury, Dorian Duprey, Smail Meziane, Olfa Masmoudi-Kouki, Norbert Latruffe, Taoufik Ghrairi, Michel Prost, Gerard Lizard, Dominique Vervandier-Fasseur
Summary: Trans-resveratrol is a natural polyphenol with anti-tumoral and antioxidant activity. In this study, we synthesized a series of imine analogs of trans-resveratrol and evaluated their cytotoxic and antioxidant activities.
Article
Biochemistry & Molecular Biology
Imen Ghzaiel, Amira Zarrouk, Soukaina Essadek, Lucy Martine, Souha Hammouda, Aline Yammine, Mohamed Ksila, Thomas Nury, Wiem Meddeb, Mounia Tahri Joutey, Wafa Mihoubi, Claudio Caccia, Valerio Leoni, Mohammad Samadi, Niyazi Acar, Pierre Andreoletti, Sonia Hammami, Taoufik Ghrairi, Anne Vejux, Mohamed Hammami, Gerard Lizard
Summary: Peroxisomes play a crucial role in cell metabolism and RedOx homeostasis. 7 ss-hydroxycholesterol induces oxidative stress, mitochondrial dysfunction, and peroxisomal alterations, while milk thistle seed oil and alpha-tocopherol have protective effects.
Review
Biochemistry & Molecular Biology
Leila Rezig, Imen Ghzaiel, Mohamed Ksila, Aline Yammine, Thomas Nury, Amira Zarrouk, Mohammad Samadi, Moncef Chouaibi, Anne Vejux, Gerard Lizard
Summary: 7-ketocholesterol and 7 beta-hydroxycholesterol are two oxysterols formed by the autoxidation of cholesterol and are often increased in age-related and civilization diseases. These oxysterols induce oxidative stress and inflammation, and their toxicity can lead to oxidative apoptosis characterized by oxidative stress, apoptosis induction, and autophagy criteria. Nutrients in the Mediterranean diet, including tocopherols, fatty acids, and polyphenols, as well as Mediterranean oils, have shown cytoprotective activities, suggesting a potential nutraceutical approach to counteract the effects of these oxysterols.
Editorial Material
Cell Biology
Imen Ghzaiel, Thomas Nury, Amira Zarrouk, Anne Vejux, Gerard Lizard
Article
Clinical Neurology
V. Schneider, A. Vejux, T. Nury, G. Dupont, J. P. Pais de Barros, D. Lakomy, G. Lizard, T. Moreau
Summary: The study evaluates the performance of plasma biomarkers related to neurodegeneration, oxidative stress, and lipid metabolism in distinguishing between Parkinson's disease and atypical parkinsonian syndromes.
REVUE NEUROLOGIQUE
(2023)
Article
Biochemistry & Molecular Biology
Habiba Bouchab, Soukaina Essadek, Soufiane El Kamouni, Khadija Moustaid, Abdelkhalid Essamadi, Pierre Andreoletti, Mustapha Cherkaoui-Malki, Riad El Kebbaj, Boubker Nasser
Summary: Recently, there has been a focus on studying the protective powers of medicinal plants and identifying new molecules with antioxidant properties. Argan oil and olive oil have gained considerable attention due to their composition and preventive properties. This study aimed to determine the content of phenolic compounds, chlorophylls, and carotenoid pigments in these oils and evaluate their antioxidant potential.
Article
Chemistry, Applied
Leila Rezig, Lucy Martine, Thomas Nury, Kamel Msaada, Nesrine Mahfoudhi, Imen Ghzaiel, Emmanuelle Prost-Camus, Philippe Durand, Adil El Midaoui, Niyazi Acar, Norbert Latruffe, Anne Vejux, Gerard Lizard
Summary: This study analyzed the fatty acid, tocopherol, phytosterol, and polyphenol profiles of Mediterranean oils, including pumpkin, melon, and black cumin seed oils, as well as dietary argan seed oil. The results showed that these oils are rich in bioactive compounds that can provide cytoprotective properties and prevent oxidative stress.
JOURNAL OF OLEO SCIENCE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Imen Ghzaiel, Amira Zarrouk, Khouloud Sassi, Thomas Nury, Sonia Hammami, Anne Vejux, Gerard Hubert Lizard
FREE RADICAL BIOLOGY AND MEDICINE
(2022)