Article
Biochemistry & Molecular Biology
Qi Guo, Shicheng Cao, Xiaohong Wang
Summary: Exercise can improve the pathogenic changes in adiponectin and betatrophin levels in insulin-resistant mice. This effect is achieved by increasing adiponectin levels and reducing betatrophin levels through exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Su-Min Moon, Min-Jin Joo, Young-Seo Lee, Myeong-Gyu Kim
Summary: This meta-analysis found that long-term coffee consumption had a nonsignificant effect on insulin resistance and sensitivity. Further studies are needed to evaluate the effects of coffee consumption in healthy, young, and normal-weight individuals.
Article
Endocrinology & Metabolism
S-S Tong
Summary: The study found that serum betatrophin concentration was significantly increased in GDM patients, and positively correlated with BMI, TG, TC, FSI, and HOMA-IR. Insulin resistance may be a mechanism involved in the overexpression of serum betatrophin in GDM patients, suggesting that serum betatrophin could potentially be used as a biochemical indicator for predicting GDM.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Review
Biochemistry & Molecular Biology
Beatriz Isabel Garcia-Martinez, Mirna Ruiz-Ramos, Jose Pedraza-Chaverri, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: Resveratrol has the potential to improve glucose and insulin levels in patients with type 2 diabetes, with significant improvement in glucose observed at doses of 500-1000 mg/day, and improvement in insulin seen at doses lower than 500 mg/day or greater than 1000 mg/day.
Review
Pharmacology & Pharmacy
Laura Alvarez-Jimenez, Felix Morales-Palomo, Alfonso Moreno-Cabanas, Juan F. Ortega, Ricardo Mora-Rodriguez
Summary: This study provides an update on the diabetogenic effect of statins by analyzing randomized-controlled trials. The results show that statin therapy increases glycated hemoglobin levels and insulin resistance regardless of the glycemic control status. The diabetogenic effect is not influenced by the type or dosage of statin prescribed.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alper Sonmez, Teoman Dogru, Cemal Nuri Ercin, Halil Genc, Gurkan Celebi, Hasan Gurel, Serkan Tapan, Ali Fuat Cicek, Cem Barcin, Cem Haymana, Ali Kirik, Manfredi Rizzo
Summary: Betatrophin levels are higher in the early stages of NAFLD, positively correlated with age, waist circumference, lipid profile, glucose, insulin, and liver function, and negatively correlated with steatosis and NAS. Triglyceride, glucose, and NAS are independent determinants of betatrophin levels.
Article
Biochemistry & Molecular Biology
Paul Horn, Sascha Radtke, Uta Barbara Metzing, Ricardo Steidl, Christoph Sponholz, Oliver Sommerfeld, Johannes Roth, Ralf A. Claus, Andreas L. Birkenfeld, Utz Settmacher, Falk Rauchfuss, Christian von Loeffelholz
Summary: This study found that sepsis patients have significant dyslipidemia and the cytokine betatrophin/ANGPTL8 plays an important role in this metabolic disorder. Despite similar mRNA expression levels in adipose tissue, circulating betatrophin/ANGPTL8 is significantly increased in sepsis patients.
Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo
Summary: The systematic review with meta-analysis showed that resveratrol supplementation has protective effects on diabetes parameters. The analysis revealed significant reduction in insulin resistance and glycated hemoglobin, and a significant impact on fasting blood glucose in individuals with diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo, Bruna Goncalves Cordeiro da Silva, Taiciane Goncalves da Silva, Gicele Costa Mintem, Renata Moraes Bielemann, Denise Petrucci Gigante
Summary: The study found that omega-3 supplementation has significant effects in reducing fasting blood glucose and insulin resistance, but not on glycated hemoglobin levels in diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Violet Dismas Kajogoo, Mary Gorret Atim, Demeke Amare, Melka Geleta, Yilkal Muchie, Hanna Amanuel Tesfahunei, Willyhelmina Olomi, Joan Acam, Tsegahun Manyazewal
Summary: This study analyzed the impact of Protease Inhibitors (PIs) on insulin sensitivity and the onset of diabetes mellitus (DM) in HIV patients. The results showed that among PIs, atazanavir, fosamprenavir, and darunavir did not demonstrate significant changes in insulin sensitivity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Fangfang Xu, Nan Wang, Gangqiang Li, Dandan Tian, Xiaoyang Shi
Summary: The study showed that ANGPTL8/betatrophin improved glucose tolerance in older mice and exhibited metabolic changes in insulin-resistant HepG2 cells.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Endocrinology & Metabolism
Buket Engin, Scott A. Willis, Sundus Malaikah, Jack A. Sargeant, Thomas Yates, Laura J. Gray, Guruprasad P. Aithal, David J. Stensel, James A. King
Summary: This systematic review and meta-analysis examined the effects of exercise training on adipose tissue insulin sensitivity in adults. The results suggest that exercise training can improve whole-body adipose tissue insulin sensitivity, but its impact on localized adipose tissue remains uncertain.
Review
Food Science & Technology
Somaye Fatahi, Ali Nazary-Vannani, Mohammad Hassan Sohouli, Zeinab Mokhtari, Hamed Kord-Varkaneh, Vihan Moodi, Shing Cheng Tan, Teck Yew Low, Fernando Zanghelini, Farzad Shidfar
Summary: The study revealed that fasting or energy-restricting diets significantly decrease fasting blood sugars, insulin, and insulin resistance levels, with modest effects on HbA1c levels. Overweight or obese individuals on energy-restricting diets for more than 8 weeks showed greater reductions in FBS, insulin, and HOMA-IR levels compared to other subgroups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Nutrition & Dietetics
Enav Yefet, Liron Bar, Ido Izhaki, Rula Iskander, Manal Massalha, Johnny S. S. Younis, Zohar Nachum
Summary: This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplements on glycemic control and metabolic parameters in women with gestational diabetes mellitus (GDM). The results showed that compared to placebo, women receiving probiotic supplements had significantly lower fasting serum glucose, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, and VLDL levels. The use of probiotic supplements containing Lactobacillus acidophilus also led to decreased neonatal birth weight.
Review
Environmental Sciences
Hui Gao, Dan Chen, Miao Zang
Summary: A systematic review and meta-analysis investigated the effects of phthalate exposure on insulin resistance, finding a positive relationship between exposure to specific phthalate metabolites and increased insulin resistance. Sensitivity analyses indicated that exposure to certain phthalates was associated with an increased risk of HOMA-IR, while age, sex, and study site had limited impact on heterogeneity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)