期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 56, 期 -, 页码 S4-S28出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2015.1074532
关键词
Flavonoids; cytotoxic; leukemia; SAR; caspase; PARP; mitochondria; ROS; P-glycoprotein; chemoprevention; apoptosis
资金
- University of Aveiro
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal)
- European Union
- QREN
- FEDER
- COMPETE [PEst-C/QUI/UI0062/2013, FCOMP-01-0124-FEDER-037296]
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg asbl
- Een Haerz fir Kriibskrank Kanner association
- Action Lions Vaincre le Cancer Luxembourg
- Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University
- NRF by the MEST of Korea for Tumor Microenvironment GCRC [2012-0001184]
- Brain Korea (BK21) PLUS program
Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive spectrum of pharmacological activities, including antioxidants, antitumor, anti-inflammatory, and antiviral activities. These flavonoids can also act as chemopreventive agents by their interaction with different proteins and can play a vital role in chemotherapy, suggesting a positive correlation between a lower risk of cancer and a flavonoid-rich diet. These agents interfere with the main hallmarks of cancer by various individual mechanisms, such as inhibition of cell growth and proliferation by arresting the cell cycle, induction of apoptosis and differentiation, or a combination of these mechanisms. This review is an effort to highlight the therapeutic potential of natural and synthetic flavonoids as anticancer agents in leukemia treatment with respect to the structure-activity relationship (SAR) and their molecular mechanisms. Induction of cell death mechanisms, production of reactive oxygen species, and drug resistance mechanisms, including p-glycoprotein efflux, are among the best-described effects triggered by the flavonoid polyphenol family.
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