Review
Hematology
Nadia R. Sutton, Rajeev Malhotra, Cynthia St. Hilaire, Elena Aikawa, Roger S. Blumenthal, Grace Gackenbach, Parag Goyal, Adam Johnson, Sagar U. Nigwekar, Catherine M. Shanahan, Dwight A. Towler, Brooke N. Wolford, Yabing Chen
Summary: Cardiovascular disease is the leading cause of death globally, particularly in individuals over the age of 65, with myocardial infarction and stroke being the primary contributors. The development of vascular aging and vascular calcification with aging is not fully understood, but is believed to be influenced by genetic risk, environmental factors, and the ability of vascular smooth muscle cells to acquire an osteogenic phenotype. Understanding the molecular mechanisms behind age-associated vascular pathology may lead to strategies for promoting healthy vascular aging. This article provides a summary of current knowledge on age-associated vascular disease, with a focus on vascular calcification.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dae Kyu Kim, Yu Ho Lee, Jin Sug Kim, Yang Gyun Kim, So-Young Lee, Shin Young Ahn, Dong-Young Lee, Kyung Hwan Jeong, Sang-Ho Lee, Hyeon Seok Hwang, Ju-Young Moon
Summary: In hemodialysis patients, plasma VAP-1 levels are positively correlated with plasma levels of cardiac remodeling markers and higher levels are associated with left ventricular diastolic dysfunction. Patients with higher circulating VAP-1 levels have an increased risk of incident cardiovascular and cardiac events, suggesting that VAP-1 may help clinicians identify HD patients at high risk of cardiovascular events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Shijie Liu, Jinzi Wu, Amanda Stolarz, Huiliang Zhang, Marjan Boerma, Stephanie D. Byrum, Nancy J. Rusch, Zufeng Ding
Summary: This study demonstrates the significant impact of PCSK9 on efferocytosis in ECs and its implications in vascular aging. The findings suggest that PCSK9 deficiency can restore efferocytosis and inhibit the expression of aging markers. Treatment with a PCSK9 inhibitor shows potential in improving vascular aging and reducing inflammation.
Article
Biochemistry & Molecular Biology
Yoichi Takami, Cheng Wang, Hironori Nakagami, Koichi Yamamoto, Yoichi Nozato, Yuki Imaizumi, Motonori Nagasawa, Hikari Takeshita, Tsuneo Nakajima, Shuko Takeda, Yasushi Takeya, Yasufumi Kaneda, Hiromi Rakugi
Summary: This study reveals the important physiological roles of SNCA in the regulation of vascular integrity and blood pressure through its effects on endothelial cells. Exogenous SNCA promotes vascular function by activating the eNOS pathway and inhibiting inflammation, while endogenous SNCA levels decrease during cellular senescence, contributing to age-related endothelial dysfunction.
Article
Endocrinology & Metabolism
Maria Fusaro, Mario Cozzolino, Mario Plebani, Giorgio Iervasi, Markus Ketteler, Maurizio Gallieni, Andrea Aghi, Francesco Locatelli, John Cunningham, Syazrah Salam, Martina Zaninotto, Maura Ravera, Domenico Russo, Maria Cristina Mereu, Sandro Giannini, Maria Luisa Brandi, Serge Ferrari, Stefania Sella, Colin Gerard Egan, Antonio Bellasi, Luca Di Lullo, Giovanni Tripepi, Thomas Nickolas
Summary: The study found that HD patients treated with sevelamer had lower levels of MK4 and a higher incidence of MK4 deficiency, which was associated with aortic calcification. Furthermore, sevelamer may increase the impact of total BGP levels on vascular calcifications and vertebral fractures in CKD patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Medicine, General & Internal
Guang-Ming Li, Hui Zhou, Ming-Yu Liang, Shao-Ying Wu, Fang-Xu Jiang, Zhong-Ling Wang
Summary: The study aimed to investigate the diagnostic role of multislice spiral CT (MSCT) combined with clinical manifestations and laboratory tests in acute appendicitis subtypes. The study found that clinical manifestations and MSCT signs might have significant diagnostic value in acute appendicitis.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fanglin Niu, Zhuozhuo Li, Yuanyuan Ren, Zi Li, Hua Guan, Yang Li, Yan Zhang, Yirong Li, Junle Yang, Lu Qian, Wenzhen Shi, Xiaobin Fan, Jinli Li, Lele Shi, Yi Yu, Yuyan Xiong
Summary: This study found that abnormal hyperexpression of GIGYF2 was observed in senescent human endothelial cells (ECs) and the aortas of old mice. Silencing GIGYF2 can suppress the senescence and dysfunction of ECs. On the contrary, overexpression of GIGYF2 promotes senescence, dysfunction, and activation of the mTORC1-SK61 pathway in non-senescent cells. The study also revealed that GIGYF2 acts as an RNA binding protein (RBP) to enhance STAU1 mRNA stability and that LAMTOR4 expression is upregulated by the binding of STAU1 protein to its intron region. The disruption of the GIGYF2-STAU1-mTORC1 signaling cascade may be a promising therapeutic approach against vascular aging and aging-related cardiovascular diseases.
Review
Dentistry, Oral Surgery & Medicine
Li Zhen Lim, Pamela Shu Fen Koh, Shuo Cao, Raymond Chung Wen Wong
Summary: The study found that patients with carotid artery calcifications (CACs) seen on panoramic dental imaging may be more likely to experience future adverse events such as stroke, transient ischemic attack, and myocardial infarction, but not all results were statistically significant. Bilateral vessel-outlining CACs were found to be an independent risk marker for future vascular events. Therefore, further evaluation should be considered for patients who are not currently managed for cardiovascular risk factors.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Peripheral Vascular Disease
Shota Shimizu, Tomohiro Iba, Hisamichi Naito, Fitriana Nur Rahmawati, Hirotaka Konishi, Weizhen Jia, Fumitaka Muramatsu, Nobuyuki Takakura
Summary: This study found that the number of tissue-resident vascular endothelial stem cells (VESCs) was lower in aged mice and their potential to differentiate into endothelial cells was impaired. The study also discovered that inflammatory signaling was more activated in aged mice, suggesting the possible involvement of age-associated inflammation in the functional decline of VESCs.
Article
Medicine, General & Internal
Rossella Del Toro, Francesco Palmese, Francesco Feletti, Gianluca Zani, Maria Teresa Minguzzi, Ernesto Maddaloni, Nicola Napoli, Giorgio Bedogni, Marco Domenicali
Summary: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. In this study of elderly patients with SARS-CoV-2 infection, the association between vascular calcifications, bone density, muscle density, and the odds of dying was evaluated. Age was found to be the strongest predictor of body composition and death, overshadowing the relationships between these factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Nelles, Kai Roman Laukamp, Nils Grosse Hokamp, Charlotte Zaeske, Erkan Celik, Michael Hinrich Schoenfeld, Jan Borggrefe, Christoph Kabbasch, Marc Schlamann, Simon Lennartz, David Zopfs
Summary: This study assessed the diagnostic value of SDCT-derived VNC images for differentiation between vascular enhancement and wall calcifications in cystic intracranial tumors. The results demonstrated that VNC images facilitate the differentiation between these two conditions, improve diagnostic accuracy, and reduce image noise.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Alejandra Gonzalez-Loyola, Tatiana V. Petrova
Summary: The lymphatic vasculature plays a crucial role in maintaining body fluid balance, immune surveillance, and dietary fat absorption. Recent studies have shed light on the mechanisms of lymphatic vascular development and function.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Medicine, General & Internal
Balazs Sagi, Szilard Kun, Rita Klaudia Jakabfi-Csepregi, Endre Sulyok, Botond Csiky
Summary: This study found that acute vascular changes occur in chronic hemodialysis patients during the dialysis process, mediated by factors related to the endothelium. These changes are correlated with cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Samuel I. Bloom, Yu Liu, Jordan R. Tucker, Md Torikul Islam, Daniel R. Machin, Hossein Abdeahad, Tyler G. Thomas, R. Colton Bramwell, Lisa A. Lesniewski, Anthony J. Donato
Summary: In advanced age, oxidative stress and inflammation increase and impair endothelial function, leading to cardiovascular disease (CVD). Senescent endothelial cells are a possible source of this oxidative stress and inflammation. In this study, reducing the telomere shelterin protein Trf2 in young mice resulted in endothelial cell telomere dysfunction, cellular senescence, increased inflammatory signaling, oxidative stress, and impairments in endothelial function. These findings suggest that age-related telomere dysfunction leads to endothelial cell senescence, contributing to age-related increases in oxidative stress, inflammation, and cardiovascular dysfunction.
Review
Endocrinology & Metabolism
Fen Cao, Kun Wu, Yong-Zhi Zhu, Zhong-Wu Bao
Summary: DPP4 inhibitors have complex cellular mechanisms that can reverse vascular aging, prevent related diseases, and improve endothelial cell function, proliferation, migration, and senescence while inhibiting apoptosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Medicinal
Maria Albanese, Giulia Marrone, Agostino Paolino, Manuela Di Lauro, Francesca Di Daniele, Carlo Chiaramonte, Cartesio D'Agostini, Annalisa Romani, Alessandro Cavaliere, Cristina Guerriero, Andrea Magrini, Nicola Biagio Mercuri, Nicola Di Daniele, Annalisa Noce
Summary: Ultramicronized palmitoylethanolamide (um-PEA) appears to be a potential adjuvant treatment for early stages of COVID-19, with beneficial effects on inflammation, oxidative stress, and coagulative cascade alterations in asymptomatic and mild-symptomatic patients.
Article
Biochemistry & Molecular Biology
Francesca Pacifici, Chiara Salimei, Donatella Pastore, Gina Malatesta, Camillo Ricordi, Giulia Donadel, Alfonso Bellia, Valentina Rovella, Marco Tafani, Enrico Garaci, Manfredi Tesauro, Davide Lauro, Nicola Di Daniele, David Della-Morte
Summary: The combination of polyphenols and micronutrients, known as A5(+), has shown synergistic and innovative efficacy against cellular pathological processes in Parkinson's disease. It reduces inflammation, activates extracellular signal-regulated kinases, increases cell viability, and promotes cellular differentiation into dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Micaela Costacurta, Michele Basilicata, Giulia Marrone, Manuela Di Lauro, Vincenzo Campolattano, Patrizio Bollero, Raffaella Docimo, Nicola Di Daniele, Annalisa Noce
Summary: Several studies have shown a strong link between periodontal diseases and chronic kidney disease, possibly due to malnutrition, vitamin dysregulation, oxidative stress, metabolic acidosis, and low-grade inflammation. It is important for a multidisciplinary team to manage patients with these two conditions and develop treatment strategies.
Article
Environmental Sciences
Elisa Grazioli, Eliana Tranchita, Giulia Marrone, Silvia Urciuoli, Manuela Di Lauro, Claudia Cerulli, Nicolo Piacentini, Arianna Murri, Roberto Celotto, Annalisa Romani, Attilio Parisi, Nicola Di Daniele, Annalisa Noce
Summary: This pilot study aimed to evaluate the effects of functional anti-inflammatory and antioxidant bars combined with adapted physical activity on uremic sarcopenia and other comorbidities in chronic kidney disease (CKD) patients. The study found that participants who underwent physical exercise and consumed functional bars showed improvements in body composition, blood pressure, lipid metabolism, and functional tests.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Michele Basilicata, Manuela Di Lauro, Vincenzo Campolattano, Giulia Marrone, Roberto Celotto, Anna Paola Mitterhofer, Patrizio Bollero, Nicola Di Daniele, Annalisa Noce
Summary: Chronic kidney disease (CKD) is a global public health problem and recent studies have shown a causal relationship between CKD and oral diseases. Oral diseases are common in CKD patients, including chronic periodontitis, bone lesions, oral infections, and oral cancer. Standardized therapy for oral diseases is currently lacking, however, natural bioactive compounds (NBCs) could serve as a new possible adjuvant therapy for managing these conditions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Giulia Marrone, Silvia Urciuoli, Manuela Di Lauro, Jessica Ruzzolini, Francesca Ieri, Pamela Vignolini, Francesca Di Daniele, Cristina Guerriero, Chiara Nediani, Nicola Di Daniele, Annalisa Noce
Summary: This study evaluated the cardioprotective effects of extra virgin olive oil (EVOO) containing high levels of minor phenolic compounds (MPCs) in CKD patients. The results showed that EVOO intake reduced inflammation and oxidative stress, improved lipid and purine metabolism, and lowered the risk of atherosclerosis.
Article
Nutrition & Dietetics
Silverio Rotondi, Lida Tartaglione, Marzia Pasquali, Maria Jose Ceravolo, Anna Paola Mitterhofer, Annalisa Noce, Monica Tavilla, Silvia Lai, Francesca Tinti, Maria Luisa Muci, Alessio Farcomeni, Sandro Mazzaferro
Summary: This study evaluated the association between cognitive impairment (evaluated using MoCA scores) and nutritional status (evaluated using MIS scores) in hemodialysis patients. The results showed that both cognitive impairment and malnutrition were prevalent in hemodialysis patients, and malnutrition was identified as a risk factor for cognitive impairment.
Article
Environmental Sciences
Isabella Polidori, Laura Marullo, Cristiano Ialongo, Flaminia Tomassetti, Roberto Colombo, Francesca di Gaudio, Graziella Calugi, Giulia Marrone, Annalisa Noce, Sergio Bernardini, Francesco Broccolo, Massimo Pieri
Summary: This study examines the dysbiosis status in the Italian population, specifically focusing on patients with type 2 diabetes (T2D) and metabolic disorders. The results show a bias towards Proteobacteria in T2D patients, potentially influenced by their dietary habits. It was also observed that T2D females have altered gut permeability, which may increase the risk of vaginal infections.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Chemistry, Multidisciplinary
Michele Basilicata, Giulia Marrone, Manuela Di Lauro, Eleonora Sargentini, Vincenza Paolino, Redan Hassan, Giuseppe D'Amato, Patrizio Bollero, Annalisa Noce
Summary: Gaucher disease (GD) is a lysosomal storage disorder caused by a mutation in the GBA1 gene, resulting in deficient activity of the enzyme glucocerebrosidase and abnormal storage of glucosylceramide. GD has various clinical types and affects multiple organs, including the hematopoietic system, liver, bones, nervous system, lungs, cardiovascular system, and kidneys. Oral and dental manifestations, such as spontaneous bleeding and bone involvement, can also occur. Enzyme replacement therapy is the main treatment option, but there are also promising developments in other pharmacological approaches and gene therapy.
APPLIED SCIENCES-BASEL
(2023)
Review
Oncology
Annalisa Noce, Giulia Marrone, Manuela Di Lauro, Anna Paola Mitterhofer, Maria Jose Ceravolo, Nicola Di Daniele, Guglielmo Manenti, Antonino De Lorenzo
Summary: The onco-nephrology field focuses on the interaction between cancer and kidney disease. This review discusses the impact of new chemotherapeutic agents on renal function and the development of chronic kidney disease in cancer survivors. It also highlights the challenges in providing optimal cancer treatment to patients with pre-existing chronic kidney disease. Nephrologists should prioritize nephroprotective strategies to prevent acute kidney injury and further deterioration of renal function in cancer patients.
Article
Cell Biology
Francesca Pacifici, Gina Malatesta, Caterina Mammi, Donatella Pastore, Vincenzo Marzolla, Camillo Ricordi, Francesca Chiereghin, Marco Infante, Giulia Donadel, Francesco Curcio, Annalisa Noce, Valentina Rovella, Davide Lauro, Manfredi Tesauro, Nicola Di Daniele, Enrico Garaci, Massimiliano Caprio, David Della-Morte
Summary: This study investigated the effects of a natural mixture of polyphenols and micronutrients (A5(+)) on counteracting white adipogenesis and promoting fat browning. The results showed that A5(+) significantly reduced lipids accumulation, inhibited cellular proliferation, and decreased the release of pro-inflammatory cytokines. Additionally, A5(+) promoted fat browning and fatty acid oxidation by increasing the expression of genes related to brown adipose tissue.
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Review
Nutrition & Dietetics
Manuela Di Lauro, Cristina Guerriero, Kevin Cornali, Maria Albanese, Micaela Costacurta, Nicola Biagio Mercuri, Nicola Di Daniele, Annalisa Noce
Summary: Migraine, one of the most common causes of disability in adults, has been associated with gut dysbiosis, as the intestine is capable of modulating central nervous system activities. In addition to conventional pharmacological treatments, modifying nutrition and lifestyle to positively influence gut microbiota composition may serve as a beneficial adjunct therapy for various migraine subtypes.
Review
Biochemistry & Molecular Biology
Michele Basilicata, Massimo Pieri, Giulia Marrone, Eleonora Nicolai, Manuela Di Lauro, Vincenza Paolino, Flaminia Tomassetti, Ilaria Vivarini, Patrizio Bollero, Sergio Bernardini, Annalisa Noce
Summary: Saliva is a complex fluid that plays a crucial role in various physiological processes and functions, including oral health, taste, digestion, and immunological defenses. The composition of saliva and the oral microbiome can be influenced by factors such as diet and smoking habits, and changes in these factors can lead to the development of systemic illnesses. This review explores the potential of saliva as a new tool for early detection of conditions such as oral diseases and chronic non-communicable diseases, including chronic kidney disease. The correlation between oral and systemic diseases as well as oral and gut microbiota dysbiosis is also examined. Salivary parameters could serve as a new device for detecting oral and systemic pathologies, and modulating oral and gut microbiota through prebiotics, postbiotics, or symbiotics may offer a new approach for managing oral diseases and chronic kidney disease.