Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells

The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice

(2016) Nan Wu et al.   HEPATOLOGY

Functional Role of Cellular Senescence in Biliary Injury

(2015) Luke Meng et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy and senescence in fibrosing cholangiopathies

(2015) Yasuni Nakanuma et al.   JOURNAL OF HEPATOLOGY

Potent effects of dioscin against liver fibrosis

(2015) Xiaoling Zhang et al.   Scientific Reports

Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth

(2014) Fanyin Meng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Involvement of substance P and the NK-1 receptor in human pathology

(2014) Miguel Muñoz et al.   AMINO ACIDS

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling

(2014) Erawan Borkham-Kamphorst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Secretin Stimulates Biliary Cell Proliferation by Regulating Expression of MicroRNA 125b and MicroRNA let7a in Mice

(2014) Shannon Glaser et al.   GASTROENTEROLOGY

Extrahepatic Platelet-Derived Growth Factor-β, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice

(2014) Shuhei Yoshida et al.   GASTROENTEROLOGY

Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis

(2014) James H. Tabibian et al.   HEPATOLOGY

Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis

(2014) James H Tabibian et al.   LABORATORY INVESTIGATION

Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease

(2014) Martin S. Steinhoff et al.   PHYSIOLOGICAL REVIEWS

Chemokine–Chemokine Receptor CCL2–CCR2 and CX3CL1–CX3CR1 Axis May Play a Role in the Aggravated Inflammation in Primary Biliary Cirrhosis

(2013) Motoko Sasaki et al.   DIGESTIVE DISEASES AND SCIENCES

Recent advances in the morphological and functional heterogeneity of the biliary epithelium

(2013) Yuyan Han et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Selective Expansion of Allogeneic Regulatory T Cells by Hepatic Stellate Cells: Role of Endotoxin and Implications for Allograft Tolerance

(2012) A. Dangi et al.   JOURNAL OF IMMUNOLOGY

Hepatic Stellate Cells Undermine the Allostimulatory Function of Liver Myeloid Dendritic Cells via STAT3-Dependent Induction of IDO

(2012) T. L. Sumpter et al.   JOURNAL OF IMMUNOLOGY

Synergism between fibronectin and transforming growth factor-β1 in the production of substance P in monocytes of patients with myelofibrosis

(2012) Victor T. Chang et al.   LEUKEMIA & LYMPHOMA

Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice

(2011) Shannon Glaser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Ductular Cells Undergoing Cellular Senescence Increase in Chronic Liver Diseases Along With Fibrous Progression

(2010) Motoko Sasaki et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Substance P Modulates Colitis-Asscociated Fibrosis

(2010) Hon Wai Koon et al.   AMERICAN JOURNAL OF PATHOLOGY

Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation

(2010) A. Baghdasaryan et al.   GUT

EASL Clinical Practice Guidelines: Management of cholestatic liver diseases

(2009)   JOURNAL OF HEPATOLOGY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Crosstalk of Liver, Bile Ducts and the Gut

(2008) Ulrich Beuers   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY