Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance

Multi-organ Mapping of Cancer Risk

(2016) Liqin Zhu et al.   CELL

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

(2015) Tung-Hung Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway

(2015) X Zhao et al.   Cell Death & Disease

Type 1 TNF Receptor Forms a Complex with and Uses Jak2 and c-Src to Selectively Engage Signaling Pathways That Regulate Transcription Factor Activity

(2014) R. Pincheira et al.   JOURNAL OF IMMUNOLOGY

A preventable cancer

(2014) Lucas Laursen   NATURE

Sox2 Cooperates with Inflammation-Mediated Stat3 Activation in the Malignant Transformation of Foregut Basal Progenitor Cells

(2013) Kuancan Liu et al.   Cell Stem Cell

Modeling Pathogenesis of Primary Liver Cancer in Lineage-Specific Mouse Cell Types

(2013) Ágnes Holczbauer et al.   GASTROENTEROLOGY

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas

(2013) Olivier Govaere et al.   GUT

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

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p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis

(2012) You–Wen Qian et al.   GASTROENTEROLOGY

Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development

(2012) Kun Wu et al.   HEPATOLOGY

Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma

(2012) Juanjuan Shan et al.   HEPATOLOGY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

(2011) Olga A. Guryanova et al.   CANCER CELL

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

(2011) Terence Kin Wah Lee et al.   Cell Stem Cell

Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells

(2011) Wen Sun et al.   HEPATOLOGY

Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin 19 expression and a poor prognosis

(2011) Haeryoung Kim et al.   HEPATOLOGY

FAT10 mediates the effect of TNF-  in inducing chromosomal instability

(2011) J. Ren et al.   JOURNAL OF CELL SCIENCE

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Inflammation and Liver Cancer

(2009) C. Berasain et al.   Annals of the New York Academy of Sciences

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2

(2009) Boris R. A. Blechacz et al.   HEPATOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Liver Cancer Stem Cells

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