Article
Gastroenterology & Hepatology
Sigurdur Olafsson, Sigurjon Rognvaldsson, Ottar M. Bergmann, Jon G. Jonasson, Ubaldo Benitez Hernandez, Einar S. Bjornsson
Summary: The incidence of cirrhosis in Iceland has increased significantly, mainly due to increased alcohol consumption, rising obesity rates, and hepatitis C transmission. The study found that a specific cause for cirrhosis could be identified in 94% of patients.
Article
Gastroenterology & Hepatology
Ali Wakil, Mujtaba Mohamed, Zaid Tafesh, Mumtaz Niazi, Raquel Olivo, Weiyi Xia, Patricia Greenberg, Nikolaos Pyrsopoulos
Summary: According to data from the NIS database, there was a significant increase in AH-related inpatient hospitalizations in the USA from 2011 to 2017. Most patients were white males aged between 45-65 years. The mortality rate of AH remained between 5.3% and 5.5%. The majority of patients had medical charges ranging from $25242.62 to $34874.50.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Axel Wester, Nelson Ndegwa, Hannes Hagstrom
Summary: This study analyzed the epidemiological characteristics of alcohol-related cirrhosis in a case-control study and the association between alcohol-related cirrhosis and the risk of fractures and postfracture mortality. The results showed that patients with alcohol-related cirrhosis had a higher incidence of fractures and higher postfracture mortality compared to the control group. Therefore, preventive interventions to reduce modifiable fracture risk factors in this population are justified.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Surgery
Gretchen E. White, Richard E. Boles, Anita P. Courcoulas, Susan Z. Yanovski, Meg H. Zeller, Todd M. Jenkins, Thomas H. Inge
Summary: This study aimed to describe alcohol use, alcohol-related harm, and alcohol-related problems in adolescents preoperatively and up to 8 years following metabolic and bariatric surgery (MBS). The results showed that the frequency and quantity of alcohol consumption increased after MBS in adolescents, and nearly half of the patients screened positively for alcohol-related harm or problems 8 years post-surgery. Therefore, the evaluation and treatment of alcohol use and alcohol-related problems should be integrated into routine long-term care for adolescents undergoing MBS.
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Maja Thiele, Bjorn Roelstraete, Jonas Soderling, Jonas F. Ludvigsson
Summary: A study conducted in Sweden found that patients with biopsy-proven ALD have a nearly fivefold increased risk of death compared to the general population, and those with ALD without cirrhosis also have a higher risk of death. These results suggest the need to strengthen the management and monitoring of these patients.
Article
Nutrition & Dietetics
Wen Guo, Xinyuan Ge, Jing Lu, Xin Xu, Jiaxin Gao, Quanrongzi Wang, Ci Song, Qun Zhang, Chengxiao Yu
Summary: This large prospective cohort study reveals that an increased intake of food from the Western dietary pattern could be correlated with an increased risk of chronic liver diseases, while the prudent pattern was only correlated with a reduced risk of liver cirrhosis. Higher consumption of red meat and lower consumption of fruit, cereal, tea, and dietary fiber were significantly associated with a higher risk of NAFLD, cirrhosis, and liver cancer.
Article
Biochemistry & Molecular Biology
Hans Dieter Nischalke, Franziska Schmalz, Stephan Buch, Janett Fischer, Christine Moeller, Madlen Matz-Soja, Benjamin Kraemer, Bettina Langhans, Alexandra Klueners, Michael Soyka, Felix Stickel, Jacob Nattermann, Thomas Berg, Christian P. Strassburg, Philipp Lutz
Summary: Hepatocellular carcinoma (HCC) is a severe complication of advanced alcoholic liver disease. This study found an association between genetic variation in SAMM50 and HCC in patients with alcoholic liver disease. Although minor variants of SAMM50 were strongly associated with alcoholic HCC, this association was found to be dependent on the presence of the well-known risk variant PNPLA3 148M.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Silvia Ferri, Bernardo Stefanini, Lorenzo Mulazzani, Margherita Alvisi, Francesco Tovoli, Simona Leoni, Luca Muratori, Tommaso Lotti, Alessandro Granito, Luigi Bolondi, Fabio Piscaglia
Summary: The role of moderate alcohol consumption in the evolution of NAFLD is still debated. This study evaluated the impact of current and lifelong alcohol consumption in NAFLD patients using a new estimation tool called LACU. The results showed that very low alcohol consumption was associated with lower rates of cirrhosis and hepatocellular carcinoma compared to abstainers and moderate consumers.
Article
Medicine, General & Internal
Bhautesh Dinesh Jani, Ross McQueenie, Barbara I. Nicholl, Ryan Field, Peter Hanlon, Katie I. Gallacher, Frances S. Mair, Jim Lewsey
Summary: The study found that drinking red wine, consuming alcohol with food, and spreading alcohol intake over 3-4 days were associated with lower risk of mortality and vascular events among regular alcohol drinkers. Drinking spirits and beer/cider was associated with higher mortality risk.
Article
Medicine, General & Internal
Nina Weis, Terese L. Katzenstein, Mathilde Orbaek, Merete Storgaard, Gitte Pedersen, Isik S. Johansen, Ellen Moseholm
Summary: The Danish HIV Birth Cohort (DHBC) aims to investigate the impact of HIV infection during pregnancy and after delivery in women living with HIV in Denmark, as well as their children. Findings reveal that HIV-exposed, but uninfected children born to these women have higher risks of low birth weight and intrauterine growth retardation compared to children born to the general population. Future plans include continued research on the significance of HIV infection and antiretroviral therapy in pregnant women living with HIV and their children, comparing these findings with children born to the general population.
Article
Medicine, General & Internal
Janne S. Tolstrup, Sofie Kruckow, Ulrik Becker, Ove Andersen, Susan M. Sawyer, Srinivasa Vittal Katikireddi, Sanne Pagh Moller
Summary: This study investigated the association between socioeconomic position (SEP) and alcohol-related hospital contacts in adolescents, and whether differences in risk can be explained by levels of alcohol consumption, drinking pattern, and substance use. The findings showed that despite similar levels of alcohol consumption, socioeconomically disadvantaged adolescents are more likely to experience alcohol-related harm, regardless of differences in drinking pattern or substance use. Therefore, future preventive strategies should prioritize young adolescents, especially those who are most disadvantaged.
Article
Oncology
Dominik Safcak, Sylvia Drazilova, Jakub Gazda, Igor Andrasina, Svetlana Adamcova-Selcanova, Radovan Barila, Michal Mego, Marek Rac, L'ubomir Skladany, Miroslav Zigrai, Martin Janicko, Peter Jarcuska
Summary: Alcoholic liver disease is the most common cause of hepatocellular carcinoma in Slovakia, with distinct clinical characteristics such as higher cirrhosis stages and poorer performance status. However, there were no significant differences in overall survival and progression-free survival between alcoholic liver disease-related HCC and other etiology-related HCC.
Article
Gastroenterology & Hepatology
Dongsub Jeon, Ye-Jee Kim, Seonok Kim, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
Summary: This study aimed to determine the risk of herpes zoster in patients with liver cirrhosis, finding that the incidence rates of herpes zoster and herpes zoster-related hospitalization were significantly higher in patients with liver cirrhosis compared to the general population.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: This study found that patients with newly diagnosed atrial fibrillation who abstained from alcohol or were non-drinkers had a lower risk of ischemic stroke compared to current drinkers.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Sofie Kruckow, Ziggi Ivan Santini, Louise Hjarnaa, Ulrik Becker, Ove Andersen, Janne S. Tolstrup
Summary: This study investigated the dose-response relationship between alcohol intake and the risk of hospital contacts due to alcohol and unintentional injuries in adolescents. The results showed that adolescents who drink alcohol have an increased risk of hospital admissions due to alcohol and unintentional injuries, suggesting the need for awareness and prevention measures for youth drinking.
Article
Public, Environmental & Occupational Health
Kamilla Kragelund, Janne S. Tolstrup, Cathrine J. Lau, Anne Christensen, Maja B. Jorgensen
Summary: This study found that smokers are at a higher risk of unemployment and sickness absence, and have a lower chance of getting re-employed compared to never smokers. Thus, more efforts should be put into smoking prevention and cessation in relation to job seeking and absence.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Sanne Pagh Moller, Janne S. Tolstrup, Signe Skovgaard Hviid, Pernille Bendtsen
Summary: There is a strong association between parental alcohol norms and alcohol intake among high school students, and this association persists across different levels of school alcohol intake and level of trustful communication with parents.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Molager Christensen, Sidsel Marie Bernt Jorgensen, Mohamad El-Chouli, Matthew Phelps, Anne-Marie Schjerning, Thomas S. G. Sehested, Thomas Gerds, Caroline Sindet-Pedersen, Tor Biering-Sorensen, Christian Torp-Pedersen, Morten Schou, Gunnar Gislason
Summary: Influenza vaccine uptake among patients with cardiovascular disease in a universal-access healthcare system is suboptimal, especially among young patients.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Sidsel Marie Bernt Jorgensen, Thomas Alexander Gerds, Nina Fons Johnsen, Gunnar Gislason, Mohamad El-Chouli, Stig Brondum, Thomas Maribo, Maria Kristiansen
Summary: Returning to work and maintaining employment after cardiovascular disease is crucial for working-age individuals. Individuals with heart failure have the highest probability of not returning to work, highlighting the need for effective vocational rehabilitation strategies in comprehensive cardiac rehabilitation programs.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Anne Sofie Plum Christensen, Veronica Pisinger, Anne Friis Krarup, Peter Dalum, Lau Caspar Thygesen, Janne Schurmann Tolstrup
Summary: Excessive alcohol consumption among young people is a global public health concern due to its negative impact on short- and long-term well-being. This study investigated the association between weekly alcohol consumption and various measures of poor well-being among students aged 15-25 years in Denmark. The findings revealed a U-shaped relationship, where both non-drinkers and heavy drinkers had higher odds of poor well-being compared to moderate drinkers. Understanding these associations can contribute to reducing alcohol consumption and promoting well-being among young students.
PREVENTIVE MEDICINE REPORTS
(2023)
Article
Substance Abuse
Ulrik Becker, Amalie Timmermann, Ola Ekholm, Morten Gronbaek, Asbjorn Mohr Drewes, Srdan Novovic, Camilla Nojgaard, Soren Schou Olesen, Janne Schurmann Tolstrup
Summary: This study analyzed the effects of drinking pattern and type of alcohol on the risk of acute and chronic pancreatitis. The results showed that increased alcohol intake was associated with increased development of pancreatitis. Frequent binge drinking and long-term drinking (daily drinking) were associated with the development of pancreatitis. The intake of large amounts of spirits and beer was associated with the development of acute and chronic pancreatitis, while the consumption of wine was not associated with the development of pancreatitis.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Public, Environmental & Occupational Health
Mikkel Porsborg Andersen, Elisabeth Helen Anna Mills, Alessandra Meddis, Kathrine Kold Sorensen, Jawad Haider Butt, Lars Kober, Henrik Enghusen Poulsen, Matthew Phelps, Gunnar Gislason, Helle Collatz Christensen, Morten Schou, Emil L. Fosbol, Thomas Alexander Gerds, Kristian Kragholm, Christian Torp-Pedersen
Summary: A substantial portion of COVID-19-related deaths occurred among nursing home residents, causing concern globally. This nationwide study in Denmark examines nursing home mortality in relation to pre-pandemic mortality rates, providing important insights into the impact of the pandemic on this vulnerable population.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Stine Schramm, Thorkild I. A. Sorensen, Michael Davidsen, Janne S. Tolstrup
Summary: Obesity prevalence in Denmark has steadily increased from 6.1% in 1987 to 18.4% in 2021, affecting both men and women across all age groups. The increase is primarily due to secular changes over time, and not influenced by birth cohorts.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Jorg G. Morland, Per Magnus, Stein Emil Vollset, David A. Leon, Randi Selmer, Aage Tverdal
Summary: The benefits of elevated high-density lipoprotein cholesterol (HDL-C) levels are challenged by U-shaped relations with all-cause mortality. The association with cause-specific mortality is less studied. Higher HDL-C levels were associated with increased mortality risk for several diseases, which have also been associated with heavy drinking.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Jonas L. Isaksen, Jonas Ghouse, Morten W. Skov, Morten S. Olesen, Anders G. Holst, Adrian Pietersen, Jonas B. Nielsen, Anja Maier, Claus Graff, Thomas A. Gerds, Ruth Frikke-Schmidt, Jorgen K. Kanters
Summary: By examining a large population, this study found that several common ECG markers are associated with Alzheimer's disease and can improve risk prediction.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Caroline Holt Udesen, Signe Skovgaard Hviid, Ulrik Becker, Janne S. Tolstrup
Summary: Adolescents and young adults aged 15-24 years are disproportionately affected by alcohol-related deaths. This study aimed to explore the extent and circumstances surrounding these deaths, as well as the potential differences in socioeconomic background and ethnicity compared to the general population.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Public, Environmental & Occupational Health
Kristine Romer Thomsen, Lotte Vallentin-Holbech, Synnove Xylander, Kaare Bro Wellnitz, Janne Tolstrup, Anette Sogaard Nielsen, Sarah W. Feldstein Ewing
Summary: The study examines the efficacy, feasibility, and acceptability of prevention interventions targeting school, parent, and student levels at Danish high schools. It hypothesizes that a structural intervention combined with group-based Motivational Interviewing can reduce hazardous alcohol use and related health issues among adolescents.
Article
Public, Environmental & Occupational Health
Nanna Schneekloth Jarlstrup, Lau C. Thygesen, Charlotta Pisinger, Jorgen Vestbo, Morten Gronbaek, Janne S. Tolstrup
Summary: The national smoking ban in Denmark did not have a significant impact on the incidence of smoking-related diseases, and there were no differences observed among socioeconomic groups. Therefore, future tobacco control measures in Denmark should focus on targeting low socioeconomic groups to address the strong socioeconomic inequality in health.
Article
Cardiac & Cardiovascular Systems
Caroline Sindet-Pedersen, Felix Michalik, Jarl Emanuel Strange, Daniel Molager Christensen, Nina Nouhravesh, Thomas Alexander Gerds, Charlotte Andersson, Fredrik Folke, Tor Biering-Sorensen, Emil Fosbol, Christian Torp-Pedersen, Gunnar H. Gislason, Lars Kober, Morten Schou
Summary: This study investigates the association between mRNA vaccines and the risks of all-cause mortality, worsening heart failure, venous thromboembolism, and myocarditis in patients with heart failure. The findings suggest that receiving an mRNA vaccine is not associated with an increased risk of these outcomes.
CIRCULATION-HEART FAILURE
(2023)
Article
Public, Environmental & Occupational Health
Marcella Broccia, Anders Munch, Bo Molholm Hansen, Kathrine Kold Sorensen, Thomas Larsen, Katrine Strandberg-Larsen, Thomas Alexander Gerds, Christian Torp-Pedersen, Ulrik Schioler Kesmodel
Summary: This Danish study investigated the morbidity risk in children exposed to heavy prenatal alcohol and found an increased risk of various diseases and health problems, particularly related to brain function, behavioral disorders, infections, and neonatal conditions. The findings highlight the importance of addressing prenatal alcohol exposure as a key public health issue and emphasizing pre-conceptional care.
LANCET PUBLIC HEALTH
(2023)