Article
Biochemistry & Molecular Biology
Morteza Esmaeili, Riyas Vettukattil
Summary: Magnetic resonance spectroscopy (MRS) is a non-invasive technique that allows for the study of cardiac metabolism in vivo. However, technical limitations currently restrict its utility. Further improvements are needed for clinical application.
Review
Physiology
Craig A. Lygate
Summary: In order to fully understand gene function, it is necessary to study the effects in an intact organism. The creation of the first knockout mouse revolutionized the field of integrative physiology, with focus on potential problems in interpretation of in vivo cardiac phenotypes. The study of creatine kinase energy system in intact organisms highlights the impact of genetic background, sex, and age, and the challenges in interpreting results from knockout models.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Liam F. Fitzgerald, Miles F. Bartlett, Rajakumar Nagarajan, Ericber Jimenez Francisco, Frank C. Sup, Jane A. Kent
Summary: Muscle metabolic economy (ME) is similar in young and older adults during some isometric contractions, but age-related differences exist during dynamic contractions. Older adults have lower ME during dynamic contractions, despite similar muscle oxidative capacity and ATP flux compared to younger adults. This suggests a dissociation between cross-bridge activity and ATP utilization with age.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Pharmacology & Pharmacy
Aya Shiraki, Jun-ichi Oyama, Takahiko Shimizu, Takayuki Nakajima, Takashi Yokota, Koichi Node
Summary: This study found that empagliflozin can improve cardiac mitochondrial function, enhance energy metabolism, and improve the survival rate and cardiac fibrosis in HF mice. The findings provide novel mechanisms for the beneficial effects of SGLT2 inhibitors on HF.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biology
Giampaolo Morciano, Veronica Angela Maria Vitto, Esmaa Bouhamida, Carlotta Giorgi, Paolo Pinton
Summary: The heart is crucial for the circulation of blood and oxygen in the body, and its function relies on a delicate balance of energy consumption and generation. Mitochondrial dysfunctions have been identified as key factors in the development of various heart diseases, particularly heart failure.
Article
Cell Biology
Ravi A. Kumar, Trace Thome, Omar M. Sharaf, Terence E. Ryan, George J. Arnaoutakis, Eric Jeng, Leonardo F. Ferreira
Summary: Cardiomyocyte dysfunction in patients with end-stage heart failure with reduced ejection fraction is associated with mitochondrial dysfunction. Reversible thiol oxidation can modulate mitochondrial function, but other components of mitochondrial energy transfer are limiting factors in end-stage heart failure.
Article
Cardiac & Cardiovascular Systems
Gentaro Ikeda, Michelle R. Santoso, Yuko Tada, Albert M. Li, Evgeniya Vaskova, Ji-Hye Jung, Connor O'Brien, Elizabeth Egan, Jiangbin Ye, Phillip C. Yang
Summary: This study demonstrated that extracellular vesicle-mediated transfer of autologous mitochondria can enhance cardiac function by restoring myocardial bioenergetics. The therapy shows potential as a precision therapeutic for mitochondria-related diseases such as heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning, Jiqiu Wang, Ruiyan Zhang, Kang Chen, Xiaoxiang Yan
Summary: This study reveals the significant role of DYRK1B in mitochondrial bioenergetics and the progression of cardiac hypertrophy and heart failure. DYRK1B promotes impaired mitochondrial bioenergetics by directly binding with STAT3, leading to the downregulation of PGC-1 alpha. Inhibition of DYRK1B or STAT3 activity restores cardiac performance by rejuvenating mitochondrial bioenergetics. These findings may offer new therapeutic options for heart failure patients.
Review
Biology
Christina Schenkl, Estelle Heyne, Torsten Doenst, Paul Christian Schulze, Tien Dung Nguyen
Summary: Despite advances in treating cardiac disorders, heart failure (HF) continues to increase globally and poses a medical and economic burden. HF is characterized by metabolic remodeling in the mitochondria, affecting energy homeostasis, calcium handling, oxidative stress, and inflammation. This study focuses on highlighting mitochondrial metabolic alterations and their impact on the pathophysiology of HF, as well as discussing potential metabolic approaches to improve cardiac function.
Article
Cardiac & Cardiovascular Systems
Jianyi Zhang, Roberto Bolli, Daniel J. Garry, Eduardo Marban, Philippe Menasche, Wolfram-Hubertus Zimmermann, Timothy J. Kamp, Joseph C. Wu, Victor J. Dzau
Summary: This paper provides an update on the recent preclinical and clinical trials using cell therapy and engineered heart tissues for postinfarction left ventricular remodeling and heart failure. The authors discuss novel approaches for cardiac remuscularization through activating proliferative mechanisms or direct reprogramming, aiming to facilitate the translation of discoveries in regenerative myocardial therapies to the clinic.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Heiko Bugger, Nikole J. Byrne, E. Dale Abel
Summary: This article examines the regulation of metabolic pathways in the heart and their role in maintaining myocardial function. It highlights the importance of animal models in studying these pathways.
CIRCULATION RESEARCH
(2022)
Review
Physiology
Magda Correia, Bruno Bernardes de Jesus, Sandrina Nobrega-Pereira
Summary: Heart disease is the leading cause of mortality in developed countries, characterized by loss of cardiomyocytes leading to heart failure. While adult mammalian hearts have limited regenerative capacity, neonatal hearts have stronger regenerative potential. The role of metabolic pathways and lncRNAs in cardiac regeneration requires further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Timothy N. Audam, Caitlin M. Howard, Lauren F. Garrett, Yi Wei Zheng, James A. Bradley, Kenneth R. Brittian, Matthew W. Frank, Kyle L. Fulghum, Miklos Polos, Szilvia Herczeg, Bela Merkely, Tamas Radovits, Shizuka Uchida, Bradford G. Hill, Sujith Dassanayaka, Suzanne Jackowski, Steven P. Jones
Summary: This study shows that limiting cardiac CoA levels via PANK deletion exacerbated ventricular remodeling during pressure overload. The metabolic alterations associated with Pank1 deletion may underlie the exacerbated cardiac phenotype during pressure overload.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
E. Douglas Lewandowski
Summary: Cardiac function relies on efficient metabolic support, which is a dynamic process that adjusts to the demands of the heart. Flux through metabolic pathways provides energy and signaling molecules to meet these demands. Inability of metabolic flux to keep pace with cardiomyocyte demands leads to dysfunction and contributes to cardiac disease. Studying metabolic mechanisms as therapeutic targets and detecting metabolic flux in the heart will provide important insights into cardiac function and disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)