期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 40, 期 3, 页码 596-604出版社
WILEY
DOI: 10.1002/hed.25031
关键词
head and neck cancer; major oncologic surgery; nutrition; risk factors; surgical site infection
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF), Ministry of Science, ICT, and Future Planning [2015R1A2A1A15054540]
- Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), Ministry of Health and Welfare, Seoul, Republic of Korea [HI15C2920]
BackgroundSurgical site infection is a complication of surgery for patients with head and neck cancer. We examined the risk factors for surgical site infection in patients undergoing surgery for head and neck cancer. MethodsThe study involved 369 patients who underwent surgery for head and neck cancer. Hematological and nutritional parameters were measured preoperatively and postoperatively. Univariate and multivariate analyses were used to determine the risk factors for surgical site infection. ResultsOf the 369 patients, 104 (28.2%) had surgical site infections: 45 (12.2%) superficial incisional; 6 (1.6%) deep incisional; and 53 (14.4%) organ/space infections. Multivariate analyses showed that history of radiotherapy, weight loss at diagnosis (>5%), preoperative hypoalbuminemia, neutrophil/lymphocyte ratio (NLR), reconstructive surgery, and tracheostomy were the independent factors predictive of surgical site infection. Patients with preoperative low serum albumin levels (<3.3g/L) had a 3-fold higher risk of surgical site infection. ConclusionOur study shows that patient nutritional and hematological markers are associated with the risk of surgical site infection after major surgery for head and neck cancer.
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