Article
Medicine, General & Internal
Ichiro Wakabayashi, Harald Sourij, Yoko Sotoda, Takashi Daimon, Klaus Groschner, Peter P. Rainer
Summary: There were no significant differences in serum levels of ALDH2- and ADH1B-related miRNAs between Austrian and Japanese middle-aged men. However, miR-150-3p and miR-4314 showed higher expression levels in Austrian men compared to Japanese men, indicating they may play a role in the ethnic difference in sensitivity to alcohol through modifying the expression of ADH1B.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Satoshi Yano, Jinyun Wang, Shigeru Kabayama, Taichi Hara
Summary: Excessive alcohol consumption can lead to multi-systemic diseases, with alcoholic liver disease being the most common and severe one. Electrolytic hydrogen water (EHW) has been shown to inhibit ethanol-induced hepatocellular damage by regulating the metabolism of ethanol and acetaldehyde in liver cells. This suggests that EHW may be beneficial in the prevention of alcoholic liver disease.
Article
Medicine, General & Internal
Blanka Wolszczak-Biedrzycka, Elzbieta Zasimowicz-Majewska, Anna Bienkowska, Grzegorz Biedrzycki, Justyna Dorf, Wojciech Jelski
Summary: This study demonstrates the diagnostic usefulness of determining the total ADH, ADH I, and ADH II activity in the serum of patients with alcoholic fatty liver.
MEDICINA-LITHUANIA
(2022)
Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Article
Oncology
Hui-Tzu Chien, Chia-Lung Tsai, Chi-Kuan Young, Yun-Shien Lee, Chun-Ta Liao, Chih-Ching Yeh, Angel Chao, Kai-Lun Cho, Ching-Han Chen, Shiang-Fu Huang
Summary: In this study, a case-control analysis was conducted to investigate the genetic markers for oro-/hypopharyngeal squamous cell carcinoma. The results showed that the ADH1B gene mutation was significantly associated with the susceptibility and survival of OPSCCs.
Article
Chemistry, Medicinal
Brandt C. Huddle, Edward Grimley, Mikhail Chtcherbinine, Cameron D. Buchman, Cyrus Takahashi, Bikash Debnath, Stacy C. McGonigal, Shuai Mao, Siwei Li, Jeremy Felton, Shu Pan, Bo Wen, Duxin Sun, Nouri Neamati, Ronald J. Buckanovich, Thomas D. Hurley, Scott D. Larsen
Summary: Research continues to develop pan-ALDH1A inhibitors to examine their effectiveness in combating chemotherapy-resistant ovarian cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Hua Cao, Tuoyu Zhou, Haibo Tang, Pengya Feng, Gohar Ali, Pu Liu, Xiangkai Li
Summary: The genetically modified EcN has shown effectiveness in detoxifying ethanol metabolites in liver disease models, restoring liver function, inhibiting oxidative stress, lipid peroxidation, and inflammation, as well as promoting the recovery of gut microbiota homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Genetics & Heredity
Wen-Ling Liao, Fu-Chun Chan, Kai-Ping Chang, Ya-Wen Chang, Che-Hong Chen, Wen-Hui Su, Hen-Hong Chang
Summary: In East Asian population, genetic variants in ALDH isoforms are associated with NPC susceptibility and exhibit a synergistic effect with alcohol consumption, resulting in a cumulative risk effect for NPC among both drinkers and non-drinkers.
Article
Chemistry, Multidisciplinary
Miae Won, Ji Hyeon Kim, Myung Sun Ji, Jong Seung Kim
Summary: ALDH, a cancer stem cell biomarker associated with drug resistance, can be targeted using a prodrug called DE-CPT, which efficiently decreases the population of CSCs and kills cancer cells.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell Biology
Avital Granit Mizrahi, Ahinoam Gugenheim, Haneen Hamad, Roa'a Hamed, Nino Tetro, Ofra Maimon, Salome Khutsurauli, Hovav Nechushtan, Benjamin Nisman, Deborah Duran, Widad Samman, Liron Birimberg-Schwartz, Myriam Grunewald, Sara Eyal, Tamar Peretz
Summary: This study found that histone deacetylase inhibitor valproic acid (VPA) can alter glucose metabolism in triple-negative breast cancer (TNBC) cells and is correlated with cisplatin sensitivity. Overexpression of ALDH may be one mechanism of cellular resistance to VPA, and its inhibition can enhance the therapeutic efficacy of VPA-chemotherapeutic drug combinations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Wenhao Yao, Xu Qian, Sebastian Ochsenreither, Ferrone Soldano, Albert B. DeLeo, Holger Sudhoff, Felix Oppel, Andreas Kuppig, Konrad Klinghammer, Andreas M. Kaufmann, Andreas E. Albers
Summary: DSF and DSF/Cu2+ inhibited cell proliferation in HNSCC, enhanced sensitivity to cisplatin and IR, and increased radio-chemo sensitivity by inducing apoptosis and ROS activity.
Article
Food Science & Technology
Naila Boby, Eon-Bee Lee, Muhammad Aleem Abbas, Na-Hye Park, Sam-Pin Lee, Md. Sekendar Ali, Seung-Jin Lee, Seung-Chun Park
Summary: FSC pretreatment reduces blood alcohol and acetaldehyde concentrations, modulates liver enzyme activities, increases antioxidant enzyme expression, and decreases inflammatory cytokine gene expression in the liver. Additionally, it shows no acute oral toxicity in female rats and may be beneficial for reducing alcohol-induced damage.
Article
Multidisciplinary Sciences
Jinhong Liu, Shey-Li Lim, Jia Yi Zhong, Boon Leong Lim
Summary: Developed ratiometric biosensors for pyridine nucleotides to study energy metabolism in pollen tubes and the role of pollen plastids. Found that fermentation and pyruvate dehydrogenase bypass are not essential for pollen tube growth in Arabidopsis.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Giorgia Colombo, Edoardo Luigi Maria Gelardi, Federica Carolina Balestrero, Marianna Moro, Cristina Travelli, Armando A. Genazzani
Summary: Tumor cells modify their cellular metabolism in order to sustain uncontrolled proliferation, requiring adequate amounts of NAD and NADPH to support overexpressed enzymes. This review explores the rationale for targeting key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and enzymes that consume or use NADP(H).
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Zheng Peng, Ran Wang, Xiaofeng Xia, Juan Zhang
Summary: A visualized high-throughput method was developed to screen ALDH variants, and a variant ALDH(S273N) with the highest activity was identified. This variant showed efficient degradation of acetaldehyde, making it a promising green bio-elimination technology.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Oncology
Hiroki Kawaguchi, Yusuke Demizu, Naritoshi Mukumoto, Takeaki Ishihara, Daisuke Miyawaki, Shohei Komatsu, Hiroaki Akasaka, Makoto Shinoto, Yoshiyuki Shioyama, Katsumasa Nakamura, Takumi Fukumoto, Ryohei Sasaki
Summary: The study aimed to investigate the dosimetric effects of placing spacers in IMRT planning for LAPC patients. Results showed that appropriate spacer placement can improve the percentage of planning target volume receiving the prescribed dose, thus improving patient outcomes.
ANTICANCER RESEARCH
(2021)
Letter
Oncology
Daisuke Takagi, Yuri Morikawa, Michi Kamei, Hiroyuki Ogino, Hiromitsu Iwata, Naoko Maeda, Nobuhiro Akita, Takumi Fukumoto, Ryohei Sasaki, Satoshi Kondo
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-ichi Nibu, Ryohei Sasaki
Summary: V60 > 14% and oropharyngeal or oral cancer were identified as independent risk factors for osteoradionecrosis of the jaw (ORNJ). These findings could help to minimize the incidence of ORNJ in patients with head and neck squamous cell carcinoma treated with curative radiation therapy.
RADIATION ONCOLOGY
(2021)
Article
Otorhinolaryngology
Hirotaka Shinomiya, Natsumi Uehara, Takeshi Fujita, Daisuke Miyawaki, Yoshinori Imamura, Masanori Teshima, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-ichi Nibu
Summary: Chemoradiotherapy with docetaxel, cisplatin, and 5-FU for locally advanced external auditory canal cancer has shown favorable outcomes. A phase I trial determined the recommended and maximum tolerated dose of docetaxel in this treatment regimen, with the RD and MTD determined to be 40 mg/m(2) when used alongside cisplatin and 5-FU.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hiroaki Akasaka, Kazufusa Mizonobe, Yuya Oki, Kazuyuki Uehara, Aya Harada, Shuichiro Miyazaki, Keiji Kitatani, Tomonori Yabuuchi, Takeaki Ishihara, Daisuke Miyawaki, Masao Nakayama, Naritoshi Mukumoto, Ryuichi Yada, Ai Nakaoka, Hikaru Kubota, Hiroki Kawaguchi, Satoshi Seno, Ryohei Sasaki, Hiroshi Mayahara
Summary: This study compared treatment planning for lung cancer in CyberKnife SBRT between prone and supine positions, finding that the prone set-up was more effective in reducing dose to normal lung tissue.
JOURNAL OF RADIOTHERAPY IN PRACTICE
(2022)
Article
Otorhinolaryngology
Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-ichi Nibu
Summary: This study evaluated the blowing time ratio as a screening tool for assessing swallowing pressure in patients treated for oral and oropharyngeal cancer. The results showed a significant correlation between the blowing time ratio and swallowing pressures in the oropharynx and velopharynx, supporting its usefulness in evaluating these pressures.
AURIS NASUS LARYNX
(2022)
Article
Gastroenterology & Hepatology
Yu Hashimoto, Shohei Komatsu, Kazuki Terashima, Daisuke Tsugawa, Hiroaki Yanagimoto, Masaki Suga, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, Tetsuo Ajiki, Takumi Fukumoto
Summary: This study evaluated the effectiveness of space-making particle therapy (SMPT) for the treatment of hilar cholangiocarcinoma (HC). The results showed improvements in dosimetric parameters and good treatment outcomes. SMPT could be a promising alternative for patients with unresectable HC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hiroaki Akasaka, Kazufusa Mizonobe, Yuya Oki, Kazuyuki Uehara, Masao Nakayama, Shuhei Tamura, Yoshiki Munetomo, Haruna Kawaguchi, Jun Ishida, Aya Harada, Takeaki Ishihara, Hikaru Kubota, Hiroki Kawaguchi, Ryohei Sasaki, Hiroshi Mayahara
Summary: This study investigated the relationship between the position of fiducial markers and the internal target volume (ITV) in lung cancer patients. The findings can help protect normal lung tissue from radiation exposure and improve target coverage.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Oncology
Mohammed Salah, Hiroaki Akasaka, Yasuyuki Shimizu, Kenta Morita, Yuya Nishimura, Hikaru Kubota, Hiroki Kawaguchi, Tomomi Sogawa, Naritoshi Mukumoto, Chiaki Ogino, Ryohei Sasaki
Summary: This study found that titanium peroxide nanoparticles combined with radiation have anti-cancer effects on radioresistant pancreatic cancer stem cells (CSCs). They can inhibit the proliferation and invasion abilities of CSCs, and suppress the growth of pancreatic tumors by generating reactive oxygen species (ROS). These findings suggest that the combination of TiOxNPs and radiation may be an effective therapeutic strategy for pancreatic CSCs.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Yuntao Dai, Tetsuya Kawaguchi, Miki Nishio, Junji Otani, Hironori Tashiro, Yoshito Terai, Ryohei Sasaki, Tomohiko Maehama, Akira Suzuki
Summary: This study reveals that TIGD5 may function as a tumor suppressor in ovarian cancer (OC) rather than an oncogene. Patients with elevated TIGD5 mRNA expression have poor prognosis in OC, but overexpression of TIGD5 in OC cell lines unexpectedly inhibits cell growth and invasiveness. These findings highlight the potential important role of TIGD5 in the development of OC.
Article
Oncology
Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masanori Saito, Jun Sugaya, Katsuhiro Hayashi, Hiroyuki Kawashima, Tomoaki Torigoe, Tomoki Nakamura, Hiroya Kondo, Toru Wakamatsu, Munenori Watanuki, Munehisa Kito, Satoshi Tsukushi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Shunji Nishimura, Hiroshi Kobayashi, Itsuo Watanabe, Yusuke Demizu, Ryohei Sasaki, Takumi Fukumoto, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: This study retrospectively analyzed the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS) in Japan. Osteosarcoma showed significantly worse overall survival (OS) and progression-free survival (PFS) compared to other sarcomas in the pelvis and retroperitoneum. Larger primary tumor size was the only poor prognostic factor associated with local control (LC).
Article
Oncology
Kazuma Iwashita, Hikaru Kubota, Riku Nishioka, Yuki Emoto, Daisuki Kawahara, Takeaki Ishihara, Daisuke Miyawaki, Ikuno Nishibuchi, Yasushi Nagata, Ryohei Sasaki
Summary: This study aimed to construct a prognostic survival model for esophageal cancer patients who underwent radical irradiation using skeletal muscle radiomics. The predictive model constructed by machine learning and LASSO algorithm showed good performance in predicting the survival of esophageal cancer patients, with high accuracy, specificity, sensitivity, and area under the concentration-time curve.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Kazuhiro Kitajima, Junpei Kuyama, Takashi Kawahara, Tsuyoshi Suga, Tomoaki Otani, Shigeyasu Sugawara, Yumiko Kono, Yukihisa Tamaki, Ayumi Seko-Nitta, Yoshinobu Ishiwata, Kimiteru Ito, Akira Toriihara, Shiro Watanabe, Makoto Hosono, Hideaki Miyake, Shingo Yamamoto, Ryohei Sasaki, Mitsuhiro Narita, Koichiro Yamakado
Summary: This retrospective study investigated the efficacy of change in the automated bone scan index (aBSI) as an imaging biomarker for treatment response and survival prediction in mCRPC patients treated with Ra-223. The study analyzed data from 205 Japanese mCRPC patients who received Ra-223 treatment between July 2016 and August 2020. The results showed that changes in aBSI, alkaline phosphatase (ALP), and prostate-specific antigen (PSA) were significant prognostic factors for overall survival in these patients.
Article
Materials Science, Biomaterials
Yukiya Kitayama, Takuya Yamada, Kentaro Kiguchi, Aoi Yoshida, Shuhei Hayashi, Hiroaki Akasaka, Kazunori Igarashi, Yuya Nishimura, Yu Matsumoto, Ryohei Sasaki, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi
Summary: A novel stealth radiation sensitizer based on Au-embedded molecularly imprinted polymer nanogels (Au MIP-NGs) was developed for low-dose X-ray radiation therapy. It showed good affinity and selectivity towards human serum albumin, and improved the efficiency of pancreatic cancer treatment in mouse models.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Noor Nabilah Talik Sisin, Hiroaki Akasaka, Ryohei Sasaki, Takahiro Tominaga, Hayato Miura, Masashi Nishi, Moshi Geso, Nor Fazila Che Mat, Khairunisak Abdul Razak, Wan Nordiana Rahman
Summary: This study investigated the production of intracellular reactive oxygen species (ROS) in colon cancer cells under proton beam radiotherapy in the presence of radiosensitizers. The combination of Cis and BC, as well as individual BiONPs, showed potential as radiosensitizers for proton beam therapy.
POLISH JOURNAL OF MEDICAL PHYSICS AND ENGINEERING
(2022)
