Article
Gastroenterology & Hepatology
Ami D. Sperber, Shrikant Bangdiwala, Douglas A. Drossman, Uday C. Ghoshal, Magnus Simren, Jan Tack, William E. Whitehead, Dan L. Dumitrascu, Xuicai Fang, Shin Fukudo, John Kellow, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Peter Whorwell, Timothy Archampong, Payman Adibi, Viola Andresen, Marc A. Benninga, Bruno Bonaz, Serhat Bor, Luis Bustos Fernandez, Suck Chei Choi, Enrico S. Corazziari, Carlos Francisconi, Albis Hani, Leonid Lazebnik, Yeong Yeh Lee, Agata Mulak, M. Masudur Rahman, Javier Santos, Mashiko Setshedi, Ari Fahrial Syam, Stephen Vanner, Reuben K. Wong, Aurelio Lopez-Colombo, Valeria Costa, Ram Dickman, Motoyori Kanazawa, Ammar Hassanzadeh Keshteli, Rutaba Khatun, Iradj Maleki, Pierre Poitras, Nitesh Pratap, Oksana Stefanyuk, Sandie Thomson, Judith Zeevenhooven, Olafur S. Palsson
Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.
Review
Gastroenterology & Hepatology
Douglas A. Drossman, Lin Chang, Jill K. Deutsch, Alexander C. Ford, Albena Halpert, Kurt Kroenke, Samuel Nurko, Johannah Ruddy, Julie Snyder, Ami Sperber
Summary: The changes in healthcare have negatively impacted the communication between patients and providers, but evidence shows that communication skills training can improve patient satisfaction and outcomes. More research is needed to confirm these findings and to further explore the role of communication skills in healthcare.
Article
Pediatrics
Desiree F. Baaleman, Carlos A. Velasco-Benitez, Laura M. Mendez-Guzman, Marc A. Benninga, Miguel Saps
Summary: There was minimal agreement in diagnosing FGIDs between the Rome III and Rome IV criteria in pediatric population. Differences were observed in specific disorders such as functional constipation and functional dyspepsia. Limitations with questionnaire-based prevalence measurement need to be considered.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Medicine, General & Internal
Angharad Vernon-Roberts, India Alexander, Andrew S. Day
Summary: Functional gastrointestinal disorders (FGID) are common in children, with varying prevalence rates across different age groups. The most common types of FGID differ among infants, toddlers, and older children, serving as benchmark and comparative data for the general population and those with comorbid conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Laurie Keefer, Sarah K. Ballou, Douglas A. Drossman, Gisela Ringstrom, Sigrid Elsenbruch, Brjann Ljotsson
Summary: This report summarizes the consensus and methods of an international expert team regarding the use of behavioral interventions in patients with DGBIs. By reviewing existing scientific literature, the committee confirmed the definition and evidence of BGBT, connecting it with DGBI-specific behavioral targets and techniques to support clinical decision-making in providing BGBT.
Article
Clinical Neurology
Martin A. Katzman, Francois Therrien, Erin M. MacKenzie, Fan Wang, Anne de Jong-Laird, Matthieu Boucher
Summary: This study found that adjunctive brexpiprazole can improve multiple symptom clusters in MDD patients who have inadequate response to antidepressant treatments. The improvements occur early and are sustained over 6 weeks.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Michael P. Jones, Ayesha Shah, Ronen Ben-Jacob, Nicholas J. Talley, Teressa Hansen, Marjorie M. Walker, Marcus Gray, Natasha A. Koloski, Gerald Holtmann
Summary: The study successfully differentiated between patients with functional gastrointestinal diseases and organic gastrointestinal diseases using the SAGIS symptom questionnaire. It was found that functional patients scored higher than organic patients on all dimensions and reported higher rates of psychological and extra-gastrointestinal conditions. The model performance showed high reproducibility.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Psychology, Clinical
Shinsuke Koike, Eisuke Sakakibara, Yoshihiro Satomura, Hanako Sakurada, Mika Yamagishi, Jun Matsuoka, Naohiro Okada, Kiyoto Kasai
Summary: This study reveals a robust relationship between prefrontal function and behavioral outcomes across three major psychiatric disorders through a large-sample neuroimaging study.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Ryusei Nagata, Eiji Matsuura, Satoshi Nozuma, Mika Dozono, Yutaka Noguchi, Masahiro Ando, Yu Hiramatsu, Daisuke Kodama, Masakazu Tanaka, Ryuji Kubota, Munekazu Yamakuchi, Yujiro Higuchi, Yusuke Sakiyama, Hitoshi Arata, Keiko Higashi, Teruto Hashiguchi, Shunya Nakane, Hiroshi Takashima
Summary: This study investigated the correlation between the presence of serum anti-ganglionic acetylcholine receptor (gAChR) antibodies and autonomic symptoms in patients with functional neurological symptom disorder/conversion disorder (FNSD/CD). The results showed that among the 59 FNSD/CD patients, 88.1% exhibited autonomic disturbances and 27.1% were positive for serum anti-gAChR antibodies. Patients positive for anti-gAChR antibodies had a higher prevalence of cardiovascular autonomic dysfunction but a lower prevalence of involuntary movements compared to antibody-negative patients. The findings suggest that an autoimmune mechanism mediated by anti-gAChR antibodies may be involved in the etiology of FNSD/CD in a subgroup of patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Sabrina Berens, Rainer Schaefert, Johannes C. Ehrenthal, David Baumeister, Annika Gauss, Wolfgang Eich, Jonas Tesarz
Summary: The study compared patients with chronic gastrointestinal complaints with and without somatic symptom disorder (SSD) and found that patients with SSD had higher gastrointestinal pain severity, health and work-related impairment, psychological distress, mentalizing, and personality functioning deficits compared to those without SSD. The results suggest that SSD may be a valid identifier of patients with high psychological burden independent of the medical cause of their symptoms.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Review
Clinical Neurology
Marco Onofrj, Mirella Russo, Claudia Carrarini, Stefano Delli Pizzi, Astrid Thomas, Laura Bonanni, Alberto J. Espay, Stefano L. Sensi
Summary: The presence of FND and SSD in PD is significant for its management. These disorders may manifest early in PD, interfere with treatment outcomes, and be accompanied by cognitive decline. This article reviews their features and discusses their potential pathophysiology, suggesting that they should be included among the non-motor symptoms of PD.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Pediatrics
Kee Seang Chew, Jun Min Em, Zhong Lin Koay, Muhammad Yazid Jalaludin, Ruey Terng Ng, Lucy Chai See Lum, Way Seah Lee
Summary: A study on the prevalence of FGIDs in healthy Malaysian infants found that, except for infant colic and functional constipation, the prevalence rates of other FGIDs were similar to those reported in the literature. Breastfeeding was found to protect against infant regurgitation.
PEDIATRICS AND NEONATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Caterina Strisciuglio, Sabrina Cenni, Maria Rosaria Serra, Pasquale Dolce, Sanja Kolacek, Sara Sila, Ivana Trivic, Michal Rozenfeld Bar Lev, Raanan Shamir, Aco Kostovski, Alexandra Papadopoulou, Eleftheria Roma, Christina Katsagoni, Danijela Jojkic-Pavkov, Silvia Salvatore, Licia Pensabene, Elena Scarpato, Erasmo Miele, Annamaria Staiano, Angelo Campanozzi, Maria Fotoulaki
Summary: This study assessed the prevalence of functional gastrointestinal disorders (FGIDs) in children and adolescents in the Mediterranean area using Rome IV criteria and compared the prevalence with Rome III criteria. The results showed that FGIDs are common in this population, with an increase in prevalence with age and significant variation among different European countries. The application of Rome IV criteria resulted in a significantly lower prevalence of FGIDs in children compared with Rome III criteria.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Psychiatry
Edwina L. Picon, David L. Perez, Matthew J. Burke, Chantel T. Debert, Grant L. Iverson, William J. Panenka, Noah D. Silverberg
Summary: This study found that reporting unexpected neurological and somatic symptoms after concussion was closely related to fear avoidance behavior and current anxiety levels, while exaggeration and litigation were not significant predictors of such symptoms. More research is needed to understand the intersection of FND, SSD, and persistent post-concussive symptoms.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Clinical Neurology
Adam M. Goodman, Pranav Kakulamarri, Rodolphe Nenert, Jane B. Allendorfer, Noah S. Philip, Stephen Correia, W. Curt LaFrance, Jerzy P. Szaflarski
Summary: Traumatic brain injury (TBI) may trigger functional seizures (FS). Patients with FS often have more severe psychiatric comorbidities. TBI and psychopathology are associated with changes in neural network connectivity, but their effects on networks and their relationship with FS remain unclear.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Vanessa Z. Y. McLoughlin, Noor H. A. Suaini, Kewin Siah, Evelyn X. L. Loo, Wei Wei Pang, Yap Seng Chong, Keith M. Godfrey, Kok Hian Tan, Jerry K. Y. Chan, Anne E. N. Goh, Bee Wah Lee, Lynette P. Shek, Johan G. Eriksson, Marion M. Aw, Elizabeth H. Tham
Summary: The prevalence of infant GERD peaks at 6 weeks of age and declines by 1 year, with exclusive breastfeeding at 3 weeks reducing the odds of GERD. Cultural beliefs and practices, such as eliminating certain foods and massaging the infant's abdomen, influence how Asian parents perceive and manage GERD in their infants.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Editorial Material
Gastroenterology & Hepatology
Kewin Tien Ho Siah, Sanjiv Mahadeva
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Seiji Futagami, Takaomi Kessoku, Yuki Kasai, Takuma Higurashi, Atsushi Nakajima, Shuhei Agawa, Hiroshi Yamawaki, Mayu Habiro, Nobue Ueki, Iori Sanada, Mariko Yamamoto, Yoshiyuki Watanabe, Hiroshi Yamato, Takatsugu Yamamoto, Yusuke Takasaki, Koichi Ito, Mariko Hojo, Hiroyuki Isayama, Kewin Tien Ho Siah, Kok-Ann Gwee
Summary: This study compared the clinical symptoms and eating patterns between functional dyspepsia (FD) patients and FD patients with pancreatic enzyme abnormalities (FD-P) in Singapore and Japan. The results showed significant differences in eating behaviors between FD and FD-P patients, indicating that these differences may serve as useful tools to differentiate FD-P patients from FD patients in Japan.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Schin Bek, Yao Neng Teo, Xin-Hui Tan, Kristie H. R. Fan, Kewin Tien Ho Siah
Summary: Patients with irritable bowel syndrome (IBS) are at risk of developing micronutrient deficiencies, especially in vitamin B1, B2, calcium, iron, and zinc, due to exclusion diets. Dietary management of IBS patients should include a dietitian review to ensure nutritional adequacy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Engineering, Civil
Jackie Ayoub, Na Du, X. Jessie Yang, Feng Zhou
Summary: Ensuring a safe takeover transition in conditionally automated driving is of utmost importance, with takeover time being a critical factor. Previous studies have identified various factors affecting takeover time, but few have considered them all simultaneously. In this study, we used a dataset and eXtreme Gradient Boosting (XGBoost) to predict takeover time, and SHAP (SHapley Additive exPlanation) to analyze and explain the effects of predictors. We identified seven key predictors that yield the best prediction performance and examined their main effects and interactions. The proposed approach demonstrates good performance and explainability, with implications for designing in-vehicle monitoring and alert systems to facilitate driver-automated vehicle interaction.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Computer Science, Cybernetics
Ruikun Luo, Na Du, X. Jessie Yang
Summary: This study aims to examine the temporal dynamics of autonomy transparency and its effect on trust, dependence, and performance. By developing a game and displaying the intelligent assistant's decision-making rationale, the study found that participants' trust significantly increased and became more calibrated over time.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2022)
Article
Engineering, Civil
Na Du, Lionel Robert, X. Jessie Yang
Summary: This study examines the impact of explanation timing and permission on automated vehicles, taking into account cultural differences. The results show that cultural contexts influence drivers' trust and preference for automated vehicles, particularly when permission is requested after explanations.
TRANSPORTATION RESEARCH RECORD
(2022)
Review
Gastroenterology & Hepatology
Kok-Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min-hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi Tan, Xudong Tang, Marjorie Walker, Deng-Chyang Wu, Ying-Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh
Summary: Contemporary systems categorize patients into sub-classes based on symptoms to enable targeted treatment, but overlapping symptom categories negatively impact outcomes, lacking guidance on management. An APAGE working group developed clinical practice guidelines for management of patients with functional dyspepsia (FD) who have overlaps with other functional gastrointestinal disorders. They identified putative pathophysiology and provided a management algorithm for primary and secondary care clinicians.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Allergy
Harris Jun Jie Muhammad Danial Song, Charlotte Tze Min Lee, Faye Yu Ci Ng, Benjamin Kye Jyn Tan, Kewin Tien Ho Siah, Elizabeth Huiwen Tham
Summary: Recent studies indicate that the use of acid suppressants in early childhood may elevate the risk of allergic diseases. This systematic review examined the associations between childhood acid suppressant use and the development of allergic diseases. The findings suggest that childhood use of acid suppressants is significantly associated with an increased risk of asthma, atopic dermatitis, and allergic rhinitis. However, larger studies are needed to establish causality, and more stringent guidelines should be implemented for the judicious use of these drugs in pediatric patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Robotics
Shreyas Bhat, Joseph B. Lyons, Cong Shi, X. Jessie Yang
Summary: This study introduces a framework for trust-aware sequential decision-making, which accurately captures the evolution of human agent's trust dynamics through trust update model exploration; participants' trust dynamics are categorized into three types, and relationships between different characteristics and trust dynamics are identified.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2022)
Article
Engineering, Civil
Yangtao Zhang, X. Jessie Yang, Feng Zhou
Summary: The advancement in machine learning and artificial intelligence has led to the testing and deployment of autonomous vehicles. This study built a scalable pipeline using natural language processing and deep transfer learning to collect, process, model, and analyze disengagement reports from 2014 to 2020. The analysis revealed trends and significant relationships between causes and effects of autonomous vehicle disengagement.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Computer Science, Cybernetics
Ruikun Luo, Yifan Weng, Paramsothy Jayakumar, Mark J. Brudnak, Victor Paul, Vishnu R. Desaraju, Jeffrey L. Stein, Tulga Ersal, X. Jessie Yang
Summary: Workload management is crucial for shared control of unmanned ground vehicles. Previous studies have used physiological data to estimate operators' workload, but they mostly utilized a single-model-single-feature or a single-model-multiple-feature approach. This study proposes a Bayesian inference model that leverages different machine learning models for different features to estimate workload. Experimental results with 24 participants show that the Bayesian inference model outperforms the single models with a 0.823 F-1 score, 0.824 precision, and 0.821 recall.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Review
Gastroenterology & Hepatology
Valencia Ru-Yan Zhang, Gokula Krishnan Ramachandran, Evelyn Xiu Ling Loo, Alex Yu Sen Soh, Wei Peng Yong, Kewin Tien Ho Siah
Summary: This systematic review aimed to identify volatile organic compounds (VOCs) in the diagnosis of irritable bowel syndrome (IBS) through Medline and Cochrane's databases. 57% of the studies showed that VOCs could differentiate IBS patients from healthy controls with AUC ranging from 0.83 to 0.99. Studies distinguishing IBS from inflammatory bowel disease (IBD) patients had slightly higher AUC of 0.87-0.98. Combining VOC into panels allowed the creation of discriminative algorithms. Despite limitations in VOC sampling heterogeneity and small sample sizes, our review suggests that VOC analysis has the potential to be a noninvasive point-of-care test that differentiates IBS from other organic gastrointestinal diseases.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Esther Colomier, Lieselot Holvoet, Florencia Carbone, Kee-Huat Chuah, Sanjiv Mahadeva, Kewin Siah, Gerald J. Holtmann, Hidekazu Suzuki, Takashi Ueda, Magnus Simren, Kok-Ann Gwee, Jan F. Tack
Article
Health Care Sciences & Services
V. Vien Lee, Smrithi Vijayakumar, Ni Yin Lau, Agata Blasiak, Kewin Tien Ho Siah, Dean Ho
Summary: This study aims to explore the needs and concerns of patients with chronic constipation regarding health apps, and provide user insights for the development of effective health apps.
