Review
Biochemistry & Molecular Biology
Vincent Pretre, Dimitrios Papadopoulos, Jean Regard, Marc Pelletier, Janghee Woo
Summary: Inflammation plays a significant role in the development and progression of cancer. Inflammation in the tumor microenvironment alters the adaptability of tumor cells, promoting their survival and progression. Recent studies have shown that inhibiting interleukin-1 beta (IL-1 beta) can significantly decrease the risk of lung cancer. This article reviews the role of IL-1 beta and its upstream regulator NLRP3 in solid tumor and hematologic malignancies, and discusses the pharmacologic tools used to evaluate the effects of blocking tumor-promoting inflammation.
Review
Immunology
Yang Li, Qianzhou Jiang
Summary: Inflammasomes are supramolecular platforms that respond to damage-associated and pathogen-associated patterns, activating caspases and leading to pyroptosis and cytokine secretion. The uncoupling preferences between pyroptosis and cytokine secretion have context-dependent effects and contribute to various pathological conditions. Precise coupling and uncoupling decisions are crucial for tissue repair and threat elimination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Arinna Bertoni, Federica Penco, Hilaria Mollica, Paola Bocca, Ignazia Prigione, Anna Corcione, Davide Cangelosi, Francesca Schena, Genny Del Zotto, Adriana Amaro, Noemi Paladino, Emanuele Pontali, Marcello Feasi, Sara Signa, Marta Bustaffa, Roberta Caorsi, Serena Palmeri, Paola Contini, Raffaele De Palma, Ulrich Pfeffer, Paolo Uva, Anna Rubartelli, Marco Gattorno, Stefano Volpi
Summary: This study reveals the crucial role of IL-1 beta in driving inflammatory phenotypes in severe COVID-19 patients, whose maturation and secretion are regulated by inflammasomes. The findings suggest that targeting IL-1 beta could be an effective strategy for treating COVID-19 and provide a mechanistic explanation for the strong inflammatory manifestations associated with the disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Ji Won Kim, Jeong Mi Kim, Mi Eun Choi, Eun Jeong Jeon, Jin-Mi Park, Young-Mo Kim, Jeong-Seok Choi
Summary: Dry mouth is common in the elderly, and lipid accumulation plays a critical role in cellular senescence in the salivary gland. The study suggests that ADIPOQ gene may be a potential target for regulating lipogenesis associated with salivary gland senescence.
Article
Immunology
Hyun-ju Lee, Jin-Hee Park, Hyang-Sook Hoe
Summary: This study explores the effects of idebenone on neuroinflammatory responses, cognitive function, and underlying molecular mechanisms. The results suggest that idebenone can enhance neuroprotective NRF2 expression, reduce neuroinflammation, and improve learning and memory in mice. It also targets NLRP3 inflammasome activation and decreases gliosis and proinflammatory cytokine levels. In a mouse model of Alzheimer's disease, idebenone improves cognitive dysfunction and inhibits neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Divyesh Patel, Naveen Challagundla, Dipeeka Mandaliya, Shivani Yadav, Omkar Naik, Parameswar Dalai, Dhruvi Shah, Hima Vora, Reena Agrawal-Rajput
Summary: Inhibition of caspase-1 can reduce inflammasome activation and IL-1β secretion, leading to decreased tissue damage and immune cell infiltration in β-glucan-induced lung inflammation.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Immunology
R. K. Subbarao Malireddi, Ratnakar R. Bynigeri, Balabhaskararao Kancharana, Bhesh Raj Sharma, Amanda R. Burton, Stephane Pelletier, Thirumala-Devi Kanneganti
Summary: This study generated a new line of IL-1 alpha KO mice using CRISPR-Cas9 technology. Compared to the previous model, this new model showed normal induction and activation of IL-1 beta in macrophages and normal response to multiple innate immune triggers. Furthermore, it was found that IL-1 alpha played a critical role in the expression of the neutrophil chemoattractant KC/CXCL1 independent of IL-1 beta.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Lianci Peng, Yi Lu, Hongliang Tian, Kaixiang Jia, Qi Tao, Gang Li, Chao Wan, Chao Ye, Edwin J. A. Veldhuizen, Hongwei Chen, Rendong Fang
Summary: CATH-2 has anti-inflammatory activity by promoting IL-1(i secretion, and this promotion is dependent on the NLRP3 pathway and potassium efflux. CATH-2 also activates caspase-1 and gasdermin D, and is associated with serine protease activity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Guofang Zhang, Wenhe Luo, Wenjie Yang, Su Li, Dongjie Li, Yanqiao Zeng, Yang Li
Summary: This review discusses the potential danger posed by ENM-induced immune response in the human body and the crucial roles played by IL-1 family cytokines in this process. The molecular mechanisms of IL-1 family cytokine activity triggered by ENMs are also reviewed.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Editorial Material
Immunology
Megan H. Orzalli
Summary: In this study, the researchers found that cytosolic LPS activates the NLRP3 inflammasome through a mechanism involving gasdermin D (GSDMD). They also identified the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation, which senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.
Article
Pharmacology & Pharmacy
Chia-Cheng Su, Shu-Chi Wang, I-Chen Chen, Fang-Yen Chiu, Po-Len Liu, Chi-Han Huang, Kuan-Hua Huang, Shih-Hua Fang, Wei-Chung Cheng, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Ming-Yii Huang, Chia-Yang Li
Summary: The study demonstrated that zerumbone effectively attenuates LPS-induced inflammatory response in macrophages both in vitro and ex vivo by suppressing the activation of the ERK-MAPK and NF-kappa B signaling pathways as well as blocking the activation of the NLRP3 inflammasome, suggesting its potential benefits for treating sepsis and inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jacopo Pizzicannella, Luigia Fonticoli, Simone Guarnieri, Guya D. Marconi, Thangavelu Soundara Rajan, Oriana Trubiani, Francesca Diomede
Summary: This study found that ascorbic acid can alleviate the inflammation and reactive oxygen species generation induced by lipopolysaccharide in human gingival mesenchymal stem cells and endothelial committed hGMSCs. Through suppression of specific pathways, it shows anti-inflammatory effects in vitro.
Article
Veterinary Sciences
Pei Gao, Shiyuan Zhang, Xinxin Zhang, Chenggang Xu, Libin Chen, Lei Fan, Jinlian Ren, Qiuyan Lin, Bin Xiang, Tao Ren
Summary: This study investigates the expression and tissue distribution of S1PR1 after NDV infection and demonstrates that S1PR1 regulates IL-1 beta expression mainly through the NLRP3/caspase-1 inflammasome. The findings reveal the molecular mechanism underlying the inflammatory response induced by NDV infection.
VETERINARY RESEARCH
(2022)
Article
Microbiology
Dengjin Chen, Tianbei Tuo, Yongning Zhang, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Hanchun Yang
Summary: PRRSV and CSFV are common infectious pathogens in pig populations, posing significant threats to the healthy development of the pig industry. Vaccine immunization is the main method to prevent and control these two diseases. Studies have shown that PRRSV co-infection affects the immune response to CSFV vaccine. In this study, it was found that PRRSV and CSFV co-infection significantly increased the expression of NLRP3 and ASC, activated Caspase-1, and promoted IL-1 beta maturation, leading to the inhibition of CSFV proliferation. It was also determined that the activation of NLRP3 inflammasome is regulated by the TLR4-MyD88-NF-kappa B pathways.
VETERINARY MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen Zeng, Nan Cai, Jia Liu, Kunying Liu, Shuo Lin, Longyi Zeng
Summary: Cav-1 plays an important role in regulating lipotoxicity-induced intracellular lipid accumulation and inflammation in pancreatic beta cells, reducing intracellular triglyceride accumulation induced by fatty acids and decreasing the expression of inflammatory factors.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Soo-Jin Park, Dong-Soon Im
Summary: 2-ARA-LPE has been shown to inhibit M1 macrophage polarization and reduce inflammation in mouse peritoneal macrophages, as well as suppress carrageenan-induced paw edema in vivo. This compound may have potential anti-inflammatory effects by modulating macrophage phenotypes and gene expression related to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Seulah Lee, Dong Geun Hong, Seonguk Yang, Jaehoon Kim, Minwoo Baek, Seoyeong Kim, Dinakaran Thirumalai, Hae Young Chung, Seung-Cheol Chang, Jaewon Lee
Summary: Parkinson's disease is a progressive movement disorder caused by neurodegeneration. Modulating chronic neuroinflammatory response, specifically through GSK-3 beta inhibitory peptide (IAGIP), has been shown to prevent neurodegeneration and motor dysfunction in PD models. These findings provide new therapeutic possibilities for targeting PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
So-Eun Son, Jung-Min Koh, Dong-Soon Im
Summary: This study investigated the role of FFA4 in the treatment of psoriasis. The activation of FFA4 was found to improve imiquimod-induced psoriasis, and the suppression of T(H)17 cell differentiation may contribute to its efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
So-Eun Son, Jung-Min Koh, Dong-Soon Im
Summary: Epidemiological and clinical studies have shown that intake of n-3 polyunsaturated fatty acids (PUFA) can reduce the incidence of allergic airway diseases and improve pulmonary function in patients with allergic asthma. This study investigates the molecular target of PUFA in asthma therapy and finds that activation of the free fatty acid receptor 4 (FFA4) can suppress the activation of dendritic cells and mast cells, suggesting that FFA4 agonists could be a novel therapy for allergic asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Jung-Eun Lee, Young-Whan Choi, Dong-Soon Im
Summary: The aim of this study was to identify an active phytochemical from Schisandra chinensis and evaluate its effects on AD-like symptoms. The results showed that alpha-cubebenoate, an active phytochemical in Schisandra chinensis, significantly improved AD-like symptoms by reducing skin hypertrophy and mast cell accumulation, as well as decreasing pro-inflammatory chemokine and cytokine levels. This study provides evidence for the therapeutic efficacy of alpha-cubebenoate in the treatment of AD symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Ju-Hyun Lee, Dong-Soon Im
Summary: The study evaluated the therapeutic effects of honokiol on atopic dermatitis, and found that honokiol significantly suppressed symptoms of atopic dermatitis, indicating its potential as a therapeutic agent for the disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biology
Shoko Takisawa, Yuka Takino, Jaewon Lee, Shuichi Machida, Akihito Ishigami
Summary: The study found that long-term vitamin C deficiency can cause muscle atrophy and deterioration in physical ability in both male and female mice. However, these effects can be completely restored with vitamin C supplementation. This highlights the importance of vitamin C in maintaining skeletal muscle function.
Article
Biochemistry & Molecular Biology
Ye-Ji Lee, Dong-Soon Im
Summary: This study compared the effects of LPA(2) antagonist and agonist in an experimental model of allergic asthma, finding that the drugs had different impacts on asthma-related indicators at different administration time points, demonstrating the multiple roles of LPA(2) in asthmatic responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Sohee Park, Changyu Kang, Jaejeong Kim, Sanghyun Ju, Jin-Wook Yoo, In-Soo Yoon, Min-Soo Kim, Jaewon Lee, Yunjin Jung
Summary: This study investigates the feasibility of repurposing riluzole (RLZ) as an anti-inflammatory bowel disease (IBD) drug. Oral RLZ effectively inhibits rat colitis, but has safety concerns and limited systemic absorption. By coupling RLZ with salicylic acid to form RAS, oral RAS can be targeted to the colon and inhibit inflammation, and it is more effective than current anti-IBD drugs.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Lee
Summary: In a mouse study, low-dose curcumin was found to promote hippocampal neurogenesis and enhance memory retention, suggesting its potential role in preventing age and neurodegenerative disease-related cognitive deficits.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Dong-Soon Im
Summary: GPR35, an orphan receptor, has been found to have 5-HIAA as a high potency ligand, and a transgenic knock-in mouse line with human ortholog of GPR35 has been developed for therapeutic experiments. This article reviews the recent advances and prospective therapeutic directions in GPR35 research.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Physical
Ramalingam Manikandan, Jaehoon Kim, Akihito Ishigami, Joon Young Cho, Jung Hoon Kim, Joon Tark Han, Jaewon Lee, Seung-Cheol Chang
Summary: This study presents a simple sensing methodology using a novel supra single-walled carbon nanotube-coated glassy carbon electrode for rapid detection of multiple biomolecules in human health diagnostics. The developed sensor showed simultaneous sensing of ascorbic acid, dopamine, and uric acid with high selectivity and excellent reproducibility in real samples. The sensor is rapid, low cost, scalable, and suitable for real-world applications.
Article
Immunology
So-Eun Son, Dong-Soon Im
Summary: This study found that certain angiotensin II receptor blockers (ARBs) have anti-inflammatory effects in skin diseases. Candesartan may have therapeutic implications by suppressing Th17 cell differentiation, while telmisartan might have therapeutic potential by activating PPAR-gamma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Sivaguru Jayaraman, Thenmozhi Rajarathinam, Hyeon-Geun Jang, Dinakaran Thirumalai, Jaewon Lee, Hyun-Jong Paik, Seung-Cheol Chang
Summary: This study developed a method for detecting melatonin using a ruthenium-incorporated carbon sphere sensor, which exhibited excellent electrocatalytic properties and selectivity, making it suitable for pharmaceutical quality control.
Article
Biochemistry & Molecular Biology
Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Lee
Summary: The present study found that a diet containing morin can prevent motor dysfunction and dopaminergic neuronal damage in a mouse model of Parkinson's disease. It can also significantly reduce neuroinflammation. In vitro studies showed that morin exerts its anti-inflammatory effects by blocking the ERK-p65 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
