Article
Immunology
Bo-Wei Liao, Hong-Yan Zhang, Wen-Tian Du, Yong Ran, Yan-Yi Wang, Zhi-Sheng Xu
Summary: IL-1β is a crucial mediator of inflammatory responses, and its signaling is finely regulated by various mechanisms. This study identified FAM177A1 as a negative regulator of IL-1β-induced signaling, which competitively binds to TRAF6 and impairs its downstream signaling cascade.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Afifa Noor, Muhammad Ihsan Ullah
Summary: The current study evaluated the anti-arthritic activity of n-hexane and aqueous extracts of Cassia absus seeds. The extracts showed significant inhibition of paw edema and reduction in paw size and joint diameter. The extracts also improved the levels of inflammatory and oxidative biomarkers. Polymerase chain reaction investigation revealed the modulation of various inflammatory factors by the extracts. In conclusion, Cassia absus can effectively alleviate arthritis symptoms by modulating oxidative and inflammatory biomarkers.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Qiaoyan Wu, Chengyu Zou
Summary: Microglial dysfunction, specifically the activation of the NF-kappa B pathway and RIPK1 kinase activity, plays a crucial role in exacerbating neurodegenerative diseases through increased neurotoxicity and reactive oxygen species (ROS) accumulation. Understanding the mechanistic links between these factors and their impact on microglial homeostasis is essential for developing therapeutic strategies.
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Plant Sciences
Mengsha Wei, Liping Huang, Qin Li, Xinyi Qiao, Ziming Zhao, Jie Yin, Aimin Fu, Jieru Guo, Xincai Hao, Lianghu Gu, Jianping Wang, Chunmei Chen, Hucheng Zhu, Yonghui Zhang
Summary: Five aromatic ergosterols with unique ring systems, named spectasterols A-E (1-5), were isolated from Aspergillus spectabilis. Compound 3 demonstrated cytotoxic activity and anti-inflammatory effects, inducing cell cycle arrest and apoptosis in HL60 cells, and inhibiting COX-2 levels and NF-kappa B p65 nuclear translocation.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Yue Wu, Yunjiao Yang, Lan Wang, Yiding Chen, Xuke Han, Lisha Sun, Huizhen Chen, Qiu Chen
Summary: Osteoporosis is a bone disease characterized by low bone quality and density, causing bone fragility and vulnerability to fractures. Increased osteoclast differentiation and activity contribute to bone loss, a common manifestation of osteoporosis. The TNF-a/NF-κB inflammatory pathway plays a key role in regulating osteoclast formation, along with the classical RANKL/RANK/OPG pathway. Probiotics, particularly Bifidobacterium, have shown potential beneficial effects on bone health by modulating this pathway. This review discusses the molecular mechanisms of the TNF-a/NF-κB pathway in osteoclast formation and explores the secretions produced by Bifidobacterium, providing new directions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemical Research Methods
Gabriel J. Kowalczyk, J. Agustin Cruz, Yue Guo, Qiuhong Zhang, Natalie Sauerwald, Robin E. C. Lee
Summary: dNEMO is a computational tool optimized for accurate and rapid measurement of fluorescent puncta in fixed-cell and time-lapse images. It uses a spot detection algorithm based on a computationally inexpensive method that is robust to imaging noise. The software allows almost real-time interaction with images without time-consuming pre-processing steps.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, the post-translational modification of Tollip by ubiquitination was identified. Tollip interacts with RNF167 and RNF167 functions as the E3 ligase to attach poly-ubiquitin chains to Tollip. The ubiquitination of Tollip plays a crucial role in TNF-alpha signaling.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Pharmacology & Pharmacy
Weiwei Yuan, Jinxi Huang, Shanshan Hou, Huahua Li, Liangyu Bie, Beibei Chen, Gaofeng Li, Yang Zhou, Xiaobing Chen
Summary: The study found that pretreatment of gastric cancer cells with triptolide can enhance its anti-tumor effect. This effect is dependent on the disruption of the H19/miR-204-5p/NF-kappa B/FLIP axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Guoli Wu, Guangying Qi, Yu Liu, Jinfeng Gan, Chichu Xie, Qi Wu, Wei Cui, Chunhua Wang, Zhaoyi Wang
Summary: This study found that calycosin inhibits IL-6 production in macrophages by enhancing ER-alpha 36 expression and its interaction with p65, attenuating its function as an inducer of IL-6 transcription.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)