Review
Biochemistry & Molecular Biology
Priti Gupta, Shilpa Sharma, Shagufta Jabin, Sapana Jadoun
Summary: Regenerative medicine and tissue engineering have great potential in addressing the limitations of traditional medical approaches. Chitosan, as a naturally derived biocompatible biomaterial, has played a significant role in tissue regeneration. It has unique properties and can be applied in various fields, such as agriculture, nutraceuticals, biomedicine, and food. Chitosan is also an important material for developing next-generation hydrogels and bio-scaffolds. Furthermore, chitosan can be easily modified to enhance its mechanical strength, biodegradability, and controlled release of bioactive molecules. Blending chitosan with other polymers or incorporating nanoparticles expands its possibilities in tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Engineering, Biomedical
Qi Feng, Dingguo Li, Qingtao Li, Xiaodong Cao, Hua Dong
Summary: This mini-review summarizes the fabrication strategies, unique characteristics, and applications of microgel assembly in tissue engineering and regenerative medicine, with a focus on 3D printing. The challenges for further applications of microgel assembly are also discussed.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Huifeng Wang, Samantha Huddleston, Jian Yang, Guillermo A. Ameer
Summary: Regenerative medicine aims to restore tissue and organ function, but faces barriers such as the lack of proregenerative biomaterials, a complex regulatory process, and user adoption challenges. Biodegradable polymers, although important in regenerative medicine, have limitations in their mechanical and degradation properties. Despite these limitations, a small number of biodegradable polymers have dominated the market for the past 50 years.
ADVANCED MATERIALS
(2023)
Review
Medicine, General & Internal
Karin Wallander, Ingegerd Oefverholm, Kjetil Boye, Panagiotis Tsagkozis, Andri Papakonstantinou, Yingbo Lin, Felix Haglund de Flon
Summary: Sarcoma subtype classification is currently based on histopathological morphology, but molecular analyses are becoming an important addition to sarcoma diagnostics and treatment. Molecular markers can support diagnostic workup, suggest differential diagnoses, and identify therapeutic targets. However, the use of molecular markers in sarcoma prognosis is still limited. Understanding the limitations and context of sequencing technologies is crucial for accurate interpretation of genetic findings in sarcoma diagnostics. The increasing availability of massive-parallel sequencing is expected to be utilized more in sarcoma treatment centers in the future.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Nikita Voloshin, Pyotr Tyurin-Kuzmin, Maxim Karagyaur, Zhanna Akopyan, Konstantin Kulebyakin
Summary: Immortalized cells are increasingly used in practical medicine due to their advantages, such as the ability to produce larger amounts of cells and use them for longer periods of time. However, they also have drawbacks, like the possibility of malignant transformation or major phenotype change. This review discusses ways to overcome these barriers and highlights specific fields of application where these concerns are minimal.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Izeia Lukin, Itsasne Erezuma, Lidia Maeso, Jon Zarate, Martin Federico Desimone, Taleb H. Al-Tel, Alireza Dolatshahi-Pirouz, Gorka Orive
Summary: Tissue engineering has become a viable medical alternative in response to the increasing lifespan of society. This review focuses on gelatin, a widely used biomaterial in tissue engineering, and discusses ongoing concerns and the latest developments in this field. Advancements in technology, such as 3D bioprinting and gelatin functionalization, have allowed for better replication of native tissue in gelatin-based systems. This breakthrough has implications for both the manufacturing process, making it more practical and cost-effective, and the future use of gelatin in disease detection and diagnosis rather than treatment.
Review
Biochemistry & Molecular Biology
Amelia Seifalian, Zeinab Basma, Alex Digesu, Vikram Khullar
Summary: This study critically evaluates the use of polypropylene (PP) pelvic mesh in the treatment of pelvic organ prolapse (POP), and proposes the use of advanced materials as an alternative to PP mesh. Results show that the physical properties of PP mesh, including its viscoelastic properties and lack of tissue integration, contribute to complications. The banning of PP mesh in multiple countries highlights the need for the development of alternative pelvic mesh materials.
Article
Chemistry, Physical
Ramon Rial, Natalia Hassan, Zhen Liu, Juan M. Ruso
Summary: The study successfully produced hydrogel microparticles with different morphologies and compositions by combining experimental and computational methods, incorporating drug-doped Hydroxyapatite in their inner matrix. The use of a microfluidic system to obtain crosslinked HMPs with homogeneous sizes and morphologies, as well as the adsorption kinetics and desorption profiles of the chosen drug models, were key aspects of the research. The development of these hydrogel microparticles with improved functionalities is crucial for innovative and sustainable solutions in regenerative medicine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Engineering, Biomedical
Michelle Koerselman, Lisanne C. M. Morshuis, Marcel Karperien
Summary: This article discusses the application of small molecules such as peptides, aptamers, and variable antigen-binding domain of heavy chain only antibodies in tissue engineering and regenerative medicine. It compares these biological functionalities with conventional antibodies and provides an overview of recent work in this area. The article focuses on the structural differences, modifications, and conjugation strategies of these biologicals, as well as the clinical trials involving them. The challenges associated with each of these biologicals are also highlighted.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Daniel Salthouse, Katarina Novakovic, Catharien M. U. Hilkens, Ana Marina Ferreira
Summary: This review highlights the importance of the immune response to biomaterials and discusses challenges and opportunities in the development and standardized assessment of the immune response to biomaterials, including the importance of endotoxin levels. It also explores the properties of biomaterials that impact the host immune response and the use of immunomodulatory biomaterials in regenerative medicine. Finally, a standardized in vitro pathway for evaluating the immune response to biomaterials (hydrogels) and their regenerative potential is proposed to ensure safety, consistency, and reduce costs and animal use.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Yiting Lou, Huiming Wang, Guanchen Ye, Yongzheng Li, Chao Liu, Mengfei Yu, Binbin Ying
Summary: This review discusses the important role of periosteum in bone defect repair and regeneration, as well as the need for developing tissue-engineered periosteum (TEP). The construction strategies for TEP are explored from the perspectives of materials, mechanical properties, cell-based strategies, and combination with growth factors. Current challenges and future perspectives for TEP development are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Charles M. Bowen, Frederick S. Ditmars, Ashim Gupta, Jo-Anna Reems, William Samuel Fagg
Summary: Amniotic fluid, specifically its cell-free form, has regenerative properties and can stimulate immunomodulatory and pro-growth characteristics in target cells or tissues. It has been shown to effectively treat cutaneous wounds and orthopedic degenerative conditions.
Article
Biophysics
Zhiwei Jiang, Jin He, Xueting Wang, Danji Zhu, Na Li, Lingfei Ren, Guoli Yang
Summary: Nanomaterial-based cell sheet technology has significant potential in regenerative medicine and tissue engineering. Different types of nanomaterials have been used to harvest cell sheets, categorized by mechanisms such as light-induced, thermo-responsive, magnetic-controlled, and ROS-induced. Studies have demonstrated successful outcomes in the regeneration of bone, skeletal muscle, cardiac tissue, tendon, angiogenesis, and osseointegration. However, challenges remain in terms of comprehensive preparation, safety, and cell quality.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
M. R. Poorna, R. Jayakumar, Jyh-Ping Chen, Ullas Mony
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine, and improving culture methods, such as using hydrogels as substrates, can support iPSC adhesion, proliferation, and differentiation. Using hydrogels may help generate large numbers of clinical-grade cells for potential clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Sunena Dhania, Manju Bernela, Ruma Rani, Minakshi Parsad, Sapna Grewal, Santosh Kumari, Rajesh Thakur
Summary: Tissue engineering technology utilizes biopolymer materials like polyhydroxyalkanoates to mimic and replace damaged tissues, with excellent biocompatibility and biodegradability. This technology has vast potential applications in areas such as bone grafts, cardiovascular repair, and nerve regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
