Article
Critical Care Medicine
Brittany Bolduc Lachance, Zhuoran Wang, Neeraj Badjatia, Xiaofeng Jia
Summary: In a rat model of cardiac arrest, treatment with glibenclamide resulted in improved coma recovery, arousal, and brainstem function, as well as better SSEP recovery post CA compared to the control group. Furthermore, histological analysis showed a significantly lower percentage of damaged neurons in the GBC treatment group.
NEUROCRITICAL CARE
(2022)
Review
Immunology
Sha Wei, Tingting Xu, Yuxin Chen, Kai Zhou
Summary: Klebsiella pneumoniae is a highly drug-resistant pathogen that poses a significant threat to global healthcare. The recent emergence of multidrug resistance and hypervirulence in this species has led to high mortality and worsened clinical outcomes. Understanding the mechanisms employed by K. pneumoniae to evade host immune responses, especially autophagy and cell death, is crucial for the development of effective therapeutics. This review summarizes the progress made in deciphering the cell signaling triggered by K. pneumoniae infection, particularly in the manipulation of autophagy, cell death, and cytokine production.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Plant Sciences
Omer H. M. Ibrahim, Adel D. Al-Qurashi, Khalid A. Asiry, Magdi A. A. Mousa, Nabil A. Alhakamy, Kamal A. M. Abo-Elyousr
Summary: This study characterized the phytochemical composition of Balanites aegyptiaca fruit extract and evaluated its antimicrobial and cytotoxic activities. The extract showed significant cytotoxic activity against three cancer cell lines and exhibited antimicrobial activity against selected bacterial strains. These findings suggest the potential of Balanites aegyptiaca as an effective treatment for cancer and bacterial infections.
Article
Cardiac & Cardiovascular Systems
Vincent L. Aengevaeren, Aaron L. Baggish, Eugene H. Chung, Keith George, Oyunn Kleiven, Alma M. A. Mingels, Stein Orn, Rob E. Shave, Paul D. Thompson, Thijs M. H. Eijsvogels
Summary: Serological assessment of cardiac troponins is essential in evaluating myocardial injury, and exercise-induced elevations of cardiac troponins have long been debated for their clinical relevance. Recent studies have shed new light on the mechanisms and implications of exercise-induced cardiac troponin elevations, challenging the previous view of them as benign.
Article
Cardiac & Cardiovascular Systems
Thomas Uray, Cameron Dezfulian, Abigail A. Palmer, Kristin M. Miner, Rehana K. Leak, Jason P. Stezoski, Keri Janesko-Feldman, Patrick M. Kochanek, Tomas Drabek
Summary: The study found that there are differences in cytokine responses in serum, heart, and brain between asphyxial cardiac arrest (ACA) and ventricular fibrillation cardiac arrest (VFCA), but the changes in cytokine levels and secondary injuries caused by the two types of cardiac arrest are similar.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Yoonsoo Park, Ji Hyeon Ahn, Jeong Hwi Cho, Hyun-Jin Tae, Tae-Kyeong Lee, Bora Kim, Jae-Chul Lee, Joon Ha Park, Myoung Cheol Shin, Taek Geun Ohk, Jun Hwi Cho, Moo-Ho Won
Summary: Hypothermic treatment following asphyxial cardiac arrest in rats was found to reduce liver damage by inhibiting pro-inflammatory cytokines and stimulating anti-inflammatory cytokines, thus regulating inflammation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Elham Memary, Alireza Imani, Ali Arhamidolatabadi, Parvaneh Fadavi, Marjan Aghajani, Farnoosh Mohebzadeh, Mohammad Shahverdi-Shahraki, Ali Dabbagh, Alirza Mirkheshti, Sadegh Shirian
Summary: This study investigated the effects of epinephrine (EP) alone and EP plus methylprednisolone (MP) on neurological outcomes after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a rat model. The results showed that EP alone had the poorest neurological outcomes, while the combination of EP and MP protected neurons from death induced by hypoxia and reperfusion injury.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Critical Care Medicine
Hongbo Wu, Shanxiang Xu, Mengyuan Diao, Jiangang Wang, Gongping Zhang, Jiefeng Xu
Summary: This study aims to investigate the effectiveness of Alda-1 treatment in alleviating lung injury after cardiac arrest and cardiopulmonary resuscitation in pigs. The results showed that Alda-1 treatment was effective in alleviating lung injury after CA/CPR, possibly through inhibiting cell apoptosis and ferroptosis.
Article
Chemistry, Analytical
Yaya Wang, Ruiyi Zhao, Xinyue Zhu, Hong Gao, Can Gong, Xiaoyan Liu, Haixia Zhang
Summary: Accurate evaluation of cell death types is crucial for pharmacological and pathological research. In this study, a novel fluorescent probe PNE-Lyso was designed and synthesized, which could distinguish healthy cells from dead cells by targeting the lysosome and evaluating lysosomal hexosaminidase activity. Additionally, PNE-Lyso could differentiate apoptotic and necrotic cells by visualizing lysosome morphology adjusted by the integrity of the lysosome membrane. This work represents the first time cell death types have been distinguished based on a single fluorescent probe.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yaya Wang, Ruiyi Zhao, Xinyue Zhu, Hong Gao, Can Gong, Xiaoyan Liu, Haixia Zhang
Summary: PNE-Lyso is a novel activatable fluorescent probe designed to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals, which can distinguish dead cells from healthy cells based on a dual-color mode. It has important implications for pharmacological and pathological research.
ANALYTICAL CHEMISTRY
(2022)
Article
Critical Care Medicine
Jignesh K. Patel, Niraj Sinha, Wei Hou, Rian Shah, Asem Qadeer, Linh Tran, Puja B. Parikh, Sam Parnia
Summary: Early prediction of favorable neurologic outcomes in adults after in-hospital cardiac arrest can be assisted by measuring novel inflammatory cytokines, with IL-10 levels within 6 hours being the most independent predictor. Further large-scale studies are needed to confirm these findings.
Article
Oncology
Yu Zhang, Bo Yuan, Baolin Bian, Haiyu Zhao, Anna Kiyomi, Hideki Hayashi, Yui Iwatani, Munetoshi Sugiura, Norio Takagi
Summary: The study highlights the potent cytotoxicity of Helle in human breast cancer cells, especially in inducing apoptosis and cell cycle arrest. It also demonstrates the induction of autophagy by Helle in MCF-7 cells, which contributes to its cytotoxic effects through modulation of cell death and cell cycle arrest.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Jun Wei Yeo, Zi Hui Celeste Ng, Amelia Xin Chun Goh, Jocelyn Fangjiao Gao, Nan Liu, Shao Wei Sean Lam, Yew Woon Chia, Gavin D. Perkins, Marcus Eng Hock Ong, Andrew Fu Wah Ho
Summary: This study found that care at cardiac arrest centers (CACs) was associated with improved survival and neurological outcomes for patients with nontraumatic out-of-hospital cardiac arrest. The benefits were consistent regardless of varying CAC definitions. Patients with shockable rhythms and those without prehospital return of spontaneous circulation benefited more from CACs. The evidence for bypassing hospitals or interhospital transfer remains inconclusive.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Neurosciences
Yihua He, Yuan Chang, Yuqin Peng, Juan Zhu, Kewei Liu, Jiancong Chen, Yongming Wu, Zhong Ji, Zhenzhou Lin, Shengnan Wang, Sohan Gupta, Nailiang Zang, Suyue Pan, Kaibin Huang
Summary: Glibenclamide has been found to have an anti-inflammatory effect and can reduce brain edema and improve neurological function. This anti-inflammatory effect is independent of its role in preventing brain edema and is achieved through the inhibition of the SUR1-TRPM4 channel and the blocking of NLRP3 inflammasome activation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ning Cao, Jing-jing Wang, Ji-min Wu, Wen-li Xu, Rui Wang, Xian-da Chen, Ye-nan Feng, Wen-wen Cong, You-yi Zhang, Han Xiao, Er-dan Dong
Summary: Glibenclamide alleviates cardiac inflammation induced by beta-AR overactivation by inhibiting the NLRP3 inflammasome and modulating potassium efflux and ROS generation through the suppression of the cAMP/PKA signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Nutrition & Dietetics
Ruiqi Xiong, Hua Huang, Yongming Wu, Shengnan Wang, Dongmei Wang, Zhong Ji, Zhenzhou Lin, Nailiang Zang, Suyue Pan, Kaibin Huang
Summary: The study found that RFS is not uncommon in neurocritically ill patients and is more likely to occur in patients with higher nutritional risk and more severe conditions. RFS not only leads to longer NCU stay, higher mortality rates, and poorer functional outcomes, but is also identified as an independent risk factor for 6-month mortality in neurocritically ill patients.
CLINICAL NUTRITION
(2021)
Article
Clinical Neurology
Chuqiao Li, Anqi Jiang, Qingyun Ding, Youfang Hu, Yao Wang, Ge Tian, Honghao Wang, Suyue Pan, Liying Cui, Yu Peng
Summary: Through the analysis of 379 muscles, combined clouds analysis showed superior performance in distinguishing normal, myopathic, and neuropathic muscles, with higher sensitivity. For discrimination of abnormal vs normal and neuropathic vs non-neuropathic, combined clouds analysis had higher sensitivity compared to QMUP analysis.
Article
Behavioral Sciences
Ge Tian, Zhong Ji, Zhenzhou Lin, Suyue Pan, Jia Yin
Summary: This study found that CA impairment varies in different stroke mechanisms caused by ICAS. In patients with POPA, CA was impaired ipsilaterally, while in other stroke mechanisms, CA was impaired bilaterally. CA on the ipsilateral hemisphere correlated with hypertension/hyperlipidemia in patients with POPA, and with perfusion parameters and collateral circulation status in patients with the hypoperfusion mechanism.
BRAIN AND BEHAVIOR
(2021)
Correction
Neurosciences
Xing Li, Jiajia Zhu, Kewei Liu, Yafang Hu, Kaibin Huang, Suyue Pan
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuewu Liu, Yongming Wu, Ya Zhao, Yuxiao Huang, Kaibiao Xu, Jun Wang, Suyue Pan, Jiao Liang
Summary: Cerebral malaria is the most severe complication caused by Plasmodium falciparum infection, and parasite-infected erythrocyte specific protein 2 (PIESP2) may be associated with cerebral malaria by mediating the sequestration of infected red blood cells, inducing inflammation response, and impairing the integrity of the blood-brain barrier.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Clinical Neurology
Juan Zhu, Zheqi Li, Zhong Ji, Yongming Wu, Yihua He, Kewei Liu, Yuan Chang, Yuqin Peng, Zhenzhou Lin, Shengnan Wang, Dongmei Wang, Kaibin Huang, Suyue Pan
Summary: The dynamic degradation and reconstruction of GCX may explain the biphasic changes in BBB permeability in ischemic stroke, and reveal the essential role of GCX in suppressing transcellular transport in brain endothelial cells to maintain BBB integrity. Targeting GCX may provide a novel strategy for managing BBB dysfunction and central nervous system drug delivery.
Article
Clinical Neurology
Yu Peng, Ying-shan Liu, Min-yi Wu, Chu-na Chen, Chu-qiao Li, An-qi Jiang, Chong-xin Li, Yao Wang, Ge Tian, Su-yue Pan, Ling-ling Xu
Summary: This study confirms the good diagnostic consistency and severity correlation of COMPASS-31 and Ewing's test for diagnosing DAN. Both tests are suitable for the diagnosis and treatment follow-up of DAN.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Kewei Liu, Juan Zhu, Yuan Chang, Zhenzhou Lin, Zhu Shi, Xing Li, Xing Chen, Chuman Lin, Suyue Pan, Kaibin Huang
Summary: The study suggests that post-seizure cerebral edema may impair glymphatic system function, making the brain vulnerable to p-tau aggregation and neurocognitive impairment.
Article
Clinical Neurology
Yingying Su, Huijin Huang, Mengdi Jiang, Suyue Pan, Li Ding, Le Zhang, Wen Jiang, Xiaorong Zhuang
Summary: The multicenter study compared the efficacy and safety of phenobarbital and valproate for generalized convulsive status epilepticus, with phenobarbital showing a higher rate of SE termination compared to valproate. There were no significant differences in EEG epileptic discharge nontermination rates between the two groups.
Article
Biology
Yihua He, Yuqin Peng, Yuan Chang, Juan Zhu, Zheqi Li, Kaibin Huang, Suyue Pan
Summary: The study constructed a mouse WBR model using Faxitron MultiRad 225 X-ray irradiation system with a single dose of 30 Gy, and found that this model is capable of simulating the chronic pathophysiological changes associated with radiation-induced brain injury, including activation of astrocytes and microglia, and reduced number of immature neurons in the DG area.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Dongmei Wang, Zhenzhou Lin, Ling Xie, Kaibin Huang, Zhong Ji, Chunping Gu, Shengnan Wang
Summary: This study investigated the relationship between protein provision and mortality in acute critically ill stroke patients, revealing that increased protein provision is significantly associated with reduced 30-day and 6-month mortality.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Immunology
Jiancong Chen, Yuan Chang, Juan Zhu, Yuqin Peng, Zheqi Li, Kunxue Zhang, Yuzhen Zhang, Chuman Lin, Zhenzhou Lin, Suyue Pan, Kaibin Huang
Summary: The study found that flufenamic acid (FFA) could reduce brain injury after cardiac arrest and CPR by blocking the TRPM4 channel in the neurovascular unit, leading to improved survival and neurological deficits.
JOURNAL OF NEUROINFLAMMATION
(2022)
