Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

Stress granules at the intersection of autophagy and ALS

(2016) Zachary Monahan et al.   BRAIN RESEARCH

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

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Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93Atransgenic mice

(2015) Yuko Kobayakawa et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records

(2015) Hyojung Paik et al.   Scientific Reports

The genome revolution and its role in understanding complex diseases

(2014) Marten H. Hofker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms of protein-folding diseases at a glance

(2014) J. S. Valastyan et al.   Disease Models & Mechanisms

Lipocalin-2 Protein Deficiency Ameliorates Experimental Autoimmune Encephalomyelitis

(2014) Youngpyo Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcineurin determines toxic versus beneficial responses to  -synuclein

(2014) G. Caraveo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish models of human motor neuron diseases: Advantages and limitations

(2014) Patrick J. Babin et al.   PROGRESS IN NEUROBIOLOGY

Amyotrophic lateral sclerosis: Problems and prospects

(2013) Jemeen Sreedharan et al.   ANNALS OF NEUROLOGY

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

The role of ERK1, 2, and 5 in dopamine neuron survival during aging

(2013) Mayur S. Parmar et al.   NEUROBIOLOGY OF AGING

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

ERK5 and its role in tumour development: Figure 1

(2012) Pamela A. Lochhead et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia

(2012) A. Skorupa et al.   JOURNAL OF NEUROSCIENCE

A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity

(2012) Dmitry Kryndushkin et al.   MOLECULAR MICROBIOLOGY

MEK5/ERK5 pathway: The first fifteen years

(2011) Barbara A. Drew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

(2011) Sheng Chen et al.   BRAIN PATHOLOGY

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Yeast: An Experimental Organism for 21st Century Biology

(2011) David Botstein et al.   GENETICS

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

(2011) Catherine E. Gleason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression

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Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Microarray Screening for Genes Involved in Oligodendrocyte Differentiation in the Zebrafish CNS

(2011) Ah-Young Chung et al.   Experimental Neurobiology

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

(2010) Ananthamurthy Nagabhushana et al.   BMC CELL BIOLOGY

Processing of Optineurin in Neuronal Cells

(2010) Xiang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

(2010) Mohamed M. Emara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A neuroprotective role for angiogenin in models of Parkinson’s disease

(2010) Trent U. Steidinger et al.   JOURNAL OF NEUROCHEMISTRY

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

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(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples

(2010) A. M. Smith et al.   NUCLEIC ACIDS RESEARCH

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Angiogenin protects motoneurons against hypoxic injury

(2009) J Sebastià et al.   CELL DEATH AND DIFFERENTIATION

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(2009) Philip Van Damme et al.   CURRENT OPINION IN NEUROLOGY

ERK and cell death: ERK1/2 in neuronal death

(2009) Srinivasa Subramaniam et al.   FEBS Journal

Quantitative phenotyping via deep barcode sequencing

(2009) A. M. Smith et al.   GENOME RESEARCH

Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

(2009) Daniel del Toro et al.   MOLECULAR BIOLOGY OF THE CELL

Neuron–glia interactions underlie ALS-like axonal cytoskeletal pathology

(2009) A.E. King et al.   NEUROBIOLOGY OF AGING

Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

(2009) Bolan Linghu et al.   GENOME BIOLOGY

Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking

(2008) F. M. Laird et al.   JOURNAL OF NEUROSCIENCE

Control of Motoneuron Survival by Angiogenin

(2008) D. Kieran et al.   JOURNAL OF NEUROSCIENCE

CNS-derived glia ensheath peripheral nerves and mediate motor root development

(2008) Sarah Kucenas et al.   NATURE NEUROSCIENCE

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

(2008) B. S. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA