Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

High Frequency ofCYP2D6Ultrarapid Metabolizer Genotype in the Finnish Population

(2016) Paavo Pietarinen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Rare genetic variants in cellular transporters, metabolic enzymes and nuclear receptors can be important determinants of interindividual differences in drug response

(2016) Mikael Kozyra et al.   GENETICS IN MEDICINE

Prediction of CYP2D6 phenotype from genotype across world populations

(2016) Andrea Gaedigk et al.   GENETICS IN MEDICINE

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

(2016) Volker Lauschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Patterns of genic intolerance of rare copy number variation in 59,898 human exomes

(2016) Douglas M Ruderfer et al.   NATURE GENETICS

Requirements for comprehensive pharmacogenetic genotyping platforms

(2016) Volker M Lauschke et al.   PHARMACOGENOMICS

Precision Medicine and Rare Genetic Variants

(2016) Volker M. Lauschke et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Pharmacogenomic information in drug labels: European Medicines Agency perspective

(2015) F Ehmann et al.   PHARMACOGENOMICS JOURNAL

Whole-Exome Sequencing Reveals Defective CYP3A4 Variants Predictive of Paclitaxel Dose-Limiting Neuropathy

(2014) M. Apellaniz-Ruiz et al.   CLINICAL CANCER RESEARCH

High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme

(2014) M Apellániz-Ruiz et al.   PHARMACOGENOMICS JOURNAL

Genotype-Guided vs Clinical Dosing of Warfarin and Its Analogues

(2014) Kathleen Stergiopoulos et al.   JAMA Internal Medicine

UDP-glucuronosyltransferase 2B17 genotype and the risk of lung cancer among Austrian Caucasians

(2013) Michaela Gruber et al.   Cancer Epidemiology

Detection of Clinically Relevant Copy Number Variants with Whole-Exome Sequencing

(2013) Joep de Ligt et al.   HUMAN MUTATION

A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing

(2013) Stephen E. Kimmel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Trial of Genotype-Guided Dosing of Warfarin

(2013) Munir Pirmohamed et al.   NEW ENGLAND JOURNAL OF MEDICINE

UDP-glucuronosyltransferase 2B17 genotyping in Japanese athletes and evaluation of the current sports drug testing for detecting testosterone misuse

(2012) Masato Okano et al.   Drug Testing and Analysis

Multi-ethnic cytochrome-P450 copy number profiling: novel pharmacogenetic alleles and mechanism of copy number variation formation

(2012) S Martis et al.   PHARMACOGENOMICS JOURNAL

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects

(2012) S C Sim et al.   PHARMACOGENOMICS JOURNAL

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

Human Copy Number Variation and Complex Genetic Disease

(2011) Santhosh Girirajan et al.   Annual Review of Genetics

The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers

(2011) Akihiro Yamada et al.   Pharmacogenetics and Genomics

Copy number variants in pharmacogenetic genes

(2011) Yijing He et al.   TRENDS IN MOLECULAR MEDICINE

Global patterns of genetic diversity and signals of natural selection for human ADME genes

(2010) Jing Li et al.   HUMAN MOLECULAR GENETICS

Influence of CYP2D6 Deletion, Multiplication, –1584C→G, 31G→A and 2988G→A Gene Polymorphisms on Dextromethorphan Metabolism among Mexican Tepehuanos and Mestizos

(2010) Martha Sosa-Macías et al.   PHARMACOLOGY

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

(2009) Serena Sanna et al.   HUMAN MOLECULAR GENETICS

Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes

(2009) Emma C. Davies et al.   PLoS One

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose

(2008) G. M. Cooper et al.   BLOOD

Pharmacogenomic Biomarker Information in Drug Labels Approved by the United States Food and Drug Administration: Prevalence of Related Drug Use

(2008) Felix W Frueh et al.   PHARMACOTHERAPY