Article
Fisheries
Yo-Seb Jang, Soo-Jin Kim, Su-Young Yoon, Rahul Krishnan, Myung-Joo Oh
Summary: This study demonstrated the effectiveness of a 10-day live VHSV vaccine immunization period at low temperature (17 degrees C). Viral mRNA genes were detected in vaccinated juvenile olive flounder, with lower copy numbers in the internal organs compared to non-vaccinated flounder.
AQUACULTURE REPORTS
(2023)
Article
Virology
So-Ri Han, Hetron M. Munang'andu, In-Kyu Yeo, Sung-Hyun Kim
Summary: Bacillus subtilis and its surfactin have the ability to inhibit VHSV infection.
Pre-treatment of fish with Bacillus subtilis can prevent the spread of VHSV infection to internal organs.
Bacillus subtilis has the potential to serve as an antiviral therapeutic agent against different viral infections in aquaculture.
Article
Fisheries
Jun-Young Song, Shin-Ichi Kitamura, Myung-Joo Oh, Kei Nakayama
Summary: The combined treatment of heavy oil exposure and virus infection in Japanese flounder led to increased mortality. Heavy oil exposure may promote virus replication, leading to higher mortality in the co-treated group. Gene expression profiling showed lower expression of antiviral activity-related genes in the co-treated group. These results help explain the high virus titers in fish treated with both stressors.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Yun Ju Lee, Eun Gyung Park, Woo Ryung Kim, Woo Hyeon Bae, Du Hyeong Lee, Yoonhang Lee, Do-hyung Kim, Yung Hyun Choi, Hee-Jae Cha, Suhkmann Kim, Heui-Soo Kim
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Viral infections can modulate miRNA expression to evade host immunity. This study found that viral hemorrhagic septicemia virus (VHSV) infection decreased miR-15b-5p expression and increased SOCS6 expression in olive flounder.
Article
Fisheries
Kyoung-Hui Kong, Ha-Na Jeong, K. U. Shyam, Myung-Joo Oh, Choon-Sup Kim, Hyoung Jun Kim, Wi-Sik Kim
Summary: The LFIA technology developed with seven anti-VHSV antibodies allows for rapid and specific detection of VHSV in olive flounders, with a high sensitivity and specificity. The field validation of the assay showed a diagnostic effectiveness of 97.3% with a specificity of 100% and sensitivity of 93.9%.
Article
Fisheries
Myung-Hwa Jung, Sung-Ju Jung, Taeho Kim
Summary: This study determined the safe concentrations of orally administered saponin and chitosan and demonstrated the efficacy and safety of saponin and chitosan-based vaccines with inactivated viral haemorrhagic septicaemia virus (VHSV). Additional immunisation with a combination of saponin, chitosan, and IV enhanced protection against VHSV.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Yo-Seb Jang, Soo-Jin Kim, Su-Young Yoon, Rahul Krishnan, Myung-Joo Oh
Summary: This study aimed to investigate the optimal rearing period required for immunizing olive flounder against viral hemorrhagic septicemia virus (VHSV) at suboptimal temperatures. Juvenile olive flounder reared for 5 days at 17 degrees Celsius exhibited 100% survival rate against VHSV infection, while those reared for 30 days showed delayed virus gene expression. These findings provide valuable insights into the immune response of fish to VHSV under suboptimal temperature conditions.
AQUACULTURE INTERNATIONAL
(2023)
Article
Fisheries
Sajal Kole, Su-Mi Shin, Ihn-Sil Kwak, Sung Hwoan Cho, Sung-Ju Jung
Summary: This study assessed the protective efficacy of a trivalent oral vaccine in olive flounder and found that the vaccine induced specific antibodies and upregulated immune genes, resulting in improved ability to combat pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Jae-Woong Lim, Joong-Kyeong Seo, Sung-Ju Jung, So Young Kang
Summary: This study optimized extraction conditions for licorice extract and demonstrated its potent antiviral activity against viral hemorrhagic septicemia virus (VHSV) in olive flounder farms in Korea. The extracted components glycyrrhizin and glycyrrhetinic acid showed antiviral activity as well. The results suggest the potential use of licorice extract as an anti-VHSV agent in aquaculture.
AQUACULTURE RESEARCH
(2021)
Article
Fisheries
Hyoung Jun Kim, Jeong Su Park, Se Ryun Kwon, Youngjin Park
Summary: This study aimed to identify immune-associated genes contributing to the progression of VHSV infection in the kidneys of olive flounder. The analysis revealed that VHSV infection broadly affects host metabolism and innate immune responses in the fish.
Article
Fisheries
Jae-Woong Lim, Joong-Kyeong Seo, Sung-Ju Jung, Ki Yong Lee, So Young Kang
Summary: This study developed an optimized extract of Sanguisorba officinalis L. roots with potent antiviral activity against viral hemorrhagic septicemia virus (VHSV). The extract showed high efficacy in preventing and treating VHSV infection in olive flounder, and also increased inflammatory cytokine expression, indicating enhanced innate immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Sajal Kole, Showkat Ahmad Dar, Su-Mi Shin, Hyeon-Jong Jeong, Sung-Ju Jung
Summary: Olive flounder is the most valuable aquaculture species in Korea, but faces serious disease problems in recent years. A newly developed vaccine shows good prophylactic effects against VHS, streptococcosis, and scuticociliatosis diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Showkat Ahmad Dar, Sajal Kole, Su-Mi Shin, Hyeon-Jong Jeong, Sung-Ju Jung
Summary: The profitability of the olive flounder aquaculture industry in Korea depends on high production and maintenance of flesh quality. Effective vaccination strategies against pathogens are crucial for sustaining high production levels. A vaccine containing squalene-aluminium hydroxide was found to provide moderate to high protection for flounders without side effects, offering a safe and non-invasive option for maintaining flesh quality.
Article
Immunology
Xiaoyan Wu, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: This study demonstrates that the inactivated vaccine against Edwardsiella tarda can induce a protective immune response in flounder, which is mediated through the immediate recognition of the pathogen and subsequent activation of cellular immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Kun Yang, Xueshu Zhang, Zengyu Liu, Weiqun Lu
Summary: In animals, personalities have been found to be linked to behavioral traits, health and disease susceptibility, and welfare. This study examines the performance differences of flounder offspring with different personalities (OFDP). The offspring of bold individuals (OB) were found to be heavier and have higher survival rates compared to the offspring of shy individuals (OS). The study also analyzes the variability of microsatellites and their relationship with OFDP, and finds that certain microsatellite loci are correlated with growth, heat tolerance, and disease resistance. These findings contribute to olive flounder aquaculture and provide insights for fish personality selective breeding.
Article
Fisheries
Jee Youn Hwang, Kesavan Markkandan, Mun Gyeong Kwon, Jung Soo Seo, Seung-il Yoo, Seong Don Hwang, Maeng-Hyun Son, Junhyung Park
FISH & SHELLFISH IMMUNOLOGY
(2018)
Article
Environmental Sciences
Jae-Hyun Lim, Sang Heon Lee, Junhyung Park, Jiyoung Lee, Joo-Eun Yoon, Il-Nam Kim
JOURNAL OF COASTAL RESEARCH
(2018)
Article
Genetics & Heredity
Himansu Kumar, Woncheol Park, Krishnamoorthy Srikanth, Bong-Hwan Choi, Eun-Seok Cho, Kyung-Tai Lee, Jun-Mo Kim, Kwangmin Kim, Junhyung Park, Dajeong Lim, Jong-Eun Park
Article
Multidisciplinary Sciences
Jiyoung Lee, Sung-Ho Kang, Eun Jin Yang, Alison M. Macdonald, Hyoung Min Joo, Junhyung Park, Kwangmin Kim, Gi Seop Lee, Ju-Hyoung Kim, Joo-Eun Yoon, Seong-Su Kim, Jae-Hyun Lim, Il-Nam Kim
SCIENTIFIC REPORTS
(2019)
Article
Agriculture, Dairy & Animal Science
Himansu Kumar, Yu Na Jang, Kwangmin Kim, Junhyung Park, Min Woong Jung, Jong-Eun Park
Article
Entomology
Joon Ha Lee, Hoyong Chung, Yong Pyo Shin, In-Woo Kim, Sathishkumar Natarajan, Karpagam Veerappan, Minchul Seo, Junhyung Park, Jae Sam Hwang
Article
Entomology
Joon Ha Lee, Hoyong Chung, Yong Pyo Shin, In-Woo Kim, Sathishkumar Natarajan, Karpagam Veerappan, Minchul Seo, Junhyung Park, Jae Sam Hwang
Summary: The research analyzed antimicrobial peptides in locusts, predicted promising peptides with antimicrobial effects, and found that they were non-toxic, suggesting their potential as drug candidates.
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joon Ha Lee, Hoyong Chung, Yong Pyo Shin, Mi-Ae Kim, Sathishkumar Natarajan, Karpagam Veerappan, Seong Hyun Kim, Junhyung Park, Jae Sam Hwang
Summary: This study immunized the giant meal worm and predicted numerous novel antimicrobial peptides from the transcriptome data. Some of these peptides showed potential antimicrobial activity and could be candidates for the development of antimicrobial agents.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Article
Entomology
Kang-Woon Lee, Jae-Goo Kim, Karpagam Veerappan, Hoyong Chung, Sathishkumar Natarajan, Ki-Young Kim, Junhyung Park
Summary: Research extracted antimicrobial peptides from high-altitude red spotted apollo butterflies, identifying a promising candidate with antimicrobial activity against bacteria causing periodontitis.
Article
Biochemistry & Molecular Biology
Md Ataul Islam, V. P. Subramanyam Rallabandi, Sameer Mohammed, Sridhar Srinivasan, Sathishkumar Natarajan, Dawood Babu Dudekula, Junhyung Park
Summary: In this study, structure-based virtual screening and machine learning were used to identify potential drug compounds targeting key receptors involved in cardiovascular diseases. Four promising compounds for each beta 1- and beta 2-AR were identified, suggesting their potential importance for experimental validation in treating cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Kwangmin Kim, Karpagam Veerappan, Nahyun Woo, Bohyeon Park, Sathishkumar Natarajan, Hoyong Chung, Cheolmin Kim, Junhyung Park
Summary: The study investigated the impact of Ulmus macrocarpa Hance extract (UME) on human gut microbiota in healthy adults. The results showed that the microbial response to UME supplementation was personalized, with no significant differences in species richness and abundance. However, there was an increase in specific bacterial species and functional enrichment of bacterial genes related to bile acid biosynthesis in the UME group. This preliminary study suggests that UME supplementation may enhance host immunity by modulating gut microbiota, but further larger-scale clinical studies are needed for confirmation.
JOURNAL OF MICROBIOLOGY
(2021)
Review
Plant Sciences
Karpagam Veerappan, Sathishkumar Natarajan, Hoyong Chung, Junhyung Park
Summary: Fleshy fruits, particularly those from the genus Prunus, are highly demanded due to their diverse stone/drupe fruit varieties. Peach varieties have unique palatable qualities, but shorter post-harvest life due to excessive softening, which has led to studies focusing on the molecular mechanisms and genetic basis of the softening process.
Article
Entomology
Joon Ha Lee, Hoyong Chung, Yong Pyo Shin, Mi-Ae Kim, Sathishkumar Natarajan, Karpagam Veerappan, Seong Hyun Kim, Junhyung Park, Jae Sam Hwang
Article
Entomology
Rustem A. Ilyasov, Junhyung Park, Junichi Takahashi, Hyung Wook Kwon
JOURNAL OF APICULTURAL SCIENCE
(2018)