期刊
GENES & DEVELOPMENT
卷 31, 期 9, 页码 847-848出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.301002.117
关键词
temporal gene regulation; open chromatin; ecdysone; pioneer transcription factor; genomics
资金
- National Institutes of Health [DK075607, DK108941]
Many studies have focused on defining the critical transcription factors that specify tissue morphogenesis and differentiation. Our understanding of how these spatial regulators are deployed in the proper temporal order, however, has remained less clear. In this issue of Genes & Development, Uyehara and colleagues (pp. 862-875) provide new insights into the mechanisms by which temporal and spatial regulators are coordinated to control Drosophila wing development during metamorphosis.
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