GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

(2016) Duygu Kuzuoğlu‐Öztürk et al.   EMBO JOURNAL

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation

(2016) Stefan Grüner et al.   MOLECULAR CELL

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

(2016) Rui Fu et al.   RNA

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation

(2015) Daniel Peter et al.   GENES & DEVELOPMENT

The E3 Ubiquitin Ligase ARIH1 Protects against Genotoxic Stress by Initiating a 4EHP-Mediated mRNA Translation Arrest

(2015) Louise von Stechow et al.   MOLECULAR AND CELLULAR BIOLOGY

Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs

(2015) Xianzun Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1

(2015) Naotaka Sekiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

(2014) Cátia Igreja et al.   Nature Communications

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

Investigating the Consequences of eIF4E2 (4EHP) Interaction with 4E-Transporter on Its Cellular Distribution in HeLa Cells

(2013) Dorota Kubacka et al.   PLoS One

Interaction of the Eukaryotic Initiation Factor 4E with 4E-BP2 at a Dynamic Bipartite Interface

(2013) Sabelo Lukhele et al.   STRUCTURE

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails

(2012) J. E. Wilusz et al.   GENES & DEVELOPMENT

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repression

(2012) K. Kinkelin et al.   RNA

A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E

(2011) Keum Soon Paku et al.   BIOCHEMICAL JOURNAL

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling

(2009) B. Giovannone et al.   HUMAN MOLECULAR GENETICS

Cytoplasmic Prep1 Interacts with 4EHP Inhibiting Hoxb4 Translation

(2009) J. Carlos Villaescusa et al.   PLoS One