Article
Biochemistry & Molecular Biology
Yongfeng Song, Zhichao Lv, Yue Wang, Chunxiang Li, Yue Jia, Yong Zhu, Mengna Cao, Yu Zhou, Xing Zeng, Zhenhua Wang, Lin Zhang, Hong Di
Summary: Seed storability is an important trait for grain quality and germplasm conservation. This study identified miRNAs and target genes involved in seed storability in maize by miRNA sequencing and analysis. Transcriptome sequencing and RT-PCR confirmed six pairs of differentially expressed miRNAs associated with seed storability, along with their negative target genes. The enrichment analysis suggested that the regulation of seed storability involves ethylene activation signaling pathway, hormone synthesis and signal transduction, and plant organ morphogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Qian Li, Nadil Shah, Xueqing Zhou, Huiying Wang, Wenlin Yu, Jiajie Luo, Yajun Liu, Genze Li, Chao Liu, Chunyu Zhang, Peng Chen
Summary: The study revealed that miRNAs play different roles in response to Clubroot disease infection in resistant and susceptible plants, potentially participating in the resistance mechanisms through regulating growth, cell death, and metabolic pathways.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Horticulture
Daozong Chen, Haidong Chen, Haimei Zhang, Guoqiang Dai, Wenjie Shen, Yi Liu, Chen Tan
Summary: This study identified miRNAs related to anthocyanin biosynthesis in ornamental kale and revealed their functions and regulatory networks. These findings provide important clues for understanding the regulatory mechanisms of anthocyanin biosynthesis in Brassica crops.
SCIENTIA HORTICULTURAE
(2022)
Article
Biochemistry & Molecular Biology
Nur Farah Anis Abd Halim, Mohd Shukuri Mohamad Ali, Adam Thean Chor Leow, Raja Noor Zaliha Raja Abd Rahman
Summary: This study delves into the various membrane-bound desaturases found in Brassica napus, particularly focusing on the Delta 12 fatty acid desaturase (FAD12). The research highlights the catalytic mechanism and characterization of FAD12, revealing its optimal conditions and secondary structures through GC-MS and CD analysis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Multidisciplinary
Chi Zhou, Weisong Pan, Qi Peng, Yanchao Chen, Ting Zhou, Chuan Wu, William Hartley, Juan Li, Minhui Xu, Chuwei Liu, Peng Li, Liqun Rao, Qiming Wang
Summary: In this study, widely targeted metabolomics was used to investigate the metabolites of normal-oleic-acid and high-oleic-acid rapeseed, revealing key differential metabolites. Lipid profile experiments further confirmed the impact of RNAi technology on FAD2 gene expression. Additionally, resequencing analysis of the transgenic B. napus plants was conducted, focusing on the insertion site and sequence integrity of FAD2 genes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Plant Sciences
Pandi Wang, Xiaojuan Xiong, Xiaobo Zhang, Gang Wu, Fang Liu
Summary: This paper introduces the industrial applications and health benefits of erucic acid, reviews its biosynthetic pathways and genetic engineering research, and emphasizes the importance of improving fatty acids in oilseeds through transgenic technologies.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Horticulture
Zhuang Wen, Yi Hong, Zhilang Qiu, Kun Yang, Qiandong Hou, Guang Qiao, Xiaopeng Wen
Summary: Rootstock plays a crucial role in plant growth, but the molecular mechanism of how it regulates scion growth is not well understood. The regulatory roles of miRNAs in sweet cherry grafting remain unclear. Research indicates that miRNAs mediate scion growth through various aspects in the grafting process.
SCIENTIA HORTICULTURAE
(2022)
Article
Agronomy
Yuqing Li, Usman Ali, Zhouxiao Cao, Chenghao Zeng, Mengying Xiao, Fang Wei, Xuan Yao, Liang Guo, Shaoping Lu
Summary: The BnaA09.FAX1 gene plays an important role in improving seed oil accumulation and plant growth in Brassica napus, while the function of BnaFAX1 may be compensated by other homologous genes of BnaFAX1 and other BnaFAX genes in the mutants.
MOLECULAR BREEDING
(2022)
Article
Biochemistry & Molecular Biology
Weixian Zhou, Libin Zhang, Jianjie He, Wang Chen, Feifan Zhao, Chunhua Fu, Maoteng Li
Summary: Interspecific crosses between Brassica rapa and B. napus result in transcriptome shock in the developing seeds, leading to overall changes in gene expression patterns. The hybrids show expression bias towards B. rapa and significant changes in key transcription factors, which may be responsible for phenotype change.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yue Hong, Hui Xia, Xiao Li, Ruyi Fan, Qing Li, Zhewen Ouyang, Shan Tang, Liang Guo
Summary: This study investigates the important functions of two conserved genes, BnaC06.NTT1b and BnaA07.NTT1a, in Brassica napus. These genes play a vital role in regulating ATP/ADP homeostasis in plastids and have significant effects on glycolysis and membrane lipid composition.
Article
Plant Sciences
Yingting Zhang, Junjie Yang, Lijuan Zhu, Jinyu Xue, Hailiang Hu, Jiebing Cui, Jin Xu
Summary: This study identified a possible role of miRNA-regulated pathways in needle color in Cryptomeria fortunei, a conifer tree species. A miRNA-target pigment biosynthesis regulatory network was constructed, with miRNA-MYBs confirmed as key regulators of needle discoloration. These findings offer new insight into posttranscriptional regulatory mechanisms in gymnosperms and may contribute to genetic improvement of evergreen C. fortunei needles mediated by miRNAs.
Review
Biology
Jian Li, Yangyang Li, Rongyuan Wang, Jiangyan Fu, Xinxing Zhou, Yujie Fang, Youping Wang, Yaju Liu
Summary: This article summarizes the research progress on using the miRNA-mRNA regulatory network to respond to climate change challenges in rapeseed and discusses the functional role of miRNAs in rapeseed as well as strategies for miRNA manipulation in plants. The article states that constructing the miRNA regulatory network can promote the development of climate change-tolerant rapeseed.
Article
Biotechnology & Applied Microbiology
Xuequn Chen, Chaobo Tong, Xingtan Zhang, Aixia Song, Ming Hu, Wei Dong, Fei Chen, Youping Wang, Jinxing Tu, Shengyi Liu, Haibao Tang, Liangsheng Zhang
Summary: The study presents a high-quality genome assembly of a rapeseed cultivar 'Zhongshuang11', revealing characteristics and genomic features. It serves as an important resource for rapeseed genomics research and understanding genetic variations associated with important agronomic traits.
PLANT BIOTECHNOLOGY JOURNAL
(2021)
Article
Plant Sciences
Chao Zhang, Wei Chang, Xiaodong Li, Bo Yang, Liyuan Zhang, Zhongchun Xiao, Jiana Li, Kun Lu
Summary: This study revealed the mechanisms shaping harvest index (HI) in B. napus during the seed-filling stage using mRNA and small RNA sequencing. Differentially expressed genes and microRNAs related to HI were identified, and the involvement of circadian rhythms and response to stimulus in HI was discovered. Transporter activity-related genes were found to be critical to enhancing HI in good cultivation environments.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Han Liu, Baogang Lin, Yun Ren, Pengfei Hao, Lan Huang, Bowen Xue, Lixi Jiang, Yang Zhu, Shuijin Hua
Summary: In this study, a precise genome editing method was established to edit the A5 and C5 loci of BnFAD2 in rapeseed, resulting in a significant increase in seed oleic acid content. The mutants showed a relative proportion of oleic acid greater than 85% in both the T-1 and T-4 generations, indicating a successful editing of the targeted genes. There were no significant differences in seed yield and oil content between the mutants and the wild type, but the mutants exhibited a markedly higher relative proportion of oleic acid.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yan Qiao, Jinjin Zhang, Jinwen Zhang, Zhiwei Wang, An Ran, Haixia Guo, Di Wang, Junlian Zhang
MOLECULAR GENETICS AND GENOMICS
(2017)
Article
Biochemistry & Molecular Biology
Hui-Juan Gao, Xin-pei Lue, Ling Zhang, Yan Qiao, Qi Zhao, Yong-Ping Wang, Meng-Fei Li, Jin-Lin Zhang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Plant Sciences
Qing-Qing Han, Xin-Pei Lu, Jiang-Ping Bai, Yan Qiao, Paul W. Pare, Suo-Min Wang, Jin-Lin Zhang, Yong-Na Wu, Xiao-Pan Pang, Wen-Bo Xu, Zhi-Liang Wang
FRONTIERS IN PLANT SCIENCE
(2014)
Article
Chemistry, Applied
Feicui Zhang, Zhenmin Ma, Yan Qiao, Zhanqi Wang, Wenchao Chen, Shan Zheng, Chenliang Yu, Lili Song, Heqiang Lou, Jiasheng Wu
Summary: This study investigated the flavonoids in Torreya grandis kernels using transcriptome sequencing and metabolomics analysis. A total of 124 flavonoids were identified, and 9 of them were highly correlated with antioxidant activity. Transient overexpression of TgDFR1 resulted in increased antioxidant activity. Additionally, several transcription factors were identified as potential regulators of flavonoid biosynthesis.
Article
Biology
Yong-Jian Guan, Chang-Qing Yu, Yan Qiao, Li-Ping Li, Zhu-Hong You, Zhong-Hao Ren, Yue-Chao Li, Jie Pan
Summary: This study presents a computational method called MFIDMA for predicting drug-miRNA associations. The proposed model demonstrates excellent performance in experiments and can be used for the development and research of miRNA-targeted drugs, providing new perspectives on miRNA therapeutics research and drug discovery.
Article
Agronomy
Yan Qiao, Fang Yang, Qian Li, Panrong Ren, Peipei An, Dan Li, Junfei Xiao
Summary: The accumulation of chlorophyll and glycoalkaloids in potato tubers due to light exposure is known to cause quality loss. This study investigated the post-transcriptional regulation of these accumulations through miRNA in Solanum chacoense tubers. The results identified several light-responsive miRNAs and their target interactions, revealing their roles in various physiological processes. Additionally, the study found that these miRNAs are pivotal for cross-tolerance responses to abiotic and biotic stresses, as well as for regulating biosynthetic pathways. These findings have implications for developing improved potato varieties with resistance to greening and lower glycoalkaloid levels.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.