Article
Chemistry, Multidisciplinary
Manuel Scherer, Andres G. Santana, Kyle Robinson, Steven Zhou, Hermen S. Overkleeft, Lorne Clarke, Stephen G. Withers
Summary: This study introduces a new class of transient GCase inactivators with improved stability in aqueous media, and validates through cellular research that treatment with these compounds can restore catalytic activity in Gaucher cells.
Article
Neurosciences
John P. Vaughen, Emma Theisen, Irma Magaly Rivas-Serna, Andrew B. Berger, Prateek Kalakuntla, Ina Anreiter, Vera C. Mazurak, Tamy Portillo Rodriguez, Joshua D. Mast, Tom Hartl, Ethan O. Perlstein, Richard J. Reimer, M. Thomas Clandinin, Thomas R. Clandinin
Summary: This study reveals the important role of glucocerebrosidase produced by specific glial cells in fruit flies in the structural plasticity of spinal neurons. The degradation of sphingolipids by glucocerebrosidase enables the dynamic remodeling of circadian rhythm, which is essential for maintaining normal circadian behavior.
Article
Cell Biology
Michael E. Baumgartner, Michael P. Dinan, Paul F. Langton, Iwo Kucinski, Eugenia Piddini
Summary: Baumgartner et al. identify proteotoxic stress as the underlying cause of the loser status in a cell competition model caused by reduced autophagic, proteasomal flux and accumulation of protein aggregates.
NATURE CELL BIOLOGY
(2021)
Article
Biology
Joyce Rigal, Ane Martin Anduaga, Elena Bitman, Emma Rivellese, Sebastian Kadener, Michael T. Marr
Summary: This study demonstrates that active transposable elements can act as effectors in the aging process by accelerating aging phenotypes and shortening lifespan in fruit flies. Increased transposable element activity leads to increased sensitivity to oxidative stress and a decline in circadian rhythmicity. Overexpression of the FOXO stress response transcription factor can partially rescue the detrimental effects of increased transposable element activity on lifespan.
Article
Biochemistry & Molecular Biology
Riho Kobayashi, Yuko Yamashita, Hiroko Suzuki, Sena Hatori, Jun Tomita, Kazuhiko Kume
Summary: Recent studies have shown that behaviorally defined sleep is conserved from insects to humans. Understanding how homologous genes regulate sleep across species is crucial for evolutionary analysis. The rdgB gene, found in both fruit flies and mammals, plays a role in sleep regulation, suggesting its conservation across species.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-Ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
Summary: The deletion of Gba2 does not rescue the pathological changes or behavioral abnormalities of gba1 KO medaka, and it may contribute to alpha-synuclein accumulation in the brain by potentially increasing sphingolipids.
Article
Biochemistry & Molecular Biology
Ruifeng Zhang, Xianguo Zhao, Juan Du, Liya Wei, Zhangwu Zhao
Summary: The study elucidates the crucial role of miR-276a in regulating sleep in fruit flies, affecting sleep duration by modulating the miR-276a pathway. MiR-276a is widely expressed in the mushroom body, pars intercerebralis, and certain clock neurons, playing a key role in sleep regulation.
Article
Chemistry, Medicinal
Kanchan Chauhan, Cindy N. Olivares-Medina, Maria V. Villagrana-Escareno, Karla Juarez-Moreno, Ruben D. Cadena-Nava, Ana G. Rodriguez-Hernandez, Rafael Vazquez-Duhalt
Summary: Encapsulated enzyme nanoreactors showed significant GCase catalytic activity and enhanced stability under physiological conditions. Targeting to macrophages was achieved through mannose receptor functionalization, suggesting potential for enzyme replacement therapy in Gaucher's disease.
Article
Biology
Tomas Andreani, Clark Rosensweig, Shiju Sisobhan, Emmanuel Ogunlana, William Kath, Ravi Allada
Summary: This study reveals the circuit and molecular mechanisms by which discrete circadian clock neurons program a homeostatic sleep center in fruit flies. The effects of sleep deprivation depend on morning and evening clock neurons, independent of their roles in circadian locomotor activity. Higher morning rebound and elevated gene and protein expression levels as well as calcium levels in sleep homeostat neurons suggest regulation by clock circuits.
Article
Multidisciplinary Sciences
J. D. Kaufman, Y. Seidler, H. R. Bailey, L. Whitacre, F. Bargo, K. Lueersen, G. Rimbach, G. M. Pighetti, I. R. Ipharraguerre, A. G. Rius
Summary: Heat stress is detrimental to animal productivity, and global warming may exacerbate this issue. Nutritional interventions and postbiotics have been shown to reduce systemic inflammation induced by heat stress, enhancing thermal tolerance and increasing milk production in dairy cows.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Michele Brischigliaro, Erika Fernandez-Vizarra, Carlo Viscomi
Summary: The fruit fly Drosophila melanogaster is a valuable model organism for studying basic physiological processes and genetic diseases. With the availability of genetic tools, it offers insights into the mechanisms of mitochondrial diseases. Recent development of D. melanogaster models of mitochondrial disease has provided important information on molecular mechanisms and pathological consequences of mitochondrial dysfunction. This article provides an overview of these models and highlights the significance of D. melanogaster as a model for studying mitochondrial disorders.
Article
Genetics & Heredity
Junfei Xie, Hao Chen, Wenping Zheng, Zhaohui Cai, Xiaoxue Li, Hongyu Zhang
Summary: Increasing evidence suggests that miRNAs play important regulatory roles in insect physiological processes, including energy metabolism. This study found that the miR-275/305 cluster is crucial for maintaining energy metabolic homeostasis in Bactrocera dorsalis. miR-275 and miR-305 were shown to repress the expression of SLC2A1 and GLIS2, respectively, through binding to their 3'UTR regions. These findings contribute to our understanding of metabolic adaptation to different dietary stimulations and provide insights into potential targets of important miRNAs in non-model organisms.
Article
Cell Biology
Jery Joy, Lara Barrio, Celia Santos-Tapia, Daniela Romao, Nikolaos Nikiforos Giakoumakis, Marta Clemente-Ruiz, Marco Milan
Summary: Aneuploidy, an unbalanced number of chromosomes, leads to cellular senescence with the activation of protein quality control mechanisms and compromised mitophagy. The role of c-Jun N-terminal kinase (JNK) in driving senescence as a consequence of dysfunctional mitochondria and ROS is uncovered. Activating protein quality control mechanisms and mitophagy can mitigate the deleterious effects of aneuploidy, and senescence plays a crucial role in proteostasis and compensatory proliferation for tissue repair.
DEVELOPMENTAL CELL
(2021)
Article
Neurosciences
Jun Tomita, Gosuke Ban, Yoshiaki S. Kato, Kazuhiko Kume
Summary: A novel sleep-regulating neuronal circuit in the protocerebral bridge of the central complex has been discovered, involving neurons that promote sleep and wakefulness. Analysis of synaptic contacts and dopamine signaling revealed the regulatory relationships between these neurons.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yeongmi Cheon, Sunggyu Yoon, Jae-Hyuk Lee, Kiyoung Kim, Hyung-Jun Kim, Sung Wook Hong, Ye -Rang Yun, Jiwon Shim, Sung-Hak Kim, Bingwei Lu, Mihye Lee, Seongsoo Lee
Summary: We identified a novel interaction between MFN2/Marf and kinase MARK4/PAR-1 in both Drosophila and mammalian cells. This interaction is critical for maintaining synaptic structure and mitochondrial homeostasis. Furthermore, knockdown of MARK4/PAR-1 can rescue the mitochondrial hyperfusion and aberrant respiratory function caused by MFN2/Marf overexpression.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.