Review
Endocrinology & Metabolism
Steffane McLennan, Kevin Verhoeff, Kieran Purich, Jerry Dang, Janice Y. Kung, Valentin Mocanu
Summary: This systematic review and meta-analysis finds that duodenal-jejunal bypass liners (DJBLs) provide significant improvements in metabolic and anthropometric outcomes for patients with obesity. However, uncertainty about the long-term effects after device removal may limit their use as a standalone treatment for obesity and associated metabolic complications.
Article
Surgery
Aruchuna Ruban, Alexander D. Miras, Michael A. Glaysher, Anthony P. Goldstone, Christina G. Prechtl, Nicholas Johnson, Navpreet Chhina, Werd Al-Najim, Madhawi Aldhwayan, Natalia Klimowska-Nassar, Claire Smith, Joanne Lord, Jia V. Li, Lilliam Flores, Moaz Al-Lababidi, Georgios K. Dimitriadis, Mayank Patel, Michael Moore, Harvinder Chahal, Ahmed R. Ahmed, Jonathan Cousins, Ghadah Aldubaikhi, Ben Glover, Emanuela Falaschetti, Hutan Ashrafian, Carel W. Le Roux, Ara Darzi, James P. Byrne, Julian P. Teare
Summary: This study examined the clinical efficacy and safety of the duodenal-jejunal bypass liner (DJBL) in situ for 12 months and for 12 months after explantation. The results showed that adding DJBL to intensive medical care led to superior weight loss, improvements in cardiometabolic risk factors, and markers of fatty liver disease, but had no significant impact on glycemia. However, there were more adverse events associated with the use of DJBL.
Article
Nutrition & Dietetics
Michael A. Glaysher, James Ward, Madhawi Aldhwayan, Aruchuna Ruban, Christina Gabriele Prechtl, Helena L. Fisk, Navpreet Chhina, Werd Al-Najim, Claire Smith, Natalia Klimowska-Nassar, Nicholas Johnson, Emmanuela Falaschetti, Anthony P. Goldstone, Alexander Dimitri Miras, James P. Byrne, Philip C. Calder, Julian P. Teare
Summary: DJBL therapy results in superior weight loss and reductions in blood lipid levels, but also leads to depletion of essential fatty acids and their derivatives. It may be necessary to maintain adequate dietary intake or supplement with polyunsaturated fatty acids during the therapy.
CLINICAL NUTRITION
(2021)
Review
Endocrinology & Metabolism
Ji-Hua Chen, Zi-Han Yu, Qin-Ling Fei Liu, Qing-Guo Meng, Xin Chen
Summary: With the development of the economy and improvement of people's living standards, the incidence of obesity and type 2 diabetes mellitus (T2DM) has significantly increased, with obesity also becoming one of the most important risk factors of T2DM. DJBL, which mimics RYGB, has been proven to play a key role in weight loss and control of T2DM, offering a reversible, less invasive treatment option.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Surgery
Thomas Karlas, David Petroff, Juergen Feisthammel, Sebastian Beer, Matthias Blueher, Tatjana Schuetz, Ralf Lichtinghagen, Albrecht Hoffmeister, Johannes Wiegand
Summary: The study found that one year of DJBL therapy is associated with significant improvements in non-invasive markers of steatosis and NASH, but not fibrosis, and is accompanied by a substantial number of complications.
Article
Surgery
Rebecca L. Paszkiewicz, Miguel A. Burch, Isaac Asare Bediako, Hasmik Mkrtchyan, Francesca Piccinini, Marilyn Ader, Catherine Bresee, Richard N. Bergman
Summary: This study assessed the effects of duodenal exclusion on glucose homeostasis using a DJBL in a nonobese canine model. The results showed that duodenal exclusion induced weight loss and negative metabolic effects, which were reversed upon re-exposure to nutrients.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Review
Surgery
Erika Yuki Yvamoto, Diogo Turiani Hourneaux de Moura, Igor Mendonca Proenca, Epifanio Silvino do Monte Junior, Igor Braga Ribeiro, Pedro Henrique Boraschi Vieira Ribas, Matheus Candido Hemerly, Victor Lira de Oliveira, Sergio A. Sanchez-Luna, Wanderley Marques Bernardo, Eduardo Guimaraes Hourneaux de Moura
Summary: This study evaluated the effectiveness and safety of duodenal-jejunal bypass liner (DJBL). The results showed that DJBL can effectively reduce excess weight and have a positive effect on blood glucose control. However, there is a certain occurrence rate of side effects, so cautious use is needed.
Article
Surgery
Sarah J. Guenthert, Aysegul Aksan, Oliver Schroeder, Gunther Meyer, Johannes Hausmann, Jurgen Stein, Christine Stier
Summary: Both RYGB and DJBL showed similar remission rates of hyperglycemia after one year in patients with obesity and T2DM, but RYGB induced more significant weight loss compared to DJBL.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biotechnology & Applied Microbiology
Qingnan Zhao, Jiaxin Cheng, Aimei Gao, Jianqiao Wang, Huiping Lu, Shan Jiang, Xiaojing Li, Jiahao Ni, Wenmin Dong, Shenjin Lai, Jingru Gong, Han Zhu, Yongjun Liang
Summary: This study demonstrates that DJB can remodel ECM and improve energy metabolism in adipose tissues.
Article
Surgery
Fa-Guang Liu, Shu-Wei Chang, Kuo-Feng Hsu, Yen-Ju Chen, Hsin-Mei Pan, Guo-Shiou Liao, Chien-Hua Lin, Sheng-Chun Wang
Summary: This article presents a case study of a 27-year-old Asian female patient who underwent a revisional bariatric surgery after poor response to the primary surgery. The laparoscopic procedure successfully controlled her weight and achieved remission of diabetes without any complications.
Article
Multidisciplinary Sciences
Shohei Okikawa, Hideya Kashihara, Mitsuo Shimada, Kozo Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Yuma Wada, Toshiaki Yoshimoto
Summary: Metabolic surgery, specifically duodenal-jejunal bypass (DJB), is effective in improving glucose tolerance in the early postoperative period for non-obese rats with type 2 diabetes mellitus (T2DM). This improvement is associated with changes in glucose transporter expression, with high levels of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1), and low levels of GLUT2 in the alimentary limb (AL) of DJB-operated rats.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Jean-Michel Gonzalez, Sohaib Ouazzani, Stephane Berdah, Nicolas Cauche, Cecilia Delattre, Joyce A. Peetermans, Agostina Santoro-Schulte, Ornela Gjata, Marc Barthet
Summary: This study assessed a new natural orifice transluminal endoscopic surgery (NOTES) bariatric endoscopic procedure in obese adult pigs. The results showed weight loss in the test animals but also raised safety concerns.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Natascha Roehlen, Katharina Laubner, Leonard Nicolaus, Henning Schwacha, Dominik Bettinger, Andreas Krebs, Robert Thimme, Jochen Seufert
Summary: This study demonstrates significant effects of DJBL treatment on biochemical and clinical markers of NAFLD activity. DJBL therapy can reduce fatty liver index, alanine aminotransferase, and cytokeratin-18 fragments levels. Furthermore, DJBL implantation can decrease NAFLD fibrosis and APRI scores.
Article
Gastroenterology & Hepatology
Hai-Feng Han, Shao-Zhuang Liu, Xiang Zhang, Meng Wei, Xin Huang, Wen-Bin Yu
Summary: This study aimed to investigate the effects of duodenal-jejunal bypass (DJB) surgery on duodenal SIRT1 expression and the potential links between bile acids (BAs) and SIRT1. The results showed that DJB surgery increased intra-duodenal BA levels and activated the duodenal BA signaling pathway, leading to upregulation of duodenal SIRT1 expression and improved glucose homeostasis after DJB.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Taha Gokmen Ulger, Muhittin Tayfur, Funda Pinar Cakiroglu, Cigdem Ozcan
Summary: Endoscopic bariatric procedures, including DJBL, have shown significant weight reduction effects and improvements in metabolic syndrome and cardiovascular disease parameters. However, the impact on liver, pancreatic functions, and inflammation markers remains unclear, and the complication rate is high, leading to lack of FDA approval. Safety improvements are needed despite the positive effects on obesity and related comorbidities.
AIMS MEDICAL SCIENCE
(2021)
Article
Surgery
Abel Boerboom, Mellody Cooiman, Edo Aarts, Theo Aufenacker, Eric Hazebroek, Frits Berends
Article
Surgery
Laura Heusschen, Wendy Schijns, Nadine Ploeger, Laura N. Deden, Eric J. Hazebroek, Frits J. Berends, Edo O. Aarts
Article
Surgery
M. I. Cooiman, L. Kleinendorst, E. O. Aarts, I. M. C. Janssen, H. K. Ploos van Amstel, A. I. Blakemore, E. J. Hazebroek, H. J. Meijers-Heijboer, B. van der Zwaag, F. J. Berends, M. M. van Haelst
Letter
Surgery
Frits Berends, Edo Oscar Aarts
Article
Surgery
Abel Boerboom, Edo Aarts, Volker Lange, Andreas Plamper, Karl Rheinwalt, Katja Linke, Ralph Peterli, Frits Berends, Eric Hazebroek
Article
Nutrition & Dietetics
Wendy Schijns, Abel Boerboom, Margot de Bruyn Kops, Christel de Raaff, Bart van Wagensveld, Frits J. Berends, Ignace M. C. Janssen, Cees J. H. M. van Laarhoven, Hans de Boer, Edo O. Aarts
CLINICAL NUTRITION
(2020)
Article
Surgery
Malou A. H. Nuijten, Valerie M. Monpellier, Thijs Eijsvogels, Ignace M. C. Janssen, Eric J. Hazebroek, Maria T. E. Hopman
Article
Health Care Sciences & Services
Valerie M. Monpellier, Luella W. Smith, Vera Voorwinde, Ignace M. C. Janssen, Maartje M. van Stralen
QUALITY OF LIFE RESEARCH
(2020)
Article
Surgery
Pascal M. Burger, Valerie M. Monpellier, Laura N. Deden, Laurens B. R. Kooiman, Ronald S. L. Liem, Eric J. Hazebroek, Ignace M. C. Janssen, Jan Westerink
SURGERY FOR OBESITY AND RELATED DISEASES
(2020)
Article
Surgery
Anne Jacobs, Ronald S. L. Liem, Ignace M. C. Janssen, Rob A. E. M. Tollenaar, Valerie M. Monpellier
Summary: This study concluded that delaying qualification for bariatric surgery compared with immediate qualification does not have a clinically relevant impact on postoperative weight loss 3 years after surgery.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Review
Endocrinology & Metabolism
Malou A. H. Nuijten, Thijs M. H. Eijsvogels, Valerie M. Monpellier, Ignace M. C. Janssen, Eric J. Hazebroek, Maria T. E. Hopman
Summary: The meta-analysis revealed significant loss of lean body mass and fat-free mass within the first year post-bariatric surgery, with a majority of the losses occurring within the first 3 months post-surgery. Interventions should be implemented perioperatively to mitigate these losses.
Article
Surgery
Claire E. E. de Vries, Dennis J. S. Makarawung, Valerie M. Monpellier, Ignace M. C. Janssen, Steve M. M. de Castro, Ruben N. van Veen
Summary: The study found that the RAND-36 was not sufficiently validated in patients undergoing bariatric surgery in the Netherlands, making it unable to accurately assess the HRQoL of these patients. Future research should utilize PROMs specifically designed for assessing HRQoL in patients undergoing bariatric surgery.
Article
Surgery
Malou A. H. Nuijten, Onno M. Tettero, Rens J. Wolf, Esmee A. Bakker, Thijs M. H. Eijsvogels, Valerie M. Monpellier, Eric J. Hazebroek, Ignace M. C. Janssen, Maria T. E. Hopman
Summary: This study found that bariatric patients who successfully improved their physical activity had better body composition, fitness, and quality of life at 2 years post-surgery. This highlights the importance of perioperative bariatric care programs in changing lifestyle and achieving sustainable improvements in physical activity levels.
Article
Endocrinology & Metabolism
Karlijn J. Vermeer, Valerie M. Monpellier, Wiepke Cahn, Ignace M. C. Janssen