期刊
GASTROENTEROLOGY
卷 152, 期 4, 页码 762-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2016.12.001
关键词
SPEM; Organoids; CD44 Variant 9; Atp4b-Cre
资金
- National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases [R01s DK094989, DK105129]
- Siteman Cancer Center Investment Program
- National Institute of General Medical Sciences Cell and Molecular Biology [GM007067]
- Department of Veterans Affairs Merit Review Award [I01BX000930]
- National Institutes of Health [R01 DK071590]
Parietal cell atrophy is considered to cause metaplasia in the stomach. We developed mice that express the diphtheria toxin receptor specifically in parietal cells to induce their death, and found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells. Furthermore, the metaplasia-inducing agents tamoxifen or DMP-777 still induced metaplasia even after previous destruction of parietal cells by diphtheria toxin. Atrophy of parietal cells alone therefore is not sufficient to induce metaplasia: completion of metaplastic reprogramming of chief cells requires mechanisms beyond parietal cell injury or death.
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