Article
Clinical Neurology
M. M. Gonzales, V. R. Garbarino, E. Marques Zilli, R. C. Petersen, J. L. Kirkland, T. Tchkonia, N. Musi, S. Seshadri, S. Craft, M. E. Orr
Summary: Preclinical studies have shown age-associated accumulation of senescent cells in various organ systems, with tau protein accumulation potentially driving cellular senescence in brain diseases like Alzheimer's. Pharmacologically clearing senescent cells, especially through intermittent dosing of senolytics like dasatinib plus quercetin, has shown promise in reducing brain pathogenesis. Clinical trials are now being planned to further explore the safety, feasibility, and efficacy of senolytics in modulating the progression of Alzheimer's disease.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Gastroenterology & Hepatology
Abhinav Vasudevan, Danny Con, Peter De Cruz, Miles P. Sparrow, Antony B. Friedman, Mayur Garg, Soleiman Kashkooli, Peter R. Gibson, Daniel R. van Langenberg
Summary: This study compared the use of thiopurine-allopurinol combination therapy with standard thiopurine therapy in IBD. The results showed that the thiopurine-allopurinol group had better outcomes in the primary efficacy assessment, fewer adverse events, and less frequent thiopurine dose adjustments.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell & Tissue Engineering
Henrique Rodrigues Scherer Coelho, Silvia Cordeiro das Neves, Jovino Nogueira da Silva Menezes, Andreia Conceicao Milan Brochado Antoniolli-Silva, Rodrigo Juliano Oliveira
Summary: This research evaluated the effects of cell therapy with adipose tissue-derived stem cells on the treatment of detrusor underactivity in men. The results showed that cell therapy improved voiding function, increased maximum flow and urinated volume, and reduced residual volume. The International Consultation on Incontinence Questionnaire scores also decreased, indicating an improvement in quality of life. Adipose tissue-derived stem cell therapy is a safe and effective new option for the treatment of detrusor underactivity.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Immunology
Maximilian Wiendl, Emily Becker, Tanja M. Mueller, Caroline J. Voskens, Markus F. Neurath, Sebastian Zundler
Summary: Inflammatory bowel diseases such as Crohn's disease (CD) and ulcerative colitis (UC) are multifactorial diseases with an increasing prevalence and incidence worldwide. Targeting immune cell homing has become an important pillar of IBD therapy, with potential for further therapeutic interventions. Leukocyte trafficking and tissue-derived chemokines offer untapped resources for potential therapeutic interventions in IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Richard K. Burt, Roumen Balabanov, Xiaoqiang Han, Kathleen Quigley, Indira Arnautovic, Irene Helenowski, John Rose, Teepu Siddique
Summary: This study aimed to test the safety and efficacy of autologous nonmyeloablative hematopoietic stem cell transplantation in treating stiff-person spectrum disorder. Results showed that the treatment was safe overall, with a majority of participants responding positively and experiencing remission. However, the beneficial effects were more prominent in participants with specific clinical characteristics, such as episodic spasms and normal reflexes, highlighting the variability in treatment outcomes for different subgroups.
Article
Immunology
Pedro S. Couto, Nada Al-Arawe, Igor S. Filgueiras, Dennyson L. M. Fonseca, Irene Hinterseher, Rusan A. Catar, Raghavan Chinnadurai, Alexey Bersenev, Otavio Cabral-Marques, Guido Moll, Frances Verter
Summary: This study summarizes 195 clinical trials of advanced cell therapies targeting COVID-19 that were registered over the two years between January 2020 to December 2021. It also analyzes the cell manufacturing and clinical delivery experience of 26 trials that published their outcomes by July 2022. The study found that MSCs provide a relative risk reduction for all-cause COVID-19 mortality and highlights the important role that cell therapy products may play as an adjunct therapy in the management of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Giorgio Ottaviano, Christos Georgiadis, Soragia Athina Gkazi, Farhatullah Syed, Hong Zhan, Annie Etuk, Roland Preece, Jan Chu, Agnieszka Kubat, Stuart Adams, Paul Veys, Ajay Vora, Kanchan Rao, Waseem Qasim
Summary: This study demonstrates the feasibility, safety, and therapeutic potential of CRISPR-engineered immunotherapy. By using genome editing techniques, allogeneic T cells were modified to provide off-the-shelf alternatives to autologous CAR T cell therapies, showing promising results in the treatment of B-ALL.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Mahshid Saleh, Amir Abbas Vaezi, Rasoul Aliannejad, Amir Ali Sohrabpour, Seyedeh Zahra Fotook Kiaei, Mahdi Shadnoush, Vahid Siavashi, Leila Aghaghazvini, Batoul Khoundabi, Shahriyar Abdoli, Bahram Chahardouli, Iman Seyhoun, Neda Alijani, Javad Verdi
Summary: The study evaluated the safety and efficacy of intravenous Wharton's jelly-derived MSCs in treating COVID-19 patients. Results showed improvement in inflammation responses and no serious complications, indicating that severe COVID-19 patients in the inflammatory phase may respond well to cell therapy. More extensive clinical trials are needed in this area.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Danielle M. Wiese, Catherine A. Wood, Lorena R. Braid
Summary: Retrospective analysis of clinical trial outcomes is crucial for efficient translation of cellular therapies, especially for mesenchymal stem/stromal cell (MSC) products. However, current clinical trial reports lack sufficient information on the methodology of cell preparation and handling, leading to significant variability in cell products between trials and hindering the identification of optimal handling protocols.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Eva Gine, Fatima de la Cruz, Ana Jimenez Ubieto, Javier Lopez Jimenez, Alejandro Martin Garcia-Sancho, M. Jose Terol, Eva Gonzalez Barca, Maria Casanova, Adolfo de la Fuente, Ana Marin-Niebla, Ana Muntanola, Tomas Jose Gonzalez-Lopez, Marta Aymerich, Xavier Setoain, Montserrat Cortes-Romera, Amanda Rotger, Sonia Rodriguez, Alejandro Medina Herrera, Ramon Garcia Sanz, Ferran Nadeu, Silvia Bea, Elias Campo, Armando Lopez-Guillermo
Summary: The study investigated the effectiveness of tailored treatment with ibrutinib in combination with rituximab (IR) in MCL patients, indicating significant responses in indolent clinical forms of MCL. The frontline IR combination achieved a high rate of complete responses and undetectable minimal residual disease in these patients.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Penella Woll, Piers Gaunt, Sarah Danson, Nicola Steele, Samreen Ahmed, Clive Mulatero, Riyaz Shah, Jaishree Bhosle, Elizabeth Hodgkinson, Ben Watkins, Lucinda Billingham
Summary: This study evaluated the activity and safety of olaparib as maintenance treatment for chemoresponsive small cell lung cancer patients. The results showed no significant difference in progression-free survival between olaparib and placebo, and the toxicity of olaparib was similar to other studies.
Article
Medicine, General & Internal
Jennifer McVean, Gregory P. Forlenza, Roy W. Beck, Colleen Bauza, Ryan Bailey, Bruce Buckingham, Linda A. DiMeglio, Jennifer L. Sherr, Mark Clements, Anna Neyman, Carmella Evans-Molina, Emily K. Sims, Laurel H. Messer, Laya Ekhlaspour, Ryan McDonough, Michelle Van Name, Diana Rojas, Shannon Beasley, Stephanie DuBose, Craig Kollman, Antoinette Moran, CLVer Study Grp
Summary: The study aimed to determine the effectiveness of intensive diabetes management to achieve near normalization of glucose levels on preservation of pancreatic beta cell function in youth with newly diagnosed type 1 diabetes. The results showed that although the intensive management group achieved excellent glucose control, it did not affect the decline in pancreatic C-peptide secretion at 52 weeks.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Sophie Vieujean, James O. Lindsay, Ferdinando D'Amico, Vineet Ahuja, Mark S. Silverberg, Ajit Sood, Jesus K. Yamamoto-Furusho, Masakazu Nagahori, Mamoru Watanabe, Ioannis E. Koutroubakis, Kalliopi Foteinogiannopoulou, Irit Avni Biron, Alissa Walsh, An Outtier, Rie Louise Moller Nordestgaard, Maria T. Abreu, Marla Dubinsky, Corey Siegel, Edouard Louis, Iris Dotan, Walter Reinisch, Silvio Danese, David T. Rubin, Laurent Peyrin-Biroulet
Summary: This study analyzes the reasons for non-enrollment of IBD patients in RCTs and finds that patients are lost at each step, with eligibility criteria, the risk of placebo assignment, and insufficient disease activity being the main barriers.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Oncology
David J. Sher, Dominic H. Moon, Dat Vo, Jing Wang, Liyuan Chen, Michael Dohopolski, Randall Hughes, Baran D. Sumer, Chul Ahn, Vladimir Avkshtol
Summary: This prospective phase II study indicates that elective neck irradiation is no longer mandatory for head and neck squamous cell carcinoma treatment, and radiation therapy can effectively reduce tumor recurrence and improve patients' quality of life.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Timothy S. Fenske
Summary: The Oncology Grand Rounds series aims to provide clinical context for original reports published in the Journal. This article presents a case of a 73-year-old woman with mantle cell lymphoma (MCL) who achieved remission with bendamustine and rituximab. The relevant literature is reviewed, including prospective clinical trials and large retrospective real-world cohorts. The findings highlight the challenges in frontline treatment selection for MCL patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Cell & Tissue Engineering
Timothy D. Wiltshire, Michael C. Deeds, Darcie J. Radel, Alexander M. Bornschlegl, Clint S. Schmidt, Julia M. Thebiay, Linda L. Pelleymounter, Eapen K. Jacob, James R. Stubbs, Dennis A. Gastineau, Allan B. Dietz
Summary: The rise of investigative and commercially available cell therapy products adds a new dynamic to academic medical centers in managing patient-specific cell products. Establishing a dedicated unit for handling living cell products from collection to delivery is essential for integrating externally manufactured cell therapies into clinical practice efficiently. This system is believed to be scalable for addressing the growth of cell therapy products in the future.
Article
Cardiac & Cardiovascular Systems
Michel T. Corban, Takumi Toya, Diana Albers, Faten Sebaali, Bradley R. Lewis, John Bois, Rajiv Gulati, Abhiram Prasad, Patricia J. M. Best, Malcolm R. Bell, Charanjit S. Rihal, Megha Prasad, Ali Ahmad, Lilach O. Lerman, Mary L. Solseth, Jeffrey L. Winters, Allan B. Dietz, Amir Lerman
Summary: The study suggests that intracoronary infusion of autologous CD34+ cells can be a safe and potentially effective therapy for coronary endothelial dysfunction (CED). The infusion improves microvascular CED, reduces angina severity and nitroglycerin use, and improves quality of life without significant impact on exercise capacity.
CIRCULATION RESEARCH
(2022)
Article
Cell & Tissue Engineering
Elena Atanasova, Dragana Milosevic, Svetlana Bornschlegl, Karen P. Krucker, Eapen K. Jacob, Eva M. Carmona Porquera, Dagny K. Anderson, Ashley M. Egan, Andrew H. Limper, Allan B. Dietz
Summary: This study found no differences in autologous adipose-derived MSCs (aMSCs) from IPF patients and healthy controls in terms of their stem cell properties, suggesting that aMSCs may be a viable option for IPF therapy. Additionally, IPF patients had altered immune systems, which may serve as valuable biomarkers for assessing disease burden and monitoring therapeutic response.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Genetics & Heredity
Ying Zhang, Ling Ling, Arya Ajay D. O. Ajayakumar, Yating Michelle Eio, Andre J. van Wijnen, Victor Nurcombe, Simon M. Cool
Summary: This study reveals a positive correlation between FGFR2 expression and osteogenic potential in human adult bone marrow-derived MSCs. Knockdown of FGFR2 leads to downregulation of pro-osteogenic genes and upregulation of pro-adipogenic genes, suppressing osteogenesis. Furthermore, FGFR2 knockdown results in upregulation of EZH2, an enzyme that regulates MSC lineage commitment and suppresses osteogenesis under osteogenic induction.
Editorial Material
Orthopedics
Andre J. van Wijnen, Eric A. Lewallen
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Multidisciplinary Sciences
Coralee E. Tye, Prachi N. Ghule, Jonathan A. R. Gordon, Fleur S. Kabala, Natalie A. Page, Michelle M. Falcone, Kirsten M. Tracy, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein
Summary: This study reveals a long non-coding RNA (MIR181A1HG) that is highly expressed in multipotent mesenchymal stromal cells (MSCs) and down-regulated during osteogenic differentiation. Knockdown of MIR181A1HG impedes cell cycle progression in MSCs and enhances their differentiation into osteo-chondroprogenitors. This study suggests that MIR181A1HG may serve as a regulator of new bone formation in skeletal disorders.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Insug O-Sullivan, Arivarasu Natarajan Anbazhagan, Gurjit Singh, Kaige Ma, Stefan J. Green, Megha Singhal, Jun Wang, Anoop Kumar, Pradeep K. Dudeja, Terry G. Unterman, Gina Votta-Velis, Benjamin Bruce, Andre J. van Wijnen, Hee-Jeong Im
Summary: The study found that probiotic therapy with Lactobacillus acidophilus can rapidly alleviate inflammatory knee joint pain and prevent further progression of osteoarthritis. This treatment also reduces the levels of cartilage-degrading enzymes, pain markers, and inflammatory factors. Additionally, the probiotic treatment significantly alters the fecal microbiota.
Article
Hematology
Maggie Li, Evan J. Beck, Oliver Laeyendecker, Yolanda Eby, Aaron A. R. Tobian, Patrizio Caturegli, Camille Wouters, Gregory R. Chiklis, William Block, Robert O. McKie, Michael J. Joyner, Timothy D. Wiltshire, Allan B. Dietz, Thomas J. Gniadek, Arell J. Shapiro, Anusha Yarava, Karen Lane, Daniel F. Hanley, Evan M. Bloch, Shmuel Shoham, Edward R. Cachay, Barry R. Meisenberg, Moises A. Huaman, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, James H. Paxton, Shweta Anjan, Jonathan M. Gerber, Kelly A. Gebo, Arturo Casadevall, Andrew Pekosz, David J. Sullivan, CSSC grp
Summary: The COVID-19 convalescent plasma (CCP) with high antibody levels effectively reduces hospitalization for immunocompetent outpatient. The study found that CCP can effectively neutralize the three variants.
Article
Gastroenterology & Hepatology
Eric J. Dozois, Amy L. Lightner, Allan B. Dietz, Joel G. Fletcher, Yong S. Lee, Jessica J. Friton, William A. Faubion
Summary: This study aimed to assess the safety and feasibility of using a bioabsorbable fistula plug loaded with autologous adipose-derived mesenchymal stem cells for the treatment of refractory perianal Crohn's disease. The results showed that the stem cell-loaded plug could safely and effectively deliver cell-based therapy for patients with single-tract fistulizing perianal Crohn's disease.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Genetics & Heredity
Parisa Dashti, Jeroen van de Peppel, Roman Thaler, Christopher R. Paradise, Gary S. Stein, Martin A. Montecino, Johannes P. T. M. van Leeuwen, Bram J. van der Eerden, Amel Dudakovic, Andre J. van Wijnen
Summary: This study found that Smyd2 inhibits proliferation and mineral deposition by osteoblasts, and operates parallel to the suppressive effects of Ezh2 and H3K27 trimethylation on osteoblast differentiation.
Article
Cell & Tissue Engineering
Seyed M. Hosseiniasl, Philipp Felgendreff, Mohammad Tharwat, Bruce Amiot, Anan AbuRmilah, Anna M. Minshew, Alexander M. Bornschlegl, Nidhi Jalan-Sakrikar, Michele Smart, Allan B. Dietz, Robert C. Huebert, Scott L. Nyberg
Summary: This study evaluated the beneficial impact of a novel intraluminal MSC delivery system in a porcine model of Roux en y anastomosis. The results demonstrated that intraluminal delivery of AD-MSCs successfully reduced peri-biliary fibrosis and increased neo-angiogenesis.
Editorial Material
Orthopedics
Andre J. van Wijnen, Eric A. Lewallen
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Review
Biochemistry & Molecular Biology
Praneet Dara, Zeba Farooqui, Fackson Mwale, Chungyoul Choe, Andre J. van Wijnen, Hee-Jeong Im
Summary: Chronic pain conditions caused by arthritis have devastating effects on both individuals and society. The main objective of pharmacological treatments is to reduce pain, and several types of drugs have been considered. Naltrexone, an oral-activated opioid antagonist, has been shown to have beneficial effects on chronic pain conditions such as fibromyalgia and multiple sclerosis.
Article
Orthopedics
Hayman Lui, Cedryck Vaquette, Janet M. Denbeigh, Randy Bindra, Andre J. van Wijnen, Sanjeev Kakar
Summary: This study aims to assess the use of growth factors (BMP2 and GDF5) for bone and ligament regeneration in a multiphasic scaffold in a rabbit knee model. The addition of BMP2 and GDF5 in the BLB scaffold resulted in heterotopic bone formation and ligament failure.
JOURNAL OF WRIST SURGERY
(2023)
Article
Endocrinology & Metabolism
Stephane Blouin, Farzaneh Khani, Phaedra Messmer, Paul Roschger, Markus A. Hartmann, Andre J. van Wijnen, Roman Thaler, Barbara M. Misof
Summary: Vitamin C is crucial for bone health and low levels of serum Vitamin C increase the risk of skeletal fractures. This study examined the effects of Vitamin C on femoral structure, bone formation, and bone mineralization density distribution in mice. The results showed that Vitamin C depletion significantly reduced cortical thickness and bone volume, as well as diminished the amount of newly formed bone tissue. Additionally, Vitamin C supplementation led to higher calcium concentrations and suggested a longer bone tissue age. Female mice were found to be more sensitive to Vitamin C deficiency. These findings highlight the key role of Vitamin C in bone formation rate and its potential in preventing bone-degenerative diseases, especially in females.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
