Review
Chemistry, Applied
Xingwei Li, Caixia Yin, Le Zhang, Fangjun Huo
Summary: This review paper discusses recent research progress in the detection of liver cancer-related enzymes (LAP, GGT, and ALP) using fluorescence imaging, which is essential for early diagnosis and treatment of liver cancer. The advantages and disadvantages of various fluorescent probes are compared, and their future development trends are discussed.
Article
Medicine, General & Internal
Toshiya Fujii, Norio Aoyama, Sayuri Kida, Kentaro Taniguchi, Tomomi Yata, Masato Minabe, Motohiro Komaki
Summary: A relationship between periodontitis and liver function has been suggested. This study aimed to clarify the relationship between liver function markers (AST, ALT, and GGT) and the periodontal inflammatory surface area (PISA). The results showed that participants with high PISA scores were more likely to have increased GGT levels, while AST and ALT levels did not differ based on PISA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Dinghao Zheng, Xiaoyun Zhang, Lili You, Feng Li, Diaozhu Lin, Kan Sun, Meng Ren, Li Yan, Wei Wang
Summary: This study found that liver enzymes are correlated with the risk of diabetes mellitus in a middle-aged Chinese population. Specifically, the concentration of serum GGT is positively correlated with diabetes risk in certain subgroups, while ALT and AST concentrations have no significant correlation. However, the correlation disappears when waist circumference exceeds a certain threshold. Therefore, GGT concentration has limited value in predicting diabetes risk in individuals with large waist circumference.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Daniele Pastori, Arianna Pani, Arianna Di Rocco, Danilo Menichelli, Gianluca Gazzaniga, Alessio Farcomeni, Laura D'Erasmo, Francesco Angelico, Maria Del Ben, Francesco Baratta
Summary: The study found that statin treatment significantly reduced ALT, AST, and GGT levels in NAFLD patients in interventional studies, while observational studies showed no significant effect, indicating the liver safety of statins in NAFLD patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yusuke Takahashi, Yuya Seko, Kanji Yamaguchi, Kento Takeuchi, Kota Yano, Seita Kataoka, Michihisa Moriguchi, Yoshito Itoh
Summary: The aim of this retrospective study is to identify predictors of pemafibrate efficacy in nonalcoholic fatty liver disease (NAFLD) patients. The study found that age and baseline gamma-glutamyl transferase (GGT) level were significantly associated with improvement in pemafibrate efficacy. Patients over 50 years of age and with a GGT level of 90 IU/L or higher showed significantly greater improvement.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Hiroshi Ito, Takeshi Kimura, Shimbo Takuro, Michiaki Higashitani, Kazuki Yamamoto, Daiki Kobayashi
Summary: This study investigated the association between liver indicators (FIB-4 index, NFS, FLI) and cancer development in patients without preexisting liver disease. The results showed that higher liver indicator scores were associated with an increased risk of digestive organ cancer. However, patients with a medium FIB-4 index or NFS had a lower risk of developing breast cancer, while those with a medium FLI had an increased risk.
Article
Gastroenterology & Hepatology
Xiang Zhang, Olabisi Oluwabukola Coker, Eagle Sh Chu, Kaili Fu, Harry C. H. Lau, Yi-Xiang Wang, Anthony W. H. Chan, Hong Wei, Xiaoyong Yang, Joseph J. Y. Sung, Jun Yu
Summary: High dietary cholesterol leads to sequential progression of steatosis, steatohepatitis, fibrosis and eventually HCC in mice, concomitant with insulin resistance. Cholesterol-induced NAFLD-HCC formation is associated with gut microbiota dysbiosis, with specific bacterial composition changes between stages of liver disease. Alterations in gut bacterial metabolites were also observed with dietary cholesterol intake. Therapies targeting cholesterol and gut microbiota may be effective for preventing NAFLD-HCC.
Article
Medicine, General & Internal
Lars-Olav Harnisch, Sophie Baumann, Diana Mihaylov, Michael Kiehntopf, Michael Bauer, Onnen Moerer, Michael Quintel
Summary: The study found that early hypoxic liver and cholangiocyte injury in ARDS patients are not directly related to the severity of hypoxemia. GGT levels can serve as a sensitive marker for liver function, influenced significantly by total bile acid levels.
Review
Gastroenterology & Hepatology
Bichitra Paul, Monika Lewinska, Jesper B. Andersen
Summary: Lipids have crucial roles in physiological processes and cancer, and alterations in liver lipids are associated with various diseases. However, limited understanding of the complex nature of hepatic lipidome hinders the development of effective therapies.
Article
Oncology
Alfonso Pompella, Alessandro Corti, Athanase Visvikis
Summary: The involvement of gamma-glutamyltransferase 1 (GGT1) in triple-negative breast cancer (TNBC) has been confirmed. GGT1 plays a role in CDDP resistance by promoting cellular resupply of antioxidant glutathione (GSH) and forming adducts with CDDP, hindering its access to the cell.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Michael A. Vera, Christopher D. Koch, AnnMarie Liapakis, Joseph K. Lim, Joe M. El-Khoury
Summary: This study aimed to investigate the differences in alanine aminotransferase (ALT) upper reference limits (URL) in different populations, and the results suggest that whether individuals consume alcohol may be an important factor contributing to URL variability.
CLINICA CHIMICA ACTA
(2022)
Article
Immunology
Zhan Zeng, Hongxiao Hao, Xiaoyue Bi, Yanjie Lin, Liu Yang, Shiyu Wang, Ge Shen, Min Chang, Tingting Jiang, Wen Deng, Huihui Lu, Fangfang Sun, Yao Lu, Yuanjiao Gao, Ruyu Liu, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Lu Zhang, Minghui Li, Yao Xie
Summary: This study aimed to compare liver histopathological findings in chronic hepatitis B (CHB) patients with different alanine aminotransferase (ALT) normal values to explore the occurrence of liver inflammation. A total of 1474 patients were enrolled, and ALT, HBsAg, and HBeAg status were found to be relevant factors in the occurrence of significant hepatic histopathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Camilo Jaramillo, David L. Renaud, Luis G. Arroyo, Daniel G. Kenney, Lisa Gamsjaeger, Diego E. Gomez
Summary: This study investigated the association between serum haptoglobin (Hp) and glutamic dehydrogenase (GLDH) and systemic inflammatory response syndrome (SIRS) and survival in sick calves. The results suggest that these two markers cannot be recommended for predicting survival in sick calves.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Li-Shan Shen, Quan-Xi Li, Xiao-Wen Luo, Hui-Jun Tang, You-Jie Tang, Wen-Jie Tang, Ruo-Mi Guo
Summary: Using magnetic resonance imaging-determined proton density fat fraction (PDFF), there is a high correlation between liver fat content and hepatic perfusion disorders (HPD) after radiofrequency ablation (RFA) for liver cancer. Higher liver fat content increases the risk of hyperperfusion abnormalities, but has little impact on hypoperfusion abnormalities.
Article
Biochemistry & Molecular Biology
Lillian Russo-Savage, Ira G. Schulman
Summary: Liver X receptors are ligand-dependent transcription factors that regulate transcription by directly binding cholesterol derivatives, playing important roles in lipid homeostasis throughout the body. In the liver, LXR controls cholesterol and fatty acid metabolism, and modifying LXR activity can influence the pathology of liver diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Gastroenterology & Hepatology
Shiv Chitturi, Vincent Wai-Sun Wong, Wah-Kheong Chan, Grace Lai-Hung Wong, Simon Kin-Hung Wong, Jose Sollano, Yen-Hsuan Ni, Chun-Jen Liu, Yu-Cheng Lin, Laurentius Adrianto Lesmana, Seung Up Kim, Etsuko Hashimoto, Masahide Hamaguchi, Khean-Lee Goh, Jiangao Fan, Ajay Duseja, Yock Young Dan, Yogesh Chawla, Geoff Farrell, Henry Lik-Yuen Chan
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
Chen-Hua Liu, Chun-Jen Liu, Chun-Ming Hong, Tung-Hung Su, Hung-Chih Yang, Kuei-Ming Chen, Yi-Ping Huang, Yu-Ming Yeh, Hui-Lan Tien, Yuan-Chih Liu, Jia-Horng Kao, Ding-Shinn Chen, Pei-Jer Chen
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Review
Gastroenterology & Hepatology
Vincent Wai-Sun Wong, Wah-Kheong Chan, Shiv Chitturi, Yogesh Chawla, Yock Young Dan, Ajay Duseja, Jiangao Fan, Khean-Lee Goh, Masahide Hamaguchi, Etsuko Hashimoto, Seung Up Kim, Laurentius Adrianto Lesmana, Yu-Cheng Lin, Chun-Jen Liu, Yen-Hsuan Ni, Jose Sollano, Simon Kin-Hung Wong, Grace Lai-Hung Wong, Henry Lik-Yuen Chan, Geoff Farrell
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
C-H Liu, Y. Sun, C-J Liu, W-H Sheng, S-M Hsieh, Y-C Lo, W-C Liu, T-H Su, H-C Yang, C-M Hong, T-C Tseng, P-J Chen, D-S Chen, C-C Hung, J-H Kao
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Gastroenterology & Hepatology
Chun-Jen Liu, Wan-Long Chuang, I-Shyan Sheen, Horng-Yuan Wang, Chi-Yi Chen, Kuo-Chih Tseng, Ting-Tsung Chang, Benedetta Massetto, Jenny C. Yang, Chohee Yun, Steven J. Knox, Anu Osinusi, Gregory Camus, Deyuan Jiang, Diana M. Brainard, John G. McHutchison, Tsung-Hui Hu, You-Chun Hsu, Gin-Ho Lo, Chi-Jen Chu, Jyh-Jou Chen, Cheng-Yuan Peng, Ron-Nan Chien, Pei-Jer Chen
Article
Gastroenterology & Hepatology
George V. Papatheodoridis, Spilios Manolakopoulos, Tung-Hung Su, Spyros Siakavellas, Chun-Jen Liu, Anastasia Kourikou, Hung-Chih Yang, Jia-Horng Kao
Article
Gastroenterology & Hepatology
Chen-Hua Liu, Chun-Jen Liu, Tung-Hung Su, Hung-Chih Yang, Chun-Ming Hong, Tai-Chung Tseng, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Immunology
Tung-Hung Su, Hung-Chih Yang, Tai-Chung Tseng, Jyh-Ming Liou, Chen-Hua Liu, Chi-Ling Chen, Pei-Jer Chen, Ding-Shinn Chen, Chun-Jen Liu, Jia-Horng Kao
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Medicine, General & Internal
Meng-Hsuan Hsieh, Ming-Lun Yeh, Tung-Hung Su, Ta-Wei Liu, Chuang-Feng Huang, Ching-I. Huang, Shu-Chi Wang, Jee-Fu Huang, Chia-Yen Dai, Jia-Horng Kao, Wan-Long Chuang, Pei-Jer Chen, Chun-Jen Liu, Ming-Lung Yu
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2018)
Review
Biochemistry & Molecular Biology
Chieh Liu, Yi-Fen Shih, Chun-Jen Liu
Summary: Acute flares of chronic hepatitis B usually occur during the immune-active stage, causing liver injuries and complications. Understanding the immunopathogenesis of flares is crucial for improving the clinical outcomes of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Chen-Hua Liu, Chun-Jen Liu, Tung-Hung Su, Shang-Chin Huang, Tai-Chung Tseng, Jo-Hsuan Wu, Pei-Jer Chen, Jia-Horng Kao
Summary: This study found a strong correlation between serum M2BPGi levels and the severity of hepatic fibrosis in patients with HCV infection, and identified specific cutoff values that can be used for accurate diagnosis.
Article
Oncology
Ming-Whei Yu, Chih-Lin Lin, Chun-Jen Liu, Wan-Jung Wu, Jui-Ting Hu, Yi-Wen Huang
Summary: Concomitant hepatic steatosis is common in patients with chronic hepatitis B, but its impact on the natural history of the disease is still unclear. In this study, the authors investigated the association between metabolic-associated fatty liver disease (MAFLD) and hepatocellular carcinoma (HCC) risk in patients with chronic hepatitis B. They found that MAFLD was not associated with an increased risk of HCC, but was associated with a higher probability of functional cure for chronic hepatitis B in terms of HBsAg loss. On the other hand, metabolic abnormalities such as diabetes and obesity were robustly associated with an increased risk of HCC, regardless of the presence of hepatic steatosis or HBsAg seroclearance.
Article
Medicine, General & Internal
Chen-Hua Liu, Yu-Jen Fang, Chun-Jen Liu, Tung-Hung Su, Shang-Chin Huang, Tai-Chung Tseng, Jo-Hsuan Wu, Pei-Jer Chen, Jia-Horng Kao
Summary: Retrospective study showed that the splenic arterial pulsatility index (SAPI) was closely associated with the severity of hepatic fibrosis in hemodialysis patients with chronic HCV infection. The diagnostic accuracy of SAPI was comparable to the fibrosis index based on four parameters (FIB-4) and superior to the aspartate transaminase (AST)-to-platelet ratio index (APRI). The positive predictive value (PPV) for >= F1 was 79.5%, and the negative predictive values (NPVs) for >= F2, >= F3, and F4 were 79.8%, 92.6%, and 96.9%, respectively, when the maximal Youden indices were used.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Chen-Hua Liu, Yih-Sharng Chen, Sheoi-Shen Wang, Chun-Jen Liu, Tung-Hung Su, Hung-Chih Yang, Chun-Ming Hong, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
CLINICAL INFECTIOUS DISEASES
(2018)