Review
Medicine, General & Internal
Lei Feng, Wenqing Liu, Yunhuo Lv, Baojun Qiao
Summary: The aim of this study is to determine the association of HOTAIR expression with overall survival, progression-free survival, and clinical features in HCC. The findings of this systematic review and meta-analysis may provide a novel diagnostic indicator and potential therapeutic target of HCC.
Review
Pathology
Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hamed Haddad Kashani, Alireza Milajerdi, Zahra Zare Dehghanani, Hassan Hassani Bafrani, Hossein Nikzad
Summary: This study investigated the association between dysregulation of long non-coding RNAs (lncRNAs) and the prognosis of ovarian cancer patients. The results showed that altered lncRNAs expression was correlated with overall survival, progression-free survival, and disease-free survival in patients with ovarian cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Kaili Wang, Shanshan Mei, Mengcheng Cai, Dongxia Zhai, Danying Zhang, Jin Yu, Zhexin Ni, Chaoqin Yu
Summary: This study explores the potential of ferroptosis-related genes as biomarkers and molecular targets for ovarian cancer (OC) diagnosis and intervention. Eight lncRNAs are identified as potential diagnostic markers and intervention targets. The risk scoring model based on ferroptosis-related lncRNAs shows good performance in predicting OC patient prognosis and may support the implementation of precise immunotherapy for OC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Toshihiko Takeiwa, Yuichi Mitobe, Kazuhiro Ikeda, Kosei Hasegawa, Kuniko Horie, Satoshi Inoue
Summary: Recent studies have identified an overexpressed lincRNA, termed OIN1, in ovarian cancer tissues which, when silenced by specific siRNA, significantly inhibits proliferation and enhances apoptosis in ovarian cancer cells. RNA sequencing revealed a negative correlation between OIN1 expression and apoptosis-related genes RASSF5 and ADORA1, which were upregulated by OIN1 knockdown. OIN1-specific siRNA injection effectively suppressed in vivo tumor growth of ovarian cancer cells in immunodeficient mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Weiwei Chen, Fei Wang, Xinyuan Yu, Jingjing Qi, Hongliang Dong, Bingjie Cui, Qian Zhang, Yan Wu, Jiajia An, Na Ni, Cuilan Liu, Yuchen Han, Shuo Zhang, Clemens A. Schmitt, Jiong Deng, Yong Yu, Jing Du
Summary: Non-coding RNA plays a crucial role in oncogenesis and stemness development in various cancers, including lung cancer. MIR31HG, a lncRNA, is significantly upregulated in lung cancer tissues and peripheral sera of patients, indicating a poor prognosis. Mechanistically, MIR31HG promotes stemness-associated malignant features of non-small cell lung cancer cells by modulating GLI2 expression via H3K4me and H3K27Ace modifications mediated by the WDR5/MLL3/P300 complex. In vivo studies showed that repression of MIR31HG attenuated tumor growth and distal organ metastasis, while its promotion encouraged cellular invasion in lung and liver tissues. Hence, MIR31HG has the potential to serve as a diagnostic indicator and therapeutic target for lung cancer patients.
Article
Cell Biology
Lin Li, Jie Chen, Ao Wang, Ke Yi
Summary: ALKBH5 regulates the malignant behavior and chemosensitivity of ovarian cancer by regulating PVT1/FOXM1.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Louis Delhaye, Edith De Bruycker, Pieter-Jan Volders, Daria Fijalkowska, Delphine De Sutter, Sven Degroeve, Lennart Martens, Pieter Mestdagh, Sven Eyckerman
Summary: Accumulating evidence has shown the importance of long non-coding RNAs (lncRNAs) in cellular homeostasis and their role in disease. This study combines two RNA-centric methods to identify the proteins that interact with HOTAIR, a well-known lncRNA associated with metastasis in cancer. The data sets reveal an association of HOTAIR with mitoribosomes, suggesting additional functions beyond its known transcriptional mode-of-action.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Facai Zhang, Xiaoming Wang, Huan Hu, Yubo Yang, Jiahao Wang, Yin Tang, Dengxiong Li, Yunjin Bai, Ping Han
Summary: The study developed a hypoxia-related lncRNA signature to predict survival outcomes in bladder cancer patients, accurately predicting survival outcomes and showing associations with immune cell infiltration, tumor mutation burden, and gene set enrichment.
Article
Oncology
Chiara Corradi, Manuel Gentiluomo, Laszlo Gajdan, Giulia Martina Cavestro, Edita Kreivenaite, Gregorio Di Franco, Cosimo Sperti, Matteo Giaccherini, Maria Chiara Petrone, Francesca Tavano, Domenica Gioffreda, Luca Morelli, Pavel Soucek, Angelo Andriulli, Jakob R. Izbicki, Niccolo Napoli, Ewa Malecka-Panas, Peter Hegyi, John P. Neoptolemos, Stefano Landi, Yogesh Vashist, Claudio Pasquali, Ye Lu, Klara Cervena, George E. Theodoropoulos, Stefania Moz, Gabriele Capurso, Oliver Strobel, Silvia Carrara, Thilo Hackert, Viktor Hlavac, Livia Archibugi, Martin Oliverius, Giuseppe Vanella, Pavel Vodicka, Paolo Giorgio Arcidiacono, Raffaele Pezzilli, Anna Caterina Milanetto, Rita T. Lawlor, Audrius Ivanauskas, Andrea Szentesi, Juozas Kupcinskas, Sabrina G. G. Testoni, Martin Lovecek, Michael Nentwich, Maria Gazouli, Claudio Luchini, Raffaella Alessia Zuppardo, Erika Darvasi, Hermann Brenner, Cristian Gheorghe, Krzysztof Jamroziak, Federico Canzian, Daniele Campa
Summary: A new PDAC risk locus was identified, with genetic variation disrupting the binding between lncRNA and miRNA possibly affecting the development of PDAC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Cell Biology
Shenglei Song, Shuhao Liu, Zhewei Wei, Xinghan Jin, Deli Mao, Yulong He, Bo Li, Changhua Zhang
Summary: The study successfully integrated an IRlncRNAPs model to predict the clinical outcomes, immune features, and chemotherapeutic efficacy of GC. The prognostic signature designed has high sensitivity and accuracy, aiding in the classification of GC patients and showing promise in clinical decision-making.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kyung Jin Eoh, Dae Woo Lee, Eun Ji Nam, Jae In Kim, Hanna Moon, Sang Wun Kim, Young Tae Kim
Summary: HOXA cluster antisense RNA 3 (HOXA-AS3) is associated with ovarian cancer progression and can be used as a prognostic marker and therapeutic target in epithelial ovarian cancer (EOC). The expression of HOXA-AS3 is higher in ovarian cancer tissues compared to normal ovarian tissues. Knockdown of HOXA-AS3 inhibits cell proliferation and migration in ovarian cancer cell lines, and HOXA-AS3 modulates the expression of epithelial-mesenchymal transition (EMT) markers.
Article
Biotechnology & Applied Microbiology
Tianyi Ma, Tianyu Qiao, Ziming Yuan, Guiyu Wang, Rui Huang, Meng Wang, Hanqing Hu, Yihao Zhu, Xiaoming Zou, Xishan Wang
Summary: JAKMIP2-AS1 is significantly upregulated in colorectal cancer tissues, promoting cell proliferation and associated with poor prognosis. Inhibition of JAKMIP2-AS1 by RNAi decreases cell proliferation and hinders cell growth.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ricardo Noriega-Rivera, Mariela Rivera-Serrano, Robert J. Rabelo-Fernandez, Josue Perez-Santiago, Fatima Valiyeva, Pablo E. Vivas-Mejia
Summary: In this study, it was found that the long noncoding RNA CASC10 is upregulated in cisplatin-resistant ovarian cancer cells and patients. Knockdown of CASC10 reduces cell proliferation and invasion, and increases sensitivity to cisplatin treatment. Moreover, liposomal CASC10-siRNA can inhibit tumor growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Sasidharanpillai Sabeena
Summary: This review discusses the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancer. The existing studies on microRNA signatures in body fluids and cervical cancer tissues lack consistency and lack validated assays. The precise evaluation of immune-associated long noncoding RNA signatures in clinical samples is necessary. Research on the safe delivery methods, toxicities, and side effects of lncRNAs to tumor tissues is needed. Prospective studies on the diagnostic and prognostic roles of circulating lncRNAs and Piwil RNAs in cervical cancer cases are crucial. Comprehensive research is required for the clinical application of lncRNA-based biomarkers, as the impact of noncoding transcripts on molecular pathways is complex. Standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are essential.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lili Zhong, Xin Li, Yicun Wang, Bin Liu, Xiangfu Ding, Yinlong Zhao
Summary: Long noncoding RNAs (lncRNAs) are RNA molecules with a length of more than 200 nt that can regulate gene expression and biological activities in ovarian cancer through various pathways. This review analyzes the relationship between lncRNAs and ovarian cancer in terms of occurrence, development, and clinical significance, providing a theoretical basis for further research and clinical applications.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
