Article
Infectious Diseases
Tommaso Cai, Umberto Anceschi, Irene Tamanini, Serena Migno, Michele Rizzo, Giovanni Liguori, Alejandro Garcia-Larrosa, Alessandro Palmieri, Paolo Verze, Vincenzo Mirone, Truls E. Bjerklund Johansen
Summary: This study conducted a systematic review and meta-analysis to compare the effectiveness and safety profile of a medical device containing xyloglucan, hibiscus, and propolis with a comparator in the treatment of uncomplicated cystitis in women. The results showed that the medical device was more effective in achieving clinical or microbiological resolution without causing clinically significant adverse effects.
Article
Microbiology
Ge Huang, Yizheng Zhou, Hai Cheng, Tao Lv, Lisi Zheng, Chengbin Li, Yunbo Chen
Summary: Through genomic and transcriptomic analysis, we found differences in carbon metabolism and amino acids between endogenously infected and only-colonized Enterococcus faecium, suggesting metabolic diversity as a strategy for endogenous infection.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Virginia Perez-Carrasco, Ana Soriano-Lerma, Miguel Soriano, Jose Gutierrez-Fernandez, Jose A. Garcia-Salcedo
Summary: The application of next generation sequencing techniques has revealed that the urinary tract is not sterile, contrary to previous beliefs. Microbial communities in the urinary tract play a crucial role in maintaining health and are associated with various urinary pathologies. Understanding the urinary microbiome in health and disease could lead to the development of new therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
S. J. Ryan Arends, Deborah Butler, Nicole Scangarella-Oman, Mariana Castanheira, Rodrigo E. Mendes
Summary: The in vitro activities of gepotidacin against a large collection of Escherichia coli and Staphylococcus saprophyticus strains, including those resistant to other standard-of-care antibiotics, were determined. Gepotidacin exhibited potent activity, inhibiting the majority of isolates at low concentrations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Immunology
Robin Patel, Christopher R. Polage, Jennifer Dien Bard, Larissa May, Francesca M. Lee, Valeria Fabre, Mary K. Hayden, Sarah D. B. Doernberg, David A. Haake, Barbara W. Trautner, Larissa Grigoryan, Ephraim L. Tsalik, Kimberly E. Hanson
Summary: Urinary tract infections (UTIs) are common bacterial infections in the United States and contribute significantly to antibiotic use in healthcare settings. Novel UTI diagnostics have the potential to improve healthcare delivery, patient outcomes, and antibiotic use.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Masayuki Hashimoto, Bin-Hsu Mao, Chien-Shun Chiou, Wen-Chun Huang, Ida Bagus Nyoman Putra Dwija, Shuen-Lin Jeng, Jiunn-Jong Wu, Ming-Cheng Wang, Wei-Hung Lin, Chin -Chung Tseng, Ching-Hao Teng
Summary: This study focuses on Escherichia coli, which is the main pathogen of urinary tract infections, and investigates its relationship with the gut microbiota.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Ullas Valiya Chembazhi, Wesley S. Tung, Hyojeong Hwang, Yuexi Wang, Aryan Lalwani, Ka Lam Nguyen, Sushant Bangru, Danielle Yee, Kristy Chin, Jing Yang, Auinash Kalsotra, Wenyan Mei
Summary: Intestinal epithelial regeneration is driven by intestinal stem cells. Upon the loss of intestinal stem cells, differentiated intestinal epithelial cells, such as Paneth cells, are capable of acquiring multipotency and contributing to regeneration. Depletion of an RNA-binding protein named PTBP1 in mouse intestinal epithelial cells leads to intestinal stem cell death and epithelial regeneration failure.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Health Care Sciences & Services
Karel Kostev, Tommaso Cai
Summary: This study evaluated the use of a medical device containing xyloglucan, hibiscus, and propolis in reducing UTI symptoms, antibiotic prescriptions, and sick leave. The results showed that the use of this medical device could decrease UTI recurrence and lead to reduced antibiotic usage and disease burden.
Review
Medicine, General & Internal
Dong Soo Kim, Jeong Woo Lee
Summary: Urinary tract infection is a common bacterial infection that can have significant consequences for individuals and society as a whole. Advances in sequencing and culture techniques have revealed a dynamic urinary tract microbiome, challenging the previously held belief that the urinary tract is sterile. Research has identified the normal core microbiota and explored changes in microbial communities due to factors such as sex and age. The pathogenesis of recurrent urinary tract infections and antibiotic resistance has also been studied, and new therapeutic options are being investigated. However, further research is needed to fully understand the implications of the urinary microbiome in urinary tract infections.
Article
Developmental Biology
Marianne M. Ligon, Chetanchandra S. Joshi, Bisiayo E. Fashemi, Arnold M. Salazar, Indira U. Mysorekar
Summary: The global increase in older individuals raises the need to understand healthcare challenges related to aging. This review focuses on the immune system changes in older individuals, particularly in the context of urinary tract infections (UTIs). The review highlights the impact of aging and hormones on bladder immunity and homeostasis, emphasizing the potential age-associated alterations in the immune landscape that may drive the increased susceptibility to UTIs in older individuals.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Paulo A. Schueroff, Cecilia M. Abe, Jonatas W. Silva, Cideli de Paula Coelho, Fernanda B. Andrade, Rodrigo T. Hernandes, Ulrich Dobrindt, Tania A. T. Gomes, Waldir P. Elias
Summary: This study evaluated the involvement of AFP and other adhesins in the uropathogenicity and intestinal colonization of bacteria. The results showed a synergistic role of AFP and TIF in the adherence and colonization of intestinal and urinary epithelia.
Review
Infectious Diseases
Yveline Ansaldi, Begona Martinez de Tejada Weber
Summary: Urinary tract infections (UTIs) during pregnancy can have significant consequences for both the mother and the baby. Treating asymptomatic bacteriuria (ASB) can reduce the risk of low birth weight and preterm birth. Further research is needed to understand the complications of ASB and to explore preventive measures.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Microbiology
Meital Elbaz, Amanda Chikly, Ronnie Meilik, Ronen Ben-Ami
Summary: The urinary tract is an uncommon source of Candida bloodstream infection (CBSI), but the frequency of U-CBSI may be increasing. Patients with U-CBSI are typically older with a higher incidence of dementia, and risk factors include bladder catheterization and urologic procedures. U-CBSI tends to occur earlier and have a lower mortality rate compared to CBSI of undetermined origin.
Article
Medicine, General & Internal
Jung Ki Jo, Dong Seob Kim, Younghun Sim, Soorack Ryu, Kyu Shik Kim
Summary: The study found that the severity of UTI is higher in patients with catheters, and the infecting strains vary depending on the presence of a catheter. Fosfomycin has a success rate of over 50% in treating UTIs, even in patients with catheters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tomas Raul Wiche Salinas, Annie Gosselin, Laurence Raymond Marchand, Etiene Moreira Gabriel, Olivier Tastet, Jean-Philippe Goulet, Yuwei Zhang, Dragos Vlad, Hanane Touil, Jean-Pierre Routy, Mariana G. Bego, Mohamed El-Far, Nicolas Chomont, Alan L. Landay, Eric A. Cohen, Cecile Tremblay, Petronela Ancuta
Summary: The crosstalk between IECs and Th17-polarized CD4(+) T cells is crucial for mucosal homeostasis, with IL-17A acting in synergy with TNF to promote HIV trans-infection and outgrowth, while also inducing a pro-inflammatory and pro-viral molecular signature.
Article
Anatomy & Morphology
Victor Benno Meyer-Rochow, Mar Royuela
Article
Endocrinology & Metabolism
Norelia Torrealba, Gonzalo Rodriguez-Berriguete, Raul Vera, Benito Fraile, Gabriel Olmedilla, Pilar Martinez-Onsurbe, Manuel Sanchez-Chapado, Ricardo Paniagua, Mar Royuela
Article
Endocrinology & Metabolism
Norelia Torrealba, Gonzalo Rodriguez-Berriguete, Benito Fraile, Gabriel Olmedilla, Pilar Martinez-Onsurbe, Manuel Sanchez-Chapado, Ricardo Paniagua, Mar Royuela
Article
Medicine, Research & Experimental
Yosra Bouraoui, Mongia Achour, Mar Royuela, Ridha Oueslati
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2018)
Article
Endocrinology & Metabolism
Norelia Torrealba, Raul Vera, Benito Fraile, Pilar Martinez-Onsurbe, Ricardo Paniagua, Mar Royuela
Review
Biochemistry & Molecular Biology
Nuria Pique, Mercedes Berlanga, David Minana-Galbis
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Microbiology
Montserrat Palau, Nuria Pique, Andre M. Comeau, Gavin M. Douglas, M. Jose Ramirez-Lazaro, Sergio Lario, Xavier Calvet, Morgan G. Langille, David Minana-Galbis
Article
Microbiology
Montserrat Palau, NUria Pique, M. Jose Ramirez-Lazaro, Sergio Lario, Xavier Calvet, David Minana-Galbis
Summary: This study analyzed three complete genomes of Helicobacter pylori isolates from a stomach of a patient with adenocarcinoma, revealing differences in genetic characteristics among the isolates, with B508A-T2A showing the most distinct genome. Although no significant differences were found in virulence and isolate origin, some characteristics of the B508A-T2A genome could be linked to the pathogenicity of H. pylori.
Article
Environmental Sciences
Guillermo Pardo-Zamora, Antonio Jose Ortiz-Ruiz, Fabio Camacho-Alonso, Jose Francisco Martinez-Marco, Juan Manuel Molina-Gonzalez, Nuria Pique-Clusella, Ascension Vicente-Hernandez
Summary: This study concluded that short implants (7 and 8.5 mm) can be as effective as standard-length implants in the treatment of posterior atrophic alveolar ridges, with similar survival rates, stability, and crestal bone loss.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Microbiology
Pablo Casino, Asuncion Lopez, Sara Peiro, Martin Rios, Santiago Rios, Aldous Porta, Gemma Agusti, Daniel Asensio, Ana Maria Marques, Nuria Pique
Summary: GVPC is a recommended medium for the detection of Legionella spp. in water samples. However, its recovery of Legionella spp. and selectivity properties can be improved. Modifying the GVPC manufacturing process by removing oxygen during autoclaving and introducing nitrogen during ingredient stirring can enhance the growth of Legionella pneumophila and Legionella anisa, as well as improve the selectivity properties. The introduction of these modifications in routine practice can lead to better detection of Legionella spp. in water samples.
MICROBIOLOGY SPECTRUM
(2022)
Article
Health Policy & Services
Gabriel Mercadal-Orfila, Julia Font, Marta Pons, Ignacio Blasco Mascaro, Nuria Pique
Summary: This study aims to investigate the management of comorbidities and polypharmacy in HIV-infected patients, with a focus on gender differences. Differences were found between male and female HIV patients in disease stage and symptoms. Moreover, female HIV patients had higher exposures to anticholinergic drugs and more drug-to-drug interactions, highlighting the importance of implementing specific measures for HIV-infected women and evaluating the risk of polypharmacy and drug-to-drug interactions.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Biochemistry & Molecular Biology
Pablo Casino, Asuncion Lopez, Sara Peiro, Ines Terrones, Gemma Agusti, Daniela Terlevich, Daniel Asensio, Ana Maria Marques, Nuria Pique
Summary: Chocolate agar (CA) is a enriched medium used for isolation and identification of fastidious bacteria. Blood powder (BP) is a potentially cheaper alternative to defibrinated blood for CA manufacture, but its pre-treatment using autoclaving may affect the media quality. Further research is needed to optimize BP as a substitute for defibrinated blood in CA manufacture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Pablo Casino, Asuncion Lopez, Sara Peiro, Santiago Rios, Aldous Porta, Gemma Agusti, Daniela Terlevich, Daniel Asensio, Ana Maria Marques, Nuria Pique
Summary: The type of filtration membrane material used in water sample analysis can affect the recovery of Legionella species. Comparing different membranes, polyethersulfone (PES) filters showed the best performance, with higher counts and colony sizes of Legionella bacteria.
Review
Genetics & Heredity
Miguel A. Ortega, Diego De Leon-Oliva, Cielo Garcia-Montero, Oscar Fraile-Martinez, Diego Liviu Boaru, Maria del Val Toledo Lobo, Ignacio Garcia-Tunon, Mar Royuela, Natalio Garcia-Honduvilla, Julia Bujan, Luis G. Guijarro, Melchor Alvarez-Mon, Miguel Angel Alvarez-Mon
Summary: Histone acetylation is essential for chromatin organization, gene expression, and cell cycle control. Histone acetyltransferase 1 (HAT1), the first identified acetyltransferase, remains poorly understood. HAT1 acetylates newly synthesized H4 and H2A in the cytoplasm but loses acetylation marks after 20 minutes of assembly. It also has noncanonical functions, including regulating nuclear translocation, DNA replication, histone production, DNA damage repair, and various diseases. HAT1 has emerged as a promising therapeutic target, and new therapeutic approaches are being explored.
Article
Education & Educational Research
Francesc Garcia Grau, Cristina Valls, Nuria Pique, Hector Ruiz-Martin
Summary: The study found that the long-term effects on students' conceptual learning improved after the introduction of the 5E model in schools, with no significant improvements observed in the control group schools.
INTERNATIONAL JOURNAL OF SCIENCE EDUCATION
(2021)
