Progress in the medicinal chemistry of silicon: C/Si exchange and beyond

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

(2016) Jenny-Lee Panayides et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317

(2016) Hirozumi Toyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of novel ROR inverse agonists with a dibenzosilole scaffold as a hydrophobic core structure

(2015) Hirozumi Toyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists

(2015) Daisuke Kajita et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Pharmacological Properties of Silicon-Containing GPR81 and GPR109A Agonists

(2015) Marcel Geyer et al.   ChemMedChem

Can Silicon Make an Excellent Drug Even Better? An in vitro and in vivo Head-to-Head Comparison between Loperamide and Its Silicon Analogue Sila-Loperamide

(2015) Marcel Geyer et al.   ChemMedChem

5′-Silylated 3′-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus

(2015) Sanjeev Kumar V. Vernekar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Si- and C-Functional Organosilicon Building Blocks for Synthesis Based on 4-Silacyclohexan-1-ones Containing the Silicon Protecting Groups MOP (4-Methoxyphenyl), DMOP (2,6-Dimethoxyphenyl), or TMOP (2,4,6-Trimethoxyphenyl)

(2015) Marcel Geyer et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure

(2015) B. Seetharamsingh et al.   ACS Medicinal Chemistry Letters

Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation

(2015) Gorakhnath R. Jachak et al.   ACS Medicinal Chemistry Letters

Structure–activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand

(2014) Yuko Nishiyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors

(2014) Hirozumi Toyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character

(2014) Daisuke Kajita et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress

(2014) H. Fu et al.   CURRENT MEDICINAL CHEMISTRY

Silicate Esters of Paclitaxel and Docetaxel: Synthesis, Hydrophobicity, Hydrolytic Stability, Cytotoxicity, and Prodrug Potential

(2014) Adam R. Wohl et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Olfactory Characterization of Sila-Methyl Pamplemousse and Related Odorants with a 2,2,5-Trimethyl-2-silahex-4-ene Skeleton

(2014) Julian Friedrich et al.   ORGANOMETALLICS

Synthesis of 4-Silacyclohexan-1-ones and (4-Silacyclohexan-1-yl)amines Containing the Silicon Protecting Groups MOP (4-Methoxyphenyl), DMOP (2,4-Dimethoxyphenyl), or TMOP (2,4,6-Trimethoxyphenyl): Versatile Si- and C-Functional Building Blocks for Synthesis

(2014) Markus Fischer et al.   ORGANOMETALLICS

Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: Selectivity switching by C/Si exchange

(2013) Masaharu Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of silicon-containing tubulin polymerization inhibitors: Replacement of the ethylene moiety of combretastatin A-4 with a silicon linker

(2013) Masaharu Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1-11

(2013) Andreas S. Madsen et al.   ChemMedChem

Sila-rhubafuran and Derivatives: Synthesis and Olfactory Characterization of Novel Silicon-Containing Odorants

(2013) Bettina Förster et al.   ORGANOMETALLICS

Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs

(2012) Hui Chen et al.   ANTIVIRAL RESEARCH

Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators

(2012) Yonggang Xiang et al.   CHEMICAL COMMUNICATIONS

Synthesis and Evaluation of Silanediols as Highly Selective Uncompetitive Inhibitors of Human Neutrophil Elastase

(2012) Julie L. H. Madsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organosilicon Molecules with Medicinal Applications

(2012) Annaliese K. Franz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased Hydrophobicity and Estrogenic Activity of Simple Phenols with Silicon and Germanium-Containing Substituents

(2012) Shinya Fujii et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation

(2012) Josef B. G. Gluyas et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

High-Affinity, Selective σ Ligands of the 1,2,3,4-Tetrahydro-1,4′-silaspiro[naphthalene-1,4′-piperidine] Type: Syntheses, Structures, and Pharmacological Properties

(2011) Reinhold Tacke et al.   ChemMedChem

Novel Silicon-Containing Analogues of the Retinoid Agonist Bexarotene: Syntheses and Biological Effects on Human Pluripotent Stem Cells

(2011) Jennifer B. Bauer et al.   ChemMedChem

Silicon Analogues of the Nonpeptidic GnRH Antagonist AG-045572: Syntheses, Crystal Structure Analyses, and Pharmacological Characterization

(2011) Matthew J. Barnes et al.   ChemMedChem

Crystal Structure oftert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

(2011) Kalyan Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Silanetriols as in vitro inhibitors for AChE

(2010) Martina Blunder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Silatranes: a review on their synthesis, structure, reactivity and applications

(2010) J. K. Puri et al.   CHEMICAL SOCIETY REVIEWS

Further Studies toward the Stereocontrolled Synthesis of Silicon-Containing Peptide Mimics

(2010) Dácil Hernández et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of rac-2′-(trimethylsilyl)isovaline: A novel silicon-containing α,α-dialkylated α-amino acid

(2010) Steffen Falgner et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Sila-Trifluperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Trifluperidol: Synthesis and Pharmacological Characterization

(2010) Reinhold Tacke et al.   ORGANOMETALLICS

Therapeutic Potential of "Rexinoids" in Cancer Prevention and Treatment

(2009) T. Tanaka et al.   CANCER RESEARCH

Synthesis and Pharmacological Characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, Silicon Analogues of the RARα-Selective Retinoid Agonists AM80 (Tamibarotene) and AM580

(2009) Reinhold Tacke et al.   ChemMedChem

Silicon Analogues of the RXR-Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology

(2009) W. Peter Lippert et al.   ChemMedChem

The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor- /  Inverse Agonist

(2009) N. Kumar et al.   MOLECULAR PHARMACOLOGY

A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma

(2008) Kimberly B. Higginbotham et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Direct and Selective Arylation of Tertiary Silanes with Rhodium Catalyst

(2008) Yoshinori Yamanoi et al.   JOURNAL OF ORGANIC CHEMISTRY

Sila-Haloperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Haloperidol: Synthesis, Pharmacological Properties, and Metabolic Fate

(2007) Reinhold Tacke et al.   ChemMedChem