Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
出版年份 2017 全文链接
标题
Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
作者
关键词
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出版物
Future Medicinal Chemistry
Volume 9, Issue 10, Pages 1015-1038
出版商
Future Science, LTD
发表日期
2017-06-21
DOI
10.4155/fmc-2017-0030
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture
- (2017) Timo T. Myöhänen et al. NEUROSCIENCE LETTERS
- Novel Therapeutics for Diabetes: Uptake, Usage Trends, and Comparative Effectiveness
- (2016) Vishal Ahuja et al. Current Diabetes Reports
- Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
- (2015) Lucie Cahlíková et al. FITOTERAPIA
- Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction
- (2015) Mari H. Savolainen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension
- (2015) Jiarong Lan et al. JOURNAL OF ETHNOPHARMACOLOGY
- Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
- (2015) Eugenie Nepovimova et al. JOURNAL OF MEDICINAL CHEMISTRY
- The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients
- (2015) Jofre Tenorio-Laranga et al. Journal of Neuroinflammation
- The effects of baicalein and baicalin on mitochondrial function and dynamics: A review
- (2015) Marcos Roberto de Oliveira et al. PHARMACOLOGICAL RESEARCH
- Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase
- (2015) Kenneth W. Jackson et al. NEOPLASIA
- Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects
- (2014) Min Li et al. JOURNAL OF ETHNOPHARMACOLOGY
- From arrow poison to herbal medicine – The ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae)
- (2014) Deepak Kumar Semwal et al. JOURNAL OF ETHNOPHARMACOLOGY
- The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
- (2014) Mari H. Savolainen et al. NEUROBIOLOGY OF DISEASE
- KYP-2047 Penetrates Mouse Brain and Effectively Inhibits Mouse Prolyl Oligopeptidase
- (2013) Aaro J. Jalkanen et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome
- (2013) Jofre Tenorio-Laranga et al. BIOCHEMICAL PHARMACOLOGY
- In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects
- (2013) Abeer E Abd El-Wahab et al. BMC Complementary and Alternative Medicine
- Multi-Target Compounds Acting in the Central Nervous System Designed From Natural Products
- (2013) X. Chen et al. CURRENT MEDICINAL CHEMISTRY
- Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis
- (2013) I. Bastos et al. CURRENT MEDICINAL CHEMISTRY
- Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase
- (2013) Sarah E. Poplawski et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protein degradation pathways in Parkinson’s disease: curse or blessing
- (2012) Darius Ebrahimi-Fakhari et al. ACTA NEUROPATHOLOGICA
- Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase
- (2012) Karol Kaszuba et al. BIOCHIMIE
- A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease
- (2012) TT Myöhänen et al. BRITISH JOURNAL OF PHARMACOLOGY
- A Herbal Composition ofScutellaria baicalensisandEleutherococcus senticosusShows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
- (2012) Nan Zhang et al. Evidence-based Complementary and Alternative Medicine
- Berberine and its derivatives: a patent review (2009 – 2012)
- (2012) Inder Pal Singh et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy
- (2012) Pieter Van der Veken et al. JOURNAL OF MEDICINAL CHEMISTRY
- Virtual Screening and Computational Optimization for the Discovery of Covalent Prolyl Oligopeptidase Inhibitors with Activity in Human Cells
- (2012) Stéphane De Cesco et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands
- (2012) Jonah Cheung et al. JOURNAL OF MEDICINAL CHEMISTRY
- The pharmacological landscape and therapeutic potential of serine hydrolases
- (2012) Daniel A. Bachovchin et al. NATURE REVIEWS DRUG DISCOVERY
- Brain Pharmacokinetics of Two Prolyl Oligopeptidase Inhibitors, JTP-4819 and KYP-2047, in the Rat
- (2011) Aaro J. Jalkanen et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer’s disease
- (2011) Huailei Jiang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation
- (2011) Jia-Hong Lu et al. CHEMBIOCHEM
- Interaction of Prolyl Oligopeptidase with α-Synuclein
- (2011) Anne-Marie Lambeir CNS & Neurological Disorders-Drug Targets
- Prolyl Oligopeptidase: A Rising Star on the Stage of Neuroinflammation Research
- (2011) Anne Penttinen et al. CNS & Neurological Disorders-Drug Targets
- Structure and Function Relationship in Prolyl Oligopeptidase
- (2011) Roos Van Elzen et al. CNS & Neurological Disorders-Drug Targets
- Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis
- (2011) Marta Perro Neves et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation
- (2011) Wen-Jun Shan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Low molecular weight inhibitors of Prolyl Oligopeptidase: a review of compounds patented from 2003 to 2010
- (2011) Abraham López et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Translational research on prolyl oligopeptidase inhibitors: the long road ahead
- (2011) Anne-Marie Lambeir EXPERT OPINION ON THERAPEUTIC PATENTS
- Synthesis of Ring A-Modified Baicalein Derivatives
- (2011) Jun-Fei Wang et al. HELVETICA CHIMICA ACTA
- Use of Umbrella Sampling to Calculate the Entrance/Exit Pathway for Z-Pro-Prolinal Inhibitor in Prolyl Oligopeptidase
- (2011) Jean-François St-Pierre et al. Journal of Chemical Theory and Computation
- Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- (2011) Hong-Fang Ji et al. MOLECULES
- Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum
- (2011) Aaro J. Jalkanen et al. NEUROSCIENCE LETTERS
- Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Aβ aggregation in SH-SY5Y cells
- (2011) Fei Yin et al. NEUROSCIENCE LETTERS
- Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y Cells
- (2011) M. José Moreno-Baylach et al. NEUROSIGNALS
- Structural Analysis of Prolyl Oligopeptidases Using Molecular Docking and Dynamics: Insights into Conformational Changes and Ligand Binding
- (2011) Swati Kaushik et al. PLoS One
- Inhibitory Effects of Baicalein on the Influenza Virus in Vivo Is Determined by Baicalin in the Serum
- (2010) Ge Xu et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Prolyl oligopeptidase induces angiogenesis bothin vitroandin vivoin a novel regulatory manner
- (2010) TT Myöhänen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Total synthesis of baicalein
- (2010) Duo-Zhi Chen et al. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
- Inhibitors of Prolyl Oligopeptidases for the Therapy of Human Diseases: Defining Diseases and Inhibitors
- (2010) Janice Lawandi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis
- (2010) Jofre Tenorio-Laranga et al. Journal of Neuroinflammation
- Increased prolyl endopeptidase activity in human neoplasia
- (2010) Gorka Larrinaga et al. REGULATORY PEPTIDES
- Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain
- (2009) Jofre Tenorio-Laranga et al. ANALYTICAL BIOCHEMISTRY
- Peptidomics of Prolyl Endopeptidase in the Central Nervous System
- (2009) Whitney M. Nolte et al. BIOCHEMISTRY
- Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
- (2009) Hyun Ah Jung et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors
- (2009) Ling Huang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Inhibition of α-synuclein fibril assembly by small molecules: Analysis using epitope-specific antibodies
- (2009) Masami Masuda et al. FEBS LETTERS
- The Prolyl-Aminodipeptidases and their Inhibitors as Therapeutic Targets for Fibrogenic Disorders
- (2009) Lucienne Juillerat-Jeanneret et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Lipoxygenase-derived Metabolites Are Regulators of Peroxisome Proliferator-activated Receptor -2 Expression in Human Vascular Smooth Muscle Cells
- (2008) R. Limor et al. AMERICAN JOURNAL OF HYPERTENSION
- Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor
- (2008) Teresa Tarragó et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)
- (2008) Curt D. Haffner et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats
- (2008) Chandragiri Janakiraman Thirupurasundari et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Genetic Characterization and Phytochemical Analysis of Wild and Cultivated Populations ofScutellaria baicalensis
- (2008) Su Su et al. CHEMISTRY & BIODIVERSITY
- Structure, Function and Biological Relevance of Prolyl Oligopeptidase
- (2008) Laszlo Polgar et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- On the mechanism of antidepressant-like action of berberine chloride
- (2008) Shrinivas K. Kulkarni et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Synthesis and Biological Evaluation of Novel C(6) Modified Baicalein Derivatives as Antioxidative Agents
- (2008) Jin-Yi Wu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters
- (2008) Timo T. Myöhänen et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Prolyl Oligopeptidase Inhibition byN-Acyl-pro-pyrrolidine-type Molecules†
- (2008) Károly Kánai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prolyl oligopeptidase stimulates the aggregation of α-synuclein
- (2008) Inger Brandt et al. PEPTIDES
- Antiinflammatory effect of the ethanol extract ofBerberis koreanain a gerbil model of cerebral ischemia/reperfusion
- (2008) Ki-Yeon Yoo et al. PHYTOTHERAPY RESEARCH
- Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine
- (2008) Mohsen Imanshahidi et al. PHYTOTHERAPY RESEARCH
- Oligopeptidase B: A processing peptidase involved in pathogenesis
- (2007) Theresa H.T. Coetzer et al. BIOCHIMIE
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