Review
Pharmacology & Pharmacy
R. Cappadona, A. De Giorgi, E. Di Simone, B. Zucchi, M. A. Rodriguez-Borrego, P. J. Lopez-Soto, F. Fabbian, R. Manfredini
Summary: Sleep disorders appear to be more common in women, while sex-related differences exist for dreams and nightmares. Differences related to dreams include dream content, self-reported perspective, dream sharing, lucid dreaming, and daydreaming. Nightmares are more frequent in women and are often associated with sleep disorders and psychiatric disorders like depression and anxiety.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Kai Triebner, Ersilia Bifulco, Jose Barrera-Gomez, Xavier Basagan, Bryndis Benediktsdottir, Bertil Forsberg, Karl A. Franklin, Vanessa Garcia-Larsen, Benedicte Leynaert, Eva Lindberg, Jesus Martinez-Moratalla, Nerea Muniozguren-Agirre, Isabelle Pin, Chantal Raherison, Antonio Pereira-Vega, Vivi Schlunssen, Antonia Valentin, Steinar Hustad, Francisco Gomez Real, Payam Dadvand
Summary: The study found that exposure to solar ultraviolet radiation (UVR) is associated with decreased estrogen levels and increased gonadotropin levels in postmenopausal women, which may be related to adverse health effects such as osteoporosis and decline in lung function. Managing UVR exposure has the potential to influence hormone balance and mitigate negative health conditions after menopause.
Article
Geriatrics & Gerontology
Sarah T. Stahl, Stephen F. Smagula, Juleen Rodakowski, Mary Amanda Dew, Jordan F. Karp, Steven M. Albert, Meryl Butters, Ariel Gildengers, Charles F. Reynolds
Summary: The study identified two trajectories of inflammation in older adults, with one group showing consistently lower levels and the other group showing consistently higher levels. Poor sleep quality may lead to consistently elevated levels of inflammation.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Biology
Manuel Spitschan, Nayantara Santhi, Amrita Ahluwalia, Dorothee Fischer, Lilian Hunt, Natasha A. Karp, Francis Levi, Ines Pineda-Torra, Parisa Vidafar, Rhiannon White
Summary: Growing evidence suggests that sex differences have a significant impact on various aspects of human biology. This review focuses on exploring the influence of sex on the circadian and sleep physiology of humans and identifies a data gap in investigating the non-visual effects of light. A virtual workshop on the biomedical implications of sex differences in sleep and circadian physiology highlights the need for inclusive and accessible research design, recruitment strategies to achieve a balanced sample size, utilization of data visualization to understand the influence of sex, statistical analyses that incorporate sex as a factor, and making participant-level data open for future meta-analytic efforts.
Article
Immunology
Sara Gianella, Stephen A. Rawlings, Curtis Dobrowolski, Masato Nakazawa, Antoine Chaillon, Matthew Strain, Laura Layman, Gemma Caballero, Eileen Scully, Brianna Scott, Caitleen Pacis, Kathleen M. Weber, Alan Landay, Christy Anderson, Jonathan Karn
Summary: There are sex differences in the dynamics of HIV reservoir. The HIV reservoir in women is more dynamic, with a slower decline in total HIV DNA and an increase in replication-competent virus reservoir after menopause.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Kai Ma, Qiang Dong
Summary: The study aimed to examine the association between sleep quality and benign prostate hyperplasia (BPH) among middle-aged and older men in India. The results showed that worse sleep quality was significantly associated with a higher incidence of BPH among middle-aged and older Indian men. Further prospective studies are needed to clarify this association and explore potential mechanisms.
Article
Endocrinology & Metabolism
Matthew C. Babcock, Lyndsey E. DuBose, Teresa L. Witten, Brian L. Stauffer, Kerry L. Hildreth, Robert S. Schwartz, Wendy M. Kohrt, Kerrie L. Moreau
Summary: Low testosterone in middle-aged/older men is associated with age-associated endothelial dysfunction, potentially due to increased oxidative stress and inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Clinical Neurology
Maria C. Ysrraelit, Jorge Correale
Summary: Andropause is caused by the natural decrease in testosterone levels, unlike menopause which is a well-characterized process. Lower testosterone levels have been associated with a higher risk of Multiple sclerosis, and men tend to develop MS at a later age compared to women, possibly due to declining protective testosterone levels.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Lacy K. Goode, Allison R. Fusilier, Natalie Remiszewski, Jacob M. Reeves, Kavitha Abiraman, Matthew Defenderfer, Jodi R. Paul, Lori L. McMahon, Karen L. Gamble
Summary: This study investigated the influence of sex and time-of-day on hippocampal neurophysiology and memory in mice. The results showed that both time-of-day and sex had an impact on memory performance and hippocampal synaptic activity. The study emphasizes the importance of understanding how sex and circadian rhythms affect hippocampal physiology, which can improve the relevance of treatments and inform the timing of therapy.
Article
Multidisciplinary Sciences
Frank A. J. L. Scheer, Michael F. Hilton, Heather L. Evoniuk, Sally A. Shiels, Atul Malhotra, Rena Sugarbaker, R. Timothy Ayers, Elliot Israel, Anthony F. Massaro, Steven A. Shea
Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
Sarah L. Chellappa
Summary: Individual differences in sensitivity to light have significant implications for the effects on sleep and circadian rhythms, yet these differences are often overlooked in real-life settings. Studies based on human laboratory and field research have identified links between individual traits such as age, sex, chronotype, genetic haplotypes, and the impact of evening/night light exposure on sleep and circadian rhythms. This highlights the importance of considering personalized lighting solutions to promote quality of life and health.
Review
Cell Biology
Deeksha Malhan, Britt Schoenrock, Muege Yalcin, Dieter Blottner, Angela Relogio
Summary: Alterations in the circadian system are common in aging on Earth and also observed in astronauts during and after space exploration. However, little is known about the common molecular alterations underlying terrestrial aging and space-related aging. This review focuses on the role of the circadian clock in visual, cardiovascular, central nervous, and musculoskeletal systems and summarizes the known molecular alterations associated with spaceflight.
Article
Neurosciences
Hannah K. Ballard, T. Bryan Jackson, Abigail C. Symm, Tracey H. Hicks, Jessica A. Bernard
Summary: Age is associated with changes in the organization of functional brain networks, which affect adult behavior. Functional networks become less segregated and more integrated with age. However, the decline of network segregation in relation to age and sex differences is not well understood, particularly in the context of female reproductive stage.
HUMAN BRAIN MAPPING
(2023)
Article
Peripheral Vascular Disease
Benard O. Ogola, Gabrielle L. Clark, Caleb M. Abshire, Nicholas R. Harris, Kaylee L. Gentry, Shreya S. Gunda, Isabella Kilanowski-Doroh, Tristen J. Wong, Bruna Visniauskas, Dylan J. Lawrence, Margaret A. Zimmerman, Carolyn L. Bayer, Leanne Groban, Kristin S. Miller, Sarah H. Lindsey
Summary: Estrogen may play a protective role in arterial stiffness post-menopause through GPER. Female mice adapt to hypertension by increasing carotid wall thickness, maintaining stiffness, while males show stiffness-related changes in response to blood pressure.
Article
Multidisciplinary Sciences
Reto Huber, Arko Ghosh
Summary: The study found that cognitive and physical activities are dominated by diurnal and infra-radian rhythms, but cognitive performance has a weaker rhythm than physical activity. Before bedtime, people continue to interact with their smartphones while at physical rest, leading to a decline in cognitive performance.
Article
Clinical Neurology
Veronica Guadagni, Lauren L. Drogos, Amanda Tyndall, Margie H. Davenport, Todd J. Anderson, Gail A. Eskes, R. Stewart Longman, Michael D. Hill, David B. Hogan, Marc J. Poulin
Article
Clinical Neurology
Shannon Hall, Samuel Deurveilher, George S. Robertson, Kazue Semba
Article
Biochemistry & Molecular Biology
Samuel Deurveilher, Tatjana Golovin, Shannon Hall, Kazue Semba
Summary: Sleep plays a crucial role in brain function, and microglia have been found to have important roles in sleep regulation. The interactions between microglia and neurons at synapses impact sleep cycles and neuronal activities. Recent research has also focused on how microglia respond to sleep deprivation.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Clinical Neurology
Samuel Deurveilher, Stephanie M. Shewchuk, Kazue Semba
Summary: Chronic sleep insufficiency has negative impacts on cognitive and health. Sleep regulation may be altered, but subsequent homeostatic responses to acute sleep loss are not affected after a 4-day 3/1 sleep restriction protocol.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Neurosciences
Menno P. Veldman, Nina Dolfen, Mareike A. Gann, Julie Carrier, Bradley R. King, Genevieve Albouy
Summary: Research has shown that the effects of somatosensory targeted memory reactivation (TMR) on motor memory consolidation are still unclear. The study found that applying somatosensory TMR during sleep and wakefulness can lead to changes in brain oscillatory activity, but these changes do not impact motor performance.
Article
Neurosciences
Samuel Deurveilher, Michael Antonchuk, Brock St. C. Saumure, Andrew Baldin, Kazue Semba
Summary: The study did not find significant differences in the numbers of orexin and locus coeruleus noradrenergic neurons in rats following one or four cycles of a sleep restriction protocol. Sleep restriction also did not affect the densities of orexin axon terminals and noradrenergic dendrites in the brain cortex.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Maude Bouchard, Jean-Marc Lina, Pierre-Olivier Gaudreault, Alexandre Lafreniere, Jonathan Dube, Nadia Gosselin, Julie Carrier
Summary: Two types of slow waves, slow switchers and fast switchers, were found to coexist in humans. Older individuals showed lower temporal dissipation of sleep pressure and decreased flexibility in EEG connectivity at the microscale of the oscillations.
Review
Neurosciences
Julie Legault, Cynthia Thompson, Marie-Eve Martineau-Dussault, Claire Andre, Andree-Ann Baril, Guillermo Martinez Villar, Julie Carrier, Nadia Gosselin
Summary: Around 40% of dementia risk is attributable to modifiable factors such as physical inactivity, hypertension, diabetes, and obesity, with sleep disorders like obstructive sleep apnea also being considered. However, there is still no consensus on whether OSA increases the risk of dementia or not. The heterogeneity in previous studies may be related to individual characteristics that modulate the association between OSA and cognitive decline.
Article
Clinical Neurology
Yanan Wang, Marcel van de Wouw, Lauren Drogos, Elnaz Vaghef-Mehrabani, Raylene A. Reimer, Lianne Tomfohr-Madsen, Gerald F. Giesbrecht
Summary: The study reveals a novel association between sleep and gut microbiota in preschool-aged children. Longer night-time sleep and greater sleep efficiency were associated with specific commensal bacteria that may regulate sleep through modulating neurotransmitter metabolism and the immune system. Additionally, fecal metabolites like tryptophan and propionate show associations with sleep parameters.
Article
Biology
Judith Nicolas, Bradley R. King, David Levesque, Latifa Lazzouni, Emily Coffey, Stephan Swinnen, Julien Doyon, Julie Carrier, Genevieve Albouy
Summary: Targeted memory reactivation during sleep can enhance motor memory consolidation, and the coordination between slow and sigma oscillations plays a crucial role in memory reinstatement or protection against irrelevant information.
Article
Clinical Neurology
Alexandre Lafreniere, Jean-Marc Lina, Jimmy Hernandez, Maude Bouchard, Nadia Gosselin, Julie Carrier
Summary: This study compared the sleep slow-wave (SW) transition speed and other characteristics between older adults with amnestic mild cognitive impairment (aMCI) and cognitively normal (CN) controls, and examined their associations with memory and cognitive changes. The results showed that aMCI participants had a slower SW transition speed and a higher proportion of slow-switchers. Additionally, the transition speed of fast-switchers was slower in participants with obstructive sleep apnea (OSA). These SW measures were correlated with memory decline in aMCI and cognitive improvements in CN participants.
Article
Clinical Neurology
Anna-Francesca Boatswain-Jacques, Charlotte Dusablon, Catherine Cimon-Paquet, Elie YuTong Guo, Rosalie Menard, Celia Matte-Gagne, Julie Carrier, Annie Bernier
Summary: This study examines the sleep trajectories and developmental changes in pre- and early adolescents. The research shows significant changes in sleep-wake cycles, including delayed sleep onset, offset, and midpoint, and decreased total sleep time. Weekend-weekday differences in sleep offset and midpoint become more pronounced over time. Intra-individual variability in sleep increases with age. Important between-person and sex differences are also observed.
Article
Clinical Neurology
Samuel Deurveilher, Kristin Robin Ko, Brock St C. Saumure, George S. Robertson, Benjamin Rusak, Kazue Semba
Summary: Sleep and circadian rhythm disruptions are common in individuals with schizophrenia. STOP knockout mice exhibit behavioral impairments similar to symptoms of schizophrenia, including less sleep, more fragmented sleep, and more waking. The study found that STOP KO mice had lower activity levels, less stable activity rhythms, and spent more time awake and less time in REMS and NREMS sleep compared to wild-type mice. The results suggest that the STOP null mutation altered sleep/wake physiology and activity rhythm expression in mice, without grossly disrupting circadian mechanisms.
Article
Psychology, Clinical
Lauren L. Drogos, Kirsti Toivonen, Laura Labelle, Tavis S. Campbell, Linda E. Carlson
Summary: While mindfulness-based interventions have been effective in reducing stress, improving quality of life, and enhancing coping skills in cancer survivors, this study found that there was no significant change in cortisol and cardiovascular reactivity to an acute laboratory stress task after the intervention. Blunted cortisol response was observed in both groups, suggesting a potential lack of intervention effect in this aspect.
JOURNAL OF BEHAVIORAL MEDICINE
(2021)
Article
Behavioral Sciences
Amanda V. Tyndall, R. Stewart Longman, Tolulope T. Sajobi, Jillian S. Parboosingh, Lauren L. Drogos, Margie H. Davenport, Gail A. Eskes, David B. Hogan, Michael D. Hill, Marc J. Poulin
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2020)
Review
Endocrinology & Metabolism
Francesca R. Luberti, Justin M. Carre
Summary: This study comprehensively reviewed the evidence on the impact of testosterone on human mating and parenting behaviors. The findings suggest that basal testosterone levels are related to mating and parenting behaviors in both men and women. Testosterone responds to reproduction-relevant cues and acute changes in testosterone levels are associated with subsequent mating and parenting behaviors. Single-dose exogenous testosterone administration may causally affect mating and parenting behaviors. However, the support for trade-off interpretations of testosterone's adaptive function is mixed, indicating that the role of testosterone in modulating human mating and parenting is complex and context-dependent.
FRONTIERS IN NEUROENDOCRINOLOGY
(2024)
