Intracellular methylglyoxal induces oxidative damage to pancreatic beta cell line INS-1 cell through Ire1α-JNK and mitochondrial apoptotic pathway

Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress

(2016) Zhen Wang et al.   CELL BIOLOGY INTERNATIONAL

Involvement of Endoplasmic Reticulum Stress, Autophagy and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury

(2016) Chih-Kang Chiang et al.   Scientific Reports

Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

(2014) James L. Figarola et al.   APOPTOSIS

Assay of methylglyoxal-derived protein and nucleotide AGEs

(2014) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Matrix Metalloproteinase 2 Contributes to Pancreatic Beta Cell Injury Induced by Oxidative Stress

(2014) Chongxiao Liu et al.   PLoS One

Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 初诊2型糖尿病患者血浆甲基乙二醛水平升高

(2014) Xiang Kong et al.   Journal of Diabetes

New directions in ER stress-induced cell death

(2013) Susan E. Logue et al.   APOPTOSIS

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IRE1α dissociates with BiP and inhibits ER stress-mediated apoptosis in cartilage development

(2013) Xiaofeng Han et al.   CELLULAR SIGNALLING

Advanced glycation end-products induce injury to pancreatic beta cells through oxidative stress

(2012) N. Lin et al.   DIABETES & METABOLISM

Methylglyoxal, Cognitive Function and Cerebral Atrophy in Older People

(2012) Velandai Srikanth et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

(2012) W. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights

(2012) Margaret G. Distler et al.   Frontiers in Genetics

Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

(2011) Arti Dhar et al.   DIABETES

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E

(2011) F. Fiory et al.   DIABETOLOGIA

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

(2010) Jianxin Lu et al.   CLINICAL BIOCHEMISTRY

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Methylglyoxal Is a Predictor in Type 2 Diabetic Patients of Intima-Media Thickening and Elevation of Blood Pressure

(2010) Susumu Ogawa et al.   HYPERTENSION

Hyperglycemia Impairs Proteasome Function by Methylglyoxal

(2009) M. A. Queisser et al.   DIABETES

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats

(2009) Qi Guo et al.   JOURNAL OF HYPERTENSION