Article
Neurosciences
Manish Kumar, Nitin Bansal
Summary: Alzheimer's disease is a prevalent type of dementia in the elderly population, with complex pathophysiological processes involving cell apoptosis, tauopathy, beta-amyloidopathy, etc. Despite significant advancements in understanding the pathogenesis, treatment remains a challenge. The PI3K-Akt pathway may serve as a crucial therapeutic target in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Zhao Fang, Yushanjiang Feierkaiti, Guangji Wang, Xiaoxin Zheng, Xuejun Jiang
Summary: This study aimed to investigate the protective effect of germacrone against cardiac remodeling. The results showed that germacrone could attenuate oxidative stress, inflammation, and apoptosis induced by cardiac remodeling by inhibiting the PI3K/AKT pathway, thus representing a promising therapeutic approach for the treatment of cardiac remodeling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hucheng Ma, Haozhen Ren, Jun Wang, Xianwen Yuan, Xinyu Wu, Xiaolei Shi
Summary: Glabridin can significantly alleviate oxidative stress, inflammation, and apoptosis induced by APAP, exerting a protective effect by activating the PI3K/Akt/Nrf2/HO-1 pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Yanhui Liu, Haobo Kong, Heping Cai, Guanru Chen, Huiying Chen, Wenyi Ruan
Summary: This paper reviews the association between the PI3K/Akt pathway and COPD, aiming to identify new therapeutic targets for clinical intervention in this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Jianpeng Chen, Zhikai Jiang, Xuao Liu, Kaitao Wang, Weijian Fan, Tingxiang Chen, Zhijie Li, Dingsheng Lin
Summary: The study found that berberine can improve the survival rate of random skin flaps by promoting angiogenesis, inhibiting inflammation, attenuating oxidative stress, and reducing apoptosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Xavier Capo, David Mateos, Lucia Ugarriza, Josep A. Tur, Antoni Sureda
Summary: The study found that inflammatory biomarkers increased in the plasma and PBMCs of obese patients, while antioxidant enzyme activities also increased with BMI, providing useful biomarkers for monitoring the progression and reversal of obesity.
Review
Medicine, Research & Experimental
Pamela Carvalho Da Rosa, Judit Borras Bertomeu, Luis Fernando Freire Royes, Raul Osiecki
Summary: Peripheral blood mononuclear cells (PBMCs) are specialized immune cells produced in the bone marrow that protect the body from pathogens and can serve as a sentinel tissue source for monitoring physiological changes. Physical exercise has been shown to influence the metabolic state and immune system through its interactions with PBMCs. However, the specific metabolic processes and biomarkers related to exercise-induced changes in PBMCs are not fully understood. This review aims to summarize the current literature on the inflammatory and oxidative stress responses of PBMCs to physical exercise and highlights their potential for assessing exercise-induced metabolic adaptations.
Article
Medicine, Research & Experimental
Yaoxing Dou, Ronglei Huang, Qiaoping Li, Yuhong Liu, Yucui Li, Hanbin Chen, Gaoxiang Ai, Jianhui Xie, Huifang Zeng, Jiannan Chen, Chaodan Luo, Ziren Su
Summary: This study compared the performance and effects of BBR and OBB in vivo, with both primarily existing in a protein-bound form and OBB showing superior anti-diabetic effects. In addition, antibiotics significantly compromised the anti-diabetic effect of BBR.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Yanyu Lu, Qianqian Min, Xiaoyan Zhao, Li Li, Guojun Zhao, Jianzeng Dong
Summary: Eupatilin has various biological activities, including anticancer, anti-inflammatory, antioxidant, neuroprotective, anti-allergic, and cardioprotective effects. This study aimed to investigate the protective effects of eupatilin on doxorubicin-induced cardiotoxicity. The results demonstrated that eupatilin attenuated inflammation, oxidative stress, and cardiomyocyte apoptosis, and improved doxorubicin-induced cardiac dysfunction by activating the PI3K-AKT signaling pathway. This study provides the first evidence for the therapeutic potential of eupatilin in doxorubicin-induced cardiotoxicity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Chemistry, Medicinal
Xue Wang, Xiaomei Liu, Radouil Tzekov, Chaofeng Yu, Jiasong Yang, Yuliang Feng, Yajun Wu, Yali Xu, Shiying Li, Wensheng Li
Summary: The study found that fenofibrate improved RPE cell damage induced by excessive fat in vitro and in vivo by activating the PI3K/AKT signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Rajasekar Janani, Rani Elavarasan Anitha, Peethambaran Divya, Muzaffar Chonche, Vallikannan Baskaran
Summary: Astaxanthin protects retinal cells from inflammation induced by hyperglycemia by modulating NF-kappa B through the ROS-PI3K/Akt signaling cascade.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Chih-Yao Chung, Kritarth Singh, Vassilios N. Kotiadis, Gabriel E. Valdebenito, Jee Hwan Ahn, Emilie Topley, Joycelyn Tan, William D. Andrews, Benoit Bilanges, Robert D. S. Pitceathly, Gyorgy Szabadkai, Mariia Yuneva, Michael R. Duchen
Summary: Heteroplasmic mtDNA mutations, specifically the m.3243 A > G mutation, lead to activated PI3K-Akt-mTORC1 pathway in cells, and inhibiting this pathway reduces mutant mtDNA load. Pharmacological inhibition of PI3K, Akt, or mTORC1 can potentially benefit people with the consequences of the m.3243 A > G mutation by reducing mutant mtDNA load and improving cellular bioenergetic function.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Francois Sauer, Marianne Riou, Anne-Laure Charles, Alain Meyer, Emmanuel Andres, Bernard Geny, Samy Talha
Summary: Heart failure is a leading cause of hospitalization in patients aged over 65 and is associated with high mortality rates. Recent studies have focused on the mitochondrial respiration of peripheral blood circulating cells (PBMCs) in order to better understand the physiopathology of HF. These studies suggest that cardiovascular metabolic risk factors and cellular switch may contribute to decreased PBMC mitochondrial respiration, which is associated with HF severity. Further research is needed to investigate the potential diagnostic, prognostic, and therapeutic utility of monitoring PBMC mitochondrial function and mitoDAMPs in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Haoliang Li, Renhao Jiang, Lejing Lou, Chao Jia, Linfang Zou, Mochuan Chen
Summary: Formononetin demonstrated dose-dependent promotion of skin flap viability by reducing oxidative stress and inflammation and enhancing angiogenesis. Its antioxidant effects were mediated through Nrf2 activation, indicating its potential as a candidate drug for enhancing skin flap survival.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Hsuan Chang, Chia-Hsin Liu, Yi-Ru Wang, Yen-Shi Lo, Chun-Wei Chang, Hsiu-Chuan Wu, Chiung-Mei Chen
Summary: This study measured the expression levels of 52 genes related to oxidative stress and inflammation in peripheral blood mononuclear cells of Parkinson's disease (PD) patients. It found that four genes were upregulated in PD patients, and this upregulation was validated in a second cohort. The expression levels of APAF1 and CSF1R were correlated with clinical scores.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Diego Martin-Sanchez, Juan Guerrero-Mauvecin, Miguel Fontecha-Barriuso, Nerea Mendez-Barbero, Maria Laura Saiz, Ana M. Lopez-Diaz, Maria D. Sanchez-Nino, Susana Carrasco, Pablo Cannata-Ortiz, Marta Ruiz-Ortega, Alberto Ortiz, Ana B. Sanz
Summary: RIPK3 plays a key role in kidney inflammation by mediating NF-κB activation independently of tubular cell death. Targeting bone marrow-derived RIPK3 may help limit kidney inflammation effectively.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Patricia Branco, Ana Rita Martins, Rita Calca, Catarina Mateus, Maria Joao Jervis, Anabela Rodrigues, Sofia Azeredo Lopes, Ester Civantos, Sebastian Mas-Fontao, Augusta Gaspar, Sancia Ramos, Judit Morello, Daniel Pinto Gomes, Sofia Azeredo Pereira
Summary: This study found that some patients already have fibrosis of the peritoneal membrane before starting dialysis, while others do not. The results suggest that alpha-Klotho may be implicated in fibrosis of the peritoneal membrane.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Jose Luis Morgado-Pascual, Beatriz Suarez-Alvarez, Vanessa Marchant, Pamela Basantes, Pierre-Louis Tharaux, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: This study found that the use of iBET drugs can reduce collagen accumulation in experimental glomerulosclerosis by inhibiting the accumulation and overexpression of collagen IV. The study also found that SOX9 plays an important role in kidney fibrosis, and iBET drugs can prevent the translocation of SOX9 into the nucleus. These findings provide further research evidence for the application of iBET drugs in the treatment of glomerulosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Sandra Rayego-Mateos, Raul R. Rodrigues-Diez, Beatriz Fernandez-Fernandez, Carmen Mora-Ferna, Vanessa Marchant, Javier Donate-Correa, Juan F. Navarro-Gonza, Alberto Ortiz, Marta Ruiz-Ortega
Summary: Diabetic kidney disease (DKD) is a rapidly growing cause of chronic kidney disease and associated morbidity and mortality. Recent advances in treatment strategies, such as sodium-glucose cotransporter-2 inhibitors and mineralocorticoid receptor antagonist finerenone, have changed the standard of care and rendered older studies targeting inflammatory mediators obsolete. This review discusses the impact of current standard of care and potential novel therapeutic strategies on kidney inflammation in DKD, providing a roadmap for future research.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Ivan Damgov, Maria Bartosova, Iva Marinovic, Obaida Istanbuly, Meinhard Kieser, Mark Lambie, Simon J. Davies, Claus Peter Schmitt
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Patricia Branco, Rita Calca, Ana Rita Martins, Catarina Mateus, Maria Joao Jervis, Daniel Pinto Gomes, Sofia Azeredo-Lopes, Antonio Ferreira Junior De Melo, Catia Sousa, Ester Civantos, Sebastian Mas-Fontao, Augusta Gaspar, Sancia Ramos, Judit Morello, Fernando Nolasco, Anabela Rodrigues, Sofia Azeredo Pereira
Summary: This study investigated the predictors of long-term peritoneal dialysis (PD) outcomes, including peritoneal membrane status, clinical data, and aging-related molecules. It found that fibrosis of the peritoneal membrane was associated with major cardiovascular events (MACE) occurrence, while serum alpha-Klotho below 742 pg/mL was related to submesothelial thickness. Uremic levels of galectin-3 were associated with PD failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Flavia Trionfetti, Vanessa Marchant, Guadalupe. T. T. Gonzalez-Mateo, Edyta Kawka, Laura Marquez-Exposito, Alberto Ortiz, Manuel Lopez-Cabrera, Marta Ruiz-Ortega, Raffaele Strippoli
Summary: The global incidence of chronic kidney disease (CKD) is increasing, leading to a significant number of CKD patients developing end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient home therapy for KRT, but it can lead to damage of the peritoneal membrane (PM) due to the exposure to PD fluids containing high concentrations of glucose or other osmotic agents. This damage involves inflammation and fibrosis, which can be worsened by peritonitis episodes. In this article, we review the role of immune cells in PM damage during KRT and infections, as well as the anti-inflammatory properties of current clinical treatments for CKD patients in KRT and their potential effect on preserving PM integrity. Additionally, we discuss the implications of COVID-19 in CKD and KRT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Romina P. Martinelli, Sandra Rayego-Mateos, Matilde Alique, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Alberto Ortiz, Emilio Gonzalez-Parra, Marta Ruiz-Ortega
Summary: With the increase in life expectancy, age-related diseases such as chronic kidney disease are becoming more prevalent, posing a significant health issue in some countries. The lack of biomarkers for early detection of kidney damage and prediction of renal failure progression is a major problem, as current treatments only slow down disease progression. Preclinical research has highlighted the involvement of cellular senescence-related mechanisms in kidney injury and natural aging. In this context, vitamin D or its analogs have shown potential in protecting against kidney injury, with vitamin D deficiency being observed in patients with kidney diseases. This review provides recent evidence on the relationship between vitamin D and kidney diseases, focusing on the underlying mechanisms and the modulation of cellular senescence mechanisms.
Article
Nutrition & Dietetics
M. L. Sanchez-Tocino, S. Mas-Fontao, C. Gracia-Iguacel, M. Pereira, I. Gonzalez-Ibarguren, A. Ortiz, M. D. Arenas, E. Gonzalez Parra
Summary: This study aimed to develop a sarcopenia index based on malnutrition parameters for screening muscle wasting in elderly hemodialysis patients. The results showed that the combination of loss of strength, loss of muscle mass, and low physical performance correlated with malnutrition. Regression equations were developed to predict the severity of sarcopenia, and easily accessible anthropometric and nutritional parameters were used for screening.
Article
Nutrition & Dietetics
Octavian Parascinet, Sebastian Mas, Tianyu Hang, Carolina Llavero, Oscar Lorenzo, Jaime Ruiz-Tovar
Summary: This pilot study suggests that the administration of a multi-strain probiotic containing lactobacillus and bifidobacterium species can help reduce body weight and cardiovascular risk factors in obese patients. This effect may be related to the production of short-chain fatty acids.
Article
Medicine, General & Internal
Rafael Gabriel, Nisa Boukichou-Abdelkader, Aleksandra Gilis-Januszewska, Konstantinos Makrilakis, Ricardo Gomez-Huelgas, Zdravko Kamenov, Bernhard Paulweber, Ilhan Satman, Predrag Djordjevic, Abdullah Alkandari, Asimina Mitrakou, Nebojsa Lalic, Jesus Egido, Sebastian Mas-Fontao, Jean Henri Calvet, Jose Carlos Pastor, Jaana Lindstrom, Marcus Lind, Tania Acosta, Luis Silva, Jaakko Tuomilehto
Summary: The objective of this study was to compare the impact of glucose-lowering drugs on peripheral nerve and kidney function in prediabetes. The results showed that the use of metformin alone, linagliptin alone, or the combination of both reduced the risk of small fiber peripheral neuropathy and slowed down the decrease in estimated glomerular filtration rate compared to the placebo. These findings suggest that treatment with metformin and linagliptin, either alone or in combination, can effectively protect prediabetes patients from developing peripheral nerve diseases and maintain kidney function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sandra Rayego-Mateos, Pamela Basantes, Jose Luis Morgado-Pascual, Beatriz Brazal Prieto, Beatriz Suarez-Alvarez, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega
Summary: Mitochondrial dysfunction plays a significant role in the progression of kidney disease, while epigenetic drugs such as iBET have shown beneficial effects by inhibiting proliferative and inflammatory responses. In both in vitro and in vivo studies, iBET was found to prevent mitochondrial damage, restore oxidative phosphorylation chain components, improve mitochondrial dynamics, and reduce oxidative stress.
Article
Medicine, General & Internal
Carlos Carpio, Ana Qasem, Antonio Buno, Alberto M. Borobia, Francisco Arnalich, Vega Rey, Teresa Lazaro, Pablo Mariscal, Daniel Laorden, Giorgina Salgueiro, Alberto Moreno, Concepcion Peiro, Oscar Lorenzo, Rodolfo Alvarez-Sala, COVID HULP Working Group, POSTCOVID HULP Working Group
Summary: In this retrospective cohort study, we evaluated KL-6 levels in medium-term post-COVID patients and found that levels of KL-6 were lower in patients with mild COVID-19 compared to those with moderate or severe disease. KL-6 was associated with systemic inflammatory, hepatic enzyme, and thrombosis biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)