Article
Biochemistry & Molecular Biology
Monica Zocchi, Laura Locatelli, Gian Vincenzo Zuccotti, Andre Mazur, Daniel Bechet, Jeanette A. Maier, Sara Castiglioni
Summary: This study found that the concentration of magnesium and its transporters change during myogenic differentiation. MagT1 and SLC41A1 are involved in regulating intracellular magnesium concentration, while TRPM7 is downregulated and undetectable in myotubes. These findings highlight the importance of magnesium in skeletal muscle health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Na Liang, Jia He, Jiaqi Yan, Xueying Han, Xiaoqian Zhang, Yamei Niu, Wuga Sha, Jun Li
Summary: DBC1 knockdown in skeletal muscle leads to muscle atrophy and impairs muscle regeneration through the regulation of FOXO3. This research highlights the importance of DBC1 for healthy skeletal muscle function and its connection to muscular atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Jianjun Jin, Mengmeng Du, Jian Wang, Yubo Guo, Jiali Zhang, Hao Zuo, Yunqing Hou, Shanshan Wang, Wei Lv, Wei Bai, Jin Wang, Xizhen Zhan, Yaxin Peng, Qian Tong, Jin Chai, Zaiyan Xu, Bo Zuo
Summary: The study identified SYISL as a conserved lncRNA that modulates myogenesis in mice, pigs, and humans, and also demonstrated its previously unknown ability to promote muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Yi-Ju Chen, Rathinasamy Baskaran, Ching Fang Chang, Zuhair M. Mohammedsaleh, Wan-Teng Lin
Summary: Sarcopenia, age-related muscle loss, has negative health consequences such as decreased strength and insulin resistance. The bioactive peptide DI-10 promotes myoblast differentiation and upregulates mitochondrial-related transcription factors under hyperglycemic conditions. This suggests DI-10's potential as a therapeutic candidate for preventing muscle degeneration in sarcopenia.
Article
Food Science & Technology
Shanyao Pan, Shanshan Guo, Jiaru Dai, Yanrong Gu, Guoxiang Wang, Yulong Wang, Zhenghong Qin, Li Luo
Summary: Exercise and trehalose can improve learning and memory, activate autophagy, and modulate autophagy through different pathways in aged mice. However, a combination of exercise and trehalose does not exert synergistic effects.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Lishan Huang, Ruiyu Chen, Libin Liu, Yu Zhou, Zhou Chen
Summary: Lactoferrin has been shown to ameliorate pathological cardiac hypertrophy in aged mice by reducing apoptosis, improving mitochondrial morphology and dynamics, increasing lysosome-dependent autophagy, and inhibiting factors detrimental to the mitochondrial-lysosomal axis.
Article
Biochemical Research Methods
Irina N. Saburina, Nastasia Kosheleva, Arthur T. Kopylov, Tatiana Lipina, Marina E. Krasina, Irina M. Zurina, Anastasiya A. Gorkun, Svetlana S. Girina, Andrey A. Pulin, Anna L. Kaysheva, Sergey G. Morozov
Summary: Myocyte differentiation involves processes such as mitochondria repopulation and cytoskeleton re-organization. Differences between monolayer and spheroid cultured cells at the proteomic level were found, with spheroid cells enriched in mitochondria biogenesis and cytoskeleton-related proteins, while Rab-related transducers were inhibited. Ultrastructural differences in mitochondria suggest active biogenesis under three-dimensional conditions.
Article
Public, Environmental & Occupational Health
Chen Zhang, Weiwei Wang, Xiaotian Chang, Siyan Zhan, Shengfeng Wang, Lei Feng, Yongfeng Song
Summary: This cohort study examined the relationship between obesity and hearing loss among middle-aged and older adults. It found that central obesity was significantly associated with hearing loss, especially in males. Among males, the underweight group had the highest risk of hearing loss, while the obese groups had a lower risk compared to the normal weight group. Among females, only the overweight group had a lower risk of hearing loss than the normal weight group.
Article
Nutrition & Dietetics
Toshio Norikura, Yutaro Sasaki, Akiko Kojima-Yuasa, Atsushi Kon
Summary: In this study, the researchers found that glyoxylic acid, an alpha-keto acid metabolite derived from glycine, promotes myogenesis and suppresses muscle atrophy induced by dexamethasone. It is also metabolized to amino acids in muscle cells. These findings suggest that glyoxylic acid may be a beneficial nutrient for patients with chronic kidney disease on a strict dietary protein restriction.
Article
Biochemistry & Molecular Biology
Athanasios Moustogiannis, Anastassios Philippou, Orjona Taso, Evangelos Zevolis, Maria Pappa, Antonios Chatzigeorgiou, Michael Koutsilieris
Summary: This study investigated the impact of senescence/aging on skeletal myogenesis through in vitro experiments. Aged myoblasts showed cell cycle arrest, DNA damage, increased SA-beta-gal activity, and altered expression of various factors compared to control cells during differentiation. The findings suggest that aging disrupts myogenic lineage and leads to a reduction in differentiation capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ryuni Kim, Jee Won Kim, Hyerim Choi, Ji-Eun Oh, Tae Hyun Kim, Ga-Yeon Go, Sang-Jin Lee, Gyu-Un Bae
Summary: This study reveals the effects of Ginsenoside Rg5 on muscle differentiation, growth, and prevention of muscle atrophy. Rg5 promotes myogenesis and hypertrophy by activating p38MAPK and Akt/mTOR signaling pathways. This research suggests that Rg5 has potential therapeutic applications in muscle weakness and atrophy.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Cocchiararo, Olivia Cattaneo, Jayasimman Rajendran, Florent Chabry, Melanie Cornut, Hadrien Soldati, Anne Bigot, Kamel Mamchaoui, Sara Gibertini, Axelle Bouche, Daniel J. Ham, Thomas Laumonier, Alexandre Prola, Perrine Castets
Summary: Defective lysosomal acidification caused by VMA21 gene mutations is responsible for a variety of multi-systemic disorders associated with impaired autophagy. This study discovered two previously unreported isoforms of VMA21 protein (VMA21-120 and VMA21-101), with VMA21-120 showing predominant expression in skeletal muscle. Activation or blockade of autophagy had no significant impact on the expression of VMA21 isoforms, while mutations associated with XMEA led to deficiency in VMA21-101 and loss of VMA21-120 expression.
HUMAN MOLECULAR GENETICS
(2023)
Article
Agriculture, Dairy & Animal Science
Lijin Guo, Siyu Zhang, Yibin Xu, Yulin Huang, Wei Luo, Qi Wen, Guanxuan Liu, Weiling Huang, Haiping Xu, Biao Chen, Qinghua Nie
Summary: The missense mutation of Arg84Lys in ISPD was found to be associated with well-developed muscles and demonstrated to improve chicken muscles' development.
Article
Biochemistry & Molecular Biology
Joseph Balnis, Lisa A. Drake, Diane Singer, Catherine E. Vincent, Tanner C. Korponay, Jeanine D'Armiento, Chun Geun Lee, Jack A. Elias, Harold A. Singer, Ariel Jaitovich
Summary: This study found that patients with chronic obstructive pulmonary disease (COPD)-pulmonary emphysema often develop locomotor muscle dysfunction, which is associated with worse outcomes. The study suggests that dysregulated autophagy plays a key role in muscle dysfunction, and stimulating autophagy and satellite cell activation could improve the muscle dysfunction caused by pulmonary emphysema.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Di Lian, Ming-Ming Chen, Hanyu Wu, Shoulong Deng, Xiaoxiang Hu
Summary: This review summarizes the sources, causes, and key role of oxidative stress in skeletal muscle, as well as its relationship with muscle homeostasis and physiopathology. It provides targets for antioxidant therapy and repair of inflammatory damage in noninflammatory muscle diseases.
Article
Oncology
Emma Newport, Ana Rita Pedrosa, Delphine Lees, Matthew Dukinfield, Edward Carter, Jesus Gomez-Escudero, Pedro Casado, Vinothini Rajeeve, Louise E. Reynolds, Pedro R. Cutillas, Stephen W. Duffy, Beatriz De Luxan Delgado, Kairbaan Hodivala-Dilke
Summary: The study identified the impact of EC FAK kinase activity on tumor cell sensitivity to DNA-damaging therapies, suggesting a modulation of tumor growth and chemotherapy response.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemical Research Methods
Gabriel Martin, Susana Rojo-Alba, Cristian Castello-Abietar, Fatima Abreu-Salinas, Isabel Costales, Jose Antonio Boga, Santiago Melon, Marta Elena Alvarez-Arguelles
Summary: Among the methods used to diagnose COVID-19, genomic detection by q(RT)-PCR is the most sensitive. However, the increase in demand for extraction reagents has hindered the supply of commercial reagents. Homemade reagents and procedures can be an effective alternative, as our study shows that these procedures using common and cheap reagents can successfully extract the RNA or DNA of SARS-CoV-2 and human beta-globin. These procedures can be easily adopted by routine diagnostic laboratories to aid in the fight against the COVID-19 pandemic.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Biology
Laura Amado-Rodriguez, Estefania Salgado Del Riego, Juan Gomez de Ona, Ines Lopez Alonso, Helena Gil-Pena, Cecilia Lopez-Martinez, Paula Martin-Vicente, Antonio Lopez-Vazquez, Adrian Gonzalez Lopez, Elias Cuesta-Llavona, Raquel Rodriguez-Garcia, Jose Antonio Boga, Marta Elena Alvarez-Arguelles, Juan Mayordomo-Colunga, Jose Ramon Vidal-Castineira, Irene Crespo, Margarita Fernandez, Loreto Criado, Victoria Salvadores, Francisco Jose Jimeno-Demuth, Lluis Blanch, Belen Prieto, Alejandra Fernandez-Fernandez, Carlos Lopez-Larrea, Eliecer Coto, Guillermo M. Albaiceta
Summary: Patients with the IFIH1 rs1990760 TT variant show an attenuated inflammatory response and better outcomes. Dexamethasone may reverse this anti-inflammatory phenotype.
Article
Geriatrics & Gerontology
Laura Gonzalez-Blanco, Manuel Bermudez, Juan C. Bermejo-Millo, Jose Gutierrez-Rodriguez, Juan J. Solano, Eduardo Antuna, Ivan Menendez-Valle, Beatriz Caballero, Ignacio Vega-Naredo, Yaiza Potes, Ana Coto-Montes
Summary: Functionally dependent patients exhibit severe alterations in their cellular interactome at the muscle level. Protein synthesis capacity decreases, cellular control systems fail to respond adequately; autophagy is blocked, mitochondria malfunction; muscle unable to be replaced, resulting in loss of muscle mass and functionality.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Oncology
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxan-Delgado, Oscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J. G. Drake, Jesus Gomez-Escudero, Frances M. Richards, Celine Weller, Christof Dormann, Ya-Ming Meng, Peter B. Vermeulen, Dieter Saur, Victoria Sanz-Moreno, Ping-Pui Wong, Cyrill Geraud, Pedro R. Cutillas, Kairbaan Hodivala-Dilke
Summary: This study reveals that endothelial cell focal adhesion kinase (FAK) plays a role in regulating pancreatic ductal adenocarcinoma (PDAC) metastasis and impacting the outcome of gemcitabine treatment. The findings suggest the potential clinical utility of combinatorial endothelial cell FAK targeting with gemcitabine in controlling metastasis in PDAC patients.
Article
Biochemistry & Molecular Biology
Cristina Cachan-Vega, Ignacio Vega-Naredo, Yaiza Potes, Juan Carlos Bermejo-Millo, Adrian Rubio-Gonzalez, Claudia Garcia-Gonzalez, Eduardo Antuna, Manuel Bermudez, Jose Gutierrez-Rodriguez, Jose Antonio Boga, Ana Coto-Montes, Beatriz Caballero
Summary: This study evaluated the effects of chronic melatonin treatment on neurodegeneration and hippocampal neurogenesis in aged and neurodegenerative brains. The findings suggest that melatonin can decrease neurodegenerative processes and improve the functionality of adult hippocampal neurogenesis.
Review
Biochemistry & Molecular Biology
Eduardo Antuna, Cristina Cachan-Vega, Juan Carlos Bermejo-Millo, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes, Claudia Garcia-Gonzalez
Summary: In a world where life expectancy is increasing, understanding and promoting healthy aging has become a contemporary demand. Inflammaging, a chronic and low-grade systemic inflammation in the elderly, is linked with many age-associated diseases. There are correlations between sarcopenia, the loss of strength and mass in skeletal muscle related to aging, and inflammaging. Inflammatory signals from chronic diseases negatively affect skeletal muscle, and autophagic mechanisms play a role in inflammation. Strategies such as using melatonin or senotherapeutic compounds could counteract inflammation in the muscle. This review aims to present the factors regulating skeletal muscle inflammaging and their implications in sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yaiza Potes, Cristina Cachan-Vega, Eduardo Antuna, Claudia Garcia-Gonzalez, Nerea Menendez-Coto, Jose Antonio Boga, Jose Gutierrez-Rodriguez, Manuel Bermudez, Veronica Sierra, Ignacio Vega-Naredo, Ana Coto-Montes, Beatriz Caballero
Summary: Melatonin has beneficial effects on adult brain neurogenesis, including cell proliferation, neural differentiation, and neuronal maturation, making it a potential treatment for neurological disorders. Its antioxidant, anti-inflammatory, and pro-survival effects, as well as its ability to modulate neurogenesis processes, contribute to its therapeutic potential. Further research is needed to fully understand the benefits of melatonin in brain disorders related to glucose and insulin homeostasis impairments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Yaiza Potes, Beatriz Caballero
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)