Article
Food Science & Technology
Xiaoqing Shao, Cunfang Wang, Xipeng Wang, Zhenghao Li, Mengjia Ma, Hongyan Sun, Meifeng Li, Xiaoning Zhang
Summary: This study investigated the effects of ultrasound on the functional properties of beta-Lactoglobulin (beta Lg)-Epigallocatechin-3-gallate (EGCG) conjugates. The results showed that ultrasound treatment improved the properties and functions of the conjugates, as well as promoted the interaction between EGCG and beta Lg.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yaohui You, Liu Yang, Hong Chen, Linying Xiong, Fan Yang
Summary: In this study, soy protein isolate (SPI) was noncovalently modified by (-)-epigallocatechin-3-gallate (EGCG), leading to an improvement in its foaming, emulsifying, and antioxidant properties. The interaction between SPI and EGCG was found to involve hydrophobic force and hydrogen bonds, resulting in looser SPI structure and more active groups exposed. This modification process enhanced the functional properties of SPI significantly.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Siduo Zhou, Ling Meng, Yanfei Lin, Xueqian Dong, Mingsheng Dong
Summary: This study investigates the noncovalent interaction mechanisms between soybean 7S globulin and three polyphenols and finds that different compounds have different effects on the protein. Various techniques, such as thermodynamic experiments and fluorescence experiments, provide strong evidence for explaining these interactions.
Article
Chemistry, Applied
Shuangwen Fei, Jianwen Zhou, Yong Wu, Ping Tong, Jingyan Gao, Hongbing Chen, Xin Li
Summary: This study investigated the effects of metal ions and temperature on the aggregation of bovine beta-lactoglobulin. It was found that Cu2+ and Mg2+ treatments led to more amorphous aggregates, while Ca2+ and Mg2+ decreased the antigenicity and potential allergenicity of the aggregates. All ion-treated groups showed similar digestive stability in intestinal digestion.
Article
Agricultural Engineering
Yu-qi Song, Guanglong Yao, Jian Chen, Na Li
Summary: This study explores the interaction between whey protein and epigallocatechin gallate (EGCG), and finds that the addition of β-cyclodextrin can regulate this interaction. The addition of EGCG reduces the light transmittance and fluorescence intensity of whey protein, while also weakening the antioxidant activity of EGCG. β-cyclodextrin improves certain properties of the EGCG-whey protein hybrid system.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nanoscience & Nanotechnology
Xiangfei Song, Zhiyuan Zheng, Sixue Ouyang, Huiting Chen, Mingyan Sun, Peiru Lin, Yuying Chen, Yuanyuan You, Wenwen Hao, Jia Tao, Peng Zhao
Summary: Researchers have developed macrophage cell membrane-camouflaged nanoparticles that can effectively treat rheumatoid arthritis with reduced side effects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Mariusz Sandomierski, Martyna Chojnacka, Maria Ratajczak, Adam Voelkel
Summary: This study presents the potential use of zeolites containing divalent ions as carriers for epigallocatechin gallate (EGCG), a compound with high therapeutic potential in osteoporosis and cancer treatment. These new carriers exhibit strong interactions with divalent ions, allowing for controlled release of EGCG from the carrier-ion-EGCG drug delivery system. The results show the effectiveness of these new carriers, and their pH-dependent release of EGCG makes them suitable for both osteoporosis and cancer treatment. The choice of divalent ion used in the carriers affects the drug sorption and release, demonstrating the superiority of the proposed carriers over those described in previous literature.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Agriculture, Multidisciplinary
Huimin Yong, Huixia Hu, Zhihao Wang, Dawei Yun, Juan Kan, Jun Liu
Summary: By using acid-mediated coupling method, catechins were successfully conjugated onto dialdehyde starch to form stable dialdehyde starch-catechin conjugates. The conjugates exhibited improved thermal stability and enhanced stability of catechins in buffered solution. Furthermore, the conjugates showed higher antioxidant activity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Nanoscience & Nanotechnology
Nicholas Andrikopoulos, Yuhuan Li, Aparna Nandakumar, John F. Quinn, Thomas P. Davis, Feng Ding, Nabanita Saikia, Pu Chun Ke
Summary: This study developed a biocompatible metal-phenolic network (MPN) consisting of epigallocatechin gallate (EGCG) and physiological Zn(II), which showed remarkable potency against amyloid aggregation in Alzheimer's disease. The MPN@AuNP nanoconstruct exhibited superior performance in inhibiting amyloid aggregation and toxicity compared to EGCG@AuNP, due to its larger surface area. The atomic coordination of Zn(II)-EGCG and the structure and dynamics of amyloid aggregation modulated by MPN were analyzed, suggesting potential applications for regulating AD pathology.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mantas Ziaunys, Kamile Mikalauskaite, Andrius Sakalauskas, Vytautas Smirnovas
Summary: The fluctuation in solution ionic strength has a significant impact on the inhibitory effect of the protein aggregation inhibitor, epigallocatechin-3-gallate, with different amyloid-forming proteins exhibiting unique responses.
Article
Chemistry, Physical
Mahla Tabasi, Parvaneh Maghami, Zeinab Amiri-Tehranizadeh, Mohammad Reza Saberi, Jamshidkhan Chamani
Summary: Understanding the interaction between nano-curcumin and milk proteins is essential for its therapeutic applications. This study investigated the interactions of nano-curcumin with beta-lactoglobulin and alpha lactalbumin through various biophysical methods. The results revealed changes in fluorescence emission and secondary structure upon binding, and provided insights into the dynamic behavior of protein-nano-curcumin complexes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Nan Zhang, Chaoren Yan, Changji Yin, Xiaoling Hu, Ping Guan, Yuan Cheng
Summary: Epigallocatechin-3gallate (EGCG) extracted from green tea is a promising small-molecule drug candidate for Alzheimer's disease. This study used molecular dynamics simulations and experiments to investigate the mechanism of EGCG-induced remodeling of Aβ fibrils.
Review
Food Science & Technology
Shuling Zhang, Bingyong Mao, Cui Shumao, Qiuxiang Zhang, Jianxin Zhao, Xin Tang, Wei Chen
Summary: Epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, has various bioactivities but limited bioavailability. This review discusses the absorption and metabolism of EGCG, focusing on its interactions with gut microbiota. The bioactivities of key metabolites, biotransformation by microorganisms, and catabolism by specific bacteria are also summarized. Understanding the absorption, metabolism, and biotransformation of EGCG can optimize its disease-preventive and therapeutic properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.