期刊
FOOD CHEMISTRY
卷 227, 期 -, 页码 9-15出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.01.081
关键词
Nanodispersion; Nanoparticle; Astaxanthin; Chitosan; DNA; Cellular uptake; Antioxidant
资金
- National Natural Science Foundation of China [31301420, 31571937]
- China Postdoctoral Science Foundation [2014M551965]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
DNA/chitosan co-assemblies were initially used as nanocarriers for efficient astaxanthin encapsulation and delivery. The obtained astaxanthin-loaded DNA/chitosan (ADC) colloidal system was transparent and homogenous, with astaxanthin content up to 65 mu g/ml. Compared to free astaxanthin, ADC nanoparticles with an astaxanthin concentration as low as 3.35 nM still showed a more powerful cytoprotective effect on H2O2-induced oxidative cell damage, and improved cell viability from 49.9% to 61.9%. The ROS scavenging efficiency of ADC nanoparticles was as high as 54.3%, which was 2-fold higher than that of free astaxanthin. Besides this, ADC nanoparticles were easily engulfed by Caco-2 cells in a short time, indicating that the encapsulated astaxanthin could be absorbed through endocytosis by intestinal epithelial cells. The improved antioxidation capability and facilitated cellular uptake enabled the ADC nanoparticles to be good candidates for efficient delivery and absorption of astaxanthin. (C) 2017 Elsevier Ltd. All rights reserved.
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