Article
Engineering, Environmental
Linlin Yao, Yuanyuan Wang, Jianbo Shi, Yanna Liu, Hao Guo, Xiaoxi Yang, Yaquan Liu, Junjie Ma, Danyang Li, Ziniu Wang, Zikang Li, Qian Luo, Jianjie Fu, Qinghua Zhang, Guangbo Qu, Yanxin Wang, Guibin Jiang
Summary: The study demonstrated that environmentally relevant levels of TBBPA and TBBPA-BDBPE are toxic to the liver, causing lipid metabolism imbalance and immune cell alterations, even at very low concentrations. Further investigation on the chronic effects induced by TBBPA and its derivatives is warranted.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Shuang Wang, Chenglong Ji, Fei Li, Junfei Zhan, Tao Sun, Jianhui Tang, Huifeng Wu
Summary: The study evaluated the reproductive endocrine-disrupting effects of TBBPA on mussels, showing that TBBPA treatment promotes gametogenesis and alters vertebrate sex hormone levels in mussels, while also affecting the transcription levels of SULT1E1 and STS. These findings provide new insights into assessing the impact of TBBPA and monitoring TBBPA in the marine environment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Physical
Bozena Bukowska
Summary: The study found that TCEP and TCPP only disrupted redox balance in very high concentrations, increasing ROS and methemoglobin levels and inducing morphological changes, hemolysis, and eryptosis in the studied cells. TCPP exhibited a stronger oxidative, eryptotic, and hemolytic potential than TCEP in human red blood cells. Comparing these findings with published data, it confirms a much lower toxicity of OPFRs compared to brominated flame retardants.
Article
Engineering, Environmental
Zongshan Zhao, Haimei Li, Jiaqiang Yao, Jing Lan, Yan Bao, Lining Zhao, Wansong Zong, Qing Zhang, Henner Hollert, Xingchen Zhao
Summary: This study investigated the effects of brominated flame retardant (BFR) binding and corona formation on polystyrene nanoplastics (PNs) using human serum albumin (HSA) as a model protein. HSA helped disperse PNs under physiological conditions but promoted aggregate formation in the presence of tetrabromobisphenol A (TBBPA) and S (TBBPS). The aggregates became larger and had fewer electrostatic repulsion effects at pH 4. The effects of HSA and BFR binding varied due to structural differences of TBBPA and TBBPS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Rajaganesan Ramaswamy, Siyan Zhao, Sungwoo Bae, Jianzhong He
Summary: TBBPA, a widely used brominated flame retardant, can be bioremediated by Dehalococcoides mccartyi strain CG1, leading to insights into its versatile dehalogenation capabilities and role in in situ remediation of persistent organic pollutants in the environment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Haiyan Xu, Liang Meng, Xulei Zhao, Jing Chen, Junhe Lu, Jean-Marc Chovelon, Yuefei Ji
Summary: The study showed that unactivated peroxymonosulfate effectively oxidized Tetrabromobisphenol S (TBBPS) in aqueous solution and exhibited autocatalytic behavior. The oxidation process likely began through a single electron transfer mechanism, leading to accelerated reactions catalyzed by bromine, and ultimately resulting in the formation of brominated intermediate products.
Article
Engineering, Environmental
Xuran Liu, Qi Lu, Mingting Du, Qing Xu, Dongbo Wang
Summary: TBBPA exhibits hormesis-like effects on anaerobic digestion, affecting methane production. It binds with proteins in the extracellular polymeric substances of anaerobes and induces an increase in reactive oxygen species. Different anaerobes show varied tolerance to TBBPA.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Weilong Xing, Liangchen Zhong, Wen Gu, Mengyuan Liang, Lei Wang, Zhen Wang, Lili Shi, Shuai Sun
Summary: Surface soil and river sediment samples were collected from the downstream of Chuhe River basin in East China to investigate the occurrence and accumulation characteristics of legacy and novel brominated flame retardants (NBFRs). The concentrations of BDE-209 and nine NBFRs ranged from n.d. to 41.4 ng/g dw and from 0.29 to 19.73 ng/g dw in the collected samples. BTBPE was the predominant NBFR in both soil and sediment samples. The calculated concentration ratios of the total of the nine NBFRs to BDE-209 in most of the analyzed samples exceeded 1, indicating a clear shift from legacy brominated flame retardants to NBFRs in the downstream of Chuhe River basin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Brigid Carr, Pere Masque, Carlos M. Alonso-Hernandez, David Huertas, Philippe Bersuder, Imma Tolosa
Summary: This study analyzed sediment from Cienfuegos Bay, Cuba to examine the occurrence of organic pollutants from 1990 to 2015. The results showed the presence of regulated contaminants such as PCBs, OCPs, and PBDEs, with a decline in PCB contamination since 2007. Emerging contaminants, including PAEs, OPEs, and aHFRs, showed sharp increases, possibly due to the growing global usage of flame retardants and plasticizer additives. Local sources, such as a plastic recycling plant and urban waste outfalls, may contribute to these trends. Further research is needed to understand the influx of these emerging contaminants.
Article
Chemistry, Analytical
Zijuan Peng, Mingwu Shao, Miao Yu, Boling Lu, Xingchen Zhao, Penghui Li, Shanjun Song, Qian Liu, Tao Zhou, Qinghe Zhang
Summary: A novel approach using solubility parameters as indicators for the extraction of additives in plastic products was developed and verified in various plastic materials. The results demonstrated the accuracy and feasibility of this method for field sample analysis.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Songfeng Wang, Xuan Wu, Rong Guo, Qilin Wang, Hongyan Guo, Philippe Francois-Xavier Corvini, Feifei Sun, Rong Ji
Summary: This study investigated the dissipation and metabolism of TBBPA in situ, finding that rice-wheat rotation and monocultural reed growth can accelerate the removal of TBBPA by stimulating anaerobic debromination and aerobic O-methylation, especially the oxidative skeletal cleavage pathway.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Zengze Liu, Fang Tan, Ziwei Zheng, Yanlin Liu, Yangwei Chen, Lufeng Chen, Yanqun Liu
Summary: This study developed reduced graphene oxide (rGO)-based self-propelled micromotors with manganese oxide (MnO2) nanoparticles for efficient removal of tetrabromobisphenol A (TBBPA) from water. The micromotors showed outstanding adsorption and catalytic oxidation performance due to the synergistic effect of MnO2 and rGO. After optimization of the treatment conditions, the micromotors achieved over 90% removal of TBBPA within 60 minutes at an initial concentration of 100 mg L-1. The micromotors also demonstrated good stability and reusability. The results provide a novel approach for the removal of TBBPA from aqueous solutions.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Labeeb Ali, Kaushik Sivaramakrishnan, Mohamed Shafi Kuttiyathil, Vignesh Chandrasekaran, Oday H. Ahmed, Mohammad Al-Harahsheh, Mohammednoor Altarawneh
Summary: Thermal treatment with metal oxides is a mainstream strategy for recycling bromine-contaminated polymers. By reacting with metal oxides, such as calcium hydroxide, the bromine content can be captured and pure bromine-free hydrocarbons can be produced.
Review
Environmental Sciences
Yulong Ma, William A. Stubbings, Mohamed Abou-Elwafa Abdallah, Reginald Cline-Cole, Stuart Harrad
Summary: The extensive use of HFRs and OPEs has raised concerns about their adverse effects on the environment, ecology, and human health. Emissions of these chemicals occur through mechanisms such as volatilization, abrasion, and leaching, with potential impacts on outdoor air and soil in the vicinity of waste treatment facilities. Improper waste management may contribute to contamination of HFRs and OPEs in ambient air.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Monika Jarosiewicz, Piotr Duchnowicz, Pawel Jarosiewicz, Bogumila Huras, Bozena Bukowska
Summary: Brominated flame retardants are commonly used in plastics, with TBBPA being a widely utilized compound. Due to concerns about its toxicity, TBBPS has been considered as an alternative. Research has shown that both TBBPA and TBBPS can impact the fluidity and protein conformation of the erythrocyte membrane, as well as ATP levels in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ewelina Wozniak, Edyta Reszka, Ewa Jablonska, Jaromir Michalowicz, Bogumila Huras, Bozena Bukowska
Summary: The research found that glyphosate and AMPA can alter the expression of genes related to chromatin structure in human PBMCs, with glyphosate affecting multiple genes and showing a stronger effect at lower concentrations compared to AMPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kinga Kik, Bozena Bukowska, Anita Krokosz, Paulina Sicinska
Summary: The study evaluated the effects of different diameters of polystyrene nanoparticles on oxidative stress and cell viability of human peripheral blood mononuclear cells. It showed that these nanoparticles disrupted the redox balance in cells, leading to oxidative stress and cell death. The toxicity and oxidative properties of the nanoparticles depended significantly on their diameter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Monika Jarosiewicz, Piotr Duchnowicz, Pawel Jarosiewicz, Bogumila Huras, Bozena Bukowska
Summary: Brominated flame retardants are commonly used in plastics, with TBBPA being a widely utilized compound. Due to concerns about its toxicity, TBBPS has been considered as an alternative. Research has shown that both TBBPA and TBBPS can impact the fluidity and protein conformation of the erythrocyte membrane, as well as ATP levels in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agricultural Engineering
Przemyslaw LIczbinski, Bozena Bukowska
Summary: Tea and coffee are rich in polyphenolic compounds that exhibit health-promoting properties, including antioxidant and neuroprotective effects, and can even play a role in treating covid-19 and enhancing fertility. The fermentation of tea and roasting of coffee impact the composition of polyphenols and their antioxidant properties, influencing their biological activities in the human body.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Biochemistry & Molecular Biology
Bozena Bukowska, Piotr Duchnowicz
Summary: BaP is a carcinogenic substance that induces oxidative stress through the production of reactive oxygen species and disturbance of antioxidant enzyme activity. Various chemicals, such as curcumin and vitamins, can reduce the oxidative stress induced by BaP by regulating gene expression and increasing the levels of antioxidants. These substances have the potential to protect against BaP activity.
Review
Environmental Sciences
Jaromir Michalowicz, Anna Wluka, Bozena Bukowska
Summary: This review focuses on the sources and impact of three commonly used brominated phenols in the industry, as well as their toxicity and transformation processes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Bozena Bukowska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Benzo[a]pyrene (B[a]P) is a representative polycyclic aromatic hydrocarbon (PAH) that is commonly found in the environment and human surroundings. It has been shown to have toxic effects on DNA, reproduction, neurology, and development. The metabolism of B[a]P is mediated by cytochrome P450 (CYP P450) and its polymorphism determines the sensitivity to B[a]P. Additionally, B[a]P may facilitate the replication of viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Paulina Sicinska, Ewa Jablonska, Bozena Bukowska, Aneta Balcerczyk, Edyta Reszka
Summary: This study investigated the effects of phthalates on selected epigenetic parameters in human peripheral blood mononuclear cells. The results showed that phthalates led to a significant reduction in global DNA methylation level and altered the methylation pattern and expression of key genes.
TOXICOLOGY IN VITRO
(2022)
Review
Environmental Sciences
Bozena Bukowska, Ewelina Wozniak, Paulina Sicinska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Glyphosate has been shown to induce epigenetic changes that may be associated with carcinogenesis. These changes include alterations in DNA methylation, gene expression, chromatin structure, and the regulation of non-coding RNA molecules. These epigenetic changes can persist over time and be passed on to future generations, potentially leading to the development of diseases such as prostate disease or obesity. More research is needed to fully understand the metabolic effects of these changes on organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Food Science & Technology
Bozena Bukowska, Piotr Duchnowicz, Tugba Boyunegmez Tumer, Jaromir Michalowicz, Anita Krokosz
Summary: Food quality and composition have a significant impact on human health. Harmful substances like heavy metals, pesticides, mycotoxins, and certain compounds formed during food processing can enter our bodies through food. These substances can lead to the formation of DNA adducts, which may result in mutations and the development of cancer. This paper provides an overview of precancerogens in various food products, their interaction with DNA, and the biological consequences of adduct formation. It also discusses strategies for reducing the levels of these contaminants in food.
Article
Toxicology
Kamil Pluciennik, Paulina Sicinska, Piotr Duchnowicz, Dorota Bonarska-Kujawa, Katarzyna Meczarska, Katarzyna Solarska-Sciuk, Katarzyna Milowska, Bozena Bukowska
Summary: In this study, the potential toxicity of non-functionalized polystyrene nanoparticles (PS-NPs) on human erythrocytes was evaluated. PS-NPs with different diameters (-30 nm, -45 nm, -70 nm) were found to induce haemolysis, alter the fluidity of erythrocyte membrane, and change the shape of the cells. The observed effects were dependent on the size of the nanoparticles, with the smallest PS-NPs causing the greatest haemolysis and the largest PS-NPs causing the greatest changes in erythrocyte shape and stomatocytes formation.
TOXICOLOGY IN VITRO
(2023)
Review
Biochemistry & Molecular Biology
Agata Pyrzanowska-Banasiak, Tugba Boyunegmez Tumer, Bozena Bukowska, Anita Krokosz
Summary: This article reviews the impact of GR24 strigolactone on the human body, including its anti-cancer, anti-inflammatory, antioxidant, antimicrobial, and antiviral properties. Strigolactones have versatile action and unique biological activities in relation to various mammalian cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Kinga Malinowska, Bozena Bukowska, Ireneusz Piwonski, Marek Foksinski, Aneta Kisielewska, Ewelina Zarakowska, Daniel Gackowski, Paulina Sicinska
Summary: This study investigated the genotoxic potential of non-functionalized polystyrene nanoparticles (PS-NPs) of different diameters on human peripheral blood mononuclear cells (PBMCs). The results showed that PS-NPs decreased the metabolic activity of PBMCs, increased DNA strand break formation, oxidized purines and pyrimidines, and increased 8-oxodG levels. The extent of genotoxic changes in PBMCs depended on the size of the particles and their zeta-potential value.
Article
Biochemistry & Molecular Biology
Anna Baranska, Bozena Bukowska, Jaromir Michalowicz
Summary: The study found that both TBBPA and TBBPS can induce apoptosis in human leukocytes, primarily through the mitochondrial pathway.
