期刊
FITOTERAPIA
卷 122, 期 -, 页码 16-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.08.009
关键词
Breynia nivosa; Amides; Dioxopiperazines; Cytotoxicity; Antimicrobial activity
资金
- Willmar Schwabe grant by the Society for Medicinal Plant and Natural Product Research
- Manchot Foundation
The first chemical investigation of leaves of Breynia nivosa from Nigeria resulted in the isolation of two new amide derivatives breynivosamides A and B (1 and 2) and two new dioxopiperazine derivatives breynivosines A and B (4 and 5) together with seven known compounds (3, 6-11). The structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS data as well as by comparison with the literature. All isolated compounds were tested for the cytotoxic and antimicrobial activities. Only cristatin A (6) showed cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 13.9 mu M while breynivosamide A (1) exhibited moderate antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 25 mu M.
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